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| 1 | Crystal structure of plant PLDα1 reveals catalytic and regulatory mechanisms of eukaryotic phospholipase D显示文摘Phospholipase D(PLD)hydrolyzes the phosphodiester bond of glycerophospholipids and produces phosphatidic acid(PA),which acts as a second messenger in many living organisms.A large number of PLDs have been identified in eukaryotes,and are viewed as promising targets for drug design because these enzymes are known to be tightly regulated and to function in the pathophysiology of many human diseases.However,the underlying molecular mechanisms of catalysis and regulation of eukaryotic PLD remain elusive.Here,we determined the crystal structure of full-length plant PLDα1 in the apo state and in complex with PA.The structure shows that the N-terminal C2 domain hydrophobically interacts with the C-terminal catalytic domain that features two HKD motifs.Our analysis reveals the catalytic site,substrate-binding mechanism,and a new Ca2+-binding site that is required for the activation of PLD.In addition,we tested several efficient small-molecule inhibitors against PLDα1,and suggested a possible competitive inhibition mechanism according to structure-based docking analysis.This study explains many long-standing questions about PLDs and provides structural insights into PLD-targeted inhibitor/drug design. | Jianxu Li Fang Yu Hui Guo Renxue Xiong Wenjing Zhang Fangyuan He Minhua Zhang Peng Zhang | 2020 | Cell Research2020，30，1： | 3 |
| 2 | An effective poly(p-phenylenevinylene) polymer adhesion route toward three-dimensional nitrogen-doped carbon nanotube/reduced graphene oxide composite for direct electrocatalytic oxygen reduction显示文摘做 Heteroatom 的 nanocarbons 在氧减小反应(ORR ) 为使用有优秀潜力。然而,建设三维(3D ) 有好 electrocatalytic 表演遗体的做 N 的碳材料挑战。此处,一(p-phenylenevinylene )(PPV ) poly,先锋粘附线路为 3D 的建设被开发做 N 的减少的 graphene oxide-PPV 锻烧碳的 nanotubes (N-RGO-PPV (c)-CNTs) 。在合成, PPV 先锋为 RGO 和 CNT 的强壮的粘附起胶水的作用。在高温度, PPV 能从玻璃质的状态经历转变到一粘滞状态。因此,与多多孔的结构合成、如脊的 N-RGO-PPV (c)-CNT 合拢了 graphene 薄片能在高温度在 nitridation 期间被形成,它为为 ORR 的更活跃的地点的生产是有利的。作为 ORR 催化剂, N-RGO-PPV (c)-CNT composites 在碱的电解质展出了优异催化活动。获得的发作潜力(E 0.92 V 和 5.7 mAe 的催化当前的密度的发作 ) 并且最大化空间利用。有五的 DI-TENG 在 12 厘米物浥湥?景愠氠睯漠敶灲瑯湥楴污漠?的体积重复了单位??噭琠?捡楨癥??‰?敬畣慬?敤潳灲楴湯?硅数楲敭瑮污祬洠慥?敲?楤晦牥湥楴污眠牯?畦据楴湯愠??畦据楴湯漠?整灭牥瑡牵?桳睯?敤潳灲楴湯瀠慥獫愠??愠摮????桴楥?汥'虪罐嫖蹫u潲数瑲敩?桳睯朠敲瑡瀠瑯湥楴污映牯爠慥?楴敭?湩猠瑩?潭楮潴楲杮漠?潭敬畣慬?摡潳灲楴湯愠摮搠獥牯瑰潩??瑬潨杵?桴?潭敬畣慬?摡潳灲楴湯椭摮'讚涌畺{?湩琠敨攠敬瑣潲楮?潷歲映湵瑣潩?獩瘠牥?敳獮瑩癩?椠?潤獥渠瑯栠癡?湡?...?睯癥牥?桴?整灭牥瑡牵?敤数摮湥祣漠?桴? | Yu Fu Chungui Tian Fangyuan Liu Lei Wang Haijing Yan Bai Yang | 2016 | Nano Research2016，9，11： | 3 |
| 3 | High and ultra-stable energy storage from all-carbon sodium-ion capacitor with 3D framework carbon as cathode and carbon nanosheet as anode显示文摘Sodium-ion capacitors(SICs)are extremely promising due to the combined merits of high energy-power characteristics and considerable price advantage.However,it is still difficult to achieve high energypower outputs and cycle stability in a typical configuration of the metal-based battery-type anode and activated carbon capacitor-type cathode due to the kinetic mismatching.In this work,a carbon nanosheet(PSCS-600)with large interlayer spacing of 0.41 nm derived from the bio-waste pine cone shell was prepared.Besides,the covalent triazine framework derived carbon(OPDN-CTF-A)was obtained through ionothermal synthesis strategy,exhibiting beneficial hierarchical pores(0.5-6 nm)and high heteroatoms(5.6 at%N,6.6 at%O).On this basis,the all-carbon SICs were fabricated by the integration of PSCS-600 anode and OPDN-CTF-A cathode.The device delivered high energy density 111 Wh kg^(-1),high power output of 14,200 W kg^(-1) and ultra-stable cycling life(~90.7%capacitance retention after 10,000 cycles).This work provides new ideas in fabricating carbon-carbon architectural SICs with high energy storage for practical application. | Fangyuan Hu Siyang Liu Shengming Li Cheng Liu Guipeng Yu Ce Song Wenlong Shao Tianpeng Zhang Xigao Jian | 2021 | Journal of Energy Chemistry2021，30，4： | 2 |
| 4 | Gold nanomaterials for treatment of metastatic cancer显示文摘Nanomedicine has shown good potentials for cancer diagnosis and treatment since the last decades. Among the various nanoparticles exploited for cancer management so far, gold nanomaterials(e.g., spherical gold nanoparticles and gold nanorods)were extensively investigated due to their unique chemo-physical properties. We herein summarize the emerging application and discuss the challenges of using gold nanomaterials for therapy of metastatic cancer. | Bing Feng Fangyuan Zhou Dangge Wang Zhiai Xu Haijun Yu Yaping Li | 2016 | Science China Chemistry2016，59，8： | 2 |
| 5 | Gold nanoparticle-directed autophagy intervention for antitumor immunotherapy via inhibiting tumor-associated macrophage M2 polarization显示文摘Tumor-associated macrophages(TAMs),one of the dominating constituents of tumor microenvironment,are important contributors to cancer progression and treatment resistance.Therefore,regulation of TAMs polarization from M2 phenotype towards M1 phenotype has emerged as a new strategy for tumor immunotherapy.Herein,we successfully initiated antitumor immunotherapy by inhibiting TAMs M2 polarization via autophagy intervention with polyethylene glycol-conjugated gold nanoparticles(PEG-Au NPs).PEG-Au NPs suppressed TAMs M2 polarization in both in vitro and in vivo models,elicited antitumor immunotherapy and inhibited subcutaneous tumor growth in mice.As demonstrated by the m RFP-GFP-LC3 assay and analyzing the autophagy-related proteins(LC3,beclin1 and P62),PEGAu NPs induced autophagic flux inhibition in TAMs,which is attributed to the PEG-Au NPs induced lysosome alkalization and membrane permeabilization.Besides,TAMs were prone to polarize towards M2phenotype following autophagy activation,whereas inhibition of autophagic flux could reduce the M2polarization of TAMs.Our results revealed a mechanism underlying PEG-Au NPs induced antitumor immunotherapy,where PEG-Au NPs reduce TAMs M2 polarization via induction of lysosome dysfunction and autophagic flux inhibition.This study elucidated the biological effects of nanomaterials on TAMs polarization and provided insight into harnessing the intrinsic immunomodulation capacity of nanomaterials for effective cancer treatment. | Siyue Zhang Fangyuan Xie Kaichun Li He Zhang You Yin Yuan Yu Guangzhao Lu Shihao Zhang Yan Wei Ke Xu Yan Wu Hong Jin Lan Xiao Leilei Bao Can Xu Yulin Li Ying Lu Jie Gao | 2022 | Acta Pharmaceutica Sinica B2022，12，7： | 2 |
| 6 | Heterogeneous junctions of magnetic Ni core@binary dielectric shells toward high-efficiency microwave attenuation显示文摘Metal-organic-frameworks(MOFs)derived carbon-based composites with balanced impedance matching and synergistic dielectric/magnetic loss are considered as promising microwave absorbers.With the aim to promote interfacial polarization,herein,heterogeneous junctions composed of magnetic Ni core and binary dielectric shells(C and PEDOT)are synthesized by annealing Ni-MOFs precursors and an in-situ polymerization strategy,forming Ni@C@PEDOT spheres with multilayer heterogeneous interfaces.The results indicate that the final absorption attenuation is sensitive to the thickness of the dielectric PEDOT layer,when the thickness of the PEDOT layer is 224 nm,an optimal reflection loss of-72.4 d B is achieved at 2 mm and the effective absorption bandwidth reaches 6.4 GHz with a thickness of only 1.85 mm,the excellent absorption attenuation is accredited to the promoted impedance matching,enhanced conduction loss as well as the synergistic interfacial polarization induced by magnetic core and binary dielectric shells.Meanwhile,this work offers a simple and significant strategy in preparation for ideal microwave absorbers by rational design of multilayer heterogeneous interfaces. | Jijun Wang Songlin Yu Qingqing Wu Yan Li Fangyuan Li Xiao Zhou Yuhua Chen Bingzhen Li Panbo Liu | 2022 | Journal of Materials Science & Technology2022，，20： | 1 |
| 7 | Porous Single-Crystalline Monolith to Enhance Catalytic Activity and Stability显示文摘Engineering the catalytic activity and stability of materials would require the identification of the structural features that can tailor active sites at surfaces.Porous single crystals combine the ordered lattice structures and disordered interconnected pores,and they would therefore provide the advantages of precise structure features to identify and engineer the active sites at surfaces.Herein,we fabricate porous single-crystalline vanadium nitride(VN)at centimeter scale and further dope Fe(Fe0.1V0.9N)and Co(Co0.1V0.9N)in lattice to engineer the active sites at surface.We demonstrate that the active surface is composed of unsaturated coordination of V-N,Fe-N,and Co-N structures which lead to the generation of high-density active sites at the porous single-crystalline monolith surface.The interconnected pores aid the pore-enhanced fluxion to facilitate species diffusion in the porous architectures.In the nonoxidative dehydrogenation of ethane to ethylene,we demonstrate the outstanding performance with ethane conversion of 36%and ethylene selectivity of 99%at 660°C.Remarkably stability as a result of their single-crystalline structure,the monoliths achieve the outstanding performance without degradation being observed even after 200 hours of a continuous operation in a monolithic reactor.This work not only demonstrates the effective structural engineering to simultaneously enhance the stability and overall performance for practically useful catalytic materials but also provide a new route for the element doping of porous single crystals at large scale for the potential application in other fields. | Xiaoyan Yu Fangyuan Cheng Xiuyun Duan Kui Xie | 2022 | Research2022，，4： | 1 |
| 8 | Linking the past and present to predict the distribution of Asian crested ibis(Nipponia nippon)under global changes显示文摘Understanding how species’ecological niches adapt to environmental changes through time is critical for predicting the effect of future global change on endangered species.Yet few studies have incorporated knowledge of past niche shifting into the assessment of species’future fate in a changing world.In this study,we integrated the ecological niche dynamics into the species distribution modeling of the Asian crested ibis(Nipponia nippon)in East Asia.Specifically,we compared historical and present ecological niches of crested ibis in four-dimensional environmental space based on species occurrence and environmental data.We then employed a multi-temporal ecological niche model to estimate the potential geographical distribution of crested ibis under future climate and land-use changes.Our results show that crested ibis retained similar though not identical ecological niches over time.Compared to the historical baseline range,the current suitable habitat for crested ibis has been reduced by 39.6%.The effects of human activity outweigh those of climate change regarding the distribution of crested ibis.We conclude that the ecological niche of crested ibis was tended to be conservative,and future potentially suitable habitat may encounter northeastward and northwestward shift,and possibly expand by 18.7%referred to the historical range.Thefindings of our study are of clear importance for the conservation and successful reintroduction of crested ibis in East Asia. | Fangyuan YU Yiwen SUN Tiejun WANG Andrew KSKIDMORE Changqing DING Xinping YE | 2022 | Integrative Zoology2022，17，6： | 1 |
| 9 | Trends of SARS-CoV-2 Infection in Rural Area in Sentinel Community-Based Surveillance——China,December 2022 to January 2023显示文摘Introduction:In late 2022,a rapid transmission of Omicron variants of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)occurred throughout China.The purpose of this study was to provide the latest data and evaluate trends of SARS-CoV-2 infection in rural China among the community population.Methods:Data on SARS-CoV-2 infection among approximately 90,000 participants in rural China were collected by the National Sentinel Community-Based Surveillance(NSCS)system.Participants were tested for SARS-CoV-2 infection(defined as positive for SARS-CoV-2 nucleic acid or antigen)twice weekly from December 16,2022 to January 12,2023.The daily average of newly positive rate and its estimated daily percentage change were calculated to describe the national and regional trends of SARS-CoV-2 infection in rural China.Results:In rural China,the daily average new positive rate of SARS-CoV-2 infection peaked at 4.79%between December 20–22,2022 and then decreased to 0.57%between January 10–12,2023,with an average decrease of 29.95%per round.The peak of new SARS-CoV-2 infection was slightly earlier and lower in North China(5.28%between December 20–22,2022)than in South China(5.63%between December 23–26,2022),and then converged from December 30,2022 to January 2,2023.The peak of 6.09%occurred between December 20–22,2022 in eastern China,while the peak of 5.99%occurred later,between December 27–29,2022,in central China.Conclusions:Overall,the epidemic wave in rural China peaked between December 20–22,2022,and passed quickly following the optimization of prevention and control measures.Currently,SARSCoV-2 infection in community populations in rural China is sporadic. | Wenzhan Jing Fan Ding Yanping Zhang Guoqing Shi Jue Liu Yu Wu Fangyuan Li Wenxin Yan Chenyuan Qin Min Liu Qun Li Wannian Liang | 2023 | China CDC weekly2023，5，11： | 1 |
| 10 | Anthraquinone Covalently Modified Carbon Nanotubes for Efficient and Steady Electrocatalytic H2O2 Generation显示文摘Anthraquinone(AQ)modified carbon materials could be endowed with significantly improved oxygen re-duction reaction(ORR)activity.However,the application of these materials in the generation of hydrogen peroxide(H2O2)has been rarely investigated.For this motivation,AQ covalently modified carbon nanotube(AQ-CNT)was pur-posely synthesized for H2O2 generation.It was found that the cumulative H2O2 concentration reached up to 187.18 mg(Lh)over AQ(40)-CNT catalyst,nearly 2.0 times higher than that over CNT,and being superior to those over most carbon materials reported.The enhanced activity stemmed from the improved mass transfer fficiency of oxygen and the enhanced electrocatalytic activity.Noteworthily,the AQ(40)-CNT material exhibited satisfactory stability for H2O2 generation,which was ascribed to the strong interaction force of C-N covalent bond.The present work could provide a vital idea for designing electrode material with simultancously improved activity and stability for H2O2 gencration. | YU Fangyuan WANG Kai WANG Chuan HE Xinxia LIAO Yang ZHAO Shilin MAO Hui LI Xiaoting MA Jun | 2020 | Chemical Research in Chinese Universities2020，36，6： | 1 |
| 11 | The effects of scale factor on the aero-thermodynamic and infrared radiation performance of naval gas turbine exhaust system with infrared signature suppression device显示文摘 | Zhong Fangyuan Dai Yu | | 0，，02： | 1 |
| 12 | Variable chlorophyll fluorescence in response to water plus heat stress treatments in three coniferous tree seedling 显示文摘 | YU Fangyuan GUY R D | 2004 | J For Res2004，15，1： | 1 |
| 13 | Trends of SARS-CoV-2 Infection in Sentinel Community-Based Surveillance After the Optimization of Prevention and Control Measures—China,December 2022-January 2023显示文摘Introduction:On December 7,2022,China implemented the“Ten New Measures”to optimize its prevention and control measures for coronavirus disease 2019(COVID-19).To provide the latest data after the optimization,we evaluated trends of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection among the community population in China.Methods:We utilized data from the National Sentinel Community-Based Surveillance(NSCS)system in China to assess trends of SARS-CoV-2 infection.NSCS is a national community-based surveillance cohort with 0.42 million participants from all 31 provincial-level administrative divisions(PLADs)and Xinjiang Production and Construction Corps(XPCC).Participants were tested for infection twice a week(a total of eight rounds)from December 16,2022 to January 12,2023.SARS-CoV-2 infection was defined as testing positive for SARS-CoV-2 nucleic acid or antigen.We calculated the daily average of newly positive rates of SARS-CoV-2 infection.Results:In this national cohort,the daily average newly positive rate of SARS-CoV-2 infection decreased from 4.13% in Round 1(December 16-19,2022)to 0.69% in Round 8(January 10-12,2023).The epidemic peak occurred in Round 2(December 20-22,2022).Similar trends were observed in urban areas(decreasing from 4.65% to 0.73%),rural areas(decreasing from 2.83% to 0.57%),the eastern region(decreasing from 4.18% to 0.67%),the central region(decreasing from 5.43% to 0.61%),and the western region(decreasing from 3.01%to 0.77%).Conclusions:NSCS data showed that the peak of SARS-CoV-2 infection in China had passed.SARSCoV-2 infection in community populations in China is currently at a low epidemic level. | Jue Liu Fan Ding Yu Wu Wenzhan Jing Wenxin Yan Chenyuan Qin Fangyuan Li Yanping Zhang Min Liu Wannian Liang Qun Li | 2023 | China CDC weekly2023，5，7： | 0 |
| 14 | 4–λ hybrid InGaAsP-Si evanescent laser array with low power consumption for on-chip optical interconnects显示文摘A 4 –λ hybrid InGaAsP-Si evanescent laser array is obtained by bonding III–V distributed feedback lasers to a silicon on insulator(SOI) substrate using a selective area metal bonding technique. Multiple wavelengths are realized by varying the width of the III–V ridge waveguide. The threshold current is less than 10 mA for all wavelength channels under continuous-wave(CW) operation at room temperature, and the lowest threshold current density is 0.76 kA∕cm2. The side mode suppression ratio(SMSR) is higher than 40 dB for all wavelength channels when the injection current is between 20 mA and 70 mA at room temperature, and the highest SMSR is up to 51 dB. A characteristic temperature of 51 K and thermal impedance of 144°C/W are achieved on average.The 4 –λ hybrid InGaAsP-Si evanescent laser array exhibits a low threshold and high SMSR under CW operation at room temperature. The low power consumption of this device makes it very attractive for on-chip optical interconnects. | YAJIE LI HONGYAN YU WENGYU YANG CHAOYANG GE PENGFEI WANG FANGYUAN MENG GUANGZHEN LUO MENGQI WANG XULIANG ZHOU DAN LU GUANGZHAO RAN JIAOQING PAN | 2019 | Photonics Research2019，7，6： | 0 |
| 15 | Low fabrication cost wavelength tunable WG-FP hybrid-cavity laser working over 1.7μm显示文摘A wide wavelength tuning range and single-mode hybrid cavity laser consists of a square Whispering-Gallery(WG)microcavity and a Fabry–Pérot(FP)was introduced and demonstrated.A wavelength tuning range over 12.5 nm from 1760.87 to 1773.39 nm which was single-mode emitting was obtained with the side-mode suppression ratio over 30 dB.The hybrid cavity laser does not need grating etching and special epitaxial structure,which reduces the fabrication difficulty and cost,and shows the potential for gas sensing with absorption lines in this range. | Fangyuan Meng Hongyan Yu Xuliang Zhou Mengqi Wang Yejin Zhang Wenyu Yang Jiaoqing Pan | 2022 | Journal of Semiconductors2022，43，6： | 0 |
| 16 | Systemic and single cell level responses to 1 nm size biomaterials demonstrate distinct biological effects revealed by multi-omics atlas显示文摘Although ultra-small nanoclusters(USNCs,<2 nm)have immense application capabilities in biomedicine,the investigation on body-wide organ responses towards USNCs is scant.Here,applying a novel strategy of single-cell mass cytometry combined with Nano Genome Atlas of multi-tissues,we systematically evaluate the interactions between the host and calcium phosphate(CaP)USNCs at the organism level.Combining single-cell mass cytometry,and magnetic luminex assay results,we identify dynamic immune responses to CaP USNCs at the single cell resolution.The innate immune is initially activated and followed by adaptive immune activation,as evidenced by dynamic immune cells proportions.Furthermore,using Nano Genome Atlas of multi-tissues,we uncover CaP USNCs induce stronger activation of the immune responses in the cartilage and subchondral bone among the five local tissues while promote metabolic activities in the liver and kidney.Moreover,based on the immunological response profiles,histological evaluation of major organs and local tissue,and a body-wide transcriptomics,we demonstrate that CaP USNCs are not more hazardous than the Food and Drug Administration-approved CaP nanoparticles after 14 days of injection.Our findings provide valuable information on the future clinical applications of USNCs and introduce an innovative strategy to decipher the whole body response to implants. | Tao Zhang Tingyun Lei Ruojin Yan Bo Zhou Chunmei Fan Yanyan Zhao Shasha Yao Haihua Pan Yangwu Chen Bingbing Wu Yuwei Yang Lijuan Hu Shen Gu Xiaoyi Chen Fangyuan Bao Yu Li Hanqi Xie Ruikang Tang Xiao Chen Zi Yin | 2022 | Bioactive Materials2022，7，12： | 0 |
| 17 | Ⅲ–Ⅴ compound materials and lasers on silicon显示文摘Silicon-based photonic integration has attracted the interest of semiconductor scientists because it has high luminous efficiency and electron mobility.Breakthroughs have been made in silicon-based integrated lasers over the past few decades.Here we review three main methods of integration ofⅢ–Ⅴ materials on Si,namely direct growth,bonding,and selectivearea hetero-epitaxy.TheⅢ–Ⅴmaterials we introduced mainly include materials such as GaAs and InP.The lasers are mainly lasers of related communication bands.We also introduced the advantages and challenges of the three methods. | Wenyu Yang Yajie Li Fangyuan Meng Hongyan Yu Mengqi Wang Pengfei Wang Guangzhen Luo Xuliang Zhou Jiaoqing Pan | 2019 | Journal of Semiconductors2019，40，10： | 0 |
| 18 | Apios americana Medik flower extract protects high-glucose-treated hepatocytes and Caenorhabditis elegans显示文摘Type 2 diabetes(T2D)is a chronic metabolic disease related to glucose metabolism disorders.Increasing evidences indicate that flavonoids obtained from plants have beneficial effects on T2D.Apios americana Medik,originally cultivated in North America,is rich in flavonoids.In this study,A.americana flower extract(AFE)was purified and flavonoids were identified.The beneficial effects of AFE on glucose metabolism disorders were investigated.Results showed that AFE protected hepatic cells from oxidative stress caused by hyperglycemia and increased glucose consumption and glucose uptake.The AKT pathway was involved in AFE-mediated hypoglycemic action in LO2 cells,accompanied by phosphorylation of FoxO1,Gsk-3βand AMPK.In vivo,AFE protected Caenorhabditis elegans(C.elegans)from oxidative stress under hyperglycemia and restored the expressions of PMK-1 and SKN-1.Furthermore,AFE decreased excessive glucose and lipid accumulation and extended the lifespans of high glucose(HG)treated C.elegans.AFE might be beneficial to decrease glucose metabolism disorders and T2D. | Su Zhou Jiafei Chen Fangyuan Fan Yani Pan Xinyu Feng Lushuang Yu Shuying Gong Xiaodong Zheng Yihong Jiang Qiang Chu | 2022 | Food Bioscience2022，45，1： | 0 |
| 19 | Zinc oxide nanoparticles and epibrassinolide enhanced growth of tomato via modulating antioxidant activity and photosynthetic performance显示文摘Nanotechnology has greatly expanded the applications of nanoparticles(NPs)domain in the scientific field.In this context,the zinc oxide nanoparticles(ZnO-NPs)and 24-epibrassinolide(EBL)has been revealed to positively regulate plant metabolism and growth.In the present study,we investigated the role of ZnO-NPs and EBL in the regulation of plant growth,photosynthetic efficiency,enzymes activities and fruit yield in tomato.Foliar treatment of ZnO-NPs at three levels(10,50 or 100 ppm)and EBL(10^(−8) M)were applied separately or in combination to the foliage of plant at 35-39 days after sowing(DAS);and the control plants were treated with double distilled water(DDW)only at the same time interval.Among different tested concentrations of ZnO-NPs and/or EBL,the combined spray of 50 ppm of ZnO-NPs and 10^(−8) M of EBL proved to be best,and considerably increased the growth,photosynthetic efficiency,biochemical enzymes activities as well as fruit yield.Besides,the performance of the antioxidant enzymes viz catalase,peroxidase and superoxide dismutase were also increased after the combined application of ZnO-NPs and EBL in Lycopersicon esculentum.Therefore,it is suggested that combined application of 50 ppm of ZnO-NPs and 10−8 M of EBL is the best combination can be applied to increase the performance and yield of L.esculentum. | MOHAMMAD FAIZAN AHMAD FARAZ SHAMSUL HAYAT JAVAID ABHAT FANGYUAN YU | 2021 | BIOCELL2021，45，4： | 0 |
| 20 | 3'-Deoxyadenosin alleviates methamphetamine-induced aberrant synaptic plasticity and seeking behavior by inhibiting the NLRP3 inflammasome显示文摘Methamphetamine addiction is a brain disorder characterized by persistent drug-seeking behavior, which has been linked with aberrant synaptic plasticity. An increasing body of evidence suggests that aberrant synaptic plasticity is associated with the activation of the NOD-like receptor family pyrin domain containing-3(NLRP3) inflammasome. 3′-Deoxyadenosin, an active component of the Chinese fungus Cordyceps militaris, has strong anti-inflammatory effects. However, whether 3′-deoxyadenosin attenuates methamphetamine-induced aberrant synaptic plasticity via an NLRP3-mediated inflammatory mechanism remains unclear. We first observed that 3′-deoxyadenosin attenuated conditioned place preference scores in methamphetamine-treated mice and decreased the expression of c-fos in hippocampal neurons. Furthermore, we found that 3′-deoxyadenosin reduced the aberrant potentiation of glutamatergic transmission and restored the methamphetamine-induced impairment of synaptic plasticity. We also found that 3′-deoxyadenosin decreased the expression of NLRP3 and neuronal injury. Importantly, a direct NLRP3 deficiency reduced methamphetamine-induced seeking behavior, attenuated the impaired synaptic plasticity, and prevented neuronal damage. Finally, NLRP3 activation reversed the effect of 3′-deoxyadenosin on behavior and synaptic plasticity, suggesting that the anti-neuroinflammatory mechanism of 3′-deoxyadenosin on aberrant synaptic plasticity reduces methamphetamine-induced seeking behavior. Taken together, 3′-deoxyadenosin alleviates methamphetamine-induced aberrant synaptic plasticity and seeking behavior by inhibiting the NLRP3 inflammasome. | Yize Qi Yao Zhou Jiyang Li Fangyuan Zhu Gengni Guo Can Wang Man Yu Yijie Wang Tengfei Ma Shanwu Feng Li Zhou | 2024 | Neural Regeneration Research2024，19，10： | 0 |
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