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| 1 | Lactobacillus rhamnosus GG reduces hepatic TNFα production and inflammation in chronic alcohol-induced liver injury显示文摘 | Yuhua Wang Yanlong Liu Irina Kirpich Zhenhua Ma Cuiling Wang Min Zhang Jill Suttles Craig McClain Wenke Feng | 2013 | The Journal of Nutritional Biochemistry2013，，： | 4 |
| 2 | Lactobacillus rhamnosusGG culture supernatant ameliorates acute alcohol-induced intestinal permeability and liver injury显示文摘 | Yuhua Wang Yanlong Liu Anju Sidhu Zhenhua Ma Craig McClain Wenke Feng | 2012 | AJP: Gastrointestinal and Liver Physiology2012，，1： | 3 |
| 3 | Crack propagation mechanism of γ-TiAl alloy with pre-existing twin boundary显示文摘The deformation and failure mechanisms of γ-TiAl alloy with pre-existing crack and twin boundary are investigated by using molecular dynamics simulation. The effects of the crack position on the deformation and failure mechanisms of γ-TiAl specimen are analysed through the snapshots of crack propagation, microstructure of crack tip and stress-strain curves. The simulation results show that the dislocation motion is impeded, the good ductility can be maintained and the strength would be improved simultaneously by the twin boundary. The microstructure evolution of crack tip would change with crack positions. Essentially,the deformation behaviour mainly results from the reaction of dislocation-dislocation, dislocation-twin and twin-twin. Besides,the hierarchical twin is a main plastic deformation mechanism leading to strength of γ-TiAl specimen enhancement with noncompromising ductility and strain hardening. Based on stress-strain curves, it can be concluded that the yield strength varies with crack positions. They are the determinant factors for variation of the yield strength with different crack positions such as dislocation behaviour, stacking fault and hierarchical twin. The ductile-brittle transition associated with the dislocation motion and the decohesion failure of crack tip atom can be observed from the lower boundary crack and the center crack models. The crack propagation caused by the coalescent of the void and the crack tip is the main failure mechanism of γ-TiAl specimen. In addition, the results reveal that the mechanism of crack propagation would be influenced by pre-existing twin boundary which can prevent the crack propagation and improve the fracture toughness. | CAO Hui RUI ZhiYuan CHEN WenKe FENG RuiCheng YAN ChangFeng | 2019 | Science China(Technological Sciences)2019，62，9： | 2 |
| 4 | Randomized trial of autologous bone marrow mesenchymal stem cells transplantation for hepatitis B virus cirrhosis: Regulation of T reg/ T h17 cells显示文摘 | Lanman Xu Yuewen Gong Benfu Wang Keqing Shi Yijun Hou Liping Wang Zuo Lin Yixiang Han Lu Lu Dazhi Chen Xiuli Lin Qiqiang Zeng Wenke Feng Yongping Chen | 2014 | J Gastroenterol Hepatol2014，，8： | 1 |
| 5 | Clinical efficacy of Aconitum-Containing traditional Chinese medicine for diabetic peripheral neuropathic pain显示文摘 | FENG Ling LIU Wenke DENG Lan | 2014 | American Journal of Chinese Medicine2014，42，1： | 1 |
| 6 | Intramolecular photoinduced electron-transfer in azobenzeneperylene diimide显示文摘 | FENG Wenke FENG Yiyu WANG Shufeng | 2010 | Chin Phys B2010，19，11： | 1 |
| 7 | Steady-state and transient-state optical properties of a charge-transfer composite material MO-PPV/SWNTs显示文摘 | Saisai Chu Wenhui Yi Shufeng Wang Fengming Li Wenke Feng Qihuang Gong | 2007 | Chemical Physics Letters2007，，1： | 1 |
| 8 | Lactobacillus rhamnosus GG reduces hepatic TNFα production and inflammation in chronic alcohol-induced liver injury显示文摘 | Yuhua Wang Yanlong Liu Irina Kirpich Zhenhua Ma Cuiling Wang Min Zhang Jill Suttles Craig McClain Wenke Feng | 2013 | The Journal of Nutritional Biochemistry2013，，： | 1 |
| 9 | Lactobacillus rhamnosusGG culture supernatant ameliorates acute alcohol-induced intestinal permeability and liver injury显示文摘 | Yuhua Wang Yanlong Liu Anju Sidhu Zhenhua Ma Craig McClain Wenke Feng | 2012 | AJP: Gastrointestinal and Liver Physiology2012，，1： | 1 |
| 10 | Microbiome dysbiosis and alcoholic liver disease显示文摘Microbiome dysbiosis is strongly associated with alcoholic liver disease(ALD).Recent studies on comprehensive analyses of microbiome compositional and functional changes have begun to uncover the mechanistic relation between microbiome and the pathogenesis of ALD.Importantly,targeting the microbiome has become a potential strategy for the prevention and treatment of ALD.In this review,we summarize the clinical evidence of microbiome dysbiosis in ALD patients,and experimental advances in microbiome and metabolomic functional changes in animals with different species and genetic backgrounds in ALD.We also summarize the studies in humanized intestinal microbiome and fecal microbiota transplantation in mice.We introduce new developments in the studies on the role of the circulating bacterial microbiome,oral bacterial microbiome and fungal microbiome in the development of ALD.We highlight the potential mechanisms by which microbiome dysbiosis contributes to ALD,including short chain fatty acid changes,bile acid metabolism,intestinal barrier function,release of bacterial and fungal products,and inflammation.In addition,we summarize the recent developments targeting the microbiome in prevention and treatment of ALD,including dietary nutrient interference,herbal medicine,antibiotics,anti-fungal agents,probiotics,engineered bacterial therapy,fecal transplantation and oral hygiene.Although recent preclinical studies have advanced our understanding of the microbiome and ALD,clinical studies,especially prospective studies with large samples,are needed to better understand the cause-effect of microbiome dysbiosis in ALD.Identifying new precision-based strategies targeting the microbiome are expected to be developed as more effective therapies in ALD.©2019 The Third Affiliated Hospital of Sun Yat-sen University.Publishing Services by Elsevier B.V.on behalf of KeAi Communications Co.,Ltd.This is an open access article under the CC BY-NC-ND license. | Fengyuan Li Craig J.McClain Wenke Feng | 2019 | Liver Research2019，3，3： | 1 |
| 11 | Lactobacillus rhamnosus GG Treatment Potentiates Intestinal Hypoxia-Inducible Factor, Promotes Intestinal Integrity and Ameliorates Alcohol-Induced Liver Injury显示文摘 | Yuhua Wang Irina Kirpich Yanlong Liu Zhenhua Ma Shirish Barve Craig J. McClain Wenke Feng | 2011 | The American Journal of Pathology2011，，6： | 1 |
| 12 | Impairment of Autophagic Flux After Hypobaric Hypoxia Potentiates Oxidative Stress and Cognitive Function Disturbances in Mice显示文摘Acute hypobaric hypoxic brain damage is a potentially fatal high-altitude sickness.Autophagy plays a critical role in ischemic brain injury,but its role in hypo-baric hypoxia(HH)remains unknown.Here we used an HH chamber to demonstrate that acute HH exposure impairs autophagic activity in both the early and late stages of the mouse brain,and is partially responsible for HH-induced oxidative stress,neuronal loss,and brain damage.The autophagic agonist rapamycin only promotes the initiation of autophagy.By proteome analysis,a screen showed that protein dynamin2(DNM2)potentially regulates autophagic flux.Overexpression of DNM2 significantly increased the formation of autolysosomes,thus maintaining autophagic flux in combination with rapamycin.Furthermore,the enhancement of autophagic activity attenuated oxidative stress and neurological deficits after HH exposure.These results contribute to evidence supporting the conclusion that DNM2-mediated autophagic flux represents a new therapeutic target in HH-induced brain damage. | Shuhui Dai Yuan Feng Chuanhao Lu Hongchen Zhang Wenke Ma Wenyu Xie Xiuquan Wu Peng Luo Lei Zhang Fei Fei Zhou Fei Xia Li | 2024 | Neuroscience Bulletin2024，40，1： | 0 |
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