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| 1 | 中国基层医疗二型糖尿病人中阳痿的普遍性,相互关联,患者态度和寻求治疗的行为显示文摘本研究探讨在基层医疗二型糖尿病人中,阳痿的普遍性、相互关联、患者态度和寻求治疗的行为。我们将一份结构性匿名自填问卷发放到十所普通科门诊诊所进行横断性调查。在603位参与者(91%回应率)中,以国际勃起功能指数(iief)作定义之阳痿的普遍性为79.1%。多数参与者患轻度阳痿(28.9%),随后为轻至中度阳痿(27.9%)、中度阳痿(13.4%)及严重阳痿(9%)。接近55%的阳痿患者并不自觉患有此症。少于10%的患者曾寻求医生治疗,76.1%的参与者表示若被确诊为阳痿,会期望得到医生治理。他们认为最重要的医生治理是临床评估(41.7%),其次是治理潜在因素(37.8%)、转介专科医生(27.5%)、教育(23.9%)、处方磷酸二酯酶5型抑制剂(16.9%),及转介辅导服务(6.7%)。与诊断阳痿最密切关联的因素是自觉患有阳痿(OR=90.49(20.00—409.48,P〈0.001))、以及较年长的组别(OR=1.043(1.011-1.076,P=0.008))。总体而言,阳痿在二型糖尿病人中非常普遍。其中大部分病人如患上阳痿都希望得到医生救治,但只有少数会真正提出此要求。建议医护人员使用结构性问卷筛选二型糖尿病人中的阳痿患者,有助于找出未被诊断的阳痿个案。 | Wai Hon Lo Sau Nga Fu Carlos King Ho Wong Ee San Chen | 2014 | Asian Journal of Andrology2014，16，5： | 8 |
| 2 | Current Status of Forest Medicine Research in China显示文摘In recent years,due to regional pollution and deteriorating environment,combined with intense social competition and heavier life pressure,an increasing number of people are affected by lifestyle-related diseases and remain in a state of being sub-healthy.Therefore,health issue has been receiving unprecedented attention.It is well known that the forest environment | HUANG Qing Dong WU Qing MAO Gen Xiang WANG San Ying JIA Bing Bing WANG Guo Fu | 2018 | Biomedical and Environmental Sciences2018，31，7： | 5 |
| 3 | Magnetotail dipolarization fronts and particle acceleration:A review显示文摘In this paper, the particle acceleration processes around magnetotail dipolarization fronts(DFs) were reviewed. We summarize the spacecraft observations(including Cluster, THEMIS, MMS) and numerical simulations(including MHD, testparticle, hybrid, LSK, PIC) of these processes. Specifically, we(1) introduce the properties of DFs at MHD scale, ion scale, and electron scale,(2) review the properties of suprathermal electrons with particular focus on the pitch-angle distributions,(3)define the particle-acceleration process and distinguish it from the particle-heating process,(4) identify the particle-acceleration process from spacecraft measurements of energy fluxes, and(5) quantify the acceleration efficiency and compare it with other processes in the magnetosphere(e.g., magnetic reconnection and radiation-belt acceleration processes). We focus on both the acceleration of electrons and ions(including light ions and heavy ions). Regarding electron acceleration, we introduce Fermi,betatron, and non-adiabatic acceleration mechanisms;regarding ion acceleration, we present Fermi, betatron, reflection, resonance, and non-adiabatic acceleration mechanisms. We also discuss the unsolved problems and open questions relevant to this topic, and suggest directions for future studies. | Huishan FU Elena EGRIGORENKO Christine GABRIELSE Chengming LIU San LU KJHWANG Xuzhi ZHOU Zhe WANG Fang CHEN | 2020 | Science China Earth Sciences2020，63，2： | 4 |
| 4 | Association between Vitamin D Levels and the Risk of Metabolic Syndrome in a Rural Chinese Population显示文摘Metabolic syndrome(MS)is a cluster of metabolic abnormalities that include obesity,dyslipidemia,hyperglycemia,and high blood pressure(BP)[1].Previous studies have shown that the prevalence of MS is increasing in both developing and developed countries[2].Currently,about a quarter of the adult population worldwide have MS,which has become a serious global public health problem. | SUN Hua Lei LONG Shao Rong FU San Xian CHEN Gai Yun WANG Ya Juan LIANG Rui WANG Su Fan ZHANG Li Ke ZHOU Li Wei LU Quan Jun LI Wen Jie | 2021 | Biomedical and Environmental Sciences2021，34，4： | 2 |
| 5 | Two new benzophenone glucosides from Cratoxylon cochinchinensis显示文摘二新 benzophenone 配糖物从 Cratoxylum cochinchinense 的弄干的茎的 60% 乙醇摘录被孤立。结构作为 3-O-β 被阐明; -d-glucopyranosyl-2′,4,6′-trihydroxy-benzophenone 和 3-O-β -d-glucopyranosyl-2′,5,6′-trihydroxybenzophenone 根据光谱、化学方法。 | Hai Yang Yu San Lin Jin Xue.Zhang Yuan Liu Yang Fu Ou Nai Li Wang Xin Sheng Yao | 2009 | Chinese Chemical Letters2009，20，4： | 2 |
| 6 | Import of Rift Valley fever to China:a potential new threat?显示文摘Several recent studies in Virologica Sinica and other journals have highlighted the enormous international challenge of emerging arboviral diseases,such as Zika virus disease,dengue,and chikungunya(Islam et al.,2015;Maurice et al.,2015;Dai et al.,2016;Deng et al.,2016;Song et al.,2016;Wang et al.,2016;Xu et al.,2016;Zhang et al.,2016;Zhou | Xinliang FU Lifang Wang Bo Fang Ruirui Ma Yun Zheng San Huang Pei Zhou Zongxi Cao Jin Tian Shoujun Li Guihong Zhang | 2016 | Virologica Sinica2016，31，5： | 2 |
| 7 | Efficacy of Magnifying chromoendosco Py for the differential diagnosis of colorectal lesions显示文摘 | San Y Saito Y Fu KI | 2005 | Digestive Endosco Py2005，17，2： | 1 |
| 8 | Recent advances of superhard nanocomposite coatings:a review显示文摘 | ZHANG SAN SUN DEEN FU YONGQING | 2003 | Surface and Coatings Technology2003，，167： | 1 |
| 9 | Adsorption equilibria and kinetics for phenol and cresol onto polymeric adsorbents: Effects of adsorbents/adsorbatcs structure and interface 显示文摘 | Liu Fu Qiang Xia Ming Fang Yao San Li | 2008 | Journal of Hazardous Materials2008，152，2： | 1 |
| 10 | Magnetron sputtering of nanocomposed(Ti,Cr)CN/DLC coatings显示文摘 | Zhang San Fu Yong-qing Du He-jun | 2003 | Surface and Coatings Technology2003，162，1： | 1 |
| 11 | Recent advances of superhard nanocomposite coatings: a review 显示文摘 | Zhang San Sun Deen Fu Yongqing | 2003 | Surface and Coatings Technology2003，167，： | 1 |
| 12 | The Analytical Trial Function Method (ATFM) for Finite Element Analysis of Plane Crack/Notch Problems显示文摘 | Fu Xiang Rong Cen Song Long Yu Qiu Jiang Xiu Gen Ju Jin San | 2008 | Key Engineering Materials2008，，385： | 1 |
| 13 | Neotuberostemonine and tuberostemonine ameliorate pulmonary fibrosis through suppressing TGF-β and SDF-1 secreted by macrophages and fibroblasts via the PI3K-dependent AKT and ERKpathways显示文摘Activated fibroblasts and M2-polarized macrophages may contribute to the progression of pulmonary fibrosis by forming a positive feedback loop.This study was aimed to investigate whether fibroblasts and macrophages form this loop by secreting SDF-1 and TGF-β and the impacts of neotuberostemonine(NTS)and tuberostemonine(TS).Mice were intratracheally injected with 3 U·kg^(-1)bleomycin and orally administered with 30 mg·kg^(-1)NTS or TS.Primary pulmonary fibroblasts(PFBs)and MH-S cells(alveolar macrophages)were used in vitro.The animal experiments showed that NTS and TS improved fibrosis related indicators,inhibited fibroblast activation and macrophage M2 polarization,and reduced the levels of TGF-β and SDF-1 in alveolar lavage fluid.Cell experiments showed that TGF-β1 may activated fibroblasts into myofibroblasts secreting SDF-1 by activating the PI3K/AKT/HIF-1αand PI3K/PAK/RAF/ERK/HIF-1αpathways.It was also found for the first time that SDF-1 was able to directly polarize macrophages into M2 phenotype secreting TGF-β through the same pathways as mentioned above.Moreover,the results of the cell coculture confirmed that fibroblasts and macrophages actually developed a feedback loop to promote fibrosis,and the secretion of TGF-β and SDF-1 was crucial for maintaining this loop.NTS and TS may disturb this loop through inhibiting both the PI3K/AKT/HIF-1αand PI3K/PAK/RAF/ERK/HIF-1α pathways to improve pulmonary fibrosis.NTS and TS are stereoisomeric alkaloids with pyrrole[1,2-ajazapine skeleton,and their effect on improving pulmonary fibrosis may be largely attributed to their parent nucleus.Moreover,this study found that inhibition of both the AKT and ERK pathways is essential for maximizing the improvement of pulmonary fibrosis. | FU San SONG Xianrui HU Yingying ZHU Qingwei LV Xinmiao TANG Xiaoyan ZHANG Mian | 2023 | Chinese Journal of Natural Medicines2023，21，7： | 0 |
| 14 | A novel approach for the prevention of ionizing radiation-induced bone loss using a designer multifunctional cerium oxide nanozyme显示文摘The disability,mortality and costs due to ionizing radiation(IR)-induced osteoporotic bone fractures are sub-stantial and no effective therapy exists.Ionizing radiation increases cellular oxidative damage,causing an imbalance in bone turnover that is primarily driven via heightened activity of the bone-resorbing osteoclast.We demonstrate that rats exposed to sublethal levels of IR develop fragile,osteoporotic bone.At reactive surface sites,cerium ions have the ability to easily undergo redox cycling:drastically adjusting their electronic con-figurations and versatile catalytic activities.These properties make cerium oxide nanomaterials fascinating.We show that an engineered artificial nanozyme composed of cerium oxide,and designed to possess a higher fraction of trivalent(Ce^(3+))surface sites,mitigates the IR-induced loss in bone area,bone architecture,and strength.These investigations also demonstrate that our nanozyme furnishes several mechanistic avenues of protection and selectively targets highly damaging reactive oxygen species,protecting the rats against IR-induced DNA damage,cellular senescence,and elevated osteoclastic activity in vitro and in vivo.Further,we reveal that our nanozyme is a previously unreported key regulator of osteoclast formation derived from macrophages while also directly targeting bone progenitor cells,favoring new bone formation despite its exposure to harmful levels of IR in vitro.These findings open a new approach for the specific prevention of IR-induced bone loss using synthesis-mediated designer multifunctional nanomaterials. | Fei Wei Craig J.Neal Tamil Selvan Sakthivel Yifei Fu Mahmoud Omer Amitava Adhikary Samuel Ward Khoa Minh Ta Samuel Moxon Marco Molinari Jackson Asiatico Michael Kinzel Sergey N.Yarmolenko Vee San Cheong Nina Orlovskaya Ranajay Ghosh Sudipta Seal Melanie Coathup | 2023 | Bioactive Materials2023，，3： | 0 |
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