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| 1 | Toripalimab plus chemotherapy as second-line treatment in previously EGFR-TKI treated patients with EGFR-mutant-advanced NSCLC:a multicenter phase-II trial显示文摘This multicenter phase-II trial aimed to investigate the efficacy,safety,and predictive biomarkers of toripalimab plus chemotherapy as second-line treatment in patients with EGFR-mutant-advanced NSCLC.Patients who failed from first-line EGFR-TKIs and did not harbor T790M mutation were enrolled.Toripalimab plus carboplatin and pemetrexed were administrated every three weeks for up to six cycles,followed by the maintenance of toripalimab and pemetrexed.The primary endpoint was objective-response rate(ORR).Integrated biomarker analysis of PD-L1 expression,tumor mutational burden(TMB),CD8+tumor-infiltrating lymphocyte(TIL)density,whole-exome,and transcriptome sequencing on tumor biopsies were also conducted.Forty patients were enrolled with an overall ORR of 50.0%and disease-control rate(DCR)of 87.5%.The median progression free survival(PFS)and overall survival were 7.0 and 23.5 months,respectively.The most common treatment-related adverse effects were leukopenia,neutropenia,anemia,ALT/AST elevation,and nausea.Biomarker analysis showed that none of PD-L1 expression,TMB level,and CD8+TIL density could serve as a predictive biomarker.Integrated analysis of whole-exome and transcriptome sequencing data revealed that patients with DSPP mutation had a decreased M2 macrophage infiltration and associated with longer PFS than those of wild type.Toripalimab plus chemotherapy showed a promising anti-tumor activity with acceptable safety profiles as the second-line setting in patients with EGFR-mutant NSCLC.DSPP mutation might serve as a potential biomarker for this combination.A phase-III trial to compare toripalimab versus placebo in combination with chemotherapy in this setting is ongoing(NCT03924050). | Tao Jiang Pingyang Wang Jie Zhang Yanqiu Zhao Jianying Zhou Yun Fan Yongqian Shu Xiaoqing Liu Helong Zhang Jianxing He Guanghui Gao Xiaoqian Mu Zhang Bao Yanjun Xu Renhua Guo Hong Wang Lin Deng Ningqiang Ma Yalei Zhang Hui Feng Sheng Yao Jiarui Wu Luonan Chen Caicun Zhou Shengxiang Ren | 2021 | Signal Transduction and Targeted Therapy2021，6，11： | 8 |
| 2 | Green synthesis of fluorescent carbon quantum dots and carbon spheres from pericarp显示文摘An economical idea was developed to synthesize fluorescent carbon quantum dots(CQDs) directly from the refluxing extraction of orange pericarp via a hydrothermal technique. Hydrothermal temperatures and times were adjusted to control the particle sizes and the quantum yields of the obtained CQDs. The as-prepared carbon quantum dots showed narrow particle size distribution, good water solubility, and acceptable fluorescence lifetimes. Due to their high stability, these obtained carbon quantum dots have great application potential in nano-biotechnology. Furthermore, carbon spheres with uniform morphology and size can be easily obtained as the reaction byproducts of this green synthesis process. | Wei Du Xiaoqian Xu Han Hao Rongmei Liu Di Zhang Feng Gao Qingyi Lu | 2015 | Science China Chemistry2015，58，5： | 8 |
| 3 | Telomere-dependent and telomereindependent roles of RAP1 in regulating human stem cell homeostasis显示文摘RAP1 is a well-known telomere-binding protein, but its functions in human stem cells have remained unclea匚 Here we generated RAP1 -deficient human embryonic stem cells (hESCs) by using CRISPR/Cas9 technique and obtained RAP1-deficient human mesenchymal stem cells (hMSCs) and neural stem cells (hNSCs) via directed differentiation. In both hMSCs and hNSCs, RAP1 not only negatively regulated telomere length but also acted as a transcriptional regulator of RELN by tuning the methylation status of its gene promoter. RAP1 deficiency enhanced self-renewal and delayed senescence in hMSCs, but not in hNSCs, suggesting complicated lineage-specific effects of RAP1 in adult stem cells.Altogether, these results demonstrate for the first time that RAP1 plays both telomeric and nontelomeric roles in regulating human stem cell homeostasis. | Xing Zhang Zunpeng Liu Xiaoqian Liu Si Wang Yiyuan Zhang Xiaojuan He Shuhui Sun Shuai Ma Ng Shyh-Chang Feng Liu Qiang Wang Xiaoqun Wang Lin Liu Weiqi Zhang Moshi Song Guang-Hui Liu Jing Qu | 2019 | Protein & Cell2019，10，9： | 7 |
| 4 | TPGS/hyaluronic acid dual-functionalized PLGA nanoparticles delivered through dissolving microneedles for markedly improved chemo-photothermal combined therapy of superficial tumor显示文摘Nanoparticles(NPs)have shown potential in cancer therapy,while a single administration conferring a satisfactory outcome is still unavailable.To address this issue,the dissolving microneedles(DMNs)were developed to locally deliver functionalized NPs with combined chemotherapy and photothermal therapy(PTT).α-Tocopheryl polyethylene glycol succinate(TPGS)/hyaluronic acid(HA)dualfunctionalized PLGA NPs(HD10 NPs)were fabricated to co-load paclitaxel and indocyanine green.HD10 NPs significantly enhanced the cytotoxicity of low-dose paclitaxel because of active and mitochondrial targeting by HA and TPGS,respectively.PTT could further sensitize tumor cells toward chemotherapy by promoting apoptosis into the advanced period,highly activating caspase 3 enzyme,and significantly reducing the expression of survivin and MMP-9 proteins.Further,the anti-tumor effects of HD10 NPs delivered through different administration routes were conducted on the 4 T1 tumorbearing mice.After a single administration,HD10 NPs delivered with DMNs showed the best antitumor effect when giving chemotherapy alone.As expected,the anti-tumor effect was profoundly enhanced after combined therapy,and complete tumor ablation was achieved in the mice treated with DMNs and intra-tumor injection.Moreover,DMNs showed better safety due to moderate hyperthermia.Therefore,the DMNs along with combined chemo-photothermal therapy provide a viable treatment option for superficial tumors. | Tingting Peng Yao Huang Xiaoqian Feng Chune Zhu Shi Yin Xinyi Wang Xuequn Bai Xin Pan Chuanbin Wu | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 4 |
| 5 | Effect of electrode Pt-loading and cathode flow-field plate type on the degradation of PEMFC显示文摘The electrode Pt-loading has an effect on the number of active sites and the thickness of catalyst layer,which has huge influence on the mass transfer and water management during dynamic process in PEMFCs. In this study, membrane electrode assemblies with different Pt-loadings were prepared, and PEMFCs were assembled using those membrane electrode assemblies with traditional solid plate and water transport plate as cathode flow-field plates, respectively. The performance and electrochemical surface area of cells were characterized to evaluate the membrane electrode assemblies degradation after rapid currentvariation cycles. Scanning electron microscope and transmission electron microscope were used to investigate the decay of catalyst layers and Pt/C catalyst. With the increase of Pt-loading, the performance degradation of membrane electrode assemblies will be mitigated. But higher Pt-loading means thicker catalyst layer, which leads to a longer pathway of mass transfer, and it may result in carbon material corrosion in membrane electrode assemblies. The decay of Pt/C catalyst in cathode is mainly caused by the corrosion of carbon support, and the degradation of anode Pt/C catalyst is a consequence of migration and aggregation of Pt particles. And using water transport plate is beneficial to alleviating the age of cathode Pt/C catalyst. | Lijuan Qu Zhiqiang Wang Xiaoqian Guo Wei Song Feng Xie Liang He Zhigang Shao Baolian Yi | 2019 | Journal of Energy Chemistry2019，28，8： | 4 |
| 6 | Phytoplankton Species Composition of Four Ecological Provinces in Yellow Sea, China显示文摘The ecological province based on phytoplankton species composition is important to understanding the interplay between environmental parameters and phytoplankton species composition. The aim of this study was to establish phytoplankton species composition ecological pattern thus elucidate the relationship between environmental factors and the phytoplankton species composition in the ecological provinces. Phytoplankton samples were collected from 31 stations in Yellow Sea(121.00?–125.00?E, 32.00?–39.22?N) in November 2014. The samples were enumerated and identified with the Uterm?hl method under an optical inverted microscope-AE2000 with magnifications of 200 × or 400 ×. In the present study, a total of 141 taxa belonging to 60 genera of 4 phyla of phytoplankton were identified, among them 101 species of 45 genera were Bacillariophyta, 36 species of 11 genera were Dinophyta, 3 species of 3 genera were Chrysophyta and 1 species of 1 genera was Chlorophyta. The study area was divided into 4 ecological provinces according to an unsupervised cluster algorithm applied to the phytoplankton biomass. A T-S(Temperature-Salinity) scatter diagram depicted with data of water temperature and salinity defined by environmental provinces matched well with the ecological provinces. The results of Canonical Correspondence Analysis(CCA) indicated that the phytoplankton species composition was mainly correlated with temperature, salinity and silicate concentration in the studied area. A method of establishing ecological provinces is useful to further understanding the environmental effects on the marine phytoplankton species composition and the consequent marine biogeochemistry. | LI Xiaoqian FENG Yuanyuan LENG Xiaoyun LIU Haijiao SUN Jun | 2017 | Journal of Ocean University of China2017，16，6： | 2 |
| 7 | SARS-CoV-2 spike protein receptor-binding domain perturbates intracellular calcium homeostasis and impairs pulmonary vascular endothelial cells显示文摘Exposure to the spike protein or receptor-binding domain(S-RBD)of SARS-CoV-2 significantly influences endothelial cells and induces pulmonary vascular endotheliopathy.In this study,angiotensin-converting enzyme 2 humanized inbred(hACE2 Tg)mice and cultured pulmonary vascular endothelial cells were used to investigate how spike protein/S-RBD impacts pulmonary vascular endothelium.Results show that S-RBD leads to acute-to-prolonged induction of the intracellular free calcium concentration([Ca^(2+)]i)via acute activation of TRPV4,and prolonged upregulation of mechanosensitive channel Piezo1 and store-operated calcium channel(SOCC)key component Orai1 in cultured human pulmonary arterial endothelial cells(PAECs).In mechanism,S-RBD interacts with ACE2 to induce formation of clusters involving Orai1,Piezo1 and TRPC1,facilitate the channel activation of Piezo1 and SOCC,and lead to elevated apoptosis.These effects are blocked by Kobophenol A,which inhibits the binding between S-RBD and ACE2,or intracellular calcium chelator,BAPTA-AM.Blockade of Piezo1 and SOCC by GsMTx4 effectively protects the S-RBDinduced pulmonary microvascular endothelial damage in hACE2 Tg mice via normalizing the elevated[Ca^(2+)]i.Comparing to prototypic strain,Omicron variants(BA.5.2 and XBB)of S-RBD induces significantly less severe cell apoptosis.Transcriptomic analysis indicates that prototypic S-RBD confers more severe acute impacts than Delta or Lambda S-RBD.In summary,this study provides compelling evidence that S-RBD could induce persistent pulmonary vascular endothelial damage by binding to ACE2 and triggering[Ca^(2+)]i through upregulation of Piezo1 and Orai1.Targeted inhibition of ACE2-Piezo1/SOCC-[Ca^(2+)]i axis proves a powerful strategy to treat S-RBD-induced pulmonary vascular diseases. | Kai Yang Shiyun Liu Han Yan Wenju Lu Xiaoqian Shan Haixia Chen Changlei Bao Huazhuo Feng Jing Liao Shuxin Liang Lei Xu Haiyang Tang Jason X-J.Yuan Nanshan Zhong Jian Wang | 2023 | Signal Transduction and Targeted Therapy2023，8，8： | 2 |
| 8 | Green synthesis of MnO_x nanostructures and studies of their supercapacitor performance显示文摘Manganese oxides with different crystalline phases and morphologies were prepared by calcining Mn CO3 precursors. The Mn CO3 precursors with different morphologies were obtained through a green route under hydrothermal conditions with orange pericarp extracting solution as the reducing agent. By calcining the precursor under different temperatures and atmospheres, Mn Ox with different stoichiometric ratios(i.e., Mn O, Mn O2, Mn2O3, and Mn3O4) can be obtained. Electrochemical studies reveal that among these manganese oxides, Mn O or Mn O2 are more suitable as supercapacitor working electrodes than Mn2O3 or Mn3O4. They exhibit high specific capacitance up to 296.6 F/g and also possess good cycling stability, which make them potential electrode materials for supercapacitors. | Wei Du Xiaoqian Xu Di Zhang Qingyi Lu Feng Gao | 2015 | Science China Chemistry2015，58，4： | 2 |
| 9 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 10 | Spring and autumn living coccolithophores in the Bohai Sea and Yellow Sea,China显示文摘The living coccolithophores(LCs) are an important class of calcified taxa of phytoplankton functional groups,and major producers of marine biogenic inorganic carbon,playing an important role in the marine carbon cycle.In this study,we report the two-demensional abundance,composition of LCs and its correlation with the environmental parameters in spring and autumn,in order to understand the ecological role of LCs in the Yellow Sea and the Bohai Sea.In spring,totally 9 taxa belonging to coccolithophyceae were identified using a polarized microscope at the 1 000× magnification.The dominant species were Emiliania huxleyi,Gephyrocapsa oceanica,Helicosphaera carteri,and Calcidiscus leptoporus.The abundance of coccosphores and coccoliths ranged 0–7.72cells/m L,and 0–216.09 coccoliths/m L,with the average values of 0.21 cells/m L,and 11.36 coccoliths/m L,respectively.The Emiliania huxleyi distribution was similar to Gephyrocapsa oceanica.The highest abundance of coccoliths was observed in the east of Shandong Peninsula in northern Yellow Sea,whereas Helicosphaera carteri distributed more widely.Emiliania huxleyi and Gephyrocapsa oceanica were the two predominant species in LCs with higher abundances.The distribution of LCs was similar to that of coccoliths.In autumn,14 taxa belonging to coccolithophyceae were identified with dominant species as Emiliania huxleyi,Gephyrocapsa oceanica,Helicosphaera carteri,Calcidiscus leptoporus and Oolithotus fragilis.The abundance of coccosphores and coccoliths ranged 0–24.69 cells/m L,and 0–507.15 coccoliths/m L,with the average values of 1.47 cells/m L,and55.89 coccoliths/m L,respectively.The highest abundance of coccoliths was located in Qingdao coastal waters and south of the survey area.The distribution of LCs was similar to the coccoliths; in addition,LCs presented large abundance in the east of the central Yellow Sea area. | JIN Hualong FENG Yuanyuan LI Xiaoqian ZHAI Weidong SUN Jun | 2015 | Acta Oceanologica Sinica2015，34，10： | 1 |
| 11 | Virus-inspired surface-nanoengineered antimicrobial liposome:A potential system to simultaneously achieve high activity and selectivity显示文摘Enveloped viruses such as SARS-CoV-2 frequently have a highly infectious nature and are considered effective natural delivery systems exhibiting high efficiency and specificity.Since simultaneously enhancing the activity and selectivity of lipopeptides is a seemingly unsolvable problem for conventional chemistry and pharmaceutical approaches,we present a biomimetic strategy to construct lipopeptide-based mimics of viral architectures and infections to enhance their antimicrobial efficacy while avoiding side effects.Herein,a surface-nanoengineered antimicrobial liposome(SNAL)is developed with the morphological features of enveloped viruses,including a moderate size range,lipid-based membrane structure,and highly lipopeptide-enriched bilayer surface.The SNAL possesses virus-like infection to bacterial cells,which can mediate high-efficiency and high-selectivity bacteria binding,rapidly attack and invade bacteria via plasma membrane fusion pathway,and induce a local“burst”release of lipopeptide to produce irreversible damage of cell membrane.Remarkably,viral mimics are effective against multiple pathogens with low minimum inhibitory concentrations(1.6-6.3μg mL1),high bactericidal efficiency of>99%within 2 h,>10-fold enhanced selectivity over free lipopeptide,99.8%reduction in skin MRSA load after a single treatment,and negligible toxicity.This bioinspired design has significant potential to enhance the therapeutic efficacy of lipopeptides and may create new opportunities for designing next-generation antimicrobials. | Yin Shi Xiaoqian Feng Liming Lin Jing Wang Jiaying Chi Biyuan Wu Guilin Zhou Feiyuan Yu Qian Xu Daojun Liu Guilan Quan Chao Lu Xin Pan Jianfeng Cai Chuanbin Wu | 2021 | Bioactive Materials2021，6，10： | 1 |
| 12 | FERONIA receptor kinase pathway suppresses abscisic acid signaling in Arabidopsis by activating ABI2 phosphatase显示文摘 | Feng Yu Lichao Qian Candida Nibau Qiaohong Duan Daniel Kita Kathryn Levasseur Xiaoqian Li Changqing Lu Hui Li Congcong Hou Legong Li Bob B. Buchanan Liangbi Chen Alice Y. Cheung Dongping Li Sheng Luan | 2012 | Proceedings of the National Academy of Sciences2012，，36： | 1 |
| 13 | Genetic background effects on QTL and QTL × environment interaction for yield and its component traits as revealed by reciprocal introgression lines in rice显示文摘QTLs for quantitative traits are influenced by genetic background(GB) and environment.Identification of QTL with GB independency and environmental stability is prerequisite for effective marker-assisted selection(MAS). In this study, QTLs and QTL × environment interactions affecting grain yield per plant(GY) and its component traits, filled grain number per panicle(FGN), panicle number per plant(PN) and 1000-grain weight(TGW) across six environments were dissected using two sets of reciprocal introgression lines(ILs) derived from the cross Lemont × Teqing and SNP genotypic data. ANOVA indicated that the differences among genotypes and environments within each set of ILs were highly significant for all traits. A total of 72 distinct QTLs for GY and its component traits including 15 for GY, 25 for FGN, 18 for PN, and 29 for TGW were detected over the six environments. Most QTLs(87.4%) showed significant QTL × environment interactions(QEIs) and appeared to be more or less environment-specific. Among 72 QTLs, 15(20.8%) QTLs and 12(16.7%) QEIs were commonly identified in both backgrounds, indicating QTL especially QEI for yield and its component traits had strong GB effects. Four QTL regions affecting GY and its component traits, including S1269707–S4288071, S16661497–S17511092, and S35861863–S36341768 on chromosome 3, and S4134205–S7643153 on chromosome 5, were detected in both backgrounds and coincided with cloned genes for yield-related traits. These regions can be the targeted in rice breeding for high yield potential through MAS. Application of QTL main effects and their environmental interaction effects in MAS was discussed in detail. | Xiaoqian Wang Yunlong Pang Jian Zhang Qiang Zhang Yonghong Tao Bo Feng Tianqing Zheng Jianlong Xu Zhikang Li | 2014 | The Crop Journal2014，2，6： | 1 |
| 14 | Nucleosome?binding protein HMGN2 exhibits antitumor activity in oralsquamous cell carcinoma显示文摘 | Ankang Hu Xiaoqian Dong Xiqian Liu Ping Zhang Yonghong Zhang Ning Su Qianming Chen Yun Feng | 2014 | Oncology Letters2014，，1： | 1 |
| 15 | Modified room temperature solid-state synthesis of yttria-stabilized zirconia(YSZ) nano-powders for solid oxide fuel cells显示文摘High-performance solid oxide fuel cell(SOFC) is in urgent need of high-quality electrolyte powders with high reactivity and chemical uniformity.Here,8 mol% Y_(2)O_(3) doped ZrO_(2)(YSZ) nano-powders were synthesized by an improved solid-state reaction method at ambient temperature,and were applied to the fabrication of SOFC electrolytes.YSZ nano-powders show average grain sizes of ^(2)0 nm and high dispersibility,which is comparable with or even better than some other chemical methods.Benefitting from their high reactivity,dense YSZ electrolytes(relative density of 97.9%) can be obtained at a relatively low sintering temperature of 1400℃.The optimized electrical conductivity reaches up to a high value of0.034 S/cm at 800 0C in air.The anode supported single cell with the construction of Ni-YSZ/YSZ/Sm_(0.2)Ce_(0.8)O_(2-δ)(SDC)/La_(0.6)Sr_(0.4)Co_(0.2)Fe_(0.8)O_(3-δ)(LSCF) exhibits the peak power density of 0.827 W/cm^(2) at800℃ while taking wet H_(2) as fuels and ambient air as oxidants. | Xiaoqian Xu Yurun Feng Zhaoyu Zhong Xue Guo Zhenhao Zhang Jiao Li Shikai Zhao Shigang Wu Haibin Sun | 2023 | Journal of Rare Earths2023，41，9： | 0 |
| 16 | A Novel Location Management Scheme based on DNS in Proxy Mobile IPv6显示文摘Proxy Mobile IPv6 (PMIPv6) is designed to provide a network-based localized mobility management protocol, but it does not handle the global mobility of hosts. In this paper, we propose a location management scheme based on Domain Name System (DNS) for PMIPv6 which can support global mobility by using DNS as a location manager. In addition, to support large numbers of mobile terminals and enhance network scalability a paging extension scheme is introduced to PMIPv6. To evaluate the proposed location management scheme, we establish an analytical model, formulate the location update cost and the paging cost, and analyze the influence of the different factors on the total signaling cost. The performance results show that our proposed scheme outperforms the basic PMIPv6 under various parameters in terms of reducing the signaling overhead and the proposed scheme reduces signaling overhead compared to the basic PMIPv6. | Qiu Feng Li Xiaoqian Su Wei Zhang Hongke | 2010 | China Communications2010，7，3： | 0 |
| 17 | Light-guided tumor diagnosis and therapeutics:From nanoclusters to polyoxometalates显示文摘Malignant tumors,with the characteristics of easy metastasis and recurrence,are a serious threat to health of mankind.It is urgent to develop promising clinical cancer targeted agents with combination of rapid diagnosis and efficient therapies.Compared with the conventional photosensitizing agents,the recent advances of nanoagents based on transition metal-oxide clusters possess unique structural and electronic properties,greatly improving cancer survival rate,meanwhile,keeping high contrast imaging.This review provides a brief introduction of metal-oxide clusters,including both nanoclusters to molecular clusters,specifically polyoxometalates(POMs).Subsequently,biocompatibility of metal-oxide clusters is emphasized from aspects of endocytosis,macropinocytosis,and phagocytosis.Through the classification of late and early transition metals oxide clusters,recent outcomes of light-guided nanoagents are represented with their intriguing chemical and optical properties in their diagnosing and photochemotherapy performance.It shed light on the summary of next generation multifunctional cancer targeting agents'developments as well as outlook of materials selection trends and research direction in the future. | Xiaofeng Fan Wei Pang Hao Feng Ruiyi Zhang Wentao Zhu Qiushi Wang Jun Miao Yiwen Li Yanjun Liu Xiaoqian Xu | 2022 | Chinese Chemical Letters2022，33，6： | 0 |
| 18 | Targeting PDE4 as a promising therapeutic strategy in chronic ulcerative colitis through modulating mucosal homeostasis显示文摘Phosphodiesterase-4(PDE4) functions as a catalyzing enzyme targeting hydrolyzation of intracellular cyclic adenosine monophosphate(c AMP) and inhibition of PDE4 has been proven to be a competitive strategy for dermatological and pulmonary inflammation. However, the pathological role of PDE4 and the therapeutic feasibility of PDE4 inhibitors in chronic ulcerative colitis(UC) are less clearly understood. This study introduced apremilast, a breakthrough in discovery of PDE4 inhibitors,to explore the therapeutic capacity in dextran sulfate sodium(DSS)-induced experimental murine chronic UC. In the inflamed tissues, overexpression of PDE4 isoforms and defective c AMP-mediating pathway were firstly identified in chronic UC patients. Therapeutically, inhibition of PDE4 by apremilast modulated c AMP-predominant protein kinase A(PKA)-c AMP-response element binding protein(CREB)signaling and ameliorated the clinical symptoms of chronic UC, as evidenced by improvements on mucosal ulcerations, tissue fibrosis, and inflammatory infiltrations. Consequently, apremilast maintained a normal intestinal physical and chemical barrier function and rebuilt the mucosal homeostasis by interfering with the cross-talk between human epithelial cells and immune cells. Furthermore, we found that apremilast could remap the landscape of gut microbiota and exert regulatory effects on antimicrobial responses and the function of mucus in the gut microenvironment. Taken together, the present studyrevealed that intervene of PDE4 provided an infusive therapeutic strategy for patients with chronic and relapsing UC. | Heng Li Yao Zhang Moting Liu Chen Fan Chunlan Feng Qiukai Lu Caigui Xiang Huimin Lu Xiaoqian Yang Bing Wu Duowu Zou Wei Tang | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 0 |
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