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| 1 | NUMB maintains bone mass by promoting degradation of PTEN and GLI1 via ubiquitination in osteoblasts显示文摘The adaptor protein NUMB is involved in asymmetric division and cell fate determination and recognized as an antagonist of Notch.Previous studies have proved that Notch activation in osteoblasts contributes to a high bone mass. In this study, however, an osteopenic phenotype was found in 9-week-old mice using osteoblastic specific Col1a1–2.3-Cre to ablate both Numb and its homologue Numbl. The trabecular bone mass decreased dramatically while the cortical bone mass was unaffected. Here, the Notch signal was not activated,while the tensin homologue deleted on human chromosome 10(PTEN), which dephosphorylates phosphatidylinositide 3-kinases, was elevated, attenuating protein kinase B(Akt). The ubiquitination assay revealed that NUMB may physiologically promote PTEN ubiquitination in the presence of neural precursor cell-expressed developmentally downregulated protein 4–1. In addition, the deficiency of Numb/Numbl also activated the Hedgehog pathway through GLI1. This process was found to improve the ratio of the receptor activator of nuclear factor-k B ligand to osteoprotegerin, which enhanced the differentiation of osteoclasts and bone resorption. In conclusion, this study provides an insight into new functons of NUMB and NUMBL on bone homeostasis. | Ling Ye Feng Lou Fanyuan Yu Demao Zhang Chenglin Wang Fanzi Wu Xin Li Yilin Ping Xiao Yang Jing Yang Dian Chen Bo Gao Dingming Huang Peng Liu | 2018 | Bone Research2018，6，4： | 3 |
| 2 | Distributed compressivespectrum sensing in cooperative multihop cognitive networks显示文摘 | Fanzi Z Li C Tian Z | 2011 | IEEE Journal of Selected Topics in Signal Processing2011，5，1： | 1 |
| 3 | Distributed Compres- sive Spectrum Sensing in Cooperative Multihop Cognitive Networks 显示文摘 | FANZI Z CHEN L ZHI T | 2011 | Selected Topics in Signal Processing IEEE Journal of2011，5，1： | 1 |
| 4 | Evaluating and im-proving wireless local area networks performance 显示文摘 | Raore Soungalo Li Renfa Zeng Fanzi | 2011 | In-ternational Journal of Advancements in Computing Tech-nology2011，3，2： | 1 |
| 5 | Distributed compressive spectrum sensing in cooperative multi-hop wideband cognitive networks 显示文摘 | Fanzi Z Chen L Tian Z | 2011 | IEEE Transactions on Signal Processing2011，5，1： | 1 |
| 6 | Distributed Compressive Spectrum Sensing in Cooperative Multi-hop Wideband Cognitive Networks 显示文摘 | Fanzi Z Chen L Tian Z | 2011 | IEEE Transactions on Signal Processing2011，5，1： | 1 |
| 7 | Distributed compres- sive spectrum sensing in cooperative muhihop cognitive networks 显示文摘 | Fanzi Zeng Chen Li and Zhi Tian | 2011 | IEEE Journal of Selected Topics on Signal Processing2011，5，1： | 1 |
| 8 | High temperature capture of CO 2 on lithium-based sorbents from rice husk ash显示文摘 | Ke Wang Xin Guo Pengfei Zhao Fanzi Wang Chuguang Zheng | 2011 | Journal of Hazardous Materials2011，，1： | 1 |
| 9 | Evaluating andimproving wireless local area networks performance显示文摘 | Traore Soungalo Li Renfa Zeng Fanzi | 2011 | IJACT2011，3，2： | 1 |
| 10 | Controlledp-andn-typedopingofFe2O3 nanobeltfieldeffecttransistors显示文摘 | FanZY WenXG YangSH etal | 2005 | AppliedPhysicsLetters2005，87，01： | 1 |
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