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| 1 | Management of lumbar zygapophysial (facet) joint pain显示文摘AIM: To investigate the diagnostic validity and therapeutic value of lumbar facet joint interventions in managing chronic low back pain.METHODS: The review process applied systematic evidence-based assessment methodology of controlled trials of diagnostic validity and randomized controlled trials of therapeutic efficacy. Inclusion criteria encompassed all facet joint interventions performed in a controlled fashion. The pain relief of greater than 50% was the outcome measure for diagnostic accuracy assessment of the controlled studies with ability to perform previously painful movements, whereas, for randomized controlled therapeutic efficacy studies, the primary outcome was significant pain relief and the secondary outcome was a positive change in functional status. For the inclusion of the diagnostic controlled studies, all studies must have utilized either placebo controlled facet joint blocks or comparative local anesthetic blocks. In assessing therapeutic interventions, short-term and long-term reliefs were defined as either up to 6 mo or greater than 6 mo of relief. The literature search was extensive utilizing various types of electronic search media including Pub Med from 1966 onwards, Cochrane library, National Guideline Clearinghouse, clinicaltrials.gov, along with other sources includingprevious systematic reviews, non-indexed journals, and abstracts until March 2015. Each manuscript included in the assessment was assessed for methodologic quality or risk of bias assessment utilizing the Quality Appraisal of Reliability Studies checklist for diagnostic interventions, and Cochrane review criteria and the Interventional Pain Management Techniques- Quality Appraisal of Reliability and Risk of Bias Assessment tool for therapeutic interventions. Evidence based on the review of the systematic assessment of controlled studies was graded utilizing a modified schema of qualitative evidence with best evidence synthesis, variable from level Ⅰ to level Ⅴ.RESULTS: Across all databases, 16 high quality diagnostic accuracy studies were identified. In addition, multiple studies assessed the influence of multiple factors on diagnostic validity. In contrast to diagnostic validity studies, therapeutic efficacy trials were limited to a total of 14 randomized controlled trials, assessing the efficacy of intraarticular injections, facet or zygapophysial joint nerve blocks, and radiofrequency neurotomy of the innervation of the facet joints. The evidence for the diagnostic validity of lumbar facet joint nerve blocks with at least 75% pain relief with ability to perform previously painful movements was level Ⅰ, based on a range of level Ⅰ to Ⅴ derived from a best evidence synthesis. For therapeutic interventions, the evidence was variable from level Ⅱ to Ⅲ, with level Ⅱ evidence for lumbar facet joint nerve blocks and radiofrequency neurotomy for long-term improvement(greater than 6 mo), and level Ⅲ evidence for lumbosacral zygapophysial joint injections for short-term improvement only.CONCLUSION: This review provides significant evidence for the diagnostic validity of facet joint nerve blocks, and moderate evidence for therapeutic radiofrequency neurotomy and therapeutic facet joint nerve blocks in managing chronic low back pain. | Laxmaiah Manchikanti Joshua A Hirsch Frank JE Falco Mark V Boswell | 2016 | World Journal of Orthopedics2016，7，5： | 9 |
| 2 | Melphalan,prednisone,and lenalidomide treatment for newly diagnosed myeloma:a report from the GIMEMA Italian multiple myeloma network显示文摘 | Palumbo A Falco P Corradini P | 2007 | J Clin Oncol2007，25，28： | 1 |
| 3 | SDF-1 involvement in endothelial phenotype and ischemia-induced recruitment of bone marrow progenitor cells显示文摘 | De Falco E Porcelli D Torella AR Straino S Iachininoto MG Orlandi A | 2004 | Blood2004，104，12： | 1 |
| 4 | Agrobiodiversi- ty, farm profits and land fragmentation: Evidence from Bulgar- ia显示文摘 | FALCO S D PENOV I ALEKSIEV A | 2010 | Land Use Policy2010，27，3： | 1 |
| 5 | Accuracy of High-Resolusion CT in Distinguishing between Pneumocystis Carinii Pneumonia and Non-Pneumocystis Carinii Pneumonia in AIDS Patients显示文摘 | Hidalgo A Falco V Mauleon S | 2003 | Eur Radiol2003，13，5： | 1 |
| 6 | Platelet activation in type 2 diabetes mellitus 显示文摘 | Ferroni P Basili S Falco A | 2004 | Thromb Haemost2004，2，8： | 1 |
| 7 | Accuracy of High-Resolution CT i n Distinguishing between Pneumocystis Carinii Pneumonia and Non-Pneumocystis Carinii Pneumonia in AIDS Patients 显示文摘 | Hidalgo A Falco V Mauleon S | 2003 | Eur Radiol2003，13，5： | 1 |
| 8 | Simple method for low colorectal anastomosis with the double stapling technique显示文摘 | Falco E Celoria G Nardini A | 1995 | Br J Surg1995，82，： | 1 |
| 9 | Clinical response,vascular change,and angiogenesis in gonadotropin-releasing hormone analogue-treated women with uterine myomas显示文摘 | Di Lieto A De Falco M Pollio F | 2005 | J Soc Gynecol Investig2005，12，2： | 1 |
| 10 | Calibration transfer in chemiluminescence analysis application to chromium determination by luminol-hydrogen peroxide reaction显示文摘 | TORTAJADA L A FALCO P C REIG F B | 2001 | Analytica Chimica Acta2001，446，： | 1 |
| 11 | The human counterpart of zebrafish shiraz shows sideroblastic-like microcytic anemia and iron overload 显示文摘 | Camaschella C Campanella A De Falco L | 2007 | Blood2007，110，4： | 1 |
| 12 | Vortex shedding and wake-induced vibrations in single and bundle cables 显示文摘 | Cigada A Diana G Falco M | 1997 | Journal of Wind Engineering and Industrial Aerodynamics1997，72，123： | 1 |
| 13 | Urine polyamines determinition using dansyl chloride derivatization in soilidphase ex- traction cartridges and HPLC 显示文摘 | LEGUA C M FALCO P C CABEZA A S | 1999 | Analyst1999，124，： | 1 |
| 14 | Lipoprotein(a) in young individuals as a marker of the presence of ischemich eart disease and the severity of coronary lesions显示文摘 | Zorio E Falco C Arnau M A | 2006 | Haemato logica2006，91，4： | 1 |
| 15 | Posterior fossa vestibular neurotomy as primary surgical treatment of Meniere's disease: a re-evaluation 显示文摘 | PARESCHI R DESTITO D FALCO RAUCCI A | 2006 | J Laryngol Otol2006，116，13： | 1 |
| 16 | Cytostatic activity of adenosine triphosphate-competitive kinase inhibitors in BRAF mutant thyroid carcinoma cells显示文摘 | Salerno P De Falco V Tamburrino A | 2010 | J Clin Endocrinol Metab2010，95，1： | 1 |
| 17 | Isoprostane formation and inhibition in atherothrombosis显示文摘 | PATRONO C FALCO A DAVI G | 2005 | Curr Opin Pharmacol2005，5，： | 1 |
| 18 | Platelet activation in type 2 diabetes mellitus显示文摘 | Ferroni P Basili S Falco A | 2004 | Thromb Haemost2004，2，8： | 1 |
| 19 | Two cases of misinterpretation of molecular results in incontinentia pigmenti, and a PCR-based method to discriminate NEMO/IKKgamma gene deletion显示文摘 | Bardaro T Falco G Sparago A | 2003 | Hum Mutat2003，21，1： | 1 |
| 20 | Transabdominal sonography of the eavum septum pellueidum in normal fetuses in the second and third trimesters of pregnaney显示文摘 | Falco P Gabrielli S Visentin A | 2000 | Ultrasound Obstet Gyneeol2000，16，6： | 1 |
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