3篇
您的检索式：作者名="Fangyu Shao"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | B cell-derived anti-beta 2 glycoprotein I antibody mediates hyperhomocysteinemia-aggravated hypertensive glomerular lesions by triggering ferroptosis显示文摘Hyperhomocysteinemia(HHcy)is a risk factor for chronic kidney diseases(CKDs)that affects about 85%CKD patients.HHcy stimulates B cells to secrete pathological antibodies,although it is unknown whether this pathway mediates kidney injury.In HHcytreated 2-kidney,1-clip(2K1C)hypertensive murine model,HHcy-activated B cells secreted anti-beta 2 glycoprotein I(β2GPI)antibodies that deposited in glomerular endothelial cells(GECs),exacerbating glomerulosclerosis and reducing renal function.Mechanistically,HHcy 2K1C mice increased phosphatidylethanolamine(PE)(18:0/20:4,18:0/22:6,16:0/20:4)in kidney tissue,as determined by lipidomics.GECs oxidative lipidomics validated the increase of oxidized phospholipids upon Hcy-activated B cells culture medium(Hcy-B CM)treatment,including PE(18:0/20:4+3[O],PE(18:0a/22:4+1[O],PE(18:0/22:4+2[O]and PE(18:0/22:4+3[O]).PE synthases ethanolamine kinase 2(etnk2)and ethanolamine-phosphate cytidylyltransferase 2(pcyt2)were increased in the kidney GECs of HHcy 2K1C mice and facilitated polyunsaturated PE synthesis to act as lipid peroxidation substrates.In HHcy 2K1C mice and Hcy-B CM-treated GECs,the oxidative environment induced by iron accumulation and the insufficient clearance of lipid peroxides caused by transferrin receptor(TFR)elevation and down-regulation of SLC7A11/glutathione peroxidase 4(GPX4)contributed to GECs ferroptosis of the kidneys.In vivo,pharmacological depletion of B cells or inhibition of ferroptosis mitigated the HHcy-aggravated hypertensive renal injury.Consequently,our findings uncovered a novel mechanism by which B cell-derived pathogenic anti-β2GPI IgG generated by HHcy exacerbated hypertensive kidney damage by inducing GECs ferroptosis.Targeting B cells or ferroptosis may be viable therapeutic strategies for ameliorating lipid peroxidative renal injury in HHcy patients with hypertensive nephropathy. | Xing Du Xiaolong Ma Ying Tan Fangyu Shao Chun Li Yang Zhao Yutong Miao Lulu Han Guohui Dang Yuwei Song Dongmin Yang Zhenling Deng Yue Wang Changtao Jiang Wei Kong Juan Feng Xian Wang | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 2 |
| 2 | Anomalous temperature dependence of absorption edge in narrow-gap HgCdTe semiconductors显示文摘 | Fangyu Yue Jun Shao Xiang Lii | 2006 | Applied Physics Letters2006，89，2： | 1 |
| 3 | Adaptive Fitting Capacity Prediction Method for Lithium‑Ion Batteries显示文摘Lithium-ion batteries have become the mainstream power source for electric vehicles because of their excellent performance.However,lithium-ion batteries still experience aging and capacity attenuation during usage.It is therefore critical to accu-rately predict battery remaining capacity for increasing battery safety and prolonging battery life.This paper first adopts the metabolism grey algorithm and a simplified electrochemical model to predict battery capacity under different operating conditions.To improve the prediction performance where the capacity changes nonlinearly,a decoupling analysis of battery capacity loss is then conducted based on the simplified electrochemical model.Finally,an adaptive fitting method is devel-oped for capacity prediction,aiming at improving the prediction accuracy at the inflection point of battery capacity diving.The prediction results indicate that the developed adaptive fitting method can achieve high prediction accuracy under battery capacity attenuation at different discharge stages with errors lower than 2.2%.And the battery capacity decay shows linear variation,and the proposed method effectively forecast the inflection point of battery capacity diving. | Xiao Chu Fangyu Xue Tao Liu Junya Shao Junfu Li | 2022 | Automotive Innovation2022，5，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员