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您的检索式：作者名="Feiyuan Yu"
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| 1 | Very Long-term Outcomes and Predictors of Percutaneous Coronary Intervention with Drug-eluting Stents Versus Coronary Artery Bypass Grafting for Patients with Unprotected Left Main Coronary Artery Disease显示文摘 | Xian-Peng Yu Chang-Yan Wu Xue-Jun Ren FeiYuan Xian-Tao song Ya-Wei Luo Ji-Qiang He Yue-Chun Gao Fang-Jiong Huang Cheng-Xiong Gu Li-Zhong Sun Shu-Zheng Lyu Fang Chen | 2016 | Chinese Medical Journal2016，，7： | 8 |
| 2 | Progressive silencing of the zinc transporter Zip8 (Sic39a8) in chronic cadmium-exposed lung epithelial cells显示文摘镉(Cd ) ,非本质的金属,暗地里由利用进口小径的必要金属进入房间。锌 transporters Zip8 , Zip14 ,和二价的金属 transporter ( Dmt1 ) 1 现在作为涉及细胞的 Cd 加入的几重要金属 transporters 正在出现,他们的表情被显示了下面调整在几Cd抵抗( Cd R )房间线,然而这些 transporters 的参与在在肺房间的Cd抵抗的发展期间是不清楚的。在这研究,我们因此在我们的以前确定的老鼠肺检查这些金属 transporters 的表示上皮的房间(LEC ) 和 Zip8 的水平是的表演日益增多地 silenced 当 LEC 被使适应增加 CdCl 2 的集中时(从 1 ~ 20 M ) 。细胞的 Cd 内容的随后的测量显示了那 Cd R LEC 展出 Cd 累积的显著减少,可能由于 Zip8 的损失表示。我们调查由 DNA hypermethylation 的 Zip8 基因的 epigenetic silencing 涉及 Zip8 表示的下面规定的可能性。Cd R LEC 比父母房间显示出 DNA methyltransferase 3b (Dnmt3b ) 的更高的 mRNA 水平。Cd 有 5-aza-2-deoxycytidine 的 R LEC, DNA methyltransferases 的一个禁止者,回复到在这些房间的 Cd 的 Zip8 和敏感的表示,为 Cd 进口显示 Zip8 的关键角色。一起拿,我们的结果证明 Zip8 表示的进步 silencing 在肺房间对 Cd 涉及抵抗的获得,代表抵抗导致 Cd 的 cytotoxicity 的适应幸存机制。 | Yangmin Gao Yanming Xu Dandan Wu Feiyuan Yu Lei Yang Yue Yao Zhanling Liang Andy T. Y. Lau | 2017 | Acta Biochimica et Biophysica Sinica2017，49，5： | 2 |
| 3 | Virus-inspired surface-nanoengineered antimicrobial liposome:A potential system to simultaneously achieve high activity and selectivity显示文摘Enveloped viruses such as SARS-CoV-2 frequently have a highly infectious nature and are considered effective natural delivery systems exhibiting high efficiency and specificity.Since simultaneously enhancing the activity and selectivity of lipopeptides is a seemingly unsolvable problem for conventional chemistry and pharmaceutical approaches,we present a biomimetic strategy to construct lipopeptide-based mimics of viral architectures and infections to enhance their antimicrobial efficacy while avoiding side effects.Herein,a surface-nanoengineered antimicrobial liposome(SNAL)is developed with the morphological features of enveloped viruses,including a moderate size range,lipid-based membrane structure,and highly lipopeptide-enriched bilayer surface.The SNAL possesses virus-like infection to bacterial cells,which can mediate high-efficiency and high-selectivity bacteria binding,rapidly attack and invade bacteria via plasma membrane fusion pathway,and induce a local“burst”release of lipopeptide to produce irreversible damage of cell membrane.Remarkably,viral mimics are effective against multiple pathogens with low minimum inhibitory concentrations(1.6-6.3μg mL1),high bactericidal efficiency of>99%within 2 h,>10-fold enhanced selectivity over free lipopeptide,99.8%reduction in skin MRSA load after a single treatment,and negligible toxicity.This bioinspired design has significant potential to enhance the therapeutic efficacy of lipopeptides and may create new opportunities for designing next-generation antimicrobials. | Yin Shi Xiaoqian Feng Liming Lin Jing Wang Jiaying Chi Biyuan Wu Guilin Zhou Feiyuan Yu Qian Xu Daojun Liu Guilan Quan Chao Lu Xin Pan Jianfeng Cai Chuanbin Wu | 2021 | Bioactive Materials2021，6，10： | 1 |
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