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| 1 | Systematic review: The placebo effect of psychological interventions in the treatment of irritable bowel syndrome显示文摘AIM To determine the placebo response rate associated with different types of placebo interventions used in psychological intervention studies for irritable bowel syndrome. METHODS Randomized controlled trials comparing psychological interventions(stress management/relaxation therapy(cognitive) behavioral therapy, short-term psychodynamic therapy, and hypnotherapy) for the treatment of adult patients with irritable bowel syndrome(IBS) diagnosed with the Manning or Rome criteria with an adequate placebo control treatment and reporting data on IBS symptom severity were identified by searching Pub Med, Embase, the Cochrane Library, CINAHL and Psyc INFO databases. Full-text articles that were written in English and published between 1966 and February 2016 in peer-reviewed journals were selected for the present review. Placebo interventions were considered to be adequate if the number of sessions and the amount of time spent with the therapist were the same as in the active treatment. The placebo response rate(PRR) was computed for IBS symptom severity(primary outcome measure) as well as for anxiety, depression and quality of life(secondary outcome measures). RESULTS Six studies, with a total of 555 patients met the inclusion criteria. Four studies used an educational intervention, whereas two studies used a form of supportive therapy as the placebo intervention. The PRR for IBS symptom severity ranged from 25% to 59%, with a pooled mean of 41.4%. The relative PRR for the secondary outcome measures ranged from 0% to 267% for anxiety, 6% to 52% for depression 20% to 125% for quality of life. The PRR associated with pharmacological treatments, treatment with dietary bran and complementary medicine ranged from 37.5% to 47%. Contrary to our expectations, the PRR in studies on psychological interventions was comparable to that in studies on pharmacological, dietary and alternative medical interventions.CONCLUSION The PRR is probably determined to a larger extent by patient-related factors, such as expectations and desire for the treatment to be effective, than the content of the placebo intervention. | Carla E Flik Laura Bakker Wijnand Laan Yanda R van Rood André JPM Smout Niek J de Wit | 2017 | World Journal of Gastroenterology2017，23，12： | 7 |
| 2 | A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor显示文摘Glucagon-like peptides(GLP-1 and GLP-2)are two proglucagon-derived intestinal hormones that mediate distinct physiological functions through two related receptors(GLP-1R and GLP-2R)which are important drug targets for metabolic disorders and Crohn's disease,respectively.Despite great progress in GLP-1 R structure determination,our understanding on the differences of peptide binding and signal transduction between these two receptors remains elusive.Here we report the electron microscopy structure of the human GLP-2R in complex with GLP-2 and a Gs heterotrimer.To accommodate GLP-2 rather than GLP-1,GLP-2R fine-tunes the conformations of the extracellular parts of transmembrane helices(TMs)1,5,7 and extracellular loop 1(ECL1).In contrast to GLP-1,the N-terminal histidine of GLP-2 penetrates into the receptor core with a unique orientation.The middle region of GLP-2 engages with TM1 and TM7 more extensively than with ECL2,and the GLP-2 C-terminus closely attaches to ECL1,which is the most protruded among 9 class B G protein-coupled receptors(GPCRs).Functional studies revealed that the above three segments of GLP-2 are essential for GLP-2 recognition and receptor activation,especially the middle region.These results provide new insights into the molecular basis of ligand specificity in class B GPCRs and may facilitate the development of more specific therapeutics. | Wen Sun Li-Nan Chen Qingtong Zhou Li-Hua Zhao Dehua Yang Huibing Zhang Zhaotong Cong Dan-Dan Shen Fenghui Zhao Fulai Zhou Xiaoqing Cai Yan Chen Yan Zhou Sarina Gadgaard Wijnand JCvan der Velden Suwen Zhao Yi Jiang Mette MRosenkilde HEric Xu Yan Zhang Ming-Wei Wang | 2020 | Cell Research2020，30，12： | 4 |
| 3 | Arginine and citrulline and the immune response in sepsis显示文摘 | Wijnands KA Castermans TM Hommen MP | 2015 | Nutrients2015，7，3： | 1 |
| 4 | First Experience in Humans Using Adipose Tissue–Derived Regenerative Cells in the Treatment of Patients With ST-Segment Elevation Myocardial Infarction显示文摘 | Jaco H. Houtgraaf Wijnand K. den Dekker Bas M. van Dalen Tirza Springeling Renate de Jong Robert J. van Geuns Marcel L. Geleijnse Francisco Fernandez-Aviles Felix Zijlsta Patrick W. Serruys Henricus J. Duckers | 2012 | Journal of the American College of Cardiology2012，，5： | 1 |
| 5 | High-and low-frequency quasi-periodic oscillations in the X-ray light curves of the black hole transient H1743-322显示文摘 | Homan J Miller J M Wijnands R | 2005 | ApJ2005，623，： | 1 |
| 6 | A pilot randomised controlled trial comparing reactive air and active alternating pressure mattresses in the prevention and treatment of pressure ulcers among medical ICU patients显示文摘 | Malbrain M Hendriks B Wijnands P | 2010 | J Tissue Viability2010，19，1： | 1 |
| 7 | Treatment of periodontitis improves the atherosclerotic profile: a systematic review and meta‐analysis显示文摘 | Wijnand J. Teeuw Dagmar E. Slot Hendri Susanto Victor E. A. Gerdes Frank Abbas Francesco D’Aiuto John J. P. Kastelein Bruno G. Loos | 2014 | J Clin Periodontol2014，，1： | 1 |
| 8 | Modelling thenumber of viable vegetative cells of Bacillus cereus passingthrough the stomach 显示文摘 | Wijnands L M Pielaat A Dufrenne J B | 2009 | J Journal Of Applied Microbiology2009，106，1： | 1 |
| 9 | Mechanisms of nanoelay-enhanced plastic foaming processes: effects of nanoclay intercalation and exfoliation 显示文摘 | Wong A Wijnands S F L Kuboki T | 2013 | J Nanopart Res2013，15，8： | 1 |
| 10 | Ochratoxin A in airborne dust and fungal conidia显示文摘 | MARIT A S WIJNAND E FREDRIK C S | 2000 | Mycopathologia2000，，151： | 1 |
| 11 | High-frequency quasi-periodic oscillations in the 2000 outburst of the galactic microquasar XTE J1550-564显示文摘 | Miller J M Wijnands R Homan J | 2001 | ApJ2001，563，： | 1 |
| 12 | Correlated X-ray spectral and timing behavior of the black hole candidate XTE J1550-564:a new interpretation of black hole states显示文摘 | Homan J Wijnands R van der Klis M | 2001 | ApJS2001，132，： | 1 |
| 13 | Detected health and well - being problems following comprehensive geriatric assessment during a home visit among community - dwelling older people: who benefits most? 显示文摘 | Stijnen MM Van Hoof MS Wijnands - Hoekstra IT | 2014 | Faro Pract2014，31，3： | 1 |
| 14 | Detection of HLA-G by a specific sandwich ELISA using monoclonal antibodies G233 and 56B显示文摘 | van Lierop MJ Wijnands F Loke YW | 2002 | Mol Hum Reprod2002，8，8： | 1 |
| 15 | Evaluation of the retrievability of the OptEase IVC filter in an animal model 显示文摘 | Reekers JA Hoogeveen YL Wijnands M | 2004 | J Vasc Interv Radiol2004，15，： | 1 |
| 16 | The efficacy of alginate encapsulated CHO-K1 single chain-TRAIL producer cells in the treatment of brain tumors显示文摘 | Jos MA Kuijlen Bart J Haan Wijnand Helfrich Jan-Freark Boer Douwe Samplonius Jan Jakob A Mooij Paul Vos | 2006 | Journal of Neuro-Oncology2006，，1： | 1 |
| 17 | Quasiperiodic X-ray brightness fluctuations in an accreting millisecond pulsar显示文摘 | Wijnands R van der Klis M Homan J | 2003 | Nature2003，424，： | 1 |
| 18 | Visual Discomfort in Stereoscopic Displays:A Review显示文摘 | Marc T M Lambooij Wijnand A IJsselsteijn Ingrid Heynderickx | 2007 | Stereoscopic Displays and Virtual Reality Systems XⅣ2007，，： | 1 |
| 19 | Reference frames fit for controlling pwm rectifiers显示文摘 | Duarte J L Zwam A V Wijnands C | 1999 | IEEE Transactions on Power Electronics1999，46，3： | 1 |
| 20 | Assessment of average, population and individual bioequivalence in two- and four-period crossover studies显示文摘 | Wijnand H P | 2003 | Computer Methods and Programs in Biomedicine2003，70，： | 1 |
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