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5篇 您的检索式:作者名="Feiwen"
    题名 作者 年代 出处 被引量
1Properties of flash hydrated and agglomerated particles of CFB fly ashes 显示文摘Li Dengxin Zhong Feiwen Guo Qingjie 2007Fuel Processing Technology2007,88,:1
2在农场和工厂间的一场土地争夺战显示文摘在山东省,北京的中车集团正在与当地农民赵苑毅(音译)家的麦田仅一路之隔、方圆227英亩、曾经是农田的土地上扩建一家轨道车辆厂。在其不远处,吉利汽车控股有限公司也正在4年前还生长着农作物的87英亩的土地上生产着轿车。沿途驱车5分钟,映入眼帘的皆是原来的农田已被灰瓦屋顶的别墅群所吞噬,而这些别墅是专为那些济南市的富人们修建的。迈克尔·佛西斯(Michael Forsythe) 鲁兹·安·贾维尔(Luzi Ann Javier) Feiwen Rong 威廉·毕(William Bi) 赵克雨(译) 2011商业周刊(中文版)2011,,6:0
3新领导层反浪费白酒跌了,珠宝涨了显示文摘春节期间零售额增幅下降,或源于中央反浪费要求 “金银珠宝销售额同比增长38.1%,增幅远高于去年”Feiwen Rong Helen Yuan Nerys Avery 2013商业周刊(中文版)2013,,4:0
4中国面临严峻的环境考验显示文摘用于净化空气和水源的费用将至少占到中国GDP的2% “如果环境问题一直得不到解决。就可能会成为中国的不稳定因素” 79岁的李平日(音译)在广州的赤岗涌边长大,他仍然记得儿时这条河碧波荡漾、鱼虾成群的景象。如今,尽管广州市为治理本市的河水和溪流已花费了486亿元人民币,赤岗涌依然臭气熏天,令他无法忍受。格莱尼丝·西姆(Glenys Sim) Feiwen Rong 张晓(译者) 2010商业周刊(中文版)2010,,11:0
5Cryo-EM structures of human organic anion transporting polypeptide OATP1B1显示文摘Members of the solute carrier organic anion transporting polypeptide(OATPs)family function as transporters for a large variety of amphipathic organic anions including endogenous metabolites and clinical drugs,such as bile salts,steroids,thyroid hormones,statins,antibiotics,antivirals,and anticancer drugs.OATP1B1 plays a vital role in transporting such substances into the liver for hepatic clearance.FDA and EMA recommend conducting in vitro testing of drug–drug interactions(DDIs)involving OATP1B1.However,the structure and working mechanism of OATPs still remains elusive.In this study,we determined cryo-EM structures of human OATP1B1 bound with representative endogenous metabolites(bilirubin and estrone-3-sulfate),a clinical drug(simeprevir),and a fluorescent indicator(2′,7′-dichlorofluorescein),in both outward-and inward-open states.These structures reveal major and minor substrate binding pockets and conformational changes during transport.In combination with mutagenesis studies and molecular dynamics simulations,our work comprehensively elucidates the transport mechanism of OATP1B1 and provides the structural basis for DDI predictions involving OATP1B1,which will greatly promote our understanding of OATPs.Ziyang Shan Xuemei Yang Huihui Liu Yafei Yuan Yuan Xiao Jing Nan Wei Zhang Wenqi Song Jufang Wang Feiwen Wei Yanqing Zhang 2023Cell Research2023,33,12:0
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