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| 1 | Clinical implications of diabetes in chronic liver disease:Diagnosis,outcomes and management,current and future perspectives显示文摘Diabetes mellitus(DM)is common in liver cirrhosis(LC).The pathophysiological association is bidirectional.DM is a risk factor of LC and LC is a diabetogenic condition.In the recent years,research on different aspects of the association DM and LC has been intensified.Nevertheless,it has been insufficient and still exist many gaps.The aims of this review are:(1)To discuss the latest understandings of the association of DM and LC in order to identify the strategies of early diagnosis;(2)To evaluate the impact of DM on outcomes of LC patients;and(3)To select the most adequate management benefiting the two conditions.Literature searches were conducted using Pub Med,Ovid and Scopus engines for DM and LC,diagnosis,outcomes and management.The authors also provided insight from their own published experience.Based on the published studies,two types of DM associated with LC have emerged:Type 2 DM(T2 DM)and hepatogenous diabetes(HD).High-quality evidences have determined that T2 DM or HD significantly increase complications and death pre and post-liver transplantation.HD has been poorly studied and has not been recognized as a complication of LC.The management of DM in LC patients continues to be difficult and should be based on drug pharmacokinetics and the degree of liver failure.In conclusion,the clinical impact of DM in outcomes of LC patients has been the most studied item recently.Nevertheless many gaps still exist particularly in the management.These most important gaps were highlighted in order to propose future lines for research. | Diego García-Compeán Emanuela Orsi Ramesh Kumar Felix Gundling Tsutomu Nishida Jesús Zacarías Villarreal-Pérez Ángel N Del Cueto-Aguilera JoséA González-González Giuseppe Pugliese | 2022 | World Journal of Gastroenterology2022，28，8： | 4 |
| 2 | High-performance oxygen reduction and evolution carbon catalysis: From mechanistic studies to device integration显示文摘能容易集成于存在的高效、便宜的氧减小和进化催化剂的发展设备为利用 O 2-H2 O 化学,例如再生燃料房间和金属空气电池。此处,我们报导 NH 3-activated 做 N 的层次碳(NHC ) 催化剂经由一条可伸缩的线路综合了,并且表明它的设备集成。NHC 催化剂为氧减小反应(ORR ) 和氧进化反应(OER ) 展出了好性能,当综合时,借助于电气化学的研究和评估示威了进一个再生燃料房间的氧电极。为 ORR 和 OER 观察的活动比得上最先进的磅和红外催化剂在碱的环境完成的那些。我们进一步通过密度为电气化学的活动作为活跃地点识别了碳缺点的关键角色功能的理论计算和高分辨率的 TEM 可视化。这个工作加亮 NHC 的潜力在再生燃料房间并且可能代替商业宝贵金属为断断续续的可更新的精力的划算的存储的金属空气电池。 | John W. F. To Jia Wei Desmond Ng Samira Siahrostami Ai Leen Koh Yangjin Lee Zhihua Chen Kara D. Fong Shucheng Chen Jiajun He Won-Gyu Bae Jennifer Wilcox Hu Young Jeong Kwanpyo Kim Felix Studt Jens K. Nфrskov Thomas F. Jaramillo Zhenan Bao | 2017 | Nano Research2017，10，4： | 4 |
| 3 | 采用椭圆形非骨水泥压配固定髋臼杯行全髋关节置换术治疗髋关节发育不良显示文摘对继发于髋关节发育不良的晚期骨性关节炎患者来说,全髋关节置换术是较好的治疗选择,但由于此类患者存在的解剖结构异常,手术变得较为复杂。在分型为HartofilakidisⅡ型的患者中,股骨头的半脱位造成髋臼顶部外上方的骨缺损,往往需要某种形式的支撑来使髋臼杯获得稳定的固定。处理这种类型的骨缺损可以采用多种不同的方法,孰优孰劣尚有争议。本文的目的是通过回顾性分析比较两种不同的骨缺损处理方法,来探讨椭圆形非骨水泥髋臼杯是否可以作为传统处理方法的替代方法。 | 王俏杰 张先龙 Boris M.Holzapfel Felix Greimel Peter M.Prodinger Hakan Pilge Ulrich Nth Hans Gollwitzer Maximilian Rudert | 2012 | 中国矫形外科杂志2012，20，17： | 3 |
| 4 | Modification in the diet can induce beneficial effects against breast cancer显示文摘The population tends to consume foods that in addition to their nutritional values can offer some benefits to their health. There are many epidemiological evidences and research studies in animal models suggesting that diet plays an important role in breast cancer prevention or progression. This review summarized some of the relevant researches about nutrition and cancer during the last years, especially in breast cancer. The analysis of probiotics and fermented products containing lactic acid bacteria in cancer prevention and/or treatment was especially discussed. It was observed that a balance of fatty acids similar to those of traditional Mediterranean diet, the consumption of fruits and vegetables, dietary fiber intake, vitamin supplementation are, along with the intake of probiotic products, the most extensivelystudied by the negative association to breast cancer risk. The consumption of probiotics and fermented products containing lactic acid bacteria was associated to reduce breast cancer risk in some epidemiological studies. The use of animal models showed the modulation of the host's immune response as one of the important effects associated to the benefices observed with most probiotics. However; future assays in human are very important before the medical community can accept the addition of probiotic or fermented milks containing lactic acid bacteria as supplements for cancer patients. | Felix Aragón Gabriela Perdigón Alejandra de Moreno de Le Blanc | 2014 | World Journal of Clinical Oncology2014，5，3： | 2 |
| 5 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 6 | Global Supplier Selection: A Fuzzy-AHP Approach显示文摘 | Felix T S C Kumar N Tiwari M K | 2008 | International Journal ofProductionResearch2008，46，14： | 1 |
| 7 | Laparoscopic hemioplasty:signifieant complications 显示文摘 | Felix E Habertson N Varteian S | 1999 | Surg Endosc1999，13，1： | 1 |
| 8 | Silibinin modulates biotran- sforming microbial enzymes and prevents 1,2-dimethylhydrazine- induced preneoplastic changes in experimental colon cancer 显示文摘 | Sang eetha N Felix AJ Nalini N | 2009 | Eur J Cancer Prev2009，18，5： | 1 |
| 9 | Global suppli- er selection : A fuzzy - AHP approach 显示文摘 | FELIX T S CHAN KUMAR N TIWARI M K | 2008 | International Journal of Production Research2008，46，14： | 1 |
| 10 | Effect of pH,biopolymer mixingratio and salts on the formation and stability of electrostaticcomplexes formed within mixtures of lentil protein isolate andanionic polysaccharides (j -carrageenan and gellan gum ) 显示文摘 | Felix N A A Michael T N | 2014 | International Journal of Food Science and Technology2014，49，： | 1 |
| 11 | H2-DMalpha(-/-) mice show the importance of major histocompatibility complex-bound peptide in cardiac allograft rejection显示文摘 | FELIX N J BRICKEY W J GRIFFITHS R | 2000 | J Exp Med2000，192，： | 1 |
| 12 | Alteration of forebrain neuro genesis after cervical spinal cord injury in the adult rat显示文摘 | Felix MS Popa N Matarazzo VA | 2012 | Front Neurosci2012，6，45： | 1 |
| 13 | A six-axis MEMS force-torque sensor with micro-Newton and nano-New-tonmeter resolution显示文摘 | Beyeler Felix Muntwyler Simon Nelso Bradly J n | 2009 | Journal of Microelectromechanical Systems2009，18，2： | 1 |
| 14 | Incidence a long terme dune radiotherapie pour cancer du larynx,sur Ⅰ'apprition d'un myxoedeme显示文摘 | Felix H Dupre N Drape M | 1961 | Lyon Med1961，93，： | 1 |
| 15 | Diabetes in sub-Saharan Africa显示文摘 | Jean Claude N Mbanya Ayesha A Motala Eugene Sobngwi Felix K Assah Sostanie T Enoru | 2010 | 2010 (9733)2010，，9733： | 1 |
| 16 | SWAT model application in a data scarce tropical complex catchment in Tanzania显示文摘 | PREKSEDIS N FELIX M AANUND K | 2008 | Physics and Chemistry of the Earth2008，33，813： | 1 |
| 17 | Silibinin modu- lates biotransforming microbial enzymes and pre- vents 1, 2-dimethylhydrazine-induced preneoplastic changes in experimental colon cancer显示文摘 | Sangeetha N Felix AJ Nalini N | 2009 | Eur J Cancer Prey2009，18，5： | 1 |
| 18 | Human papillomavirus DNA prevalence and type distribution in anal carcinomas worldwide显示文摘 | Laia Alemany Ma?lle Saunier Isabel Alvarado‐Cabrero Beatriz Quirós Jorge Salmeron Hai‐Rim Shin Edyta C. Pirog Núria Guimerà Gustavo Hernandez‐Suarez Ana Felix Omar Clavero Belen Lloveras Elena Kasamatsu Marc T. Goodman Brenda Y. Hernandez Jan Laco Leopold | 2015 | Int. J. Cancer2015，，1： | 1 |
| 19 | Prolonged survival of class Ⅱ transactivator-deficient cardiac allografts显示文摘 | JUNE BRICKEY W FELIX N J GRIFFITHS R | 2002 | Transplantation2002，74，： | 1 |
| 20 | Simultaneous determination of etoposide and its catechol metabolite in the plasma of pediatric patients by liquid chromatography / tandem mass spectrometry显示文摘 | PANG S K ZHENG N Y FELIX C A | 2001 | Journal of Mass Spectrometry2001，36，7： | 1 |
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