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| 1 | Lower extremity amputations and long-term outcomes in diabetic foot ulcers:A systematic review显示文摘BACKGROUNDDiabetes mellitus causes a large majority of non-traumatic major and minoramputations globally. Patients with diabetes are clinically complex with amultifactorial association between diabetic foot ulcers (DFU) and subsequentlower extremity amputations (LEA). Few studies show the long-term outcomeswithin the cohort of DFU-associated LEA.AIMTo highlight the long-term outcomes of LEA as a result of DFU.METHODSPubMed/MEDLINE and Google Scholar were searched for key terms, “diabetes”,“foot ulcers”, “amputations” and “outcomes”. Outcomes such as mortality, reamputation,re-ulceration and functional impact were recorded. Peer-reviewedstudies with adult patients who had DFU, subsequent amputation and follow upof at least 1 year were included. Non-English language articles or studiesinvolving children were excluded.RESULTSA total of 22 publications with a total of 2334 patients were selected against theinclusion criteria for review. The weighted mean of re-amputation was 20.14%,29.63% and 45.72% at 1, 3 and 5 years respectively. The weighted mean of mortality at 1, 3 and 5 years were 13.62%, 30.25% and 50.55% respectively withsignificantly higher rates associated with major amputation, re-amputation andischemic cardiomyopathy.CONCLUSIONPrevious LEA, level of the LEA and patient comorbidities were significant riskfactors contributing to re-ulceration, re-amputation, mortality and depreciatedfunctional status. | Ayeshmanthe Rathnayake Apoorva Saboo Usman H Malabu Henrik Falhammar | 2020 | World Journal of Diabetes2020，11，9： | 3 |
| 2 | Relationship between depression and diabetes in pregnancy: A systematic review显示文摘AIM To systematically review the literature on women with both diabetes in pregnancy(DIP) and depression during or after pregnancy. METHODS In this systematic literature review, PubM ed/MEDLINE and EMBASE were searched(13 November 2015) using terms for diabetes(type 1, type 2, or gestational), depression, and pregnancy(no language or date restrictions). Publications that reported on women who had both DIP(any type) and depression or depressive symptoms before, during, or within one year after pregnancy were considered for inclusion. All study types were eligible for inclusion; conference abstracts, narrative reviews, nonclinical letters, editorials, and commentaries were excluded, unless they provided treatment guidance.RESULTS Of 1189 articles identified, 48 articles describing women with both DIP and depression were included(sample sizes 36 to > 32 million). Overall study quality was poor; most studies were observational, and only 12 studies(mostly retrospective database studies) required clinical depression diagnosis. The prevalence of concurrent DIP(any type) and depression in general populations of pregnant women ranged from 0% to 1.6%(median 0.61%; 12 studies). The prevalence of depression among women with gestational diabetes ranged from 4.1% to 80%(median 14.7%; 16 studies). Many studies examined whether DIP was a risk factor for depression or depression was a risk factor for DIP. However, there was no clear consensus for either relationship. Importantly, we found limited guidance on the management of women with both DIP and depression. CONCLUSION Given the increasing prevalence of diabetes and depression, high-quality research and specific guidance for management of pregnant women with both conditions are warranted. | Glynis P Ross Henrik Falhammar Roger Chen Helen Barraclough Ole Kleivenes Ian Gallen | 2016 | World Journal of Diabetes2016，7，19： | 3 |
| 3 | Pregnancy and neonatal outcomes in Indigenous Australians with diabetes in pregnancy显示文摘AIM: To perform a systematic review of reported neonatal and pregnancy outcomes of Indigenous Australians with diabetes in pregnancy(DIP).METHODS: Electronic searches of Pub Med and Web of Science were carried out. Articles were selected if they contained original data on DIP outcomes in Indigenous Australians. There were no specific exclusion criteria.RESULTS: A total of eight articles, predominantly from Queensland and Western Australia were identified once inclusion criteria were applied. Birth data from midwifery registries or paper charts encompassing years 1985-2008 were used. A total of 465591 pregnant women with and without DIP were included in the eight studies, with 1363 being Indigenous women with DIP. Indigenous Australians experienced increased rates of many known adverse outcomes of DIP including: macrosomia, caesarean section, congenital deformities, low birth weight, hypoglycaemia, and neonatal trauma. There were regional differences among Indigenous Australians, particularly regional/remote vs metropolitan populations where the regional/remote data showed worse outcomes. Two of the articles did not note a difference between Aboriginals and Caucasians in the rates of measured adverse outcome. Studies varied significantly in size, measured outcomes, and subsequent analysis.CONCLUSION: The health disparities between Indigenous Australians and non-Indigenous Australians are further evidenced by poorer outcomes in DIP. This has broader implications for Indigenous health in general. | Victor Duong Bronwyn Davis Henrik Falhammar | 2015 | World Journal of Diabetes2015，6，6： | 2 |
| 4 | Fertility, sexuality and testicular adrenal rest tumors in adult males with congenital adrenal hyperplasia显示文摘 | Falhammar H Nystrom HF Ekstrom U | 2012 | Eur Endo- crinol2012，166，3： | 1 |
| 5 | Sub- optimal psyehosoeial outcomes in patients with congenital adrenal hyperplasia: epidemiological studies in a nonbi- ased national cohort in Sweden 显示文摘 | Strandqvist A Falhammar H Lichtenstein P | 2014 | Clin Endocrinol Metab2014，99，4： | 1 |
| 6 | One hundred years of congenital adrenal hyperplasia in Sweden: a retrospective, population-based cohort study 显示文摘 | Gidl6f S Falhammar H Thil6n A | 2015 | Lancet Diabetes Endocrinol2015，1，1： | 1 |
| 7 | Increased mor- tality in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency 显示文摘 | Falhammar H Fris6n L Norrby C | 2014 | J Clin Endocrinol Metab2014，99，12： | 1 |
| 8 | One hundred years of congenital adrenal hyperplasia in Sweden : a ret- rospective, population-based cohort study 显示文摘 | Gidlof S Falhammar H Thilen A | 2013 | Lancet Di- abetes Endocrino12013，1，34： | 1 |
| 9 | Epigenetie analyses of the insulin-like growth factor binding protein 1 gene in type 1 diabetes and diabetic nephropathy显示文摘 | GU T FALHAMMAR H GU H F et ol | 2014 | Clinical Epigenet- ics2014，6，： | 1 |
| 10 | Thyrotoxic periodic paralysis: clinical and molecular aspects显示文摘 | Falhammar H Thor6n M Calissendorff J | 2012 | J Endocrine2012，43，2： | 1 |
| 11 | Thyrotoxic periodic pa-ralysis: clinical and molecular aspects显示文摘 | Falhammar H Thor佴n M Calissendorff J | 2013 | Endocrine2013，43，2： | 1 |
| 12 | Increased mortality in pa- tients with congenital adrenal hyperplasia due to 21-hydroxylase defi- ciency显示文摘 | Falhammar H Fris6n L Norrby C | 2014 | J Clin Endocrinol Metab2014，99，12： | 1 |
| 13 | Clinical outcomes in the management of congenital adrenal hyperplasia显示文摘 | Henrik Falhammar Marja Thorén | 2012 | Endocrine2012，，3： | 1 |
| 14 | Genetic association analysis of the adiponectin polymorphisms in type 1 diabetes with and without diabetic nephropathy显示文摘 | Ma J Mollsten A Falhammar H | 2007 | Diabetes Complications2007，21，1： | 1 |
| 15 | Genetic association analysis of the ediponectin polymorphisms in type 1 diabetes with and without diabetic nephropathy显示文摘 | Ma J Mollsten A Falhammar H | | 0，，： | 1 |
| 16 | Sexual func- tion and surgical outcome in women with congenital adrenal hy- perplasia due to CYP21A2 deficiency: clinical perspective and the patients' perception 显示文摘 | Nordenstrom A Frisen L Falhammar H | 2010 | J Clin Endocrinol Metab2010，95，8： | 1 |
| 17 | Increased mortality in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency显示文摘 | Falhammar H Fris6n L Norrby C | 2014 | J Clin Endocrinol Metab2014，99，12： | 1 |
| 18 | Genetic association analysis of the adiponectin polymorphisms in type 1 diabetes with and without diabetic nephropathy显示文摘 | Ma J M(o)llsten A Falhammar H | 2007 | Journal of Diabetes and Its Complications2007，21，1： | 1 |
| 19 | A 31-year- old woman with infertility and polycystic ovaries diagnosed with non-classic congenital adrenal hyperplasia due to a novel CYP21 mutation 显示文摘 | FALHAMMAR H THOR~N M HAGENFELDT K | 2008 | J Endocrinol Invest2008，31，2： | 1 |
| 20 | Genetic association analysis of the adiponectin polymorphisms in type 1 diabetes with and without diabetic nephropathy显示文摘 | Ma J Mollsten A Falhammar H | 2007 | J Diabetes Complications2007，21，1： | 1 |
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