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| 1 | Lower extremity amputations and long-term outcomes in diabetic foot ulcers:A systematic review显示文摘BACKGROUNDDiabetes mellitus causes a large majority of non-traumatic major and minoramputations globally. Patients with diabetes are clinically complex with amultifactorial association between diabetic foot ulcers (DFU) and subsequentlower extremity amputations (LEA). Few studies show the long-term outcomeswithin the cohort of DFU-associated LEA.AIMTo highlight the long-term outcomes of LEA as a result of DFU.METHODSPubMed/MEDLINE and Google Scholar were searched for key terms, “diabetes”,“foot ulcers”, “amputations” and “outcomes”. Outcomes such as mortality, reamputation,re-ulceration and functional impact were recorded. Peer-reviewedstudies with adult patients who had DFU, subsequent amputation and follow upof at least 1 year were included. Non-English language articles or studiesinvolving children were excluded.RESULTSA total of 22 publications with a total of 2334 patients were selected against theinclusion criteria for review. The weighted mean of re-amputation was 20.14%,29.63% and 45.72% at 1, 3 and 5 years respectively. The weighted mean of mortality at 1, 3 and 5 years were 13.62%, 30.25% and 50.55% respectively withsignificantly higher rates associated with major amputation, re-amputation andischemic cardiomyopathy.CONCLUSIONPrevious LEA, level of the LEA and patient comorbidities were significant riskfactors contributing to re-ulceration, re-amputation, mortality and depreciatedfunctional status. | Ayeshmanthe Rathnayake Apoorva Saboo Usman H Malabu Henrik Falhammar | 2020 | World Journal of Diabetes2020，11，9： | 3 |
| 2 | Fertility, sexuality and testicular adrenal rest tumors in adult males with congenital adrenal hyperplasia显示文摘 | Falhammar H Nystrom HF Ekstrom U | 2012 | Eur Endo- crinol2012，166，3： | 1 |
| 3 | Sub- optimal psyehosoeial outcomes in patients with congenital adrenal hyperplasia: epidemiological studies in a nonbi- ased national cohort in Sweden 显示文摘 | Strandqvist A Falhammar H Lichtenstein P | 2014 | Clin Endocrinol Metab2014，99，4： | 1 |
| 4 | One hundred years of congenital adrenal hyperplasia in Sweden: a retrospective, population-based cohort study 显示文摘 | Gidl6f S Falhammar H Thil6n A | 2015 | Lancet Diabetes Endocrinol2015，1，1： | 1 |
| 5 | Increased mor- tality in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency 显示文摘 | Falhammar H Fris6n L Norrby C | 2014 | J Clin Endocrinol Metab2014，99，12： | 1 |
| 6 | One hundred years of congenital adrenal hyperplasia in Sweden : a ret- rospective, population-based cohort study 显示文摘 | Gidlof S Falhammar H Thilen A | 2013 | Lancet Di- abetes Endocrino12013，1，34： | 1 |
| 7 | Epigenetie analyses of the insulin-like growth factor binding protein 1 gene in type 1 diabetes and diabetic nephropathy显示文摘 | GU T FALHAMMAR H GU H F et ol | 2014 | Clinical Epigenet- ics2014，6，： | 1 |
| 8 | Thyrotoxic periodic paralysis: clinical and molecular aspects显示文摘 | Falhammar H Thor6n M Calissendorff J | 2012 | J Endocrine2012，43，2： | 1 |
| 9 | Thyrotoxic periodic pa-ralysis: clinical and molecular aspects显示文摘 | Falhammar H Thor佴n M Calissendorff J | 2013 | Endocrine2013，43，2： | 1 |
| 10 | Increased mortality in pa- tients with congenital adrenal hyperplasia due to 21-hydroxylase defi- ciency显示文摘 | Falhammar H Fris6n L Norrby C | 2014 | J Clin Endocrinol Metab2014，99，12： | 1 |
| 11 | Genetic association analysis of the adiponectin polymorphisms in type 1 diabetes with and without diabetic nephropathy显示文摘 | Ma J Mollsten A Falhammar H | 2007 | Diabetes Complications2007，21，1： | 1 |
| 12 | Genetic association analysis of the ediponectin polymorphisms in type 1 diabetes with and without diabetic nephropathy显示文摘 | Ma J Mollsten A Falhammar H | | 0，，： | 1 |
| 13 | Sexual func- tion and surgical outcome in women with congenital adrenal hy- perplasia due to CYP21A2 deficiency: clinical perspective and the patients' perception 显示文摘 | Nordenstrom A Frisen L Falhammar H | 2010 | J Clin Endocrinol Metab2010，95，8： | 1 |
| 14 | Increased mortality in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency显示文摘 | Falhammar H Fris6n L Norrby C | 2014 | J Clin Endocrinol Metab2014，99，12： | 1 |
| 15 | Genetic association analysis of the adiponectin polymorphisms in type 1 diabetes with and without diabetic nephropathy显示文摘 | Ma J M(o)llsten A Falhammar H | 2007 | Journal of Diabetes and Its Complications2007，21，1： | 1 |
| 16 | A 31-year- old woman with infertility and polycystic ovaries diagnosed with non-classic congenital adrenal hyperplasia due to a novel CYP21 mutation 显示文摘 | FALHAMMAR H THOR~N M HAGENFELDT K | 2008 | J Endocrinol Invest2008，31，2： | 1 |
| 17 | Genetic association analysis of the adiponectin polymorphisms in type 1 diabetes with and without diabetic nephropathy显示文摘 | Ma J Mollsten A Falhammar H | 2007 | J Diabetes Complications2007，21，1： | 1 |
| 18 | Sexual function and surgical outcome in women with congenital adrenal hyperplasia due to CYP21 A2 deficiency:clinical perspective and the patients' perception显示文摘 | Nordenstr6m A Fris6n L Falhammar H | 2010 | J Clin Endocrinol Metab2010，95，8： | 1 |
| 19 | Genetic association analysis of the adiponectin polymorphisms in type 1 diabetes with and without diabetic nephropathy显示文摘 | Ma J Mfllsten A Falhammar H | 2007 | J Diabetes Complications2007，21，： | 1 |
| 20 | Non-classic congenital adrenal hyperplasia due to 21-hydoxylase deficiency as a cause of infertility and miscarriages 显示文摘 | Falhammar H | 2010 | N Z M ed2010，123，1312： | 1 |
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