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| 1 | 磁共振胰胆管成像结合薄层T2WI扩散加权成像对胰胆道梗阻性病变的诊断价值评估显示文摘目的评价磁共振成像(MR)水成像技术结合薄层T2WI、扩散加权成像(DWI)在胰胆道梗阻性病变中的临床诊断价值。方法采用重T2加权MR水成像技术及薄层T2WI、DWI对36例患者行磁共振胰胆管成像(MRCP)检查,图像经三维最大信号强度投影及三维表面遮盖显示技术后处理。结果水成像及薄层T2WI、DWI定位诊断率达100%,定性诊断率达88.6%,此技术可清晰显示胰胆管的形态,显示各种胰胆道疾病的异常改变,诊断正确性高。结论对胰胆道梗阻性病变的患者进行MRCP结合薄层T2WI、DWI扫描,诊断胰胆管梗阻的原因更为准确,可以作为常规检查序列推广应用。 | 吕文涛 王芝文 陈刚 王强 宋宪仁 朱兆兴 段飞雪 王莉 周莉 Duan Fengxia An Guohua | 2015 | 实用医学影像杂志2015，16，2： | 8 |
| 2 | Three-Dimensional Simulation of Hydrodynamic Mechanism of Fluidized Bed Methanation显示文摘Organic solid waste(OSW)contains many renewable materials.The pyrolysis and gasification of OSW can realize resource utilization,and its products can be used for methanation reaction to produce synthetic natural gas in the specific reactor.In order to understand the dynamic characteristics of the reactor,a three-dimensional numerical model has been established by the method of Computational Fluid Dynamics(CFD).Along the height of the reactor,the particle distribution in the bed becomes thinner and the mean solid volume fraction decreases from 4.18%to 0.37%.Meanwhile,the pressure fluctuation range decreased from 398.76 Pa at the entrance to a much lower value of 74.47 Pa at the exit.In this simulation,three parameters of gas inlet velocity,operating temperature and solid particle diameter are changed to explore their influences on gas-solid multiphase flow.The results show that gas velocity has a great influence on particle distribution.When the gas inlet velocity decreases from 6.51 to 1.98 m/s,the minimum height that particles can reach decreases from 169 to 100 mm.Additionally,as the operating temperature increases,the particle holdup inside the reactor changes from 0.843%to 0.700%.This indicates that the particle residence time reduces,which is not conducive to the follow-up reaction.Moreover,with the increase of particle size,the fluctuation range of the pressure at the bottom of the reactor increases,and its standard deviation increases from 55.34 to 1266.37 Pa. | Xiaojia Wang Danyang Shao Delu Chen Yutong Gong Fengxia An | 2023 | Journal of Renewable Materials2023，11，7： | 0 |
| 3 | Application value of Qisexingtai hand diagnostic method in diagnosis of coronary artery disease显示文摘OBJECTIVE:To evaluate the diagnostic efficacy of Qisexingtai hand diagnostic method in the diagnosis of coronary artery disease(CAD).METHODS:This was an investigator-initiated,prospective,multi-center,cross-sectional study.All the participants from three hospitals in China had been diagnosed by both Qisexingtai hand diagnostic method and coronary angiography.We compared the two diagnostic methods to calculate the sensitivity,the specificity,the omission diagnostic rate,the mistaken diagnostic rate and accuracy in order to evaluate the diagnostic efficacy of Qisexingtai hand diagnostic method for CAD.RESULTS:A total of 326 subjects were enrolled,diagnosed by both Qisexingtai hand diagnostic method and coronary angiography.As a result,there were 166 positive cases according to Qisexingtai hand diagnostic method,and 131 positive cases according to coronary angiography.Compared with the results of coronary angiography,the sensitivity of Qisexingtai hand diagnostic method was 80.2%,the specificity was 68.7%,the omission diagnostic rate was 19.8%,the mistaken diagnostic rate was 31.3%,and the accuracy was 73.3%.Area under the receiver operating characteristic curve was estimated as 0.735 for all,and 0.718,0.735,0.783 for the three sub-centers.CONCLUSION:Qisexingtai hand diagnostic method with high accuracy and sensitivity has certain application value in the diagnosis of CAD. | LIU Qian ZHAO Zhupei GUO Hua WANG Shiheng HAO Mingzhao QIN Peijie WANG Liuqing LIU Xuechun ZHANG Fengxia AN Hong LI Yu SHI Xueqin ZHU Tingyu LIU Jianfeng WANG Liying XU Tao ZHANG Limei ZOU Xu | 2022 | Journal of Traditional Chinese Medicine2022，42，5： | 0 |
| 4 | 诱导性多能干细胞的低基因组稳定性使非同源末端连接增加显示文摘背景与目的诱导性多能干细胞(induced pluripotent stem cells,iPSCs)和胚胎干细胞(embryonic stem cells,ESCs)具有许多共同特征,包括相似的形态、基因表达和体外分化谱。然而,iPSCs的基因组稳定性远低于ESCs。在本研究中,我们研究了iPSCs中DNA损伤修复的改变是否为其具有更大诱变倾向的原因。方法将小鼠iPSCs、ESCs和胚胎成纤维细胞暴露于电离辐射(4 Gy),导致双链DNA断裂。照射4 h后使用全基因组重测序评估DNA损伤修复的保真度。我们还分析了分别源自iPSCs或ESCs的小鼠的基因组稳定性。结果照射后,与胚胎干细胞和胚胎成纤维细胞相比,iPSCs具有较低的DNA损伤修复能力,有更多的体细胞突变和短片段插入缺失。iPSCs有更多的非同源末端连接DNA修复和更少的同源重组DNA修复。源自iPSCs的小鼠比ESCs小鼠以及C57对照小鼠的DNA损伤修复能力更低。结论本研究结果部分表明,iPSCs的低基因组稳定性及其在体内的高致瘤性是由DNA损伤修复的低保真度所致。 | Minjie Zhang Liu Wang Ke An Jun Cai Guochao Li Caiyun Yang Huixian Liu Fengxia Du Xiao Han Zilong Zhang Zitong Zhao Duanqing Pei Yuan Long Xin Xie Qi Zhou Yingli Sun | 2019 | 癌症2019，38，8： | 0 |
| 5 | Transgenerational analysis of H3K4me3 and H3K27me3 by ChIP-Seq links epigenetic inheritance to metabolism显示文摘Histone methylation is a kind of important epigenetic modification which occurs on the lysine residue or arginine residue of histone tails(Zhang and Reinberg,2001).It takes part in multiple biological processes,including gene expression,genomic stability,stem cell maturity,genetic imprinting,mitosis and development(Fischle et al.,2005).Abnormal histone methylation pattern | Ke An Fengxia Du Hao Meng Guochao Li Minjie Zhang Zongzhi Liu Zitong Zhao Zilong Zhang Di Yu Dong Wang Caiyun Yang Wencui Ma Lin Yuan Meiting Zhou Lili Duan Li Jin Hui Li Yan Zhang Jianzhong Su Jie Qiao Yingli Sun | 2018 | Journal of Genetics and Genomics2018，45，3： | 0 |
| 6 | Deep pedigree analysis reveals family specific ‘‘fingerprint” pattern of DNA methylation for men显示文摘DNA methylation plays an essential role in mammalian development[1].However,how DNA methylation is inherited between generations and if there is family-specific DNA methylation pattern remains to be elucidated[2].In this study,we collect male blood samples including a big pedigree of the descendants of an ancient Chinese empire and samples from different haplogroups to study their whole genome DNA methylation pattern.We find 115 male family-specific methylation sites from three families.The difference of whole genome DNA methylation pattern correlates | Guochao Li Minjie Zhang Hua Chen Ke An Zongzhi Liu Fengxia Du Caiyun Yang Xiao Han Li Jin Hui Li Yan Zhang Jie Qiao Yingli Sun | 2018 | Science Bulletin2018，63，1： | 0 |
| 7 | Lower genomic stability of induced pluripotent stem cells reflects increased non-homologous end joining显示文摘Background:Induced pluripotent stem cells(iPSCs)and embryonic stem cells(ESCs)share many common features,including similar morphology,gene expression and in vitro differentiation profiles.However,genomic stability is much lower in iPSCs than in ESCs.In the current study,we examined whether changes in DNA damage repair in iPSCs are responsible for their greater tendency towards mutagenesis.Methods:Mouse iPSCs,ESCs and embryonic fibroblasts were exposed to ionizing radiation(4 Gy)to introduce dou-ble-strand DNA breaks.At 4 h later,fidelity of DNA damage repair was assessed using whole-genome re-sequencing.We also analyzed genomic stability in mice derived from iPSCs versus ESCs.Results:In comparison to ESCs and embryonic fibroblasts,iPSCs had lower DNA damage repair capacity,more somatic mutations and short indels after irradiation.iPSCs showed greater non-homologous end joining DNA repair and less homologous recombination DNA repair.Mice derived from iPSCs had lower DNA damage repair capacity than ESC-derived mice as well as C57 control mice.Conclusions:The relatively low genomic stability of iPSCs and their high rate of tumorigenesis in vivo appear to be due,at least in part,to low fidelity of DNA damage repair. | Minjie Zhang Liu Wang Ke An Jun Cai Guochao Li Caiyun Yang Huixian Liu Fengxia Du Xiao Han Zilong Zhang Zitong Zhao Duanqing Pei Yuan Long Xin Xie Qi Zhou Yingli Sun | 2018 | Cancer Communications2018，38，1： | 0 |
| 8 | Spatio-Temporal Characteristics of Heat Transfer of Methanation in Fluidized Bed for Pyrolysis and Gasification Syngas of Organic Solid Waste显示文摘Methanation is an effective way to efficiently utilize product gas generated from the pyrolysis and gasification of organic solid wastes.To deeply study the heat transfer and mass transfer mechanisms in the reactor,a successful three-dimensional comprehensive model has been established.Multiphase flow behavior and heat transfer mechanisms were investigated under reference working conditions.Temperature is determined by the heat release of the reaction and the heat transfer of the gas-solid flow.The maximum temperature can reach 951 K where the catalyst gathers.In the simulation,changes in the gas inlet velocity and catalyst flow rate were made to explore their effects on CO conversion rate and temperature for optimization purposes.As the inlet gas velocity increases from 2.78 to 4.79 m/s,the CO conversion rate decreases from 81.6%to 72.4%.However,more heat is removed from the reactor,and the temperature rise increases from 78.03 to 113.49 K.When the catalyst flow rate is increased from 7.18 to 17.96 kg/(m^(2)·s),the mass of the catalyst in the reactor is increased from 0.0019 to 0.0042 kg,and the CO conversion rate is increased from 66.8%to 81.5%.However,this increases the maximum temperature in the reactor from 940.0 to 966.4 K. | Danyang Shao Xiaojia Wang Delu Chen Fengxia An | 2023 | Journal of Renewable Materials2023，11，10： | 0 |
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