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| 1 | Cardiovascular autonomic neuropathy in diabetes:Pathophysiology,clinical assessment and implications显示文摘Cardiovascular autonomic neuropathy(CAN)is a debilitating condition that mainly occurs in long-standing type 2 diabetes patients but can manifest earlier,even before diabetes is diagnosed.CAN is a microvascular complication that results from lesions of the sympathetic and parasympathetic nerve fibers,which innervate the heart and blood vessels and promote alterations in cardiovascular autonomic control.The entire mechanism is still not elucidated,but several aspects of the pathophysiology of CAN have already been described,such as the production of advanced glycation end products,reactive oxygen species,nuclear factor kappa B,and pro-inflammatory cytokines.This microvascular complication is an important risk factor for silent myocardial ischemia,chronic kidney disease,myocardial dysfunction,major cardiovascular events,cardiac arrhythmias,and sudden death.It has also been suggested that,compared to other traditional cardiovascular risk factors,CAN progression may have a greater impact on cardiovascular disease development.However,CAN might be subclinical for several years,and a late diagnosis increases the mortality risk.The duration of the transition period from the subclinical to clinical stage remains unknown,but the progression of CAN is associated with a poor prognosis.Several tests can be used for CAN diagnosis,such as heart rate variability(HRV),cardiovascular autonomic reflex tests,and myocardial scintigraphy.Currently,it has already been described that CAN could be detected even during the subclinical stage through a reduction in HRV,which is a non-invasive test with a lower operating cost.Therefore,considering that diabetes mellitus is a global epidemic and that diabetic neuropathy is the most common chronic complication of diabetes,the early identification and treatment of CAN could be a key point to mitigate the morbidity and mortality associated with this long-lasting condition. | Alice Duque Mauro Felippe Felix Mediano Andrea De Lorenzo Luiz Fernando Rodrigues Jr | 2021 | World Journal of Diabetes2021，12，6： | 14 |
| 2 | The chemosensory appendage proteome of Amblyomma americanum (Acari: Ixodidae) reveals putative odorant-binding and other chemoreception-related proteins显示文摘Proteomic 分析在孤独的星的 2 个化学感应的附器上被做滴答响, Amblyomma americanum。蛋白质在在先 tarsi,包含嗅觉的 Hallers 机关,并且在触官,包括味觉的 sensilla,与在第三 tarsi 的蛋白质相比。另外,男性和女性滴答响被比较。蛋白质被顺序类似,并且由 3-dimensional 相同建模识别到已知的蛋白质。Proteomic 数据也与从 tick Rhipicephalus microplus 的器官特定的 transcriptomes 相比。在先 tarsi 快车没在第三 tarsi 或触官发现的 lipocalin。在先, tarsi 和触官富有地表示 2 蛋白质,它类似于昆虫有气味的东西绑定蛋白质(OBP ) 。与昆虫 OBP 相比, tick 象 OBP 一样序列缺乏半胱氨酸在 C 减 OBP 不在,并且 1 滴答响象 OBP 一样顺序有类似于 C 加 OBP 的另外的半胱氨酸。类似于抗菌素蛋白质 microplusin 的四蛋白质被发现:2 只表示了在在先 tarsi 并且 1 只在触官表示了。这些蛋白质缺乏 microplusin 铜绑定地点,而是他们被建模有一个重要的内部洞,潜在地一个 ligand 有约束力的地点。类似于 7 被发现差别的灰尘螨变应原 Der p7 和 Der f 的蛋白质在先在女性表示了 tarsi。只表示在的蛋白质在先, tarsi 有类似到否决权,它被知道涉及 ionotropic glutamate 受体聚类。这些结果组成象 OBP 一样蛋白质序列的第一份报告在滴答响并且点到几条研究大街在上滴答响化学感应的接收。 | Robert Renthal Leena Manghnani Sandra Bernal Yanyan Qu Wendell P. Griffith Kim Lohmeyer Felix O. Guerrero Ligia M.F. Borges Adalberto Perez de Leon | 2017 | Insect Science2017，24，5： | 4 |
| 3 | Self-referential processing in our brain—A meta-analysis of imaging studies on the self显示文摘 | Georg Northoff Alexander Heinzel Moritz de Greck Felix Bermpohl Henrik Dobrowolny Jaak Panksepp | 2005 | Neuroimage2005，，1： | 3 |
| 4 | Long-term follow-up of quality of life in high-risk patients undergoing transcatheter aortic valve implantation for symptomatic aortic valve stenosis显示文摘BackgroundTranscatheter 大动脉的阀门培植(TAVI ) 与严重征兆的大动脉的狭窄为病人成为了标准治疗(作为) 为外科的大动脉的阀门代替在很高的风险考虑了。这亚学习的目的是评估长期的(> 4 年) 在 octogenarians 的生活(QoL ) 的健康相关的质量经历了 TAVI.MethodsA 单个中心在在 TAVI 以后经历了框架分析评价 4 年的二十个病人的观察登记。健康相关的 QoL 被评估,用短 Form-36 ( SF-36 ),吗 EuroQoL-5D ( EQ-5D )和 questionnaires.ResultsThe 平均数 SF-36 subscale 在后续获得的视觉类似物分数(EQ管)是物理的工作 40.8 ????????????????????????????搠?潮潶???吗?湡楧灯慬瑳?????????愠杮潩牧灡票?€ 敦潭潲潰汰瑩慥???????????????愠桴牥'啼蠹溃浚? | Marjo JAG De Ronde-Tillmans Tom AJ de Jager Jeannette A Goudzwaard Nahid El Faquir Nicolas M van Mieghem Felix Zijlstra Elisabeth MWJ. Utens Francesco US Mattace-Raso MaRie J Lenzen Peter PT de Jaegere | 2018 | Journal of Geriatric Cardiology2018，15，4： | 3 |
| 5 | Modification in the diet can induce beneficial effects against breast cancer显示文摘The population tends to consume foods that in addition to their nutritional values can offer some benefits to their health. There are many epidemiological evidences and research studies in animal models suggesting that diet plays an important role in breast cancer prevention or progression. This review summarized some of the relevant researches about nutrition and cancer during the last years, especially in breast cancer. The analysis of probiotics and fermented products containing lactic acid bacteria in cancer prevention and/or treatment was especially discussed. It was observed that a balance of fatty acids similar to those of traditional Mediterranean diet, the consumption of fruits and vegetables, dietary fiber intake, vitamin supplementation are, along with the intake of probiotic products, the most extensivelystudied by the negative association to breast cancer risk. The consumption of probiotics and fermented products containing lactic acid bacteria was associated to reduce breast cancer risk in some epidemiological studies. The use of animal models showed the modulation of the host's immune response as one of the important effects associated to the benefices observed with most probiotics. However; future assays in human are very important before the medical community can accept the addition of probiotic or fermented milks containing lactic acid bacteria as supplements for cancer patients. | Felix Aragón Gabriela Perdigón Alejandra de Moreno de Le Blanc | 2014 | World Journal of Clinical Oncology2014，5，3： | 2 |
| 6 | First Pre‐Functionalised Polymeric Aromatic Framework from Mononitrotetrakis(iodophenyl)methane and its Applications显示文摘 | Ester Verde‐Sesto Mercedes Pintado‐Sierra Avelino Corma Eva M. Maya Jose G. de la Campa Marta Iglesias Felix Sánchez | 2014 | Chem. Eur. J2014，，17： | 2 |
| 7 | Angiographic Assessment of Myocardial Reperfusion in Patients Treated With Primary Angioplasty for Acute Myocardial Infarction: Myocardial Blush Grade显示文摘 | Arnoud W.J. van ’t Hof Aylee Liem Harry Suryapranata Jan C.A. Hoorntje Menko-Jan de Boer Felix Zijlstra | 1998 | Circulation1998，，23： | 2 |
| 8 | Vorapaxar for secondary prevention of thrombotic events for patients with previous myocardial infarction: a prespecified subgroup analysis of the TRA 2°P-TIMI 50 trial显示文摘 | Benjamin M Scirica Marc P Bonaca Eugene Braunwald Gaetano M De Ferrari Daniel Isaza Basil S Lewis Felix Mehrhof Piera A Merlini Sabina A Murphy Marc S Sabatine Michal Tendera Frans Van de Werf Robert Wilcox David A Morrow | 2012 | The Lancet . 2012 (9850)2012，，9850： | 1 |
| 9 | First Experience in Humans Using Adipose Tissue–Derived Regenerative Cells in the Treatment of Patients With ST-Segment Elevation Myocardial Infarction显示文摘 | Jaco H. Houtgraaf Wijnand K. den Dekker Bas M. van Dalen Tirza Springeling Renate de Jong Robert J. van Geuns Marcel L. Geleijnse Francisco Fernandez-Aviles Felix Zijlsta Patrick W. Serruys Henricus J. Duckers | 2012 | Journal of the American College of Cardiology2012，，5： | 1 |
| 10 | Etiology of esophageal atresia and tracheoesophageal fistula: 'mind the gap'显示文摘 | de Jong EM Felix JF de Klein A | 2010 | Curr Gastroenterol Rep2010，12，3： | 1 |
| 11 | Dexmedetomidine for diagnostic cardiac catheterization in a child with idiopathic pulmonary hypertension显示文摘 | Munro HM Felix DE Nykanen DG | 2009 | J Clin Anesth2009，21，6： | 1 |
| 12 | Dissection of functional domains of the voltage-dependent Ca^2+ channel alpha2 delta subunit显示文摘 | FELIX R GURNETT CA DE WAARD M | 1997 | J Neurosci1997，17，18： | 1 |
| 13 | Cofactor Engineering: a Novel Approach to Metabolic Engineering in Lactoccus lactis by Controlled Expression of NADH Oxidase 显示文摘 | Felix Lopez DE Felipe | 1998 | Journal of Bacteriology1998，15，180： | 1 |
| 14 | Acute mesenteric venous thrombosis following laparoscopic Roux-en-Y gastric bypass显示文摘 | Swartz DE Felix EL | 2004 | JSLS2004，8，2： | 1 |
| 15 | Early identification and marketing of innovative technologies: a case study of RTD result valorisation at the European Commission's Joint Research Centre显示文摘 | Pietro Moncada-Paterno-Castello Jaime Rojo Felix Bellido Fre'de'ric Fiore Alexander Tubke | 2003 | Technovation2003，23，2003： | 1 |
| 16 | Open Access and Scopus: A New Approach to Scientific Visibility from the Standpoint of Access显示文摘 | Miguel Sandra Zaida Chinchilla-Rodriguez Felix de Moya-Anegon | 2011 | Journal of the American Society for Information Science and Technology2011，62，6： | 1 |
| 17 | Lettuce genotype resistance to 'soft rot' caused by Pectobacterium carotovorum subsp earoto- vorum显示文摘 | FELIX K de OLIVEIRA W J MARIANO R | 2014 | Scientia Agricola2014，71，4： | 1 |
| 18 | Patients with mild to moderate body dysmorphic disorder may benefit from rhinoplasty 显示文摘 | Felix G A A de Brito M J A Nahas F X | 2014 | Journal of Plastic Reconstructive & Aesthetic Surgery2014，67，5： | 1 |
| 19 | Dissection of functional domains of the voltage -dependent Ca2 + channel alpha2delta subunit显示文摘 | Felix R Gumett C A De Waard M | | 0，，18： | 1 |
| 20 | Molecular and morphological characterisation of two reproductively isolated species with mirror-image anatomy (Nematoda: Cephalobidae)显示文摘 | Paul De Ley Marie-Anne Felix Linda M. Frisse Steven A. Nadler Paul W. Sternberg W. Kelley Thomas | 1999 | Nematology1999，，6： | 1 |
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