|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Molecular Mechanisms Contributing to Resistance to Tyrosine Kinase-Targeted Therapy for Non-Small Cell Lung Cancer显示文摘One of the most important pathways in non-small cell lung cancer(NSCLC) is the epidermal growth factor receptor(EGFR) pathway. This pathway affects several crucial processes in tumor development and progression,including tumor cell proliferation,apoptosis regulation,angiogenesis,and metastatic invasion.Targeting EGFR is currently being intensely explored.We are witnessing the development of a number of potential molecular-inhibiting treatments for application in clinical oncology.In the last decade,the tyrosine kinase(TK) domain of the EGFR was identified in NSCLC patients,and it has responded very well with a dramatic clinical improvement to TK inhibitors such are gefitinib and erlotinib.Unfortunately,there were primary and/or secondary resistance to these treatments,as shown by clinical trials.Subsequent molecular biology studies provided some explanations for the drug resistance phenomenon.The molecular mechanisms of resistance need to be clarified.An in-depth understanding of these targeted-therapy resistance may help us explore new strategies for overcoming or reversing the resistance to these inhibitors for the future of NSCLC treatment. | Fariz Nurwidya Akiko Murakami Fumiyuki Takahashi Kazuhisa Takahashi | 2012 | Clinical oncology and cancer resexreh2012，9，1： | 6 |
| 2 | A new SINS/GPS sensor fusion scheme for UAV localization problem using nonlinear SVSF with covariance derivation and an adaptive boundary layer显示文摘The state estimation strategy using the smooth variable structure filter(SVSF) is based on the variable structure and sliding mode concepts. As presented in its standard form with a fixed boundary layer limit, the value of the boundary layer width is not precisely known at each step and may be selected based on a priori knowledge. The boundary layer width reflects the level of uncertainty in the model parameters and disturbance characteristics, where large values of the boundary layer width lead to robustness without optimality and small values of the boundary layer width provide optimality with poor robustness. As a solution and to overcome these limitations, an adaptive smoothing boundary layer is required to achieve greater robustness and suitable accuracy.This adapted value of the boundary layer width is obtained by minimizing the trace of the a posteriori covariance matrix. In this paper, the proposed new approach will be considered as another alternative to the extended Kalman filters(EKF), nonlinear H1 and standard SVSF-based data fusion techniques for the autonomous airborne navigation and self-localization problem. This alternative is based on strapdown inertial navigation system(SINS) and GPS data using the nonlinear SVSF with a covariance derivation and adaptive boundary layer width.Furthermore, the full mathematical model of the SINS/GPS navigation system considering the unmanned aerial vehicle(UAV) position, velocity and Euler angle as well as gyro and accelerometer biases will be used in this paper to estimate the airborne position and velocity with better accuracy. | Fariz Outamazirt Fu Li Lin Yan Abdelkrim Nemra | 2016 | Chinese Journal of Aeronautics2016，29，2： | 3 |
| 3 | Effects of different corticosteroids on edema and ecchymosis inopen rhinoplasty 显示文摘 | Gurlek A Fariz A Aydogan H | 2006 | Aesthetic P|ast Surg2006，30，2： | 1 |
| 4 | Hypoxia induces gefitinib resistance in non‐small‐cell lung cancer with both mutant and wild‐type epidermal growth factor receptors显示文摘 | Kunihiko Minakata Fumiyuki Takahashi Takeshi Nara Muneaki Hashimoto Ken Tajima Akiko Murakami Fariz Nurwidya Suzu Yae Fumiaki Koizumi Hiroyuki Moriyama Kuniaki Seyama Kazuto Nishio Kazuhisa Takahashi | 2012 | Cancer Sci2012，，11： | 1 |
| 5 | Application of fault tree analysis for customer reliability assessment of a distribution power system显示文摘 | Fariz Abdul Rahman Athi Varuttamaseni Michael Kintner-Meyer John C. Lee | 2013 | Reliability Engineering and System Safety2013，，： | 1 |
| 6 | Evaluation of relationship between preoperative bone density values derived from cone beam computed tomography and implant stability parameters: a clinical study显示文摘 | Fariz Salimov Ufuk Tatli Mehmet Kürk?ü Mücahide Ako?lan Haluk ?ztun? Cem Kurto?lu | 2014 | Clin Oral Impl Res2014，，9： | 1 |
| 7 | Impulse buying: An Iranian model显示文摘 | Kambiz Heidarzadeh Hanzaee Fariz Taherikia | 2010 | China-USA Business Review2010，9，12： | 0 |
| 8 | Identification of thermal front dynamics in the northern Malacca Strait using ROMS 3D-model显示文摘The thermal front in the oceanic system is believed to have a significant effect on biological activity.During an era of climate change,changes in heat regulation between the atmosphere and oceanic interior can alter the characteristics of this important feature.Using the simulation results of the 3D Regional Ocean Modelling System(ROMS),we identified the location of thermal fronts and determined their dynamic variability in the area between the southern Andaman Sea and northern Malacca Strait.The Single Image Edge Detection(SIED)algorithm was used to detect the thermal front from model-derived temperature.Results show that a thermal front occurred every year from 2002 to 2012 with the temperature gradient at the location of the front was 0.3°C/km.Compared to the years affected by El Ni?o and negative Indian Ocean Dipole(IOD),the normal years(e.g.,May 2003)show the presence of the thermal front at every selected depth(10,25,50,and 75 m),whereas El Ni?o and negative IOD during 2010 show the presence of the thermal front only at depth of 75 m due to greater warming,leading to the thermocline deepening and enhanced stratification.During May 2003,the thermal front was separated by cooler SST in the southern Andaman Sea and warmer SST in the northern Malacca Strait.The higher SST in the northern Malacca Strait was believed due to the besieged Malacca Strait,which trapped the heat and make it difficult to release while higher chlorophyll a in Malacca Strait is due to the freshwater conduit from nearby rivers(Klang,Langat,Perak,and Selangor).Furthermore,compared to the southern Andaman Sea,the chlorophyll a in the northern Malacca Strait is easier to reach the surface area due to the shallower thermocline,which allows nutrients in the area to reach the surface faster. | Ku Nor Afiza Asnida Ku MANSOR Nur Hidayah ROSELI Poh Heng KOK Fariz Syafiq Mohamad ALI Mohd Fadzil Mohd AKHIR | 2024 | Journal of Oceanology and Limnology2024，42，1： | 0 |
| 9 | Revisiting fracture gradient:Comments on“A new approaching method to estimate fracture gradient by correcting MattheweKelly and Eaton's stress ratio”显示文摘A study performed by Marbun et al.[1]claimed that“A new methodology to predict fracture pressure from former calculations,MattheweKelly and Eaton are proposed.”Also,Marbun et al.'s paper stated that“A new value of Poisson's and a stress ratio of the formation were generated and the accuracy of fracture gradient was improved.”We found those all statements are incorrect and some misleading concepts are revealed.An attempt to expose the method of fracture gradient determination from industry practice also appears to solidify that our arguments are acceptable to against improper Marbun et al.'s claims. | Farizal Hakiki Muizzuddin Shidqi | 2018 | Petroleum2018，4，1： | 0 |
| 10 | Analyzing of Investment Strategies of Local Companies in Azerbaijan: Problems and Solutions显示文摘 | Fariz Ahmadov Matanat Salmanova | 2013 | China-USA Business Review2013，12，8： | 0 |
| 11 | Influence of urban air pollution on the population in the Klang Valley,Malaysia:a spatial approach显示文摘Background:Urban air pollution resulting from economic growth as well as urbanization impacts the health of inhabitants.This study aims to examine the spatial distribution of particulate matter(PM_(10))and the risk of exposure for the population in the Klang Valley,an urban conglomeration centred in Kuala Lumpur,Malaysia.Methods:The inverse distance weighted(IDW)interpolation technique in the ArcGIS platform was used to map the air quality from five air monitoring stations.Spatial statistics of the Global Moran’s I Spatial Autocorrelation and Optimized Hot Spot Analysis were used to estimate the spatial clustering of PM_(10).The population-weighted exposure level(PWEL)technique was used to calculate the population density susceptible to PM_(10)and the AirQ+model was applied to estimate the proportion of the adult population at risk of chronic bronchitis due to long-term exposure to PM_(10)concentrations in the Klang Valley.Results:The highest annual mean PM_(10)concentrations at the Klang station ranged between 80 and 100μg/m^(3)from 2000 to 2009 and exceeded the New Malaysia Ambient Air Quality Standard(NMAAQS)and the World Health Organi-zation Air Quality Guidelines(WHOAQG)levels of 40 and 20μg/m^(3),respectively.The Moran’s I results indicated that the statistically significant clusters of high PM_(10)in Klang present a health risk to the local community.The PWEL results showed that levels of PM_(10)in Petaling Jaya exceeded the WHOAQG limits,potentially posing a health risk to the high-density population.The AirQ+model found Klang to be a significantly high-risk area for chronic bronchitis among the adult population with 804,240 people(with a relative risk of 1.85)in 2009.Conclusion:These high-risk values are due to rapid urbanization and high motor vehicle usage in the Klang Valley and therefore the impact of PM_(10)on the population needs to be reduced.This situation should be taken seriously by the Department of Environment and Kuala Lumpur City Hall in addressing air pollution issues through stricter rules on emissions and implementing low-carbon policies to improve the well-being of residents. | Siti Haslina Mohd Shafie Mastura Mahmud Suzani Mohamad Nor Lita Fadilah Rameli Ramdzani Abdullah Ahmad Fariz Mohamed | 2022 | Ecological Processes2022，11，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员