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| 1 | Pulmonary infection control window in treatment of severe respiratory failure of chronic obstructive pulmonary diseases: a prospective, randomized controlled, multi-centred study显示文摘Background Early withdraw from invasive mechanical ventilation (MV) followed by noninvasive MV is a new strategy for changing modes of treatment. This study was conducted to estimate the feasibility and the efficacy of early extubation and sequential noninvasive MV commenced at beginning of pulmonary infection control window in patients with exacerbated hypercapnic respiratory failure caused by chronic obstructive pulmonary diseases (COPD). Methods A prospective, randomized controlled study was conducted in eleven teaching hospitals' respiratory or medical intensive care units in China. Ninety intubated COPD patients with severe hypercapnic respiratory failure triggered by pulmonary infection (pneumonia or purulent bronchitis) were involved in the study. When the pulmonary infection had been controlled by antibiotics and comprehensive therapy, the 'pulmonary infection control window (PIC window)' has been reached. Each case was randomly assigned to study group (extubation and noninvasive MV via facial mask immediately) or control group (invasive MV was received continuously after PIC window by using conventional weaning technique).Results Study group (n=47) and control group (n=43) had similar clinical characteristics initially and at the time of PIC window. Compared with control group, study group had shorter duration of invasive MV [(6.4±4.4) days vs (11.3±6.2) days, P=0.000], lower rate of ventilator associated pneumonia (VAP) (3/47 vs 12/43, P=0.014), fewer days in ICU [(12±8) days vs (16±11) days, P=0.047] and lower hospital mortality (1/47 vs 7/43, P=0.025).Conclusions In COPD patients requiring intubation and invasive MV for hypercapnic respiratory failure, which is exacerbated by pulmonary infection, early extubation followed by noninvasive MV initiated at the start of PIC window may decrease significantly the duration of invasive MV, the risk of VAP and hospital mortality. | Wang, C Zhan, QY Cao, ZX Wei, LQ Cheng, ZZ Liu, S Zhang, JL Chen, RC Luo, Q Niu, SF Zhu, L Wu, DW Fang, BM Wu, TH Wang, CZ Liu, YN | 2005 | Chinese Medical Journal2005，，19： | 6 |
| 2 | Identification of human chronic myelogenous leukemia progenitor cells with hemangioblastic characteristics显示文摘 | Fang B Zheng C Liao L Han Q Sun Z Jiang X Zhao RC | 2006 | 中国生物学文摘2006，20，5： | 3 |
| 3 | 全颗粒饲料对奶牛生产性能的影响显示文摘饲料中的中性洗涤纤维(NDF)含量和饲料颗粒直径是影响瘤胃功能的重要因素。试验评估了以颗粒饲料为主的奶牛瘤胃健康情况、NDF消化率和生产性能。选取8头荷斯坦母牛(336±30 d,体重346±35 kg),随机分配到交叉重复试验组中,奶牛安置于牛栏,自由采食。试验期为3周,前两周是适应期,最后一周为数据收集期。各组饲粮原料相同,但物理形式不同,分为全混合日粮(TMR)和颗粒料(直径=8 mm)。两组间物理有效NDF(pe NDF)不同,TMR组为39.8%,颗粒料组为11.8%。在试验过程中,干物质采食量(DMI)、饮水量、瘤胃反刍时间、瘤胃温度和pH情况均记录。3周后收集粪样,确定潜在的可消化NDF总消化率(pdNDF)。每阶段结束后计算平均日增重和饲料转化率。颗粒料组的DMI、DMI/体重和饮水量更高。而两组间平均日增重和饲料转化率无显著差异。颗粒料组的瘤胃反刍时间为241 min·d-1低于TMR组的507 min·d-1。饲料的不同物理外形对瘤胃温度、瘤胃pH无显著影响。TMR组的pdNDF总消化率为90.25%高于颗粒料组的86.82%。试验结果表明,动物易接受完整的颗粒饲料,DMI较高,且反刍时间减少,但瘤胃pH无显著变化。TMR组的pdNDF消化率显著增加。尽管两组奶牛在DMI和纤维消化方面表现不同,但总体表现相似,两组饲料的保存时间与其物理形式有关。在短期内,提供能满足NDF需求的完全颗粒饲料可改善瘤胃健康状况和动物生产性能,而较长时间的数据则需要进一步试验。 | Wang J Yang M Cao M Lin Y Che L Q Duraipandiyan V Al-Dhabi N A Fang Z F Xu S Y Feng B Liu G Wu D Bonfante E Palmonari A Mammi L Canestrari G Fustini M Formigoni A | 2016 | 饲料博览2016，0，12： | 2 |
| 4 | Synthesis and structural characterization of several tris(2-methyl-2-phenylpropyl)tin carboxylates contanining germanium显示文摘 | Fang X N Song X Q Xie Q L | | 0，，： | 2 |
| 5 | A phylogeny of new world Deltocephalus-like leafhopper genera based on mitochondrial 16S ribosomal DNA sequences显示文摘 | FANG Q W BLACK IV C BLOCKER H D | 1993 | Mol Phylogenet Evol1993，2，： | 2 |
| 6 | 舌鳞状细胞癌患者舌淋巴结转移的价值显示文摘目的:探讨舌淋巴结(LLN)转移对局部晚期舌鳞状细胞癌(SCC)患者局部控制(LRC)的作用。方法:对231例患者进行前瞻性研究,分析侧重于LLN转移与临床病理变量之间的关系,以及LLN转移在预测预后中的意义。结果:在58例患者中发现了LLNs,其中33例LLN转移阳性。LLN转移与不良病理特征显著相关。 | Fang Q Li P Qi J 赵泽亮 | 2019 | 中国口腔颌面外科杂志2019，17，4： | 2 |
| 7 | Phylogenetic relationships among selected citrus germplasm accessions revealed by inter-simple sequence repeat (ISSR) markers显示文摘 | FANG D Q KRUEGER R R ROOSEM L | 1998 | J Amer Soc Hort Sci1998，123，4： | 1 |
| 8 | Advanced glycation endproducts induce podocyte apoptosis by activation of the FOXO4 transcription factor显示文摘 | Chuang P Y Yu Q Fang W | 2007 | Kidney Int2007，72，8： | 1 |
| 9 | Use of exchanging media in ATR configurations for determination of thick new and optical constants of thin metallic films显示文摘 | YANG F Z CAO Z Q FANG J X | 1988 | Applied Optics1988，27，： | 1 |
| 10 | Damping mechanism in the novel La2Mo2Og-based oxide-ion conductors 显示文摘 | Fang Q F Wang X P Zhang G G | 2003 | J Alloys Compd2003，355，： | 1 |
| 11 | Point defect characterization of GaN and ZnO显示文摘 | Look D C Reynolds D C Fang Z Q | 1999 | Materials Science and Engineering B1999，66，1： | 1 |
| 12 | Improvement of atrial function and atrial reverse remodeling after cardiac resynchronization therapy for heart failure 显示文摘 | Yu CM Fang F Zhang Q | 2007 | J Am Coll Cardiol2007，50，8： | 1 |
| 13 | Porosity formation in modified and unmodified A356 alloy castings 显示文摘 | Granger D A | 1989 | AFS Trans1989，97，： | 1 |
| 14 | Size-dependent interaction between an edge dislocation and a nanoscale inhomogeneity with interface effects 显示文摘 | Fang Q H Liu Y W | 2006 | Acta Materialia2006，54，16： | 1 |
| 15 | A heat balance model for partially vegetated surfaces 显示文摘 | ZHANG J Q FANG X P ZHANG H X | 1997 | Infrared Phys & Technol1997，38，： | 1 |
| 16 | Formation of fine near field scanning optical microscopy tips-part Ⅰ:by static and dynamic chemical etching显示文摘 | LAZAREV A FANG N LUO Q | 2003 | Rev Sci Instrum2003，74，8： | 1 |
| 17 | Phyiogenetic relationships among selected Citrus germplasm accessions revealed by inter-simple sequence repeat(ISSR) Mark ers显示文摘 | Fang D Q Krueger R R Roose M L | 1998 | J Am Soc Hort Sci1998，123，： | 1 |
| 18 | Silicon rutile from podiform chromite of the Imohusa ophiolite, Tibel显示文摘 | Yang J S Bai W J Fang Q S | 2003 | Progress in Natural Sciences2003，，23： | 1 |
| 19 | Synthesis and properties of polyurethane modifiedwith aminoethylaminopropyl poly(dimethyl siloxane) 显示文摘 | FAN Q L FANG J L CHEN Q M | 1999 | J Appl Polym Sci1999，74，： | 1 |
| 20 | Two new oleanane saponins from Anemone flaccida显示文摘 | Zhao L Chen W M Fang Q C | 1991 | Planta Med1991，57，： | 1 |
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