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| 1 | Donor-Derived CD19-Targeted T Cell Infusion Eliminates B Cell Acute Lymphoblastic Leukemia Minimal Residual Disease with No Response to Donor Lymphocytes after Allogeneic Hematopoietic Stem Cell Transplantation显示文摘Leukemia relapse is still the leading cause of treatment failure after allogeneic hematopoietic stem cell transplantation (allo-HSCT) for B cell acute lymphoblastic leukemia (B-ALL). Relapsed patients with BALL after allo-HSCT have a very short median survival. Minimal residual disease (MRD) is predictive of forthcoming hematological relapse after hematopoietic stem cell transplantation (HSCT);furthermore, eliminating MRD effectively prevents relapse. Donor lymphoblastic infusion (DLI) is the main established approach to treat B-ALL with MRD after allo-HSCT. However, about one-third of patients with MRD are non-responsive to DLI and their prognosis worsens. Although donor-derived cluster of differentiation (CD)19-directed chimeric antigen receptor-modified (CAR) T cells (CART19s) can potentially cure leukemia, the efficiency and safety of infusions with these cells have not yet been investigated in patients with MRD after HSCT. Between September 2014 and February 2018, six patients each received one or more infusions of CART19s from HSCT donors. Five (83.33%) achieved MRD-negative remission, and one case was not responsive to the administration of CAR T cells. Three of the six patients are currently alive without leukemia. No patient developed acute graft-versus-host disease (aGVHD), and no patient died of cytokine release syndrome. Donor-derived CAR T cell infusions seem to be an effective and safe intervention for patients with MRD in B-ALL after allo-HSCT and for those who were not responsive to DLI. | Yifei Cheng Yuhong Chen Chenhua Yan Yu Wang Xiangyu Zhao Yao Chen Wei Han Lanping Xu Xiaohui Zhang Kaiyan Liu Shasha Wang Lungji Chang Lei Xiao Xiaojun Huang | 2019 | Engineering2019，5，1： | 7 |
| 2 | Radial Distribution of SiC Particles in Mechanical Stirring of A356-SiC_p Liquid显示文摘The mechanical stirring of A356-2.5 vol.% SiC p liquid was conducted in a cylindrical crucible by a straightblade stirrer.The radial distribution of SiC particles in A356 liquid was studied under the conditions of 25 deg.for gradient angle α of blade and 10 mm/s for speed of moving up and down of stirrer.The results show that there exists a nonlinear relationship between rotating speed of stirrer and radial relative deviation of SiC p content in A356 liquid between the center and the periphery of crucible.The greater the rotating speed of stirrer is,the bigger the radial relative deviation of SiC p content in A356 liquid becomes and the more nonhomogeneous the radial distribution of SiC particles in A356 liquid turns.In addition,when the rotating speed of stirrer is about 200 r/min,the vertical distribution of SiC particles in A356 liquid is relative uniform.It can be seen that the nonhomogeneous distribution of SiC particles in A356 liquid results from the nonhomogeneous radial distribution of SiC particles in A356 liquid in straight-blade mechanical stirring ultimately. | Yunhui Du Peng Zhang Jun Zhang Shasha Yao | 2012 | Journal of Materials Science & Technology2012，28，10： | 5 |
| 3 | Magnetostratigraphy of a Loess-Paleosol Sequence from Higher Terrace of the Daduhe River in the Eastern Margin of the Tibetan Plateau and Its Geological Significance显示文摘The eolian deposits distributed in the river valleys in the eastern margin of the Tibetan Plateau(TP)are very useful in neotectonic and paleoclimatic studies.Firstly,the climate in the eastern margin of the TP is mainly controlled by the Indian summer monsoon,and detailed studies on the loess-paleosol sequences in this region can provide valuable terrestrial evidence of past changes in the Indian summer monsoon.Secondly,the river terraces in the eastern margin of the TP are considered to be a sensitive recorder of neotectonism to reflect the timing and amplitude of the TP uplift.The formation ages of | QIAO Yansong WANG Yan YAO Haitao QI Lin HE Ze Xin CHENG Yu PENG Shasha GE Junyi | 2015 | Acta Geologica Sinica(English Edition)2015，89，1： | 5 |
| 4 | Clinical laboratory features of Meigs’syndrome:a retrospective study from 2009 to 2018显示文摘Meigs’syndrome(MS),a rare complication of benign ovarian tumors,is easily misdiagnosed as ovarian cancer(OC).We retrospectively reviewed the clinical laboratory data of patients diagnosed with MS from 2009 to 2018.Serum carbohydrate antigen 125 and HE4 levels were higher in the MS group than in the ovarian thecoma-fibroma(OTF)and healthy control groups(all P<0.05).However,the serum HE4 levels were lower in the MS group than in the OC group(P<0.001).A routine blood test showed that the absolute counts and percentages of lymphocytes were significantly lower in the MS group than in the OTF and control groups(all P<0.05).However,these variables were higher in the MS group than in the OC group(both P<0.05).The neutrophil-to-lymphocyte ratio(NLR)was also significantly lower,whereas the lymphocyte-to-monocyte ratio was higher in the MS group than in the OC group(both P<0.05).The NLR,platelet-to-lymphocyte ratio,and systemic immune index were significantly higher in the MS group than in the OTF and control groups(all P<0.05).The hypoxia-inducible factor-1 mRNA levels were also significantly higher,whereas the glucose transporter 1,lactate dehydrogenase,and enolase 1 mRNA levels were lower in peripheral CD4+T cells obtained preoperatively in a patient with MS than those in patients with OTF,patients with OC,and controls(all P<0.05).The expression of these four glucose metabolism genes was preferentially restored to normal levels after the tumor resection of MS(P<0.001).These clinical laboratory features can be useful in improving the preoperative diagnostic accuracy of MS. | Wenwen Shang Lei Wu Rui Xu Xian Chen Shasha Yao Peijun Huang Fang Wang | 2021 | Frontiers of Medicine2021，15，1： | 4 |
| 5 | Fabrication and luminescence of KGdF_4:Yb^(3+)/Er^(3+) nanoplates and their improving performance for polymer solar cells显示文摘Solar energy remains the most abundant renewable energy resource available to us[1].Continuous efforts have been invested to enhance the conversion of light to electricity by the diverse range of applications[2].Especially,polymer solar cells(PSCs)have reminded extensive attention own to flexibility,light-weight | Jiqing Jiao Yao Li Wenfei Shen Shasha Gai Jianguo Tang Yao Wang Linjun Huang Jixian Liu Wei Wang Laurence A.Belfiore | 2018 | Science Bulletin2018，63，4： | 2 |
| 6 | The Uniform Distribution of SiC Particles in an A356-SiC_p Composite Produced by the Tilt-blade Mechanical Stirring显示文摘The tilt-blade mechanical stirring of A356-2.5vol.%SiCp liquid was conducted in a cylindrical crucible to solve the problem of nonhomogeneous radial distribution of SiC particles in conventional straight-blade mechanical stirring. The radial distribution of SiC particles in A356 liquid was studied under the conditions of 25° for horizontal tilt angle α of the blade, 200 r/min for rotating speed of stirrer and 10 mm/s for speed of moving up and down of stirrer. The results show that there exists a nonlinear relationship between circumferential tilt angle β of the blade and radial relative deviation d of SiCp content in A356 liquid. When β is smaller than 26°, the d of SiCp content in A356 liquid between the center and the periphery of crucible decreases with increasing β. Conversely, when β is bigger than 26 , d increases with increasing β. Only when β is about 26°, d can be equal to nought i.e. uniform radial distribution of SiC particles can be realized. It can be seen that the nonhomogeneous radial distribution of SiC particles in conventional straight-blade mechanical stirring can be eliminated in this tilt-blade mechanical stirring of A356-SiCp liquid. | Yunhui DU Peng ZHANG Yujie WANG Jun ZHANG Shasha YAO Chengyu LI | 2013 | Acta Metallurgica Sinica(English Letters)2013，26，1： | 2 |
| 7 | Systemic Vasculitis:An Important and Underestimated Cause of Malignant Hypertension显示文摘Objectives:Malignant hypertension(MHT)is defi ned as severe hypertension accompanied by ischemic failure of one or more organs.The aims of this study were to evaluate the current clinical and etiologic profi les of MHT.Methods:As a retrospective study,we selected all patients admitted to our center from January 2013 to December 2016.Seventy patients with MHT were included.Results:The average age of the patients was 40 years,and more than half of the patients were male(78.57%).There were 24 patients with essential hypertension,accounting for 34.29%of the patients,and 46 with secondary hypertension,accounting for 65.71%of the patients.For secondary MHT,systemic vasculitis(25.57%)was the most common cause,followed by severe obstructive sleep apnea syndrome(15.71%),primary renal parenchymal hypertension(11.43%),primary aldosteronism(7.14%),and Cushing syndrome(1.43%)and nutcracker phenomenon(1.43%).Twenty patients with systemic vasculitis were characterized by severe hypertension accompanied by damage to two or more target organs of differing severity.The levels of white blood cells,hypersensitive C-reactive protein,serum creatinine,and 24-hour urinary protein were above their normal range.Conclusion:Systemic vasculitis may be one of the main causes of MHT,and has been underestimated in the past.In future clinical work,clinicians need to pay more attention to patients with systemic vasculitis. | Qing Zhu Shasha Liu Mulalibieke Heizhati Xiaoguang Yao Menghui Wang Qin Luo Lei Wang Delian Zhang Guijuan Chang Nanfang Li | 2019 | Cardiovascular Innovations and Applications2019，，B07： | 2 |
| 8 | Recent Development in Defects Engineered Photocatalysts:An Overview of the Experimental and Theoretical Strategies显示文摘Recently,defect architectured photocatalysis is proved to be the most versatile choice for high solar to chemical energy conversion processes.Defect engineering strategies are of great demand to effectively tune the electronic microstructure and surface morphologies of semiconductors to boost charge carrier concentration and extend light harvesting capability.This review provides a comprehensive insight to various kinds of defects along with their synthesis procedures and controlling mechanism to uplift photocatalytic activity.In addition,the contribution made by defects and material optimization techniques toward electronic band structure of the photocatalyst,the optimal concentration of defects,the key adsorption processes,charge distribution,and transfer dynamics have been explained in detail.Further,to clarify the relationship between photocatalytic activity and defect states in real,a comprehensive outlook to the versatile photocatalytic applications has been presented to highlight current challenges and future applications.Defect engineering therefore stands as the next step toward advancement in the design and configuration of modern photocatalysts for high efficiency photocatalysis. | Zaiba Zafar Shasha Yi Jinpeng Li Chuanqi Li Yongfa Zhu Amir Zada Weijing Yao Zhongyi Liu Xinzheng Yue | 2022 | Energy & Environmental Materials2022，5，1： | 1 |
| 9 | Plant growth and responses of antioxidants of Chenopodium album to long-term NaCl and KCl stress显示文摘 | Shixiang Yao Shasha Chen Dongsheng Xu Haiyan Lan | 2010 | Plant Growth Regulation2010，，2： | 1 |
| 10 | Influence of stirring speed on SiC particles distribution in A356 liquid显示文摘A straight-blade mechanical stirrer was designed to stir A356-3.5vol%SiC p liquid in a cylindrical crucible with the capability of systematically investigating the influence of rotating speed of stirrer on the distribution of SiC particles in A356 liquid.The experimental results show that the vertical distribution of SiC particles in A356 liquid can be uniform when the rotating speed of stirrer is 200 rpm,but the radial distribution of SiC particles in A356 liquid is always nonhomogeneous regardless of the rotating speed of stirrer.The radial centrifugalization ratio of SiC particles in A356 liquid between the center and the periphery of crucible increases with the rotating speed of stirrer.The results were explained in the light of SiC particles motion subject to a combination of stirring and centrifugal effect. | Yao Shasha Zhang Peng Du Yunhui Zhang Jun Lu Xiaopeng | 2012 | China Foundry2012，9，2： | 0 |
| 11 | VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway显示文摘Although VEGF-B was discovered as a VEGF-A homolog a long time ago,the angiogenic effect of VEGF-B remains poorly understood with limited and diverse findings from different groups.Notwithstanding,drugs that inhibit VEGF-B together with other VEGF family members are being used to treat patients with various neovascular diseases.It is therefore critical to have a better understanding of the angiogenic effect of VEGF-B and the underlying mechanisms.Using comprehensive in vitro and in vivo methods and models,we reveal here for the first time an unexpected and surprising function of VEGF-B as an endogenous inhibitor of angiogenesis by inhibiting the FGF2/FGFR1 pathway when the latter is abundantly expressed.Mechanistically,we unveil that VEGF-B binds to FGFR1,induces FGFR1/VEGFR1 complex formation,and suppresses FGF2-induced Erk activation,and inhibits FGF2-driven angiogenesis and tumor growth.Our work uncovers a previously unrecognized novel function of VEGF-B in tethering the FGF2/FGFR1 pathway.Given the anti-angiogenic nature of VEGF-B under conditions of high FGF2/FGFR1 levels,caution is warranted when modulating VEGF-B activity to treat neovascular diseases. | Chunsik Lee Rongyuan Chen Guangli Sun Xialin Liu Xianchai Lin Chang He Liying Xing Lixian Liu Lasse DJensen Anil Kumar Harald FLanger Xiangrong Ren Jianing Zhang Lijuan Huang Xiangke Yin JongKyong Kim Juanhua Zhu Guanqun Huang Jiani Li Weiwei Lu Wei Chen Juanxi Liu Jiaxin Hu Qihang Sun Weisi Lu Lekun Fang Shasha Wang Haiqing Kuang Yihan Zhang Geng Tian Jia Mi Bi-Ang Kang Masashi Narazaki Aaron Prodeus Luc Schoonjans David MOrnitz Jean Gariepy Guy Eelen Mieke Dewerchin Yunlong Yang Jing-Song Ou Antonio Mora Jin Yao Chen Zhao Yizhi Liu Peter Carmeliet Yihai Cao Xuri Li | 2023 | Signal Transduction and Targeted Therapy2023，8，9： | 0 |
| 12 | Systemic and single cell level responses to 1 nm size biomaterials demonstrate distinct biological effects revealed by multi-omics atlas显示文摘Although ultra-small nanoclusters(USNCs,<2 nm)have immense application capabilities in biomedicine,the investigation on body-wide organ responses towards USNCs is scant.Here,applying a novel strategy of single-cell mass cytometry combined with Nano Genome Atlas of multi-tissues,we systematically evaluate the interactions between the host and calcium phosphate(CaP)USNCs at the organism level.Combining single-cell mass cytometry,and magnetic luminex assay results,we identify dynamic immune responses to CaP USNCs at the single cell resolution.The innate immune is initially activated and followed by adaptive immune activation,as evidenced by dynamic immune cells proportions.Furthermore,using Nano Genome Atlas of multi-tissues,we uncover CaP USNCs induce stronger activation of the immune responses in the cartilage and subchondral bone among the five local tissues while promote metabolic activities in the liver and kidney.Moreover,based on the immunological response profiles,histological evaluation of major organs and local tissue,and a body-wide transcriptomics,we demonstrate that CaP USNCs are not more hazardous than the Food and Drug Administration-approved CaP nanoparticles after 14 days of injection.Our findings provide valuable information on the future clinical applications of USNCs and introduce an innovative strategy to decipher the whole body response to implants. | Tao Zhang Tingyun Lei Ruojin Yan Bo Zhou Chunmei Fan Yanyan Zhao Shasha Yao Haihua Pan Yangwu Chen Bingbing Wu Yuwei Yang Lijuan Hu Shen Gu Xiaoyi Chen Fangyuan Bao Yu Li Hanqi Xie Ruikang Tang Xiao Chen Zi Yin | 2022 | Bioactive Materials2022，7，12： | 0 |
| 13 | Crystal structures of catalytic core domain of BIV integrase: implications for the interaction between integrase and target DNA显示文摘Integrase plays a critical role in the recombination of viral DNA into the host genome.Therefore,over the past decade,it has been a hot target of drug design in the fight against type 1 human immunodeficiency virus(HIV-1).Bovine immunodeficiency virus(BIV)integrase has the same function as HIV-1 integrase.We have determined crystal structures of the BIV integrase catalytic core domain(CCD)in two different crystal forms at a resolution of 2.45Åand 2.2Å,respectively.In crystal form I,BIV integrase CCD forms a back-to-back dimer,in which the two active sites are on opposite sides.This has also been seen in many of the CCD structures of HIV-1 integrase that were determined previously.However,in crystal form II,BIV integrase CCD forms a novel face-toface dimer in which the two active sites are close to each other.Strikingly,the distance separating the two active sites is approximately 20Å,a distance that perfectly matches a 5-base pair interval.Based on these data,we propose a model for the interaction of integrase with its target DNA,which is also supported by many published biochemical data.Our results provide important clues for designing new inhibitors against HIV-1. | Xue Yao Shasha Fang Wentao Qiao Yunqi Geng Yuequan Shen | 2010 | Protein & Cell2010，1，4： | 0 |
| 14 | A Two-in-One Annealing Enables Dopant Free Block Copolymer Based Organic Solar Cells with over 16%Efficiency显示文摘The caption of Figure 4:“Figure 4(a)2D-GIWAXS patterns.(b)IP and(c)OOP line cuts.Calculated results of d-spacing and CL values for(d)IP and(e)OOP directions.”should be corrected to“Figure 4(a)Jph vs Veff relationships.(b)VOC and(c)JSC vs light intensity plots.Hole-only(d)and electron-only(e)device results.(f)Summarizedμh,μe and ratios.” | Shangfei Yao Linji Yang Shasha Shi Yang Zhou Min Long Wenhao Zhang Songlin Cai Ciyuan Huang Tao Liu Bingsuo Zou | 2023 | Chinese Journal of Chemistry2023，41，7： | 0 |
| 15 | Efficient Simultaneous Detection of Metabolites Based on Electroenzymatic Assembly Strategy显示文摘Objective and Impact Statement:We describe an electroenzymatic mediator(EM)sensor based on an electroenzymatic assembly peak separation strategy,which can efficiently realize the simultaneous detection of 3 typical cardiovascular disease(CVD)metabolites in 5μl of plasma under one test.This work has substantial implications toward improving the efficiency of chronic CVD assessment.Introduction:Monitoring CVD of metabolites is strongly associated with disease risk.Independent and time-consuming detection in hospitals is unfavorable for chronic CVD management.Methods:The EM was flexibly designed by the cross-linking of electron mediators and enzymes,and 3 EM layers with different characteristics were assembled on one electrode.Electrons were transferred under tunable potential;3 metabolites were quantitatively detected by 3 peak currents that correlated with metabolite concentrations.Results:In this study,the EM sensor showed high sensitivity for the simultaneous detection of 3 metabolites with a lower limit of 0.01 mM.The linear correlation between the sensor and clinical was greater than 0.980 for 242 patients,and the consistency of risk assessment was 94.6%.Conclusion:Metabolites could be expanded by the EM,and the sensor could be a promising candidate as a home healthcare tool for CVD risk assessment. | Anran Zheng Chao Li Shengkai Xu Zhen Guo Chuanyu Li Changsong Zhang Jia Yao Zhiqi Zhang Jinze Li Lutao Du Shasha Zhao Chuanxin Wang Wei Zhang Lianqun Zhou | 2023 | Biomedical Engineering Frontiers2023，4，1： | 0 |
| 16 | Resistance Analysis of Wheat Cultivars against Powdery Mildew in Anhui Province of China显示文摘[Objective]The paper was to determine the resistance level of the tried and pre-examination wheat cultivars against powdery mildew in Anhui Province of China.[Method]By using artificial inoculation and identification method in fields,the resistance of wheat cultivars was identified in consecutive three years from 2010 to 2012.[Result]The highly susceptible(HS)cultivar accounted for 30%,42%and 11%of total tested cultivars in the years of 2010,2011 and2012,respectively;moderately susceptible(MS)cultivar accounted for 53%of total tested cultivars in 2010,which accounted for 47%and 57%in 2011 and2012,respectively;moderately resistant(MR)cultivar accounted for 17%of total tested cultivars in 2010,which accounted for 11%and 32%in 2011 and 2012,respectively.[Conclusion]The paper can guide breeding direction,and also provide scientific basis for variety approval. | Chen Li Yao Dongming Zhang Shasha Ding Kejian | 2013 | Plant Diseases and Pests2013，4，5： | 0 |
| 17 | The Dynamics of Dopamine D_(2) Receptor-Expressing Striatal Neurons and the Downstream Circuit Underlying L-Dopa-Induced Dyskinesia in Rats显示文摘L-dopa(l-3,4-dihydroxyphenylalanine)-induced dyskinesia(LID)is a debilitating complication of dopamine replacement therapy for Parkinson’s disease.The potential contribution of striatal D_(2) receptor(D2R)-positive neurons and downstream circuits in the pathophysiology of LID remains unclear.In this study,we investigated the role of striatal D_(2)R+neurons and downstream globus pallidus externa(GPe)neurons in a rat model of LID.Intrastriatal administration of raclopride,a D_(2)R antagonist,significantly inhibited dyskinetic behavior,while intrastriatal administration of pramipexole,a D_(2)-like receptor agonist,yielded aggravation of dyskinesia in LID rats.Fiber photometry revealed the overinhibition of striatal D_(2)R+neurons and hyperactivity of downstream GPe neurons during the dyskinetic phase of LID rats.In contrast,the striatal D2R+neurons showed intermittent synchronized overactivity in the decay phase of dyskinesia.Consistent with the above findings,optogenetic activation of striatal D_(2)R+neurons or their projections in the GPe was adequate to suppress most of the dyskinetic behaviors of LID rats.Our data demonstrate that the aberrant activity of striatal D_(2)R+neurons and downstream GPe neurons is a decisive mechanism mediating dyskinetic symptoms in LID rats. | Kuncheng Liu Miaomiao Song Shasha Gao Lu Yao Li Zhang Jie Feng Ling Wang Rui Gao Yong Wang | 2023 | Neuroscience Bulletin2023，39，9： | 0 |
| 18 | mTORC1 induces plasma membrane depolarization and promotes preosteoblast senescence by regulating the sodium channel Scn1a显示文摘Senescence impairs preosteoblast expansion and differentiation into functional osteoblasts,blunts their responses to bone formation-stimulating factors and stimulates their secretion of osteoclast-activating factors.Due to these adverse effects,preosteoblast senescence is a crucial target for the treatment of age-related bone loss;however,the underlying mechanism remains unclear.We found that mTORC1 accelerated preosteoblast senescence in vitro and in a mouse model.Mechanistically,mTORC1 induced a change in the membrane potential from polarization to depolarization,thus promoting cell senescence by increasing Ca^(2+)influx and activating downstream NFAT/ATF3/p53 signaling.We further identified the sodium channel Scn1a as a mediator of membrane depolarization in senescent preosteoblasts.Scn1a expression was found to be positively regulated by mTORC1 upstream of C/EBPα,whereas its permeability to Na^(+)was found to be gated by protein kinase A(PKA)-induced phosphorylation.Prosenescent stresses increased the permeability of Scn1a to Na^(+)by suppressing PKA activity and induced depolarization in preosteoblasts.Together,our findings identify a novel pathway involving mTORC1,Scn1a expression and gating,plasma membrane depolarization,increased Ca^(2+)influx and NFAT/ATF3/p53 signaling in the regulation of preosteoblast senescence.Pharmaceutical studies of the related pathways and agents might lead to novel potential treatments for agerelated bone loss. | Ajuan Chen Jian Jin Shasha Cheng Zezheng Liu Cheng Yang Qingjing Chen Wenquan Liang Kai Li Dawei Kang Zhicong Ouyang Chenfeng Yao Xiaochun Bai Qingchu Li Dadi Jin Bin Huang | 2022 | Bone Research2022，10，2： | 0 |
| 19 | A Two-in-One Annealing Enables Dopant Free Block Copolymer Based Organic Solar Cells with over 16% Efficiency显示文摘The organic solar cells(OSCs)based on block copolymer systems bear the hope of achieving the optimal balance of power conversion efficiency(PCE)and stability,but the key index,PCE of this type devices is still low.To improve the efficiency,regulating the thin-film morphology is always the core engineering,which is usually achieved via two aspects:precursor optimization and post treatments. | Shangfei Yao Linji Yang Shasha Shi Yang Zhou Min Long Wenhao Zhang Songlin Cai Ciyuan Huang Tao Liu Bingsuo Zou | 2023 | Chinese Journal of Chemistry2023，41，6： | 0 |
| 20 | Geochemical characteristics of produced fluids from CBM wells and their indicative significance for gas accumulation in Daning-Jixian block,Ordos Basin显示文摘The Daning-Jixian block,the eastern edge of the Ordos Basin,is one of the most potential areas for CO_(2)geological storage,enhanced coalbed methane recovery(ECBM)exploration and production in China in recent decades.The ionic composition and total dissolved solids(TDS)of the produced water,coal organic matter maturity,molecular composition and carbon isotope characteristics of the produced gas were utilized to analyze the hydrogeological condition,CBM generation and migration characteristics in this area.The CBM enrichment patterns and the geological impacts on gas well production characteristics were revealed.The optimal area for CBM development and CO_(2)geological storage in the study area were also proposed.Dominated by the Xueguan reverse fault zone,the hydraulic unit in this area can be divided into two parts(i.e.,the recharge-runoff zone in the east and the weak runoff-stagnation zone in the west).The thermogenic gas is dominating CBM genesis in this area.Secondary biogenic gas replenishment is only distributed in the eastern margin area,where theδ13C1 value is less than the thermal simulation results as an influence of hydrodynamic fractionation.Finally,two models of CBM formation and accumulation were proposed,1)thermogenic CBM migrated by hydrodynamic and resorbed for preservation at impermeable fault boundaries;2)thermogenic CBM trapped by fault and accumulated by hydrodynamic in slope zone.The gas production performance,generally increased from east to west,is mainly dominated by hydrogeological conditions.Generally,the west side of the fault zone is the enrichment and high-yield area for ECBM development and CO_(2)geological storage in the study area. | Taotao YAN Chao YANG Shuai ZHENG Yadong BAI Wei CHEN Yanfei LIU Wenguang TIAN Shasha SUN Shangwen JIN Jiahang WANG Zhenxing LIU Huifang YAO | 2023 | Frontiers of Earth Science2023，17，3： | 0 |
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