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| 1 | Multimodality imaging in apical hypertrophic cardiomyopathy显示文摘Apical hypertrophic cardiomyopathy(AHCM) is a relatively rare morphologic variant of HCM in which the hypertrophy of myocardium is localized to the left ventricular apex. Symptoms of AHCM might vary from none to others mimic coronary artery disease including acute coronary syndrome, thus resulting in inappropriate hospitalization. Transthoracic echocardiography is the firstline imaging technique for the diagnosis of hypertrophic cardiomyopathies. However, when the hypertrophy of the myocardium is localized in the ventricular apex might results in missed diagnosis. Aim of this paper is to review the different imaging techniques used for the diagnosis of AHCM and their role in the detection and comprehension of this uncommon disease. | Rosario Parisi Francesca Mirabella Gioel Gabrio Secco Rossella Fattori | 2014 | World Journal of Cardiology2014，6，9： | 11 |
| 2 | How many cases of laryngopharyngeal reflux suspected by laryngoscopy are gastroesophageal reflux disease-related?显示文摘AIM:To investigate the prevalence of gastroesophageal reflux disease(GERD) in patients with a laryngoscopic diagnosis of laryngopharyngeal reflux(LPR).METHODS:Between May 2011 and October 2011,41 consecutive patients with laryngopharyngeal symptoms(LPS) and laryngoscopic diagnosis of LPR were empirically treated with proton pump inhibitors(PPIs) for at least 8 wk,and the therapeutic outcome was assessed through validated questionnaires(GERD impact scale,GIS;visual analogue scale,VAS).LPR diagnosis was performed by ear,nose and throat specialists using the reflux finding score(RFS) and reflux symptom index(RSI).After a 16-d wash-out from PPIs,all patients underwent an upper endoscopy,stationary esophageal manometry,24-h multichannel intraluminal impedance and pH(MII-pH) esophageal monitoring.A positive correlation between LPR diagnosis and GERD was supposed based on the presence of esophagitis(ERD),pathological acid exposure time(AET) in the absence of esophageal erosions(NERD),and a positive correlation between symptoms and refluxes(hypersensitive esophagus,HE).RESULTS:The male/female ratio was 0.52(14/27),the mean age ± SD was 51.5 ± 12.7 years,and the mean body mass index was 25.7 ± 3.4 kg/m 2.All subjects reported one or more LPS.Twenty-five out of 41 patients also had typical GERD symptoms(heartburn and/or regurgitation).The most frequent laryngoscopic findings were posterior laryngeal hyperemia(38/41),linear indentation in the medial edge of the vocal fold(31/41),vocal fold nodules(6/41) and diffuse infraglottic oedema(25/41).The GIS analysis showed that 10/41 patients reported symptom relief with PPI therapy(P < 0.05);conversely,23/41 did not report any clinical improvement.At the same time,the VAS analysis showed a significant reduction in typical GERD symptoms after PPI therapy(P < 0.001).A significant reduction in LPS symptoms.On the other hand,such result was not recorded for LPS.Esophagitis was detected in 2/41 patients,and ineffective esophageal motility was found in 3/41 patients.The MII-pH analysis showed an abnormal AET in 5/41 patients(2 ERD and 3 NERD);11/41 patients had a normal AET and a positive association between symptoms and refluxes(HE),and 25/41 patients had a normal AET and a negative association between symptoms and refluxes(no GERD patients).It is noteworthy that HE patients had a positive association with typical GERD-related symptoms.Gas refluxes were found more frequently in patients with globus(29.7 ± 3.6) and hoarseness(21.5 ± 7.4) than in patients with heartburn or regurgitation(7.8 ± 6.2).Gas refluxes were positively associated with extraesophageal symptoms(P < 0.05).Overall,no differences were found among the three groups of patients in terms of the frequency of laryngeal signs.The proximal reflux was abnormal in patients with ERD/NERD only.The differences observed by means of MII-pH analysis among the three subgroups of patients(ERD/NERD,HE,no GERD) were not demonstrated with the RSI and RFS.Moreover,only the number of gas refluxes was found to have a significant association with the RFS(P = 0.028 andP = 0.026,nominal and numerical correlation,respectively).CONCLUSION:MII-pH analysis confirmed GERD diagnosis in less than 40% of patients with previous diagnosis of LPR,most likely because of the low specificity of the laryngoscopic findings. | Nicola de Bortoli Andrea Nacci Edoardo Savarino Irene Martinucci Massimo Bellini Bruno Fattori Linda Ceccarelli Francesco Costa Maria Gloria Mumolo Angelo Ricchiuti Vincenzo Savarino Stefano Berrettini Santino Marchi | 2012 | World Journal of Gastroenterology2012，18，32： | 11 |
| 3 | Acute Intramural Hematoma of the Aorta: A Mystery in Evolution显示文摘 | Arturo Evangelista Debabrata Mukherjee Rajendra H. Mehta Patrick T. O’Gara Rossella Fattori Jeanna V. Cooper Dean E. Smith Jae K. Oh Stuart Hutchison Udo Sechtem Eric M. Isselbacher Christoph A. Nienaber Linda A. Pape Kim A. Eagle | 2005 | Circulation2005，，8： | 2 |
| 4 | Atom interferometry gravity-gradiometer for the determination of the Newtonian gravitational constant G显示文摘 | A. Bertoldi G. Lamporesi L. Cacciapuoti M. de Angelis M. Fattori T. Petelski A. Peters M. Prevedelli J. Stuhler G. M. Tino | 2006 | The European Physical Journal D2006，，2： | 2 |
| 5 | Randomized Comparison of Strategies for Type B Aortic Dissection: The INvestigation of STEnt Grafts in Aortic Dissection (INSTEAD) Trial显示文摘 | Christoph A. Nienaber Hervé Rousseau Holger Eggebrecht Stephan Kische Rossella Fattori Tim C. Rehders Günther Kundt Dierk Scheinert Martin Czerny Tilo Kleinfeldt Burkhart Zipfel Louis Labrousse Hüseyin Ince | 2009 | Circulation2009，，25： | 2 |
| 6 | Descending thoracic aortic diseases:stent -graft repair显示文摘 | Fattori R Napoli G Lovato L | 2003 | Radiology2003，229，1： | 1 |
| 7 | Dissection: insights from the International registry of acute aortic dissection long- term survival in patients presenting with type B acute aortic显示文摘 | Tsai TT Fattori R Trimarchi S | 2006 | Circulation2006，114，21： | 1 |
| 8 | The treatment of horizontal canal positional vertigo: our experience in 66 cases显示文摘 | Casani AP Vannucci G Fattori B | 2002 | Laryngoscope2002，112，1： | 1 |
| 9 | Genderfelated differences in acute aortic dissection显示文摘 | Nienaber CA Fattori R Mehata RH | 2004 | Circulation2004，109，： | 1 |
| 10 | Nonsurgical reconstruction of thoracic aortic dissection by stnet-graft placement显示文摘 | Nienaber CA Fattori R Lund G | | N Engl Med0，340，20： | 1 |
| 11 | Non surgical reconstruction of thoracic aortic dissection by stnet-graft placement显示文摘 | Nienaber CA Fattori R Lund G | | N Engl Med0，340，20： | 1 |
| 12 | Nonsurgical reconstruction of thoracic aortic dissection by stent-graft plac- ement 显示文摘 | Nienaber CA Fattori R Lund G | 1999 | N Engl J Med1999，340，20： | 1 |
| 13 | Sudden hypoacusis treated with hyperbaric oxygen therapy: a controlled study显示文摘 | Fattori B Berrettini A Nacci A | 2001 | ENT2001，88，： | 1 |
| 14 | Nonsur gical reconstruction of thoracic aortic dissection by stent graft placement显示文摘 | Nienaber CA Fattori R Lund G | 1999 | N Engl J Med1999，340，： | 1 |
| 15 | The role of 99Tcm-tetrofosmin scintigraphy for staging patients with laryngeal cancer显示文摘 | Fattori B Grosso M Nacci A | 2005 | Cancer Biother Radiopharm2005，20，1： | 1 |
| 16 | Drug - eluting stents invascular intervention 显示文摘 | Fattori R Piva T | 2003 | Lancet2003，361，9353： | 1 |
| 17 | Nonsurgical reconstruction of thoracic aortic dissection by stent-graft placement显示文摘 | Nienaber CA Fattori R Lund G | 1999 | N Engl Med1999，340，20： | 1 |
| 18 | Acute aor- tic dissection presenting with primarily abdominal pain: a rare manifestation of a deadly disease 显示文摘 | Upchurch GR Jr Nienaber C Fattori R | 2005 | Ann Vasc Surg2005，19，3： | 1 |
| 19 | Descending thoracic aortic diseases: stent - graft repair显示文摘 | Napoli G Lovato L | 2003 | Radiology2003，229，1： | 1 |
| 20 | Cytokine secretion in nasal mucus of normal subjects and patients with allergic rhinitis显示文摘 | SCAVUZZO M C ROCCHI V FATTORI B | 2003 | Biomed Pharma- cother2003，57，： | 1 |
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