5篇
您的检索式：作者名="Fajian Hou"
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| 1 | Reconstitution of the RIG-I Pathway Reveals a Signaling Role of Unanchored Polyubiquitin Chains in Innate Immunity显示文摘 | Wenwen Zeng Lijun Sun Xiaomo Jiang Xiang Chen Fajian Hou Anirban Adhikari Ming Xu Zhijian J. Chen | 2010 | Cell2010，，2： | 1 |
| 2 | SARS-CoV-2 infection and the antiviral innate immune response显示文摘The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)outbreak be-gan in December 2019,causing the illness known as the novel coronavirus disease 2019(COVID-19).The virus spread rapidly worldwide to become a global public health emergency.As of November 15,2020,more than 53 million confirmed cases and over 1 million deaths worldwide have been reported(World Health Organization,2020). | Hui Yang Yingying Lyu Fajian Hou | 2020 | Journal of Molecular Cell Biology2020，12，12： | 1 |
| 3 | Phosphorylation by Double-Time/CKIε and CKIα Targets Cubitus Interruptus for Slimb/β-TRCP-Mediated Proteolytic Processing显示文摘 | Jianhang Jia Lei Zhang Qing Zhang Chao Tong Bing Wang Fajian Hou Kazuhito Amanai Jin Jiang | 2005 | Developmental Cell2005，，6： | 1 |
| 4 | FBXO38 regulates macrophage polarization to control the development of cancer and colitis显示文摘Macrophages are highly plastic cells that differentially regulate multiple pathological conditions,including cancer and autoimmune diseases.In response to various stimuli,macrophages activate different intrinsic signaling pathways and polarize into distinct macrophage subsets.We aimed to identify key new effectors that could control macrophage polarization and impact the development of cancer or colitis.Following treatment with the supernatants of tumor cells,macrophages showed an upregulation in Fbxo38 expression.Subsequently,we further identified that FBXO38 promotes macrophage immunosuppressive function by upregulating the expression of M2-like genes via MAPK and IRF4 signaling without affecting M1-like macrophage polarization.Deletion of Fbxo38 in macrophages was found to block tumor development and protect against DSS-induced colitis.Considering the distinct regulation of tumor development by FBXO38 in T cells and macrophages,we suggest that a comprehensive understanding of FBXO38 function in different cell types is critical for its further translational usage. | Xin Zheng Qi Jiang Mingshun Han Fenfen Ye Mingchang Wang Ying Qiu Jialu Wang Minxia Gao Fajian Hou Hongyan Wang | 2023 | Cellular & Molecular Immunology2023，20，11： | 0 |
| 5 | Research on the Corrosion of J55 Steel Due to Oxygen-Reducing Air Flooding in Low-Permeability Reservoirs显示文摘Oxygen-reducing air flooding is a low-permeability reservoir recovery technology with safety and low-cost advantages.However,in the process of air injection and drive,carbon in the air is oxidized through the crude oil reservoir to generate CO_(2),and this can cause serious corrosion in the recovery well.In this study,experiments on the corrosion of J55 tubular steel in a fluid environment with coexisting O_(2)and CO_(2)in an autoclave are presented.In particular,a weight loss method and a 3D morphometer were used to determine the average and the local corrosion rate.The corrosion surface morphology and composition were also measured by means of scanning electron microscopy(SEM)and an X-ray diffractometer(XRD).The corrosion pattern and morphological characteristics of J55 steel were analyzed in the O2/CO_(2)environment for different degrees of oxygen-reduction.As made evident by the experimental results,the corrosion products were mainly ferrous carbonate and iron oxide.In general,air injection increases the degree of oxygen reduction,from oxygen corrosion characteristics to CO_(2)corrosion-based characteristics.As a result,the corrosion product film becomes denser,and the corrosion rate is lower. | Liang Wang Baofeng Hou Yanming Fang Jintao Zhang Fajian Nie | 2023 | Fluid Dynamics & Materials Processing2023，19，7： | 0 |
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