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| 1 | Current surgical treatment for bile duct cancer显示文摘Since extrahepatic bile duct cancer is difficult to diagnose and to cure,a safe and radical surgical strategy is needed.In this review,the modes of infiltration and spread of extrahepatic bile duct cancer and surgical strategy are discussed.Extended hemihepatectomy,with or without pancreatoduodenectomy(PD),plus extrahepatic bile duct resection and regional lymphadenectomy has recently been recognized as the standard curative treatment for hilar bile duct cancer.On the other hand,PD is the choice of treatment for middle and distal bile duct cancer.Major hepatectomy concomitant with PD(hepatopancreatoduodenectomy)has been applied to selected patients with widespread tumors.Preoperative biliary drainage(BD)followed by portal vein embolization(PVE)enables major hepatectomy in patients with hilar bile duct cancer without mortality.BD should be performed considering the surgical procedure,especially,in patients with separated intrahepatic bile ducts caused by hilar bile duct cancer.Right or left trisectoriectomy are indicated according to the tumor spread and biliary anatomy.As a result,extended radical resection offers a chance for cure of hilar bile duct cancer with improved resectability,curability,and a 5-year survival rate of 40%.A 5-year survival rate has ranged from 24% to 39% after PD for middle and distal bile duct cancer. | Yasuji Seyama Masatoshi Makuuchi | 2007 | World Journal of Gastroenterology2007，13，10： | 74 |
| 2 | KL-6 mucin expression in carcinoma of the ampulla of Vater: Association with cancer progression显示文摘AIM: To assess histochemical expression of KL-6 and its clinicopathological significance in carcinoma of the ampulla of Vater.METHODS: Ampullary carcinoma tissues were collected from 38 patients who underwent pancreatoduodenectomy or local resection. Tissues were subjected to immunohistochemical analysis using KL-6 antibody.RESULTS: Positive staining of ampullary carcinoma cells was observed in 26 (68.4%) cases. Staining was not found in the surrounding non-cancer regions of the ampullary tissues. Remarkable KL-6 expression was observed in invasive carcinoma cells in pancreatic and duodenal tissues and in metastatic carcinoma cells in lymph nodes. Positive KL-6 expression was related to lymph node metastasis (P = 0.020), pancreatic invasion (P = 0.016), duodenal invasion (P = 0.034), and advanced stage of TNM clinical classification (P = 0.010). Survival analysis showed that positive expression of KL-6 was related to a poorer prognosis (P = 0.029).CONCLUSION: The aberrant expression of KL-6 mucin is significantly related to unfavorable behaviors of carcinoma of the ampulla of Vater. | Wei Tang Yoshinori Inagaki Norihiro Kokudo Qian Guo Yasuji Seyama Munehiro Nakata Hiroshi Imamura Keiji Sano Yasuhiko Sugawara Masatoshi Makuuchi | 2005 | World Journal of Gastroenterology2005，11，35： | 10 |
| 3 | Long-Term Outcome of Extended Hemihepatectomy for Hilar Bile Duct Cancer With No Mortality and High Survival Rate显示文摘 | Yasuji Seyama Keiichi Kubota Keiji Sano Tamaki Noie Tadatoshi Takayama Tomoo Kosuge Masatoshi Makuuchi | 2003 | Annals of Surgery2003，，1： | 3 |
| 4 | Spontaneous rupture of splenic hamartoma in a patient with hepatitis C virus-related cirrhosis and portal hypertension:A case report and review of the literature显示文摘自发的破裂是脾的错构瘤的稀罕复杂并发症。文学的评论揭示了仅仅四个如此的盒子。就我们的知识而言,这是与肝肝硬化和门静脉高血压联系的脾的错构瘤的自发的破裂的第一份报告。一个 53 岁的女人,被跟随在上面因为大动脉的解剖和丙肝病毒(HCV ) 联系了肝肝硬化,与突然的左胸和肩膀疼痛被提交。腹的超声证明流血的 intraabdominal,和显示的计算断层摄影术脾肿大破裂。突现的脾切除术被执行。手术后的功课是平静的,并且病人在第 13 手术后的天被解除。病理揭示了肿瘤是一个破裂的脾的错构瘤。非肿胀的脾的实质揭示了充血变化。我们认为肝肝硬化和门静脉高血压的存在是为脾的错构瘤的自发的破裂的风险因素。 | Yasuji Seyama Nobutaka Tanaka Yoshio Suzuki Motoki Nagai Takatoshi Furuya Yukihiro Nomura Jimpei Ishii Masakazu Nobori | 2006 | World Journal of Gastroenterology2006，12，13： | 3 |
| 5 | Expression of KL-6/MUC1 in pancreatic cancer tissues and its potentialinvolvement in tumor metastasis显示文摘 | Huanli Xu Yoshinori Inagaki Yasuji Seyama Guanhua Du Fengshan Wang Norihiro Kokudo Wei Tang | 2011 | Oncology Reports2011，，2： | 2 |
| 6 | Analysis of somatic mutation frequency among persons exposed radiation from the Chemoby nuclear power plant accident 显示文摘 | Seyama T Akiyama M Kusunoki Y | 1993 | RadiatRes1993，34，： | 1 |
| 7 | Senescence marker protein-30 protects mice lungs from oxidative stress, aging, and smoking显示文摘 | Sato T Seyama K Sato Y | 2006 | Am J Respir Crit Care Med2006，174，： | 1 |
| 8 | X-ray photoelectron spectroscopic study of montmorillonite containing exchangeable divalent cation显示文摘 | SEYAMA H SOMA M | 1984 | Journal of Chemistry Society Faraday Translation 11984，80，1： | 1 |
| 9 | Overexpression of vacuolar ATPase 16-kD subunit in 10T1/2 fibroblasts enhances invasion with concomitant induction of matrix metalloproteinase-2显示文摘 | Kubota S Seyama Y | 2000 | Biochem Biophys Res Commun2000，278，2： | 1 |
| 10 | Urinary concentrations of bile acid glucuronides and sulfates in hepatobiliary diseases显示文摘 | Takikawa H Beppu T Seyama Y | 1984 | Gastroenterol Jpn1984，19，2： | 1 |
| 11 | VEGF-C-induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites显示文摘 | Seyama K Kumasaka T Souma S | 2007 | Blood2007，109，3： | 1 |
| 12 | Shock reinfusion injury to theccentral organs and the effect of freeradical scavengers in rat显示文摘 | TSUBOL H SEYAMA A | 1993 | Surg-Today1993，23，10： | 1 |
| 13 | Expression of KL-6/MUC1 in pancreatic duetal carcinoma and its potential relationship with beta- eatenin in tumor progression显示文摘 | Xu HL Inagaki Y Seyama Y | 2011 | Life Sci2011，88，2324： | 1 |
| 14 | The epidemiology of lymphangioleiomyomatosis in Japan:a nationwide cross-sectional study of presenting features and prognostic factors 显示文摘 | Hayashida M Seyama K Inoue Y | 2007 | Respirology2007，12，4： | 1 |
| 15 | ANALYSIS of somatic mutation frequence among persons exposed to radiation from the Chernobyl Nuclear Power Plant accident显示文摘 | SEYAMA T | 1993 | Radiation Res1993，134，： | 1 |
| 16 | Long-term outcome of extended hemihepatectomy for hilar bile duct cancer with no mortality and high survival rate显示文摘 | Seyama Y Kubota K Sano K | 2003 | Ann Surg2003，238，1： | 1 |
| 17 | Single and multiple resections of multiple hepatic metastases of colorectal origin显示文摘 | Imamura H Seyama Y Kokudo N | 2004 | -Surgery2004，135，5： | 1 |
| 18 | Unique association of p53 mutations with undifferentiated but not with differentiated carcinomas of the thyroid gland 显示文摘 | Ito T Seyama T Mizuno T | 1992 | Cancer Res1992，52，5： | 1 |
| 19 | Conversion of CO2 to dimethyl ether and methanol over hybrid catalysis显示文摘 | Dubojs J L Seyama K Arakawa H | 1992 | Chem Lett1992，，7： | 1 |
| 20 | Additive effects of transdermal tulobuterol to inhaled tiotropium in patients with COPD 显示文摘 | Ichinose M Seyama K Nishimura M | 2010 | Respir Med2010，104，： | 1 |
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