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| 1 | Amyloid-beta peptide and tau protein crosstalk in Alzheimer’s disease显示文摘Alzheimer’s disease is a neurodegenerative disease that accounts for most of the 50-million dementia cases worldwide in 2018.A large amount of evidence supports the amyloid cascade hypothesis,which states that amyloid-beta accumulation triggers tau hyperphosphorylation and aggregation in form of neurofibrillary tangles,and these aggregates lead to inflammation,synaptic impairment,neuronal loss,and thus to cognitive decline and behavioral abnormalities.The poor correlation found between cognitive decline and amyloid plaques,have led the scientific community to question whether amyloid-beta accumulation is actually triggering neurodegeneration in Alzheimer’s disease.The occurrence of tau neurofibrillary tangles better correlates to neuronal loss and clinical symptoms and,although amyloid-beta may initiate the cascade of events,tau impairment is likely the effector molecule of neurodegeneration.Recently,it has been shown that amyloid-beta and tau cooperatively work to impair transcription of genes involved in synaptic function and,more importantly,that downregulation of tau partially reverses transcriptional perturbations.Despite mounting evidence points to an interplay between amyloid-beta and tau,some factors could independently affect both pathologies.Thus,the dual pathway hypothesis,which states that there are common upstream triggers causing both amyloid-beta and tau abnormalities has been proposed.Among others,the immune system seems to be strongly involved in amyloid-beta and tau pathologies.Other factors,as the apolipoprotein Eε4 isoform has been suggested to act as a link between amyloid-beta and tau hyperphosphorylation.Interestingly,amyloid-beta-immunotherapy reduces not only amyloid-beta but also tau levels in animal models and in clinical trials.Likewise,it has been shown that tau-immunotherapy also reduces amyloid-beta levels.Thus,even though amyloid-beta immunotherapy is more advanced than tau-immunotherapy,combined amyloid-beta and tau-directed therapies at early stages of the disease have recently been proposed as a strategy to stop the progression of Alzheimer’s disease. | Alejandro R.Roda Gabriel Serra-Mir Laia Montoliu-Gaya Lidia Tiessler Sandra Villegas | 2022 | Neural Regeneration Research2022，17，8： | 13 |
| 2 | The Global Boundary Stratotype Section and Point for the base of the Danian Stage (Paleocene, Paleogene,"Tertiary", Cenozoic) at El Kef, Tunisia—Original definition and revision显示文摘 | Eustoquio Molina Laia Alegret Ignacio Arenillas José A. Arz Njoud Gallala Jan Hardenbol Katharina von Salis Etienne Steurbau Noeel Vandenberghe Dalila Zaghbib-Turki | 2006 | Episodes2006，29，4： | 9 |
| 3 | Cytokine production in patients with cirrhosis and TLR4 polymorphisms显示文摘AIM:To analyze the cytokine production by peripheral blood cells from cirrhotic patients with and without TLR4 D299G and/or T399I polymorphisms.METHODS:The study included nine patients with cirrhosis and TLR4 D299G and/or T399I polymorphisms,and 10 wild-type patients matched for age,sex and degree of liver failure.TLR4 polymorphisms were determined by sequence-based genotyping.Cytokine production by peripheral blood cells was assessed spontaneously and also after lipopolysaccharide(LPS)and lipoteichoic acid(LTA)stimulation.RESULTS:Patients with TLR4 polymorphisms had a higher incidence of previous hepatic encephalopathy than wild-type patients(78%vs 20%,P=0.02).Spontaneous production of interleukin(IL)-6 and IL-10 was lower in patients with TLR4 polymorphisms than in wild-type patients[IL-6:888.7(172.0-2119.3)pg/m L vs 5540.4(1159.2-26053.9)pg/m L,P<0.001;IL-10:28.7(6.5-177.1)pg/m L vs 117.8(6.5-318.1)pg/m L,P=0.02].However,the production of tumor necrosis factor-α,IL-6 and IL-10 after LPS and LTA stimulation was similar in the two groups.CONCLUSION:TLR4 polymorphisms were associated with a distinctive pattern of cytokine production in cirrhotic patients,suggesting that they play a role in the development of cirrhosis complications. | Juan Camilo Nieto Elisabet Sánchez Eva Román Silvia Vidal Laia Oliva Carlos Guarner-Argente Maria Poca Xavier Torras Cándido Juárez Carlos Guarner German Soriano | 2014 | World Journal of Gastroenterology2014，20，46： | 5 |
| 4 | Hepatocyte transplantation program:Lessons learned andfuture strategies显示文摘This review aims to share the lessons we learned over time during the setting of the hepatocyte transplantation(HT) program at the Hepatic Cell Therapy Unit at Hospital La Fe in Valencia. New sources of liver tissue for hepatocyte isolation have been explored. The hepatocyte isolation and cryopreservation procedures have been optimized and quality criteria for assessment of functionality of hepatocyte preparations and suitability for HT have been established. The results indicate that:(1) Only highly viable and functional hepatocytes allow to recover those functions lacking in the native liver;(2) Organs with steatosis(≥ 40%) and from elderly donors are declined since low hepatocyte yields, viability and cell survival after cryopreservation, are obtained;(3) Neonatal hepatocytes are cryopreserved without significant loss of viability or function representing high-quality cells to improve human HT;(4) Cryopreservation has the advantage of providing hepatocytes constantly available and of allowing the quality evaluation and suitability for transplantation; and(5) Our results from 5 adults with acute liver failure and 4 from children with inborn metabolic diseases, indicate that HT could be a veryuseful and safe cell therapy, as long as viable and metabolically functional human hepatocytes are used. | Eugenia Pareja Ibars Miriam Cortes Laia Tolosa Maria JoséGómez-Lechón Slivia López JoséVicente Castell JoséMir | 2016 | World Journal of Gastroenterology2016，22，2： | 3 |
| 5 | Global Burden of Human Papillomavirus and Related Diseases显示文摘 | David Forman Catherine de Martel Charles J. Lacey Isabelle Soerjomataram Joannie Lortet-Tieulent Laia Bruni Jerome Vignat Jacques Ferlay Freddie Bray Martyn Plummer Silvia Franceschi | 2012 | Vaccine2012，，： | 2 |
| 6 | Biology and pathology of the uterine micro environ merit and its natural killer cells显示文摘Tissues are the new frontier of discoveries in immunology.Cells of the immune system are an integral part of tissue physiology and immunity.Determining how immune cells inhabit,housekeep,and defend gut,lung,brain,liver,uterus,and other organs helps revealing the intimate details of tissue physiology and may offer new therapeutic targets to treat pathologies.The uterine microenvironment modulates the development and function of innate lymphoid cells[ILC,largely represented by natural killer(NK)cells],macrophages,T cells,and dendritic cells.These immune cells,in turn,contribute to tissue homeostasis.Regulated by ovarian hormones,the human uterine mucosa(endometrium)undergoes ~400 monthly cycles of breakdown and regeneration from menarche to menopause,with its fibroblasts,glands,blood vessels,and immune cells remodeling the tissue into the transient decidua.Even more transformative changes occur upon blastocyst implantation.Before the placenta is formed,the endometrial glands feed the embryo by histiotrophic nutrition while the uterine spiral arteries are stripped of their endothelial layer and smooth muscle actin.This arterial remodeling is carried out by invading fetal trophoblast and maternal immune cells,chiefly uterine NK(uNK)cells,which also assist fetal growth.The tran sformed arteries no Ion ger resp ond to mater nal stimuli and meet the increasi ng dema nds of the growing fetus.This review focuses on how the everchanging uterine microenvironment affects uNK cells and how uNK cells regulate homeostasis of the decidua,placenta development,and fetal growth.Determining these pathways will help understand the causes of major pregnancy complications. | Fuyan Wang Anita Ellen Qualls Laia Marques-Fernandez Francesco Colucci | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 7 | Wnt-Pathway Activation in Two Molecular Classes of Hepatocellular Carcinoma and Experimental Modulation by Sorafenib显示文摘 | Anja Lachenmayer Clara Alsinet Radoslav Savic Laia Cabellos Sara Toffanin Yujin Hoshida Augusto Villanueva Beatriz Minguez Philippa Newell Hung-Wen Tsai Jordi Barretina Swan Thung Stephen C. Ward Jordi Bruix Vincenzo Mazzaferro Myron Schwartz Scott L. Fri | 2012 | Clinical Cancer Research2012，，18： | 2 |
| 8 | Age-related changes in resting-state functional connectivity in older adults显示文摘Age-related changes in the brain connectivity of healthy older adults have been widely studied in recent years,with some differences in the obtained results.Most of these studies showed decreases in general functional connectivity,but they also found increases in some particular regions and areas.Frequently,these studies compared young individuals with older subjects,but few studies compared different age groups only in older populations.The purpose of this study is to analyze whole-brain functional connectivity in healthy older adult groups and its network characteristics through functional segregation.A total of 114 individuals,48 to 89 years old,were scanned using resting-state functional magnetic resonance imaging in a resting state paradigm and were divided into six different age groups(<60,60–64,65–69,70–74,75–79,≥80 years old).A partial correlation analysis,a pooled correlation analysis and a study of 3-cycle regions with prominent connectivity were conducted.Our results showed progressive diminution in the functional connectivity among different age groups and this was particularly pronounced between 75 and 79 years old.The oldest group(≥80 years old)showed a slight increase in functional connectivity compared to the other groups.This occurred possibly because of compensatory mechanism in brain functioning.This study provides information on the brain functional characteristics of every age group,with more specific information on the functional progressive decline,and supplies methodological tools to study functional connectivity characteristics.Approval for the study was obtained from the ethics committee of the Comision de Bioetica de la Universidad de Barcelona(approval No.PSI2012-38257)on June 5,2012,and from the ethics committee of the Barcelona’s Hospital Clinic(approval No.2009-5306 and 2011-6604)on October 22,2009 and April 7,2011 respectively. | Laia Farras-Permanyer Nuria Mancho-Fora Marc Montala-Flaquer David Bartres-Faz Lidia Vaque-Alcazar Maribel Pero-Cebollero Joan Guardia-Olmos | 2019 | Neural Regeneration Research2019，14，9： | 2 |
| 9 | Effects of environmental and job - task factors on workers gait characteristics on slippery surfaces 显示文摘 | Chioua S S Bhattacharyaa A Laia F C | 2002 | Occupational Ergonomics2002，，3： | 1 |
| 10 | Canine leishmaniosis in the Old and New Worlds: unveiled similarities and differences显示文摘 | Filipe Dantas-Torres Laia Solano-Gallego Gad Baneth Vitor Marcio Ribeiro Milena de Paiva-Cavalcanti Domenico Otranto | 2012 | Trends in Parasitology2012，，12： | 1 |
| 11 | Targeting endoplasmic reticulum stress in insulin resistance显示文摘 | Laia Salvado Xavier Palomer | 2015 | Cell2015，26，： | 1 |
| 12 | Development of a Muhiparametric Cell-based Protocol to Screen and Classify the Hepatotoxieity Potential of Drugs 显示文摘 | Laia Tolosa Sandra Pinto Teresa Donato | 2012 | Toxicological Sciences2012，127，1： | 1 |
| 13 | Form Design of Product Image Using Grey Relational Analysis and Neural Network Models显示文摘 | Laia H H Lina Y C Yeh C H | 2005 | International Journal of Industrial Ergonomics2005，32，10： | 1 |
| 14 | Reduction of liver fructokinase expression and improved hepatic inflammation and metabolism in liquid fructose-fed rats after atorvastatin treatment 显示文摘 | LAIA V ALAB R MARTA A | 2011 | Toxicol Appl Pharmaco12011，251，1： | 1 |
| 15 | Comparison of the anti-nociceptive action of crude Fuzei, the root of Aconitum, and its processed 显示文摘 | Liou S S Liua I M Laia M C | 2005 | Prod J Ethnopharmacol2005，99，： | 1 |
| 16 | Type IV secretion system is not involved in infection process in citrus 显示文摘 | Jacob T R Laia M L Moreira L M | 2014 | International Journal of Microbiology2014，，： | 1 |
| 17 | User-orien ted design for the optimal combination on product de sign显示文摘 | LAIA H H LINA Y C YEH C H | 2006 | International Journal of Production Econom ics2006，，100： | 1 |
| 18 | Regula- tion of transcription factor twist expression by the DNA architec- tural protein high mobility group A2 during epithelial-to-mes- enchymal transition显示文摘 | E-JEAN TAN SYLVIE THUAULT LAIA CAJA | 2012 | The Journal of Biological Chemistry2012，287，10： | 1 |
| 19 | Major hepatectomies are safe in patients with cholangiocarcinoma and jaundice显示文摘 | Joan Figueras Antoni Codina-Barreras Santiago López-Ben Jordi Soriano Berta Pardina Laia Falgueras Ernesto Castro Silvia Torres-Bahi Rosa Ortiz Esther Diaz Albert Maroto Eugeni Canals | 2009 | Cirugía Espa?ola (English Edition)2009，，5： | 1 |
| 20 | Combination therapy for hepatocellular carcinoma: Additive preclinical efficacy of the HDAC inhibitor panobinostat with sorafenib显示文摘 | Anja Lachenmayer Sara Toffanin Laia Cabellos Clara Alsinet Yujin Hoshida Augusto Villanueva Beatriz Minguez Hung-Wen Tsai Stephen C. Ward Swan Thung Scott L. Friedman Josep M. Llovet | 2012 | Journal of Hepatology2012，，6： | 1 |
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