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| 1 | Expression and Function of Zinc-α2-Glycoprotein显示文摘Zinc-α2-glycoprotein(ZAG), encoded by the AZGP1 gene, is a major histocompatibility complex I molecule and a lipid-mobilizing factor. ZAG has been demonstrated to promote lipid metabolism and glucose utilization, and to regulate insulin sensitivity. Apart from adipose tissue, skeletal muscle, liver, and kidney, ZAG also occurs in brain tissue, but its distribution in brain is debatable. Only a few studies have investigated ZAG in the brain. It has been found in the brains of patients with Krabbe disease and epilepsy, and in the cerebrospinal fluid of patients with Alzheimer disease, frontotemporal lobe dementia, and amyotrophic lateral sclerosis. Both ZAG protein and AZGP1 m RNA are decreased in epilepsy patients and animal models, while overexpression of ZAG suppresses seizure and epileptic discharges in animal models of epilepsy, but knowledge of the specific mechanism of ZAG in epilepsy is limited. In this review, we summarize the known roles and molecular mechanisms of ZAG in lipid metabolism and glucose metabolism, and in the regulation of insulin sensitivity, and discuss the possible mechanisms by which it suppresses epilepsy. | Xin Wei Xi Liu Changhong Tan Lijuan Mo Hui Wang Xi Peng Fen Deng Lifen Chen | 2019 | Neuroscience Bulletin2019，35，3： | 14 |
| 2 | A Novel Hierarchical Porous 3D Structured Vanadium Nitride/Carbon Membranes for High-performance Supercapacitor Negative Electrodes显示文摘Transition-metal nitrides exhibit wide potential windows and good electrochemical performance, but usually experience imbalanced practical applications in the energy storage field due to aggregation, poor circulation stability, and complicated syntheses. In this study, a novel and simple multiphase polymeric strategy was developed to fabricate hybrid vanadium nitride/carbon(VN/C) membranes for supercapacitor negative electrodes, in which VN nanoparticles were uniformly distributed in the hierarchical porous carbon 3D networks. The supercapacitor negative electrode based on VN/C membranes exhibited a high specific capacitance of 392.0 F g^(-1) at 0.5 A g^(-1) and an excellent rate capability with capacitance retention of 50.5% at 30 A g^(-1). For the asymmetric device fabricated using Ni(OH)_2//VN/C membranes, a high energy density of 43.0 Wh kg^(-1) at a power density of800 W kg^(-1) was observed. Moreover, the device also showed good cycling stability of 82.9% at a current density of 1.0 A g^(-1) after 8000 cycles. This work may throw a light on simply the fabrication of other high-performance transition-metal nitridebased supercapacitor or other energy storage devices. | Yage Wu Yunlong Yang Xiaoning Zhao Yongtao Tan Ying Liu Zhen Wang Fen Ran | 2018 | Nano-Micro Letters2018，10，4： | 13 |
| 3 | 生物合理设计光系统Ⅱ抑制剂研究(Ⅱ)3-苯甲氨基-2-氰基-3-甲硫基丙烯酸乙酯的晶体及分子结构显示文摘合成了具有良好光合作用抑制活性的标题化合物,测定了其晶体结构.确定了该类化合物的顺反构型,阐明了苯环与氨基间亚甲基对化合物抑制活性的重要作用,解释了氨基氢与酯羰基氧间没有形成氢键的原因. | LIU Hua Yin *, YANG Guang Fu, LU Rong Jian, TAN Hui Fen, YANG Hua Zheng (The Institute of Elemento Organic Chemistry, National Elemento Organic Chemistry Key Laboratory, Nankai University, Tianjin, 300071) LAI Lu Hua (The Institute of Physical Chemist | 1998 | 高等学校化学学报1998，19，6： | 10 |
| 4 | Coral reef-like polyanaline nanotubes prepared by a reactive template of manganese oxide for supercapacitor electrode显示文摘由 nanopaticles 组成的珊瑚像礁石的 PANI nanotubes 被锰氧化物的一个反应模板成功地综合。结构被使用 SEM, TEM,和英尺红外描绘,并且这些 nanotubes 的 supercapacitive 行为与周期的 voltammetry (CV ) 被调查,并且 chargedischarge 分别地测试。533 F/g 的一个最大的特定的电容能在 1 mol/L 被完成有 0.2 ~ 0.8 V 的潜在的范围的水的 H2SO4 (对浸透的甘汞电极) 在为 PANI 电极的一种一半房间安装配置,为电气化学的电容器在电极材料建议它的潜在的申请。 | Ling Ren Wang Fen Ran Yong Tao Tan Lei Zhao Ling Bin Kong Long Kang | 2011 | Chinese Chemical Letters2011，22，8： | 8 |
| 5 | Microporous carbon nanofibers prepared by combining electrospinning and phase separation methods for supercapacitor显示文摘Microporous carbon nanofibers(MCNFs) derived from polyacrylonitrile nanofibers were fabricated via electrospinning technology and phase separation in the presence of polyvinylpyrrolidone(PVP).PVP together with a mixed solvent of N,N-Dimethylformamide and dimethyl sulfoxide was used as poreforming agent.The influences of PVP content in casting solution on the structure and electrochemical performance of the MCNFs were also investigated.The highest capacitance of 200 F/g was obtained on a three-electrode system at a scan rate of 0.5 A/g.The good performance was owing to the high specific surface area and the large amount of micro-pores,which enhanced the absorption and the transportation efficiency of electrolyte ion during charge/discharge process.This research indicated that the combination of electrospinning and phase separation technology could be used to fabricate microporous carbon nanofibers as electrode materials for supercapacitors with high specific surface area and outstanding electrochemical performance. | Chang Liu Yongtao Tan Ying Liu Kuiwen Shen Bowu Peng Xiaoqin Niu Fen Ran | 2016 | Journal of Energy Chemistry2016，25，4： | 5 |
| 6 | Novel Hybrid Nanoparticles of Vanadium Nitride/Porous Carbon as an Anode Material for Symmetrical Supercapacitor显示文摘Hybrid materials of vanadium nitride and porous carbon nanoparticles(VN/PCNPs) were fabricated by a facile pyrolysis process of vanadium pentoxide(V_2O_5) xerogel and melamine at relatively low temperature of 800 °C for supercapacitor application. The effects of the feed ratio of V_2O_5 to melamine(r), and nitrogen flow rate on the microstructure and electrochemical performance were also investigated. It was found that the size of the as-synthesized nanoparticles is about 20 nm. Both r value and N_2 flow rate have enormous impacts on morphology and microstructure of the nanoparticle, which correspondingly determined the electrochemical performance of the material. The VN/C hybrid nanoparticles exhibited high capacitive properties, and a maximum specific capacitance of 255.0 Fg^(-1) was achieved at a current density of 1.0 Ag^(-1) in 2 M KOH aqueous electrolyte and the potential range from 0 to -1.15 V. In addition,symmetrical supercapacitor fabricated with the as-synthesized VN/PCNPs presents a high specific capacitance of 43.5 F g^(-1) at 0.5 A g^(-1) based on the entire cell, and an energy density of 8.0 Wh kg^(-1) when the power density was 575 W kg^(-1). Even when the power density increased to 2831.5 W kg^(-1), the energy density still remained 6.1 Wh kg^(-1). | Yunlong Yang Kuiwen Shen Ying Liu Yongtao Tan Xiaoning Zhao Jiayu Wu Xiaoqin Niu Fen Ran | 2017 | Nano-Micro Letters2017，9，1： | 5 |
| 7 | Reduced function and disassembled microtubules of cultured cardiomyocytes in spaceflight显示文摘Lack of gravity during spaceflight has profound effects on cardiovascular system, but little is known about how the cardiomyocytes respond to microgravity. In the present study, the effects of spaceflight on the structure and function of cultured cardiomyocytes were reported. The primary cultures of neo- natal rat cardiomyocytes were carried on Shenzhou-6 spacecraft and activated at 4 h in orbit. 8 samples were fixed respectively at 4, 48 and 96 h after launching for immunofluorescence of cytoskeleton, and 2 samples remained unfixed to analyze contractile and secretory functions of the cultures. Ground sam- ples were treated in our laboratory in parallel. After 115 h spaceflight, video recordings displayed that the number of spontaneous beating sites in flown samples decreased significantly, and the cells in the beating aggregate contracted in fast frequency without synchrony. Radioimmunoassay of the medium showed that the atrial natriuretic peptide secreted from flown cells reduced by 59.6%. Confocal images demonstrated the time-dependant disassembly of mirotubules versus unchanged distribution and or- ganization of microfilaments. In conclusion, above results indicate reduced function and disorganized cytoskeleton of cardiomyocytes in spaceflight, which might provide some cellular basis for further investigations to probe into the mechanisms underlying space cardiovascular dysfunction. | YANG Fen LI YingHui DING Bai NIE JieLin WANG HongHui ZHANG XiaoYou WANG ChunYan LING ShuKuan NI ChengZhi DAI ZhongQuan TAN YingJun WAN YuMin | 2008 | Chinese Science Bulletin2008，53，8： | 5 |
| 8 | Variability of microphysical characteristics in the “21·7” Henan extremely heavy rainfall event显示文摘In this study, significant rainfall microphysical variability is revealed for the extremely heavy rainfall event over Henan Province in July 2021(the “21·7” Henan EHR event) using a dense network of disdrometers and two polarimetric radars.The broad distributions of specific drop size distribution(DSD) parameters are identified in heavy rainfall from the disdrometer observations, indicating obvious microphysical variability on the surface. A K-means clustering algorithm is adopted to objectively classify the disdrometer datasets into separate groups, and distinct DSD characteristics are found among these heavy rainfall groups. Combined with the supporting microphysical structures obtained through radar observations, comprehensive microphysical features of the DSD groups are derived. An extreme rainfall group is dominantly formed in the deep convection over the plain regions, where the high number of concentrations and large mean sizes of surface raindrops are underpinned by both active ice-phase processes and efficient warm-rain collision-coalescence processes in the vertical direction. Convection located near orographic regions is characterized by restricted ice-phase processes and high coalescence efficiency of liquid hydrometeors, causing the dominant DSD group to comprise negligible large raindrops. Multiple DSD groups can coexist within certain precipitation episodes at the disdrometer stations, indicating the potential microphysical variability during the passage of convective system on the plain regions. | Gang CHEN Kun ZHAO Yinghui LU Yuanyuan ZHENG Ming XUE Zhe-Min TAN Xin XU Hao HUANG Haonan CHEN Fen XU Ji YANG Shushi ZHANG Xueqi FAN | 2022 | Science China Earth Sciences2022，65，10： | 4 |
| 9 | Homogeneous Light-Driven Catalytic Direct Carboxylation with CO2显示文摘 | Fen Tan Guoyin Yin | 2018 | Chinese Journal of Chemistry2018，36，6： | 4 |
| 10 | Effect of 15-Deoxy-A^12,14-prostaglandin J2 Nanocapsules on Inflammation and Bone Regeneration in a Rat Bone Defect Model显示文摘 | Qi Tang Li-Li Chen Fen Wei Wei-Lian Sun Li-Hong Lei Pei-Hui Ding Jing-Yi Tan Xiao-Tao Chen Yan-Min Wu | 2017 | Chinese Medical Journal2017，，3： | 3 |
| 11 | A bird nest-like manganese dioxide and its application as electrode in supercapacitors显示文摘A novel bird nest-like nanostructured MnO2(BNNS-MnO2) was prepared by a facile and cost-effective strategy. Their structures and morphologies were characterized by field emission scanning electron microscopy, transmission electron microscopy and powder X-ray diffraction. Capacitive behaviors were investigated by cyclic voltammetry and galvanostatic charge-discharge. The obtained nano-MnO2 possesses a well designed loose-assembled hierarchical nanoarchitecture with an appropriate crystallinity which gives rise to excellent performances as an electrode material for supercapacitors. A maximum specific capacitance of 917 F/g has been obtained at a current density of 5 mA/cm2 in 6 mol/L KOH aqueous solution, and a specific capacitance of 210 F/g has been maintained for 500 cycles. As the low cost of MnSO4 and KCr2O7 and the low reaction temperature, the present method avoids the requirements for complicated operations, time/energy-consuming and expensive reagents, and perhaps is ready for the industrialization of nano-MnO2 production. | Fen Ran Huili Fan Lingren Wang Lei Zhao Yongtao Tan Xuanxuan Zhang Lingbin Kong Long Kang | 2013 | Journal of Energy Chemistry2013，22，6： | 2 |
| 12 | Gastrodin ameliorates depression-like behaviors and up-regulates proliferation of hippocampal-derived neural stem cells in rats: Involvement of its anti-inflammatory action显示文摘 | Huaning Wang Ruiguo Zhang Yuting Qiao Fen Xue Huang Nie Ying Wang Zhengwu Peng Qingrong Tan | 2014 | Behavioural Brain Research2014，，： | 2 |
| 13 | Ginger-indirect moxibustion plus acupuncture versus acupuncture alone for chronic fatigue syndrome:a randomized controlled trial显示文摘OBJECTIVE:To assess the efficacy and safety of gingerindirect moxibustion for chronic fatigue syndrome(CFS).METHODS:In this central randomized,controlled trial,290 CFS participants were recruited and randomly allocated to group A(ginger-indirect moxibustion plus acupuncture)or group B(acupuncture alone).The study consisted of a treatment period of 8 weeks with a total of 24 treatments(3 sessions per week,every other day),and a follow-up period of 12 weeks.The outcome was measured by Fatigue Severity Scale(FSS),Psychological Health Report(SPHERE),the Self-rating depression scale(SDS)and the Hamilton anxiety scale(HAMA)at baseline,2,4,6,8,12 and 20 weeks.RESULTS:With the treatment undergoing,the changes of FSS,SPHERE,SDS and HAMA scores in both groups increased gradually,and the effect maintained at the 12th week.Between groups,significantly higher score changes were seen in group A in FSS after 4 weeks treatment(11.94 vs 9.12,95%CI:0.94,4.7)and in SPHERE after 2 weeks treatment(3.7 vs 2.27,95%CI:0.56,2.31).But for SDS and HAMA,the improvement did not differ significantly between groups.No severe adverse events were reported.CONCLUSION:Ginger-indirect moxibustion is a safe and effective intervention to relieve fatigue and accompanying physical symptoms of CFS. | MA Tingting WU Jie YANG Lijie FENG Fen YANG Huilin ZHANG Jinhua ZHONG Yanjin NING Qing HUANG Lirong LIN Youbing YAN Jue CHEN Guiquan HOU Tianshu WANG Li REN Yuanfang TAN Jing | 2022 | Journal of Traditional Chinese Medicine2022，42，2： | 2 |
| 14 | Influence of pore size optimization in catalyst layer on the mechanism of oxygen transport resistance in PEMFCs显示文摘In PEMFC,the oxygen transport resistance severely hinders the cell from achieving high performance.In this paper,pore-forming agent was used to optimize the pore size distribution of the catalyst layer(CL),and to study its effect on the mechanism of oxygen transport resistance,including molecular diffusion resistance,Knudsen diffusion resistance,and local O2 resistance in CL.The results showed that with the pore formation the cell performance had a significant improvement at high current density,mainly due to its better oxygen transport properties,especially under low platinum conditions.The addition of pore-forming agent moved the pore diameter toward a larger pore diameter with a range from 70 to 100 nm,and also obtaining a higher cumulative pore volume.It was found that the increase of the cumulative pore volume and larger pore size were conducive to the diffusion of oxygen molecules in CL,and the resistance caused by which was the dominant part in total transport resistance.Further tests indicated that the improvement of molecular diffusion resistance was much larger than that of Knudsen diffusion resistance in the catalyst layer after pore formed.In addition,the optimized pore structure will also get a higher number of effective pores,which resulted in an increased effective area of the ionomer on the Pt surface.The higher effective area of the ionomer was particularly beneficial for the reduction of local O_(2) resistance with low Pt loading. | Shumeng Guan Fen Zhou Jinting Tan Mu Pan | 2020 | Progress in Natural Science:Materials International2020，30，6： | 2 |
| 15 | Influence of adsorbed moisture on the properties of cyanate ester/BaTiO3 corn posites显示文摘 | Fen Chao Nicola Bowler Xiaoh Tan etaLKessle r | 2009 | Composites:Part A2009，40，8： | 1 |
| 16 | Influence of adsorbed moisture on the properties of cyanate ester/BaTiO3 composites显示文摘 | Chao Fen Bowler Nicola Tan Xiaoli | 2009 | Composites Part a Applied Science and Manufacturing2009，40，8： | 1 |
| 17 | A dandelion-like carbon microsphere/MnO_2 nanosheets composite for supercapacitors显示文摘This article reported the electrochemical performance of a novel cabon microsphere/MnO2nanosheets(CMS/MnO2) composite prepared by a in situ self-limiting deposition method under hydrothermal condition. The results of scanning electron microscopy(SEM) and transmission electron microscopy(TEM) revealed that MnO2nanosheets homogeneously grew onto the surface of CMS to form a loose-packed and dandelion-like core/shell microstructure. The unique microstructure plays a basic role in electrochemical accessibility of electrolyte to MnO2active material and a fast diffusion rate within the redox phase. The results of cyclic voltammetry, galvanostatic charge/discharge and electrochemical impedance spectrometry indicated that the prepared CMS/MnO2composite presented high capacitance of 181 F g-1and long cycle life of 61% capacity retention after 2000 charge/discharge cycles in 1 mol/L Na2SO4solution, which show strong promise for high-rate electrochemical capacitive energy storage applications. | Xuanxuan Zhang Fen Ran Huili Fan Yongtao Tan Lei Zhao Xiaoming Li Lingbin Kong Long Kang | 2014 | Journal of Energy Chemistry2014，23，1： | 1 |
| 18 | Theoretical Study on the Activity of a-COOH and b-COOH of N-Phosphoryl Aspartic Acids显示文摘The bio-mimic reactions of N-phosphoryl amino acids are very important in the study of many biochemical processes. The difference of reactivity between a-COOH and b-COOH in phosphoryl aspartic acid was studied by theoretical study (Hartree-Fock and Density Functional methods) in this paper. The intermediates II containing five-membered ring were more stable than III with six-membered ring. While for intermediates III, the isomers with six-membered ring in apical-equatorial spanning arrangement were more stable than those with di-equatorial spanning arrangement. At B3LYP/6-31G** level, it was shown that transition states IV and V involving a-COOH or b-COOH group had energy barriers of DE = 58.67 kJmol-1 and 103.94 kJmol-1, respectively. These results were in agreement with the experimental data. So the a-COOH group was involved in form of the intramolecular penta-coordinate phosphoric-carboxylic mixed anhydride intermediates, but not b-COOH group. | Zhong Zhou CHEN, Bo TAN, Yan Mei LI*, Yu Fen ZHAO Key Laboratory for Bioorganic Phosphorus Chemistry of Education Ministry, Department of Chemistry, School of Life Science and Engineering, Tsinghua University, Beijing 100084 | 2001 | Chinese Chemical Letters2001，12，12： | 1 |
| 19 | New efficient synthesis of 2,5,6-trisubstituted oxazolo[5,4-d]pyrimidi-7(6H)-ones via an oxazolyliminophosphorane显示文摘A new efficient synthesis of 2,5,6-trisubstituted oxazolo(5,4-d]pyrimidi-7(6H)-ones by consecutive azaWittig reaction was developed.The sequential three-component reaction of oxazolyliminophosphorane4,isocyanates and amines produced 2,5,6-trisubstituted oxazolo[5,4-d]pyrimidi-7(6H)-ones 7 in good overall yields in the presence of catalytic amount of EtONa. | Guo-Ping Zeng Chang-Quan Cai Fen Tan Ming-Wu Ding | 2015 | Chinese Chemical Letters2015，26，9： | 1 |
| 20 | Prediction of Ocular Irritancy of 26 Chemicals and 26 Cosmetic Products with Isolated Rabbit Eye (IRE) Test显示文摘Objective This study aims to establish and evaluate the methodology of isolated rabbit eye (IRE) test.Methods IRE test was performed according to modifications of the in vitro toxicology (INVITTOX) Protocol No.85:Rabbit enucleated eye test by European Centre for the Validation of Alternative Methods (ECVAM),and then 26 chemicals and 26 cosmetic products were tested in both in vitro IRE and in vivo Draize tests.A statistical analysis was conducted to determine the relevance of the IRE test to the data generated in the Draize test.Results IRE test was established successfully in our laboratory.It was shown that ranking correlation and class concordance were fairly well between the IRE test and the Draize test for 26 reference chemicals (Fisher's Exact Test χ 2 =51.314,P<0.001;McNemar P=0.261;Gamma=0.960,P<0.001;Kappa=0.843,P<0.001) and 26 cosmetic products (Fisher's Exact Test χ 2 =15.522,P<0.001;McNemar P=0.311;Gamma=0.967,P<0.001;Kappa=0.611,P<0.001).Conclusion IRE test was established successfully for in vitro testing of eye irritation as an alternative to Draize test. | GUO Xiang YANG Xing Fen YANG Ying HANS Raabe CAI Jing Heng XUE Jin Yu TAN Xiao Hua XIE Xiao Ping XIONG Xi Kun HUANG Jun Ming | 2012 | Biomedical and Environmental Sciences2012，25，3： | 1 |
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