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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Derivation of the adaptive equations for thermal comfort in free-running buildings in European standard EN15251显示文摘 | Fergus N Michael H | 2010 | Building and Environment2010，45，1： | 1 |
| 3 | Developing an adaptive control algorithm for Europe 显示文摘 | MCARTNEY K J FERGUS N J | 2002 | Energy Build2002，34，62： | 1 |
| 4 | The distribution of lignin in sprueewood as determined by ultraviolet microscopy显示文摘 | FERGUS B J PROCTER A R SCOTT J A N | 1969 | Wood Science and Technology1969，3，2： | 1 |
| 5 | Adaptive thermal comfort standards in the hot- -humid tropics显示文摘 | Fergus N | 2004 | Energy and Buildings2004，36，： | 1 |
| 6 | The dialectics of thermal comfort in air- conditioned office显示文摘 | FERGUS N | 1996 | ASHRAE Trans1996，106，2： | 1 |
| 7 | Blood-brain barrierr permeability and long-term clinical and imaging outcomes in cerebral small vessel disease显示文摘 | Joanna M Wardlaw Fergus N | 2013 | Stroke2013，44，2： | 1 |
| 8 | Red clover 显示文摘 | Fergus E N Hollowell E A | 1960 | Advances in Agronomy1960，12，： | 1 |
| 9 | The distribution of lignin in sprucewood as determind by ultraviolet microscopy显示文摘 | Fergus B J Procter A R Scott J A N | 1969 | Wood Sci Technol1969，3，2： | 1 |
| 10 | Blood-brain barrier permeability and long term clinical and imaging outcomes in cerebral small vessel disease显示文摘 | Joanna M Wardlaw Fergus N Doubal Maria Valdes-Hernandez | 2013 | Stroke2013，44，2： | 1 |
| 11 | Blood-brain barrier permeability and long term clinical and imaging outcomes in cerebral small vessel disease显示文摘 | Joanna M Wardlaw Fergus N Doubal Maria Valdes-Hernandez | 2013 | Stroke2013，44，2： | 1 |
| 12 | A lpha-2 and imidazoline recepter agonists显示文摘 | Khan Z P Fergu son C N Jones R M | 1999 | Anaesthesia1999，54，2： | 1 |
| 13 | Adaptive thermal comfort standards in the hot - humid tropics显示文摘 | Fergus N | 2004 | Energy and Buildings2004，36，： | 1 |
| 14 | Bowel transition points:multiplicity and posterior location at CT are associated with small-bowel volvulus显示文摘 | Parmbir S Bonnie N Fergus V | 2007 | Radiology2007，245，： | 1 |
| 15 | Dietary cancer and prevention using antimutagens显示文摘 | FERGUS L R PHILPOTT M KARUNASINGHE N | 2004 | Toxicology2004，198，13： | 1 |
| 16 | Regulation of the Ca2+-sensitive domains of the maxi-K channel in the mouse myometrium during gestation显示文摘 | Benkusky N A Fergus D J Zucchero T M | 2000 | J Biol Chem2000，275，27： | 1 |
| 17 | Cancer‐associated fibroblasts predict poor outcome and promote periostin‐dependent invasion in oesophageal adenocarcinoma显示文摘 | Timothy J Underwood Annette L Hayden Mathieu Derouet Edwin Garcia Fergus Noble Michael J White Steve Thirdborough Abbie Mead Nicholas Clemons Massimiliano Mellone Chudy Uzoho John N Primrose Jeremy P Blaydes Gareth J Thomas | 2015 | Pathol2015，，3： | 1 |
| 18 | Comparsion of a low dose polyethylene glycol electrolyte solution with Lactulose for treatment of chronic constipation显示文摘 | Attar A Leman n M Fergus on A | 1999 | Gut1999，44，： | 1 |
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