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| 1 | hSSB1 regulates both the stability and the transcriptional activity of p53显示文摘肿瘤 suppressor p53 为涉及对多样的 genotoxic 应力的反应的几个细胞的过程是必要的,包括房间周期拘捕, DNA 修理, apoptosis 和老朽。p53 的规定的研究主要集中了于它的稳定性和 transactivation;然而,为 p53 的新规章的分子经常也被识别了。这里,我们报导那人的 ssDNA 绑定蛋白质 SSB1 (hSSB1 ) ,新奇 DNA 联系损坏的蛋白质,能与 p53 交往并且保护 p53 免受调停 ubiquitin 的降级的伤害。而且, hSSB1 也与 acetyltransferase p300 联系并且被在 lysine382 影响 p53 的 acetylation 为 p53 目标基因 p21 的有效 transcriptional 激活要求。机能上地, G2/M 检查点的 hSSB1 击倒导致废除部分依赖于 p53 或 p300。一起,我们的结果显示那 hSSB1 可以调整 DNA 损坏检查点由断然 modulating p53 和它的下游的目标 p21。 | Shuangbing Xu Yuanzhong Wu Qiong Chen Jingying Cao Kaishun Hu Jianjun Tang Yi Sang Fenju Lai Li Wang Ruhua Zhang Sheng-Ping Li Yi-Xin Zeng Yuxin Yina Tiebang Kang | 2013 | Cell Research2013，23，3： | 7 |
| 2 | Clinical efficacy of CT-guided iodine-125 seed implantation therapy in patients with advanced pancreatic cancer显示文摘 | Wang Zhongmin Liu Yu Liu Fenju Chen Kemin Huang Gang | 2010 | European Radiology2010，，7： | 2 |
| 3 | Clinical efficacy of CT-guided io- dine-125 seed implantation therapy in patients with advanced pan- creatic Cancer显示文摘 | Zhongmin W Yu L Fenju L | 2010 | Eur Radiol2010，20，： | 1 |
| 4 | Clinical efficacy of CT-guided iodine-125 seed implantation therapy in patients with advanced pancreatic cancer显示文摘 | Zhongmin W Yu L Fenju L | 2010 | Eur Radiol2010，20，7： | 1 |
| 5 | Clinical efficacy of CT-guided iodine-125 seed implantation therapy in patients with advanced pancreatic cancer显示文摘 | Wang Zhongmin Liu Yu Liu Fenju Chen Kemin Huang Gang | 2010 | European Radiology2010，，7： | 1 |
| 6 | Clinical efficacy of CT-guided iodine-125 seed implantation therapy in patients with advanced pancreatic cancer显示文摘 | Zhongmin W Yu L Fenju L | 2009 | Eur Radiol2009，20，： | 1 |
| 7 | Clinical efficacy of CT-guided iodine-125 seed implantation therapy in patients with advanced pancreatic cancer显示文摘 | Zhongmin W Yu L Fenju L | 2010 | Eur Radiol2010，20，： | 1 |
| 8 | Clinical efficacy of CT-guided iodine-125 seed implantation therapy in patients with advanced pancreatic cancer显示文摘 | Zhongmin W Yu L Fenju L | 2010 | Eur Radiol2010，20，7： | 1 |
| 9 | Clinical efficacy of CT- guided iodine-125 seed implantation therapy in patients with advanced pancreatic cancer显示文摘 | Zhongmin Wang Yu Liu Fenju Liu | 2010 | European Radiology2010，20，7： | 1 |
| 10 | Downregulation of miR-210 expression inhibits proliferation, induces apoptosis and enhances radiosensitivity in hypoxic human hepatoma cells in vitro显示文摘 | Wei Yang Ting Sun Jianping Cao Fenju Liu Ye Tian Wei Zhu | 2012 | Experimental Cell Research2012，，8： | 1 |
| 11 | Intraluminal Radioactive Stent Compared with Covered Stent Alone for the Treatment of Malignant Esophageal Stricture显示文摘 | Wang Zhongmin Huang Xunbo Cao Jun Huang Gang Chen Kemin Liu Yu Liu Fenju | 2012 | CardioVascular and Interventional Radiology2012，，2： | 1 |
| 12 | An angle Measuring System for Knife Blade Based on Laser and Electroaic Clinometer显示文摘 | AN FENJU FENG YUJUN TAN ZHONGMING | 2011 | Advanced Materials Research2011，，339： | 1 |
| 13 | Clinical efficacy of CT-guided iodine-125 seed implantation therapy in patients with advanced pancreatic cancer显示文摘 | Wang Zhongmin Liu Yu Liu Fenju Chen Kemin Huang Gang | 2010 | European Radiology2010，，7： | 1 |
| 14 | Preparation of Ag+/TiO2 Composite Coating Film for Preservation of Nanfeng Citrus显示文摘Using tetrabutyl titanate as the precursor,silver nitrate as the load agent,silver-doped titanium dioxide coating film was prepared by sol-gel method.Three agent samples were characterized by X-ray diffraction( XRD) analysis to investigate the crystal structure,which confirmed a synergistic antibacterial effect.The antibacterial and preservative effects of silver-doped titanium dioxide coating film on Nanfeng citrus were investigated preliminarily. Nutritional indicators of ripe Nanfeng citrus before and after preservation were detected to investigate the preservative properties of silver-doped titanium dioxide coating film and compare the effects of different components of composite coating film. The results showed that Ag^+/TiO_2 composite coating film exhibited high antibacterial and preservative effects on Nanfeng citrus under visible light illumination condition. | Xiaoyi LONG Jinyin CHEN Fenju LAI Tianyi LU Yongqi FU Shaolin JIANG Xiaoqiang YU | 2016 | Agricultural Biotechnology2016，5，3： | 1 |
| 15 | Effects of 1800-MHz Radiofrequency Fields on Circadian Rhythm of Plasma Melatonin and Testosterone in Male Rats显示文摘 | Fenju Qin Jie Zhang Honglong Cao Cao Yi JianXiang Li Jihua Nie LiLi Chen Jiajun Wang Jian Tong | 2012 | Journal of Toxicology and Environmental Health Part A2012，，18： | 1 |
| 16 | Boronic acid-containing diarylpyrimidine derivatives as novel HIV-1NNRTIs: Design, synthesis and biological evaluation显示文摘Drug resistance remains to be a serious problem with type Ⅰ human immunodeficiency virus(HIV-1) nonnucleoside reverse transcriptase inhibitors(NNRTIs). A series of novel boronic acid-containing diarylpyrimidine(DAPY) derivatives were designed via bioisosterism and scaffold-hopping strategies,taking advantage of the ability of a boronic acid group to form multiple hydrogen bonds. The target compounds were synthesized and evaluated for their anti-HIV activities and cytotoxicity in MT-4 cells.Compound 10 j yielded the most potent activity and turned out to be a single-digit nanomolar inhibitor towards the HIV-1 ⅢB [wild-type(WT) strain], L100 I and K103 N strains, with 50% effective concentration(EC_(50)) values of 7.19–9.85 nmol/L. Moreover, 10 j inhibited the double-mutant strain RES056 with an EC_(50) value of 77.9 nmol/L, which was 3.3-more potent than that of EFV(EC_(50)= 260 nmol/L) and comparable to that of ETR(EC_(50)= 32.2 nmol/L). 10j acted like classical NNRTIs with high affinity for WT HIV-1 reverse transcriptase(RT) with 50% inhibition concentration(IC_(50)) value of 0.1837 μmol/L. Furthermore,molecular dynamics simulation indicated that 10 j was proposed as a promising molecule for fighting against HIV-1 infection through inhibiting RT activity. Overall, the results demonstrated that 10 j could serve as a lead molecule for further modification to address virus-drug resistance. | Da Feng Fenju Wei Yanying Sun Prem Prakash Sharma Tao Zhang Hao Lin Brijesh Rathi Erik De Clercq Christophe Pannecouque Dongwei Kang Peng Zhan Xinyong Liu | 2021 | Chinese Chemical Letters2021，32，12： | 1 |
| 17 | Semaphorin3B modulates radiosensitivity of human glioma U-87MG cells显示文摘This study was to determine the Semaphorin3B(SEMA3B) role in glioma cells responding to irradiation. Two glioma cell lines,which were used here was wild-type p53(U-87MG),and the other was harboring mutated p53 (U-251).The SEMA3B mRNA could be detected in the two cell lines.The expression level of SEMA3B mRNA was higher in U-87MG cells than in U-251 cells,and increased with time in U-87MG cells after irradiation.Knockdown of SEMA3B expression by shRNA decreased the radiosensitivity of U-87MG cells,this may be associated with the increased G2 accumulation after irradiation.In addition,G2 accumulation after irradiation was enhanced in SEMA3B low-expressing U-87MG cells.These results showed that the SEMA3B was implicated in glioma cells responding to irradiation. | LIU Haiyan XU Yuanvuan CHEN Yun JIANG Xin YU Jiahua YANG Lei GU Cheng LIU Fenju | 2013 | Nuclear Science and Techniques2013，24，2： | 0 |
| 18 | Human KIAA1018/FAN1 nuclease is a new mitotic substrate of APC/C^(Cdh1)显示文摘A recently identified protein, FAN1 (FANCD2-associated nuclease 1, previously known as KIAA1018), is a novel nuclease associated with monoubiquitinated FANCD2 that is required for cellular resistance against DNA interstrand crosslinking (ICL) agents. The mechanisms of FAN1 regulation have not yet been explored. Here, we provide evidence that FAN1 is degraded during mitotic exit, suggesting that FAN1 may be a mitotic substrate of the anaphase-promoting cyclosome complex (APC/C). Indeed, Cdh1, but not Cdc20, was capable of regulating the protein level of FAN1 through the KEN box and the D-box. Moreover, the up-and down-regulation of FAN1 affected the progression to mitotic exit. Collectively, these data suggest that FAN1 may be a new mitotic substrate of APC/C Cdh1 that plays a key role during mitotic exit. | Fenju Lai Kaishun Hu Yuanzhong Wu Jianjun Tang Yi Sang Jingying Cao Tiebang Kang | 2012 | Chinese Journal of Cancer2012，31，9： | 0 |
| 19 | Microarray screening of differentially expressed genes in DCX transfected U87 cells before and after irradiation显示文摘Radiation therapy plays a critical role in the treatment of neurogliocytoma and it is known that doublecortin (DCX)-transfected U87 cells can inhibit tumor cell growth. Microarray analysis to screen for differentially expressed genes in DCX-transfected U87 cells before and after radiation uncovered DCX-related genes, the functions of DCX, and downstream genes in radiation therapy of neurogliocytoma. Stably transfected U87 cells were constructed (DCX-U87) and the differentially expressed genes were screened by microarray analysis to compare U87 cells with DCX-U87 cells in both non-irradiated and irradiated conditions. Cells were irradiated using 60Co γ-ray at a dose rate of 1.0 Gy/min. Mean values were subject to paired comparison analysis and genes with a p-value of less than 0.05 were analyzed. Differentially expressed genes can correlate with radiation sensitivity and DCX transfection. DCX and SPN proteins in DCX-U87 cells were detected by two groups of 0 and 10 Gy, but not the U87 cells, and their expression levels were higher in the 10 Gy group than in the 0 Gy group. The differential gene expression in DCX-U87 cells before and after radiation is helpful for future investigations into the mechanisms of radiation therapy in neurogliocytoma cells. | FENG Shuang WANG Jie JIANG Xin XU Yuanyuan ZHANG Haowen Cao Jianping YU Jiahua LIU Fenju | 2012 | Nuclear Science and Techniques2012，23，2： | 0 |
| 20 | Exploration of the key functional proteins from an efficient cellulolytic microbial consortium using dilution-to-extinction approach显示文摘In the present study, the cellulose binding proteins(CBPs) secreted by a putative cellulolytic microbial consortium were isolated and purified by affinity digestion. The purified CBPs were subsequently separated by sodium dodecyl sulfate–polyacrylamide gel electrophoresis(SDS-PAGE). Using mass spectrometric analyses, eight CBPs were identified and annotated to be similar to known proteins secreted by Clostridium clariflavum DSM 19732 and Paenibacillus sp. W-61. In addition, in combination with dilution-to-extinction approach and zymogram analysis technique, CBPs 6(97 k Da) and 12(52 k Da) were confirmed to be the key functional proteins that influence cellulolytic activities. Moreover, structural domain analyses and enzymatic activity detection indicated that CBPs 6 and 12 contained glycoside hydrolase families(GH) 9 and 48 catalytic modules, which both revealed endoglucandase and xylanase activities. It was suggested that the coexistence of GH9 and GH48 catalytic domains present in these two proteins could synergistically promote the efficient degradation of cellulose. | Qinghua Zhang Hanguang Li Xiangdong Zhu Fenju Lai Zhijun Zhai Yuanxiu Wang | 2016 | Journal of Environmental Sciences2016，28，5： | 0 |
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