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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | BMP-6 inhibits microRNA-21 expression in breast cancer through repressing 6EF1 and AP-1显示文摘 | Jun Du Shuang Yang Di An Fen Hu Wei Yuan Chunli Zhai Tianhui Zhu | 2009 | Cell Research2009，19，4： | 44 |
| 3 | Methodology development and application of X-ray imaging beamline at SSRF显示文摘This paper introduces some latest developments regarding the X-ray imaging methodology and applications of the X-ray imaging and biomedical application beamline(BL13W1)at Shanghai Synchrotron Radiation Facility in the past 5 years.The photon energy range of the beamline is 8–72.5 keV.Several sets of X-ray imaging detectors with different pixel sizes(0.19–24 lm)are used to realize X-ray microcomputed tomography(X-ray micro-CT)and X-ray in-line phase-contrast imaging.To satisfy the requirements of user experiments,new X-ray imaging methods and image processing techniques are developed.In vivo dynamic micro-CT experiments with living insects are performed in 0.5 s(sampling rate of 2 Hz,2 tomograms/s)with a monochromatic beam from a wiggler source and in 40 ms(sampling rate of 25 Hz,25 tomograms/s)with a white beam from a bending magnet source.A new X-ray imaging method known as move contrast X-ray imaging is proposed,with which blood flow and moving tissues in raw images can be distinguished according to their moving frequencies in the time domain.Furthermore,X-ray speckle-tracking imaging with twice exposures to eliminate the edge enhancement effect is developed.A high-precision quantification method is realized to measure complex three-dimensional blood vessels obtained via X-ray micro-CT.X-ray imaging methods such as three-dimensional X-ray diffraction microscopy,small-angle X-ray scattering CT,and X-ray fluorescence CT are developed,in which the X-ray micro-CT imaging method is combined with other contrast mechanisms such as diffraction,scattering,and fluorescence contrasts respectively.Moreover,an X-ray nano-CT experiment is performed with a 100 nm spatial resolution.Typical user experimental results from the fields of material science,biomedicine,paleontology,physics,chemistry,and environmental science obtained on the beamline are provided. | Hong-Lan Xie Biao Deng Guo-Hao Du Ya-Nan Fu Han Guo Yan-Ling Xue Guan-Yun Peng Fen Tao Ling Zhang Ti-Qiao Xiao | 2020 | Nuclear Science and Techniques2020，31，10： | 7 |
| 4 | Molecular Characterization and Correlation with β-lactam Resistance of Streptococcus pneumonia Isolates in Hangzhou,China显示文摘Penicillin-binding proteins(PBPs) are the target of β-lactam antibiotics(the major treatment for Streptococcus pneumoniae infections),and mutations in PBPs are considered as a primary mechanism for the development of β-lactam resistance in S.pneumoniae.This study was conducted to investigate the mutations in the PBPs of clinical S.pneumoniae isolates in Hangzhou,China,in correlation with β-lactam resistance.Results showed that 19 F was the predominant serotype(7/27) and 14 of the S.pneumoniae isolates were resistant to both penicillin G and cephalosporin.Genotyping results suggested that β-lactam-resistant isolates primarily exhibited single-site mutations in both the STMK and SRNVP motifs of pbp1 a in combination with double-site mutations in the STMK motif of pbp2 x,which might be the primary mechanisms underlying the β-lactam resistance of the isolates in this study. | chu mei fen liu xiao xiang zhang shao ni huang yan ying du peng wang li fang ji lei yan jie sun ai hua | 2018 | Biomedical and Environmental Sciences2018，31，5： | 7 |
| 5 | Central Obesity and Metabolic Risk Factors in Middle-aged Chinese显示文摘Objective Central obesity is considered to be a central component of metabolic syndrome. Waist circumference(WC) has been widely used as a simple indicator of central obesity. This study is aimed to evaluate the sensitivity of WC cut-off values for predicting metabolic risk factors in middle-aged Chinese. Methods The study involved 923 subjects aged 40-65 years. The metabolic risk factors were defined according to the Chinese Joint Committee for Developing Chinese Guidelines on Prevention and Treatment of Dyslipidemia in Adults. WC cut-off 85-90 cm and ≥90 cm were used as cut-off values of central pre-obesity and central obesity in males, respectively, while WC 80-85 cm and ≥85 cm were used as cut-off values of central pre-obesity and central obesity in females. Results First, WC values corresponding to body mass index(BMI) 24 kg/m2 and visceral fat area(VFA) 80 cm2 were 88.55 cm and 88.51 cm in males, and 81.46 cm and 82.51 cm in females respectively. Second, receiver operating characteristic curves showed that the optimal WC cut-off of value was 88.75 cm in males, higher than that in females(81.75 cm). Third, the subjects with higher WC values were more likely to have accumulating metabolic risk factors. The prevalence of metabolic risk factors increased linearly and significantly in relation to WC levels. Conclusion WC cut-off values of central pre-/central obesity are optimal to predict multiple metabolic risk factors. | YIN Xue Yao ZHENG Fen Ping ZHOU Jia Qiang DU Ying PAN Qian Qian ZHANG Sai Fei YU Dan LI Hong | 2014 | Biomedical and Environmental Sciences2014，27，5： | 6 |
| 6 | Rapamycin inhibits ox-LDL-induced inflammation in human endothelial cells in vitro by inhibiting the mTORC2/PKC/c-Fos pathway显示文摘Rapamycin 和它的衍生物在动脉粥样硬化遗体期间在到 endothelial 房间的粘附分子表示和巨噬细胞粘附上拥有反动脉粥样硬化活动,而是它的效果不清楚。在这研究,我们在 vitro 和内在的机制在到 endothelial 房间的 ox-LDL-induced 粘附分子表示和巨噬细胞粘附上探索了 rapamycin 的效果。 Ox-LDL ( 6-48 g/mL ) dose-dependently 增加了二个粘附分子,细胞间的粘附 molecule-1 ( ICAM-1 )和 E-selectin 的蛋白质层次,在人的脐的静脉 endothelial 房间( HUVEC ),而有 rapamycin ( 1-10 mol/L )的预告的处理 dose-dependently 在到 endothelial 房间的粘附分子表示和巨噬细胞粘附禁止了 ox-LDL-induced 增加。mTOR 或 rictor 击倒,而非猛禽,模仿了 rapamycin 的效果。Ox-LDL (100 g/mL ) time-dependently 在 HUVEC 增加了 PKC phosphorylation,它被 rapamycin 或 rictor siRNA 废除。有 PKC 禁止者 staurosporine 的预告的处理显著地把 ox-LDL-stimulated 粘附分子表示和巨噬细胞粘附归结为 endothelial 房间,而有 PKC 使活跃之物 PMA/TPA 的预告的处理在粘附分子表示上稀释了 rapamycin 的禁止的效果。time-dependently 增加的 c-Fos 在 HUVEC 铺平的 Ox-LDL (100 g/mL ) ,和有 rapamycin 或 rictor siRNA 的预告的处理显著地减少了 c-Fos 的表示。c-Fos 击倒对 endothelial 房间的反对 ox-LDL-induced 粘附分子表示和巨噬细胞粘附。我们的结果证明对由禁止 mTORC2 的 endothelial 房间的 rapamycin 还原剂 ox-LDL-stimulated 粘附分子表示和巨噬细胞粘附,然而并非 mTORC1,和 mTORC2 通过表明小径的 PKC/c-Fos 行动。 | Juan-juan SUN Xiao-wei YIN Hui-hui LIU Wen-xiu DU Lu-yao SHI Ya-bo HUANG Fen WANG Chun-feng LIU Yong-jun CAO Yan-lin ZHANG | 2018 | Acta Pharmacologica Sinica2018，39，3： | 5 |
| 7 | Thymine DNA glycosylase promotes transactivation of β-catenin/TCFs by cooperating with CBP显示文摘胸腺嘧啶 DNA glycosylase (TDG ) ,开始 G/T 和 G/U 的修理的酶错配,最近被发现 crucialin 胚胎维持 epigenetic 稳定性并且便于活跃 DNA demethylation 的开发。这里,我们在作为 -catenin/TCFs 建筑群的 transcriptional 激活剂发信号的 Wnt 报导 TDG 的 novelrole。我们 TDG 绑在 thetranscriptional 因素家庭 LEF1/TCFs 并且加强的数据表演 -catenin/TCFs transactivation,当 TDG 弄空压制 Wnt3a-stimulatedreporter 活动或目标基因抄写时。下次,我们显示出那 CBP,已知的激活剂,也为在目标倡导者上形成合作建筑群的 TDG functionthrough 被要求。而且,有在人的冒号 cancertissue 的 TDG 层次的举起,并且 TDG 击倒禁止冒号房间的增长。总的来说,我们的结果表明作为新激活剂, TDG 支持 -catenin/TCFs transactivation 并且机能上地在正规 Wnt 发信号与 CBP 合作。 | Yingying Jia Fen Nie Aiying Du Zhangcheng Chen Yuanbo Qin Tao Huang Xiaomin Song Lin Li | 2014 | Journal of Molecular Cell Biology2014，8，3： | 5 |
| 8 | Study on the effect of RDX content on the properties of nitramine propellant显示文摘Four kinds of nitroamine propellants with different RDX contents(10%,20%,30%and 40%)were prepared to study the effect of RDX content on the mechanical properties and combustion properties of nitroamine propellant.The mechanical properties and combustion properties of nitroamine propellant at the normal temperature(20C)and low temperature(à40C)were test by using impact testing machine,drop hammer impact test machine and closed bomb vessel.The test results show that the impact strength of30%RDX-contained nitramine propellant is maximum,but 40%RDX-contained nitramine propellant has the minimum impact strength.And the crushing height of propellant with 20%RDX-contained was the highest,but the crushing height of propellant with 40%RDX-contained the lowest.With the increase in RDX content in nitramine propellant,the energy of nitramine propellant increases and its burning rate reduces,but 40%RDX-contained nitramine propellant did not meet this trend at the low temperature because of its poor mechanical properties. | Fen ZHANG Deng-pan ZHU Qiong LIU Zhi-tao LIU Ping DU | 2017 | Defence Technology(防务技术)2017，13，4： | 4 |
| 9 | Elastic Scattering of 7Be on Pb Target显示文摘 | Yang Yanyun Wang Jiansong Wang Qi Huang Meirong Ma Junbing Ma Peng Cao Xiguang Han Jianlong Bai Zhen Jin Shilong Hu Qiang Jin Lei Chen Jiangbo Zhang Xueying Chen Ruofu Hu Zhengguo Xu Shiwei Zhen Chuan Xu Zhiguo Xu Hushan Duan Liming Sun Zhiyu Chen Zhiqiang He Jianjun Li Songlin Lei Xiangguo Fu Fen Zhang Xueheng Yuan Xiaohua Du Chengming Yan Xinshuang Hu Jun Tang Shuwen Ye Ruiping Yang Kun Shi Fudong Zhang Wei Chen Ze Li Long Xu Xing Liu Longxiang Zhang Liyong Lin Qingyun Gou Boxing Xu Ge Zhou Xionghong Zhang Yuhu Xiao Guoqing | 2011 | IMP & HIRFL Annual Report2011，，1： | 4 |
| 10 | Steady-State Cornering Properties of a Non-pneumatic Tire with Mechanical Elastic Structure显示文摘Mechanical elastic wheel(ME-wheel)is a new type of non-inflatable safety tyre,and the structure is significantly different from traditional pneumatic tyre.In order to investigate cornering properties of ME-wheel,experimental research on mechanics characteristics of ME-wheel under steady-state cornering conditions are carried out.The test of steady-state cornering properties of ME-wheel at different experimental parameter conditions is conducted by test bench for dynamic mechanical properties of tyre.Cornering property curves are used to analyze the steady-state cornering properties of ME-wheel,namely the variation tendency of lateral force or aligning torque with the increase of side-slip angle.Moreover,evaluation indexes for cornering properties of ME-wheel are extracted and the effect of different experimental parameters(including vertical load,friction coefficient,and speed)on cornering properties of ME-wheel is contrastively analyzed.The proposed research can provide certain reference to facilitate structure parameters and cornering properties optimizing process of ME-wheel. | Fu Hongxun Zhao Youqun Lin Fen Du Xianbin Zhu Mingmin | 2017 | Transactions of Nanjing University of Aeronautics and Astronautics2017，34，5： | 2 |
| 11 | X-ray fluorescence microtomography based on polycapillary- focused X-rays from laboratory source显示文摘X-ray fluorescence microtomography(μXFCT)is a nondestructive analytical technique and has been widely used to nondestructively detect and quantify the elemental composition and distributions in samples. Usually, synchrotron radiation X-rays are used for μXFCT, due to its high flux density. In this paper, a laboratory-sourcebased μXFCT system was developed, in which a polycapillary lens is employed to focus the X-ray beam and improve the flux density. The maximum likelihood expectation maximization algorithm was used to reconstruct the computed tomography slices at a limited number of projections. The experimental results demonstrated that the developed system could reveal the elemental distribution inside the test sample, with an elemental sensitivity of 1000 ppm. | Bing-Gang Feng Fen Tao Yi-Ming Yang Tao Hu Fei-Xiang Wang Guo-Hao Du Yan-Ling Xue Ya-Jun Tong Tian-Xi Sun Biao Deng Ti-Qiao Xiao | 2018 | Nuclear Science and Techniques2018，29，6： | 2 |
| 12 | Parsimonious Model for Blood Glucose Level Monitoring in Type 2 Diabetes patients显示文摘To establish the parsimonious model for blood glucose monitoring in patients with type 2 diabetes receiving oral hypoglycemic agent treatment.One hundred and fifty-nine adult Chinese type 2diabetes patients were randomized to receive rapid-acting or sustained-release gliclazide therapy for 12 weeks.Their blood glucose levels were measured at 10 time points in a 24 h period before and after treatment,and the 24 h mean | ZHAO Fang MA Yan Fen WEN Jing Xiao DU Yan Fang LI Chun Lin LI Guang Wei | 2014 | Biomedical and Environmental Sciences2014，27，7： | 2 |
| 13 | Literature review and economic evaluation of oral and intramuscular ziprasidone treatment among patients with schizophrenia in China显示文摘Background Over 10 million Chinese are affected by schizophrenia. The annual cost of schizophrenia in China was estimated at US$2586 per patient.Aims The study has two aims:(1) to conduct a targeted literature review of the economic literature on oral ziprasidone in China, and(2) to develop an inpatient economic model that compared the cost of intramuscular ziprasidone with other regimens including electroconvulsive therapy(ECT) for the management of acute agitation in patients with schizophrenia from a hospital's perspective in China.Methods A targeted literature review was conducted using PubMed and the Chinese literature databases for studies published between January 2007 and December2017. Studies that assessed costs associated with oral ziprasidone treatment for schizophrenia in China were summarised. In the inpatient economic model,cost measures included hospital room and board,antipsychotics,ECT and medications for the management of extrapyramidal symptoms(EPS). Input for standard antipsychotic regimens and unit cost were obtained from the literature. Hospital length of stay(LOS), utilisation of ECT and incidence of EPS were derived from the literature and supplemented/validated with a survey of psychiatrists in China. Cost was presented in 2017 Chinese yuan.Results The average estimated LOS was 29 days with ziprasidone, 33 days with risperidone+benzodiazepine,32 days with olanzapine, 35 days with haloperidol and 29 days with ECT. The cost of antipsychotics was $1260 with ziprasidone, $137 with risperidone+benzodiazepine, $913 with olanzapine and $210 with haloperidol; ECT treatment costs $785. The base-case analysis suggested that higher antipsychotic cost with ziprasidone was offset by savings with shorter LOS. Using intramuscular ziprasidone for acute management was associated with a total cost of $11157, the lowest among all antipsychotic regimens($11 424 with risperidone+benzodiazepine, $11 711 with olanzapine and $11 912 with haloperidol) and slightly higher than ECT($10 606). The cost of antipsychotics and ECT accounted for 1 %-11 % of the total cost. Varying LOS between the lower and upper bounds of the 95% CI, the total cost was comparable between these regimens.Conclusions Overall, the cost for the management of acute agitation was similar between intramuscular ziprasidone and other antipsychotics. Compared with other antipsychotics, the higher medication cost of intramuscular ziprasidone can be offset by savings with shorter hospital stay. The results from this economic analysis were complementary to the findings in the published literature assessing the economic outcomes of oral ziprasidone. | Yu-Chen Yeh Xin Yu Congpei Zhang Wei Hao Fen Du Dongdong Liu Lili Yang Xin Gao | 2018 | General Psychiatry2018，31，6： | 2 |
| 14 | Structural evolution and magnetic properties of Mn - N compounds显示文摘 | FEN W J SUN N K DU J | 2008 | Solid State Communications2008，148，4： | 1 |
| 15 | Thymie stromal lymphopoie- tin from trophoblasts induces dendritic cell -mediated regulatory TH2 bias in the decidua during early gestation in humans 显示文摘 | Pei - Fen Guo Mei - Rong Du | 2010 | Blood2010，116，： | 1 |
| 16 | Mixed macromolecular crowding accelerate the oxidative refolding of reduced, denatured lysozyme 显示文摘 | Zhou Bingrui Liang Yi Du Fen | 2004 | Journal of Biological Chemistry2004，279，55： | 1 |
| 17 | In si- tu generation of palladium nanoparticles:ligand-free pal- ladium Catalyzed ultrafast Suzuki-Miyaura cross-coupling reaction in aqueous phase at room temperature 显示文摘 | DU Zheng-yin ZHOU Wan-wei WANG Fen t al | 2011 | Tet- rahedron2011，67，26： | 1 |
| 18 | Mixed macromolecular crowding accelerates the refolding of rabbit muscle creatine kinase: implications for protein folding in physiological environments 显示文摘 | Du Fen Zhou Zheng Mo Zhongying | 2006 | J Mol Biol2006，364，： | 1 |
| 19 | Effects of Aeration on Nitrification Process in a Polluted Urban River显示文摘[Objective] The study aimed to discuss the effects of aeration on nitrification process in a polluted urban river.[Method] Through indoor simulation experiments,the effects of different aeration conditions(aerating water named EW,aerating sediment named ES) on nitrification process in a polluted urban river were studied.[Result] The nitrification of the control group named EC proceeded slowly,while two kinds of aeration promoted the process of nitrification,that is,the peak values of nitrate nitrogen of EW and ES group were respectively 5.15 and 3.83 times that of EC group.During aeration,NO2--N accumulation in the overlying water of EW and ES group lasted for 10 and 14 days separately,and the maximum concentrations reached 11.41 and 7.41 mg/L respectively.Nitrification process was not consistent during the two aeration conditions,that is,the rate of nitrite oxidation in EW group was faster than that in ES group.Denitrification process was significant after aeration,and the concentration of nitrate nitrogen in EW and ES group was 1.26 and 2.82 mg/L respectively at the end of the experiment.[Conclusion] The research could provide scientific references for the restoration of polluted urban rivers. | LING Fen WANG Guo-xiang LIU Bo xu Kuan ZHOU Feng DU Xu | 2012 | Meteorological and Environmental Research2012，3，6： | 1 |
| 20 | Effects of azide on electron transport of exoelectrogens in air-cathode microbial fuel cells 显示文摘 | ZHOU X QU Y KIM B H ChOO P Y LIU J DU Y HE W CHANG I S REN N FEN N | 2014 | B ioresour Technol2014，169，： | 1 |
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