|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Potential role of Th17 cells in the pathogenesis of inflammatory bowel disease显示文摘The etiopathology of inflammatory bowel disease(IBD)remains elusive.Accumulating evidence suggests that the abnormality of innate and adaptive immunity responses plays an important role in intestinal inflammation.IBD including Crohn's disease(CD)and ulcerative colitis(UC)is a chronic inflammatory disease of the gastrointestinal tract,which is implicated in an inappropriate and overactive mucosal immune response to luminalflora.Traditionally,CD is regarded as a Th1-mediated inflammatory disorder while UC is regarded as a Th2-like disease.Recently,Th17 cells were identif ied as a new subset of T helper cells unrelated to Th1 or Th2 cells,and several cytokines [e.g.interleukin(IL)-21,IL-23] are involved in regulating their activation and differentiation.They not only play an important role in host defense against extracellular pathogens,but are also associated with the development of autoimmunity and inflammatory response such as IBD.The identif ication of Th17 cells helps us to explain some of the anomalies seen in the Th1/Th2 axis and has broadened our understanding of the immunopathological effects of Th17 cells in the development of IBD. | Zhan-Ju Liu Praveen K Yadav Jing-Ling Su Jun-Shan Wang Ke Fei | 2009 | World Journal of Gastroenterology2009，15，46： | 44 |
| 2 | Minimal invasive microscopic tooth preparation in esthetic restoration: a specialist consensus显示文摘By removing a part of the structure,the tooth preparation provides restorative space,bonding surface,and finish line for various restorations on abutment.Preparation technique plays critical role in achieving the optimal result of tooth preparation.With successful application of microscope in endodontics for>30 years,there is a full expectation of microscopic dentistry.However,as relatively little progress has been made in the application of microscopic dentistry in prosthodontics,the following assumptions have been proposed:Is it suitable to choose the tooth preparation technique under the naked eye in the microscopic vision?Is there a more accurate preparation technology intended for the microscope?To obtain long-term stable therapeutic effects,is it much easier to achieve maximum tooth preservation and retinal protection and maintain periodontal tissue and oral function health under microscopic vision?Whether the microscopic prosthodontics is a gimmick or a breakthrough in obtaining an ideal tooth preparation should be resolved in microscopic tooth preparation.This article attempts to illustrate the concept,core elements,and indications of microscopic minimally invasive tooth preparation,physiological basis of dental pulp,periodontium and functions involved in tool preparation,position ergonomics and visual basis for dentists,comparison of tooth preparation by naked eyes and a microscope,and comparison of different designs of microscopic minimally invasive tooth preparation techniques.Furthermore,a clinical protocol for microscopic minimally invasive tooth preparation based on target restorative space guide plate has been put forward and new insights on the quantity and shape of microscopic minimally invasive tooth preparation has been provided. | Haiyang Yu Yuwei Zhao Junying Li Tian Luo Jing Gao Hongchen Liu Weicai Liu Feng Liu Ke Zhao Fei Liu Chufan Ma Juergen MSetz Shanshan Liang Lin Fan Shanshan Gao Zhuoli Zhu Jiefei Shen Jian Wang Zhimin Zhu Xuedong Zhou | 2019 | International Journal of Oral Science2019，11，4： | 25 |
| 3 | Late Mesozoic extensional tectonics of the Liaodong Peninsula massif:Response of crust to continental lithosphere destruction of the North China Craton显示文摘Unlike most Precambrian cratons that have thick sub-continental lithospheric roots,the Archean lithosphere beneath the North China Craton is thin (reduced from 200 km to about 80 km),and has been replaced by a geochemically juvenile lithospheric mantle.This is a unique regional geological event,which has attracted worldwide attention.In the North China Block,Late Mesozoic extensional tectonics is evident by low-angle detachment faults,syntectonic plutons bounded by ductile faults,metamorphic core complexes (MCC) and widespread Jurassic to Cretaceous half-grabens filled by continental terrigenous deposits and volcanic rocks.At a regional scale,these structures share the same NW-SE extensional direction,while maintaining their own individual kinematics.In other words,the MCC feature a top-to-the-NW sense of shear,and syntectonic plutons are typified by a top-to-the-SE shearing deformations.Geochronological results indicate that the extensional structures were formed between 130-120 Ma.These extensional events lead to magmatic rock emplacement,distributed at the footwall of the detachment faults.Two different exhumation stages can be identified based on regional structural and magmatic interpretation:a Jurassic slow or negligible exhumation and a Cretaceous fast one assisted by normal faulting.These two cooling stages correspond to distinct geodynamic processes that occurred during the Jurassic and Cretaceous.Extensional tectonics appear to have been insignificant before the Early Cretaceous,and the process may be demonstrated by partial melting of the crust.The second stage,dominated by an extensional regime,developed after ca 120 Ma,and is tentatively correlated with crustal extension caused by lithospheric removal of the North China Craton. | LIN Wei WANG QingChen WANG Jun WANG Fei CHU Yang CHEN Ke | 2011 | Science China Earth Sciences2011，54，6： | 24 |
| 4 | A Review of Seasonal Climate Prediction Research in China显示文摘The ultimate goal of climate research is to produce climate predictions on various time scales. In China, efforts to predict the climate started in the 1930 s. Experimental operational climate forecasts have been performed since the late 1950 s,based on historical analog circulation patterns. However, due to the inherent complexity of climate variability, the forecasts produced at that time were fairly inaccurate. Only from the late 1980 s has seasonal climate prediction experienced substantial progress, when the Tropical Ocean and Global Atmosphere project of the World Climate Research program(WCRP) was launched. This paper, following a brief description of the history of seasonal climate prediction research, provides an overview of these studies in China. Processes and factors associated with the climate variability and predictability are discussed based on the literature published by Chinese scientists. These studies in China mirror aspects of the climate research effort made in other parts of the world over the past several decades, and are particularly associated with monsoon research in East Asia. As the climate warms, climate extremes, their frequency, and intensity are projected to change, with a large possibility that they will increase. Thus, seasonal climate prediction is even more important for China in order to effectively mitigate disasters produced by climate extremes, such as frequent floods, droughts, and the heavy frozen rain events of South China. | WANG Huijun FAN Ke SUN Jianqi LI Shuanglin LIN Zhaohui ZHOU Guangqing CHEN Lijuan LANG Xianmei LI Fang ZHU Yali CHEN Hong ZHENG Fei | 2015 | Advances in Atmospheric Sciences2015，32，2： | 20 |
| 5 | Intra-herb pharmacokinetics interaction between quercetin and isorhamentin显示文摘瞄准:橡黄素和 isorhamnetin 是一些植物摘录的普通成分,例如银杏叶子的摘录和 Hippophae rhamnoides L 的全部的黄酮。在 isorhamnetin 和橡黄素之间的 intra 植物 pharmacokinetics 相互作用在现在的学习被调查。方法:人的 MDR1 cDNA transfected MDCKII 房间被用来验证 isorhamnein 是否与 P-gp 交往了。Caco-2 运输试金并且一使随机化,在老鼠的 3 方法转线路 pharmacokinetics 学习被用来调查 pharmacokinetics 相互作用。HPLC 被用来决定房间运输样品。橡黄素和 isorhamnetin 的全部的血浆集中被处理被液体层析双人脚踏车团 spectrometry (LC-MS/MS ) 与 β-glucuronidase 和 sulfatase 决定。结果:越过人的 MDR1 cDNA transfected MDCKII 房间, Caco-2 房间和野类型的 MDCKII 房间的 isorhamnetin 的渗透比率(吸收性的 permeability/secretive 渗透) 分别地是 0.25 ± 0 .02, 0.74 ± 0 .05,和 1.41 ± 0 .06。这结果在 isorhamnetin 的房间流出证明了 P-gp 的角色。当越过 Caco-2 房间单层与对方一起共同搬运时, isorhamnetin 和橡黄素的渗透比率到 4.3 和 2.2 次增加了。在到老鼠的与对方一起的 coadministration 以后, C 72 h , 和 isorhamnetin 和橡黄素的 AUC 0 ∞
显著地与单个管理相比增加了的最大 , AUC 0。结论:上述结果证明了 intra 植物是在橡黄素和 isorhamentin 之间的 pharmacokinetics 相互作用。而另外的药流出抽, P-gp 可能起一个重要作用,例如多药抵抗伙伴蛋白质 2 并且乳癌抵抗蛋白质,可能被包含。除药植物相互作用以外,因此, intra 植物相互作用可能与草药底的疗法的宽使用被带进看法。 | Ke LAN Jian-lin HE Yang TIAN Fei TAN Xue-hua JIANG Ling WANG Li-ming YE | 2008 | Acta Pharmacologica Sinica2008，29，11： | 16 |
| 6 | Calcium channel blockers reduce severe fever with thrombocytopenia syndrome virus (SFTSV) related fatality显示文摘Severe fever with thrombocytopenia syndrome (SFTS),an emerging tick-borne infectious disease caused by a novel phlebovirus (SFTS virus, SFTSV), was listed among the top 10 priority infectious diseases by the World Health Organization due to its high fatality of 12%-50% and possibility of pandemic transmission. Currently, effective anti-SFTSV intervention remains unavailable. Here, by screening a library of FDA-approved drugs, we found that benidipine hydrochloride, a calcium channel blocker (CCB), inhibited SFTSV replication in vitro. Benidipine hydrochloride was revealed to inhibit virus infection through impairing virus internalization and genome replication. Further experiments showed that a broad panel of CCBs, including nifedipine, inhibited SFTSV infection. The anti-SFTSV effect of these two CCBs was further an a lyzed in a humanized mouse model in which CCB treatment resulted in reduced viral load and decreased fatality rate. Importantly, by performing a retrospective clinical investigation on a large cohort of 2087 SFTS patients, we revealed that nifedipine administration enhaneed virus clearance, improved clinical recovery, and remarkably reduced the case fatality rate by >5-fold. These findings are highly valuable for developing potential host-oriented therapeutics for SFTS and other lethal acute viral infections known to be inhibited by CCBs in vitro. | Hao Li Lei-Ke Zhang Shu-Fen Li Shao-Fei Zhang Wei-Wei Wan Yu-Lan Zhang Qi-Lin Xin Ke Dai Yuan-Yuan Hu Zhi-Bo Wang Xiang-Tao Zhu Yu-Jie Fang Ning Cui Pan-He Zhang Chun Yuan Qing-Bin Lu Jie-Ying Bai Fei Deng Geng-Fu Xiao Wei Liu Ke Peng | 2019 | Cell Research2019，29，9： | 15 |
| 7 | AKT-modified autologous intracoronary mesenchymal stem cells prevent remodeling and repair in swine infarcted myocardium显示文摘成年骨头的背景移植导出髓的间充质的干细胞(MSC ) 为心脏的修理作为策略被建议了后面的心肌的损坏。然而,代替失去的心肌层的房间移植策略被无能限制交付抵抗 peritransplantation 接枝房间死亡的大量房间。因此,我们开始孤立并且膨胀成年的猪骨头,并且设计这些房间到 overexpress AKT1 (蛋白质 kinase B )导出髓的 MSC ,为了测试假设,那 AKT1 设计了 MSC 对 apoptosis 更抵抗并且能在移植以后提高心脏的修理进 ischemic 猪 heart.Methods CDS ( AKT1 的规定领域) AKT1-cDNA 碎片被放大,并且 MSC 是有 pCDH1-AKT1 shuttling plasmid 的 transfected 追随者合成。西方的弄污分析和即时反向的抄写聚合酶链反应(RT-PCR ) 被执行。心肌的梗塞(Ml ) 模型在 Meishan 猪被构造,并且心脏的功能被磁性的回声成像(MRI ) 评估大小和 4 个星期以后的 echocardiography。所有猪被分到四个组:控制(A) , DMEM (B) , MSC (C) ,和 AKT-transfected (D) 。MSC 是有 AKT1 基因,和自体同源的标记 BrdU 的干细胞的 transfected | YU Yun-sheng SHEN Zhen-ya YE Wen-xue HUANG Hao-yue HUA Fei CHEN Yi-huan CHEN Ke LAO Wei-jie TAO Li | 2010 | Chinese Medical Journal2010，，13： | 15 |
| 8 | Three-dimensional bioprinting collagen/silk fibroin scaffold combined with neural stem cells promotes nerve regeneration after spinal cord injury显示文摘Many studies have shown that bio-scaffolds have important value for promoting axonal regeneration of injured spinal cord.Indeed,cell transplantation and bio-scaffold implantation are considered to be effective methods for neural regeneration.This study was designed to fabricate a type of three-dimensional collagen/silk fibroin scaffold (3D-CF) with cavities that simulate the anatomy of normal spinal cord.This scaffold allows cell growth in vitro and in vivo.To observe the effects of combined transplantation of neural stem cells (NSCs) and 3D-CF on the repair of spinal cord injury.Forty Sprague-Dawley rats were divided into four groups: sham (only laminectomy was performed),spinal cord injury (transection injury of T10 spinal cord without any transplantation),3D-CF (3D scaffold was transplanted into the local injured cavity),and 3D-CF + NSCs (3D scaffold co-cultured with NSCs was transplanted into the local injured cavity.Neuroelectrophysiology,imaging,hematoxylin-eosin staining,argentaffin staining,immunofluorescence staining,and western blot assay were performed.Apart from the sham group,neurological scores were significantly higher in the 3D-CF + NSCs group compared with other groups.Moreover,latency of the 3D-CF + NSCs group was significantly reduced,while the amplitude was significantly increased in motor evoked potential tests.The results of magnetic resonance imaging and diffusion tensor imaging showed that both spinal cord continuity and the filling of injury cavity were the best in the 3D-CF + NSCs group.Moreover,regenerative axons were abundant and glial scarring was reduced in the 3D-CF + NSCs group compared with other groups.These results confirm that implantation of 3D-CF combined with NSCs can promote the repair of injured spinal cord.This study was approved by the Institutional Animal Care and Use Committee of People’s Armed Police Force Medical Center in 2017 (approval No.2017-0007.2). | Ji-Peng Jiang Xiao-Yin Liu Fei Zhao Xiang Zhu Xiao-Yin Li Xue-Gang Niu Zi-Tong Yao Chen Dai Hui-You Xu Ke Ma Xu-Yi Chen Sai Zhang | 2020 | Neural Regeneration Research2020，15，5： | 14 |
| 9 | Genotypic Characterization of Methicillin-resistant Staphylococcus aureus Isolated from Pigs and Retail Foods in China显示文摘Objective To investigate the genotypic diversity of Methicillin-resistant Staphylococcus aureus(MRSA) isolated from pigs and retail foods from different geographical areas in China and further to study the routes and rates of transmission of this pathogen from animals to food. Methods Seventy-one MRSA isolates were obtained from pigs and retail foods and then characterized by multi-locus sequencing typing(MLST), spa typing, multiple-locus variable number of tandem repeat analysis(MLVA), pulsed-field gel electrophoresis(PFGE), and antimicrobial susceptibility testing. Results All isolated MRSA exhibited multi-drug resistance(MDR). Greater diversity was found in food-associated MRSA(7 STs, 8 spa types, and 10 MLVA patterns) compared to pig-associated MRSA(3 STs, 1 spa type, and 6 MLVA patterns). PFGE patterns were more diverse for pig-associated MRSA than those of food-associated isolates(40 vs. 11 pulse types). Among the pig-associated isolates, CC9-ST9-t899-MC2236 was the most prevalent clone(96.4%), and CC9-ST9-t437-MC621(20.0%) was the predominant clone among the food-associated isolates. The CC9-ST9 isolates showed significantly higher antimicrobial resistance than other clones. Interestingly, CC398-ST398-t034 clone was identified from both pig-and food-associated isolates. Of note, some community-and hospital-associated MRSA strains(t030, t172, t1244, and t4549) were also identified as food-associated isolates. Conclusion CC9-ST9-t899-MC2236-MDR was the most predominant clone in pigs, but significant genetic diversity was observed in food-associated MRSA. Our results demonstrate the great need for improved surveillance of MRSA in livestock and food and effective prevention strategies to limit MDR-MRSA infections in China. | WANG Wei LIU Feng ZULQARNAIN Baloch ZHANG Cun Shan MA Ke PENG Zi Xin YAN Shao Fei HU Yu Jie GAN Xin DONG Yin Ping BAI Yao LI Feng Qin YAN Xiao Mei MA Ai Guo XU Jin | 2017 | Biomedical and Environmental Sciences2017，30，8： | 13 |
| 10 | Synthesis and curing of a novel amino-containing phthalonitrile derivative显示文摘A novel phthalonitrile derivative containing an amino group, 3,5-bis(3,4-dicyanophenoxy)aniline (CPA), was synthesized via a nucleophilic displacement of 4-nitrophthalonitrile and 5-aminoresorcinol hydrochloride. The structure of CPA was confirmed by Fourier transform infrared spectra (FT-IR) and nuclear magnetic resonance (1H NMR). Thermal analysis performed on CPA revealed that the novel phthalonitrile derivative showed a self-promotion curing behavior and the resulting polymer exhibited outstanding heat-resistance. | Ke Zeng Ke Zhou Wen Rui Tang Yan Tang Hong Fei Zhou Tao Liu Yi Peng Wang Hai Bing Zhou Gang Yang | 2007 | Chinese Chemical Letters2007，18，5： | 12 |
| 11 | Galectin-1 knockdown in carcinoma-associated fibroblasts inhibits migration and invasion of human MDA-MB-231 breast cancer cells by modulating MMP-9 expression显示文摘联系癌的成纤维细胞(CAF ) 在在乳癌便于肿瘤前进和转移起中央作用。Galectin-1 (Gal-1 ) , CAF 的一个标记,以前被报导与肿瘤的各种各样的类型的 tumorigenesis 和转移被联系。这研究的目的是在调停 CAF 的乳癌转移和它的内在的分子的机制调查 Gal-1 的角色。我们的结果显示出与配对的正常成纤维细胞,和显著地导致的 CAF 的调节媒介(厘米) 相比从 Gal-1 高级的表示的人的胸肿瘤纸巾孤立的那 CAF 人的 MDA-MB-231 乳癌房间的迁居和侵略。在 CAF 的 Gal-1 击倒戏剧性地禁止的 CAF-CM-induced 房间移植和侵略,可能由禁止矩阵 metalloprotein 的表达式 9 (MMP-9 ) 。我们的调查结果证明 Gal-1-regulated CAF 激活由 upregulating MMP-9 表示支持乳癌房间转移,它显示在 CAF 的 Gal-1 可能是为乳癌的一个潜在的新奇目标治疗。 | Xue Zhu Ke Wang Kai Zhang Fei Xu Yongxiang Yin Ling Zhu Fanfan Zhou | 2016 | Acta Biochimica et Biophysica Sinica2016，48，5： | 10 |
| 12 | Experimental cancer gene therapy by multiple anti-survivin hammerhead ribozymes显示文摘为癌症改进基因治疗的功效,我们设计了指向 survivin mRNA 的暴露的区域的四撞木鲛 ribozyme 侵入人体气管粘膜的病菌(到 R4 的 R1 ) 。除了在里面 vitro 描述,由教材扩展包括了劈开的顺序特性的一颗决心,为细胞增长并且为的试金在 vivo 肿瘤,生长被用来为 ribozyme 效率得分。survivin 表示的产生抑制经由 caspase-3-dependent 小径导致了有丝分裂的大祸和房间死亡。重要地, ribozyme 侵入人体气管粘膜的病菌的管理在一个 hepato 细胞的癌异种皮移植老鼠模型禁止了肿瘤生长。R1, R3 和 R4 ribozymes 的合作表示 synergistically 压制了 survivin 并且当这联合指向 survivin 抄本的所有主要形式,生产了大多数有势力反癌症效果。带在这份报告描述的多重撞木鲛 ribozymes 的侵入人体气管粘膜的病菌对癌症提供了柔韧的基因治疗策略。 | Qi Fei Hongyu Zhang Lili Fu Xinlan Dai Baomei Gao Min Ni Chao Ge Jinjun Li Xia Ding Yuwen Ke Xuebiao Yao Jingde Zhu | 2008 | Acta Biochimica et Biophysica Sinica2008，40，6： | 10 |
| 13 | Synthesis of a benzoxazine monomer containing maleimide and allyloxy groups显示文摘新奇 benzoxazine 单体 3-(4-allyloxy )phenyl-3,4-dihydro-2H-6-(N-maleimido )-1,3-benzoxazine (AMB ) 被综合,结构被英尺红外证实,(1 ) H NMR。AMB 的热分析(DSC ) 证明烯丙氧基组的介绍减少了熔点并且展出了一扇狭窄、对称的治好的发热的窗户。 | Yan Tang Qing Lai Zhao Ke Zeng Pei Kai Miao Ke Zhou Wen Rui Tang Hong Fei Zhou Tao Liu Yi Peng Wang Gang Yang | 2007 | Chinese Chemical Letters2007，18，8： | 10 |
| 14 | S-1 plus gemcitabine chemotherapy followed by concurrent radiotherapy and maintenance therapy with S-1 for unresectable pancreatic cancer显示文摘AIM:To investigate the feasibility and efficacy of the combination of S-1 with gemcitabine followed by oral S-1 with concurrent radiotherapy(intensity modulated radiotherapy,IMRT) and maintenance therapy with S-1 for locally advanced pancreatic cancer.METHODS:Subjects selected in the study were patients who had unresectable and locally advanced pancreatic cancer without distant metastases,adequate organ and marrow functions,an Eastern Cooperative Oncology Group performance status of 0-1 and no prior anticancer therapy. Initially the subjects received two cycles of chemotherapy,oral administration of S-1 40 mg/m2 twice daily from day 1 to day 14 of a 21-d cycle,with 30-min intravenous infusions of gemcitabine 1000 mg/m2 on day 1 and day 8. Two weeks after the completion of chemotherapy,S-1 was administered orally with concurrent IMRT. Oral S-1 was administered at a dose of 80 mg/m2 per day twice daily from day 1 to day 14 and from day 22 to day 35. Radiation was concurrently delivered at a dose of 50.4 Gy(1.8 Gy/d,5 times per week,28 fractions). One month after the completion of chemotherapy and radiotherapy,S-1 was administered orally at a dose of 80 mg/m2 per day twice daily for 14 d,followed by a 14-d rest period. This cycle was repeated as maintenance therapy,until unacceptable toxicity occurred or the disease worsened. Thirty-two patients were involved in this study. The median followup was 15.6 mo(range:8.6-32.3 mo).RESULTS:Thirty-two patients completed the scheduled course of chemotherapy,while 30 patients(93.8%) received chemoradiotherapy with two patients ceasing to continue with radiotherapy. The major toxic effects were nausea and leukopenia. There was no grade 4 toxicity or treatment-related death. According to the Response Evaluation Criteria in Solid Tumors criteria,the objective tumor response was partial response in 17(53.1%) patients,stable disease in 9(28.1%),and progressive disease in 6(18.8%). The median overall survival and median progression-free survival were 15.2 mo and 9.3 mo,respectively. The survival rates at 1 year and 2 years were 75% and 34.4%,respectively.CONCLUSION:The combination of S-1 with gemcitabine followed by oral S-1 with IMRT and maintenance therapy with S-1 alone in patients with locally advanced pancreatic cancer may be considered a well-tolerated,promising treatment regimen. | Qing-Hua Ke Shi-Qiong Zhou Ji-Yuan Yang Wei Du Gai Liang Yong Lei Fei Luo | 2014 | World Journal of Gastroenterology2014，20，38： | 8 |
| 15 | The study of electroless Ni-W-P alloy plating on glass fibers显示文摘Ni-W-P coatings were deposited on the surface of glass fibers by the electroless plating process. The bath was very stable through the palladium salt test. There was no phenomenon of peeling and blistering on the surface of the Ni-W-P alloy glass fibers in the thermal shock test. It showed that the deposit had high impact strength and good adhesion. The morphology of the coatings was observed by scanning electron microscope (SEM). The elements and their contents were tested and analyzed by energy dispersion spectrometer (EDS). The tungsten content reached up to 12.1 wt.%. The effects of the concentrations of NiSO4, Na2WO4, and NaH2PO2·H2O on the conductivity of the coatings were studied. The resistivity of the Ni-W-P alloy glass fibers reached 7.39 × 10·3 ··cm. The alloy coatings on glass fibers were analyzed by XRD. The results indicated that the deposit had an amorphous structure and good heat stability. The suitable work temperature range was lower than 190°C. Finally, the electromagnetic parameters of the Ni-W-P alloy glass fibers were tested and analyzed primarily. The magnetic loss reached 0.04023 and the dielectric loss reached ·5.80239. The plated alloy is a kind of soft magnetic material. | HUANG Ying HUANG Fei ZHAO Wentao SHI Ke ZHAO Li WANG Yanli | 2007 | Rare Metals2007，26，4： | 8 |
| 16 | The 2020/21 Extremely Cold Winter in China Influenced by the Synergistic Effect of La Niña and Warm Arctic显示文摘In the first half of winter 2020/21,China has experienced an extremely cold period across both northern and southern regions,with record-breaking low temperatures set in many stations of China.Meanwhile,a moderate La Niña event which exceeded both oceanic and atmospheric thresholds began in August 2020 and in a few months developed into its mature phase,just prior to the 2020/21 winter.In this report,the mid−high-latitude large-scale atmospheric circulation anomalies in the Northern Hemisphere,which were forced by the negative phase of Arctic Oscillation,a strengthened Siberian High,an intensified Ural High and a deepened East Asian Trough,are considered to be the direct reason for the frequent cold surges in winter 2020/21.At the same time,the synergistic effect of the warm Arctic and the cold tropical Pacific(La Niña)provided an indispensable background,at a hemispheric scale,to intensify the atmospheric circulation anomalies in middle-to-high latitudes.In the end,a most recent La Niña prediction is provided and the on-coming evolution of climate is discussed for the remaining part of the 2020/21 winter for the purpose of future decision-making and early warning. | Fei ZHENG Yuan YUAN Yihui DING Kexin LI Xianghui FANG Yuheng ZHAO Yue SUN Jiang ZHU Zongjian KE Ji WANG Xiaolong JIA | 2022 | Advances in Atmospheric Sciences2022，39，4： | 7 |
| 17 | A new species of the genus Amolops (Anura: Ranidae) from high-altitude Sichuan, southwestern China, with a discussion on the taxonomic status of Amolops kangtingensis显示文摘A new species of the genus Amolops Cope, 1865 is described from Xinduqiao, Kangding, Sichuan. It was previously identified as Amolops kangtingensis, which is synonymized to Amolops mantzorum in this study. The new species, Amolops xinduqiao sp. nov., is distinguished from all other congeners by the following combination of characters:(1) medium body size, adult males SVL 41.2–47.5 mm(n=15, average 43.9 mm), adult females SVL 48.5–56.6 mm(n=15, average 52.5 mm);(2) head length equal to width or slightly wider than long;(3) tympanum small, but distinct;(4) vomerine teeth in two tiny rows, separated by a space about one vomerine teeth row;(5) bony projections on lower jaw absent;(6) dorsolateral folds usually absent;(7) tarsal folds or glands on tarsus absent;(8) circummarginal groove on disc of finger I absent;(9) tibiotarsal articulation reaching nostril or beyond;(10) webs of toe IV reaching to distal articulation, other toes fully webbed to disc; and(11) vocal sac absent in males. | Liang Fei Chang-Yuan Ye Yu-Fan Wang Ke Jiang | 2017 | Zoological Research2017，38，3： | 7 |
| 18 | CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta,alpha,beta,and gamma显示文摘SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape,compromising the effectiveness of existing vaccines and neutralizing antibodies.An in-depth investigation on COVID-19 pathogenesis is urgently needed to develop a strategy against SARS-CoV-2 variants.Here,we identified CD147 as a universal receptor for SARS-CoV-2 and its variants.Meanwhile,Meplazeumab,a humanized anti-CD147 antibody,could block cellular entry of SARS-CoV-2 and its variants-alpha,beta,gamma,and delta,with inhibition rates of 68.7,75.7,52.1,52.1,and 62.3%at 60μg/ml,respectively.Furthermore,humanized CD147 transgenic mice were susceptible to SARS-CoV-2 and its two variants,alpha and beta.When infected,these mice developed exudative alveolar pneumonia,featured by immune responses involving alveoli-infiltrated macrophages,neutrophils,and lymphocytes and activation of IL-17 signaling pathway.Mechanistically,we proposed that severe COVID-19-related cytokine storm is induced by a'spike protein-CD147-CyPA signaling axis':Infection of SARS-CoV-2 through CD147 initiated the JAK-STAT pathway,which further induced expression of cyclophilin A(CyPA);CyPA reciprocally bound to CD147 and triggered MAPK pathway.Consequently,the MAPK pathway regulated the expression of cytokines and chemokines,which promoted the development of cytokine storm.Importantly,Meplazumab could effectively inhibit viral entry and inflammation caused by SARS-CoV-2 and its variants.Therefore,our findings provided a new perspective for severe COVID-19-related pathogenesis.Furthermore,the validated universal receptor for SARS-CoV-2 and its variants can be targeted for COVID-19 treatment. | Jiejie Geng Liang Chen Yufeng Yuan Ke Wang Youchun Wang Chuan Qin Guizhen Wu Ruo Chen Zheng Zhang Ding Wei Peng Du Jun Zhang Peng Lin Kui Zhang Yongqiang Deng Ke Xu Jiangning Liu Xiuxuan Sun Ting Guo Xu Yang Jiao Wu Jianli Jiang Ling Li Kun Zhang Zhe Wang Jing Zhang Qingguo Yan Hua Zhu Zhaohui Zheng Jinlin Miao Xianghui Fu Fengfan Yang Xiaochun Chen Hao Tang Yang Zhang Ying Shi Yumeng Zhu Zhuo Pei Fei Huo Xue Liang Yatao Wang Qingyi Wang Wen Xie Yirong Li Mingyan Shi Huijie Bian Ping Zhu Zhi-Nan Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 6 |
| 19 | Facile fabrication of CdS-metal-organic framework nanocomposites with enhanced visible-light photocatalytic activity for organic transformation显示文摘因为低费用,相对安全,和环境友好, Visible-light-initiated 器官的转变收到了许多注意。在这个工作,也就是,我们在 visible-light-driven 光催化剂的一种新奇类型上报导 CdS-nanoparticle-decorated 金属器官的框架( MOF )的多孔的 nanocomposites ,由多孔的 MIL-100 ( Fe )在用作支持和镉醋酸盐的一个简单 solvothermal 方法准备了( Cd (交流)2)作为 CdS 先锋。当到 benzaldehyde 的本甲基酒精的选择氧化被用作探查反应时,结果证明 MIL-100 (Fe ) 和 CdS 半导体罐头的联合显著地在房间温度提高 photocatalytic 效率,作为与纯 CdS 的相比。提高的 photocatalytic 表演能由于 MIL-100 (Fe ) 的存在被归因于提高的轻吸收, photogenerated 电子洞对的更有效的分离,和 CdS 的增加的表面区域的联合效果。这个工作在太阳能的变换的域里为应用程序表明那条基于 MOF 的合成材料抓住伟人诺言进化学能。 | Fei Ke LuhuanWang Junfa Zhu | 2015 | Nano Research2015，8，6： | 6 |
| 20 | Hyperechoic demarcation line between a tumor and the muscularis propria layer as a marker for deciding the endoscopic treatment of gastric submucosal tumor显示文摘Minimally invasive endoscopic resection has been rapidly adopted as a new technique for treating patientswith gastric submucosal tumors (SMTs) originating in the muscularis propria (MP) layer. This study was conducted toevaluate the information obtained from endoscopic ultrasonography (EUS) to determine the appropriate endoscopicdissection method for treating SMTs originating in the MP layer. Between February 2014 and May 2016, a total of 50patients with gastric SMTs originating in the MP layer were enrolled in this study. The clinical features of the patientsand their endoscopic, EUS, and histopathologic findings, as well as their postoperative follow-up data, were analyzedin this retrospective study. The mean age of the patients was (55.0±10.2) years, and the male/female ratio was 17:33.Endoscopic submucosal dissection (ESD) was performed on 43 patients and an endoscopic full-thickness resection(EFR) was performed on seven patients. The most frequent location for an SMT was in the upper body region of thestomach (n=16), and the most common pathological diagnosis was a gastrointestinal stromal tumor (GIST) (n=32).The overall rates for complete resection were 95.3% (41/43) and 100.0% (7/7) when the SMTs were treated by ESDand EFR, respectively. The presence of a complete tumor capsule was significantly associated with a complete re-section (P=0.001). Of the cases treated by ESD, nine patients developed perforation, one of whom required laparo-scopic surgery. The remaining patients were closed with clips or purse-string sutures. The presence of an MP2-typetumor (P=0.018) and a wide connection with the MP layer (P=0.044) were significantly associated with perforation. Apreoperative evaluation of the integrity and the location of a tumor capsule and the length of the tumor connection withthe MP layer by EUS can improve the complete resection rate and reduce the occurrence of intraoperative complica-tions. Tumors with a complete capsule originating from the superficial MP layer or with a narrow connection with theMP layer are appropriate candidates for treatment by ESD. | Yu ZHANG Zhen WANG Ting JIN Kai-qiang LI Ke HAO WeiZHANG Bao-ying FEI | 2017 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2017，18，8： | 5 |
您所在的机构暂未开通此部分的功能，请联系管理员