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| 1 | Is rectal indomethacin effective in preventing of post-endoscopic retrograde cholangiopancreatography pancreatitis?显示文摘AIM:To investigate the effectiveness of rectally administered indomethacin in the prophylaxis of post-endoscopic retrograde cholangiopancreatography(ERCP)pancreatitis and hyperamylasaemia in a multicentre study.METHODS:A prospective,randomised,placebocontrolled multicentre study in five endoscopic units was conducted on 686 patients randomised to receive a suppository containing 100 mg indomethacin,or an inert placebo,10-15 min before ERCP.Post-ERCP pancreatitis and hyperamylasaemia were evaluated 24 h following the procedure on the basis of clinical signs and laboratory parameters,and computed tomography/magnetic resonance imaging findings if required.RESULTS:Twenty-one patients were excluded because of incompleteness of their data or because of protocol violation.The results of 665 investigations were evaluated:347 in the indomethacin group and 318 in the placebo group.The distributions of the risk factors in the two groups did not differ significantly.Pancreatitis developed in 42 patients(6.3%):it was mild in34(5.1%)and severe in eight(1.2%)cases.Hyperamylaesemia occurred in 160 patients(24.1%).There was no significant difference between the indomethacin and placebo groups in the incidence of either postERCP pancreatitis(5.8%vs 6.9%)or hyperamylasaemia(23.3%vs 24.8%).Similarly,subgroup analysis did not reveal any significant differences between the two groups.CONCLUSION:100 mg rectal indomethacin administered before ERCP did not prove effective in preventing post-ERCP pancreatitis. | Zoltán Dbrnte Zoltán Szepes Ferenc Izbéki Judit Gervain László Lakatos Gyula Pécsi Miklós Ihász Lilla Lakner Erzsébet Toldy László Czakó | 2014 | World Journal of Gastroenterology2014，20，29： | 16 |
| 2 | Relation of the IGF/IGF1R system to autophagy in colitis and colorectal cancer显示文摘Metabolic syndrome(Met S), as a chronic inflammatory disorder has a potential role in the development of inflammatory and cancerous complications of the colonic tissue. The interaction of DNA damage and inflammation is affected by the insulin-like growth factor 1 receptor(IGF1 R) signaling pathway. The IGF1 R pathway has been reported to regulate autophagy, as well, but sometimes through a bidirectional context. Targeting the IGF1 R-autophagy crosstalk could represent a promising strategy for the development of new antiinflammatory and anticancer therapies, and may help for subjects suffering from Met S who are at increased risk of colorectal cancer. However, therapeutic responses to targeted therapies are often shortlived, since a signaling crosstalk of IGF1 R with other receptor tyrosine kinases or autophagy exists, leading to acquired cellular resistance to therapy. From a pharmacological point of view, it is attractive to speculate that synergistic benefits could be achieved by inhibition of one of the key effectors of the IGF1 R pathway, in parallel with the pharmacological stimulation of the autophagy machinery, but cautiousness is also required, because pharmacologic IGF1 R modulation can initiate additional, sometimes unfavorable biologic effects. | Ferenc Sipos Hajnal Székely Imre Dániel Kis Zsolt Tulassay Gyorgyi Muzes | 2017 | World Journal of Gastroenterology2017，23，46： | 9 |
| 3 | Serrated pathway:Alternative route to colorectal cancer显示文摘Serrated polyps have been an area of intense focus for gastroenterologists over the past several years. Contrary to what was thought before,a growing body of literature indicates that these polyps can be precursors of colorectal cancer(CRC).Most of these lesions, particularly those in the proximal colon,have so far been under-recognized and missed during colonoscopy,qualifying these lesions to be the main cause of interval cancers.It is estimated that 10%-20%of CRCs evolve through this alternative,serrated pathway, with a distinct genetic and epigenetic profile.Aberrant DNA methylation plays a central role in the development of this CRC subtype.This characteristic molecular background is reflected in a unique pathological and clinical manifestation different from cancers arising via the traditional pathway.In this review we would like to highlight morphological,molecular and clinical features of this emerging pathway that are essential for gastroenterologists and may influence their everyday practice. | rpád V Patai Béla Molnár Zsolt Tulassay Ferenc Sipos | 2013 | World Journal of Gastroenterology2013，19，5： | 4 |
| 4 | Sofosbuvir plus daclatasvir for post-transplant recurrent hepatitis C: potent antiviral activity but no clinical benefit if treatment is given late显示文摘 | Adriano M. Pellicelli Marzia Montalbano Raffaella Lionetti Christine Durand Peter Ferenci Gianpiero D’Offizi Viola Knop Andrea Telese Ilaria Lenci Arnaldo Andreoli Stefan Zeuzem Mario Angelico | 2014 | Digestive and Liver Disease2014，，： | 2 |
| 5 | Analysis of TGF beta protein expression in aggressive fibromatosis (desmoid tumor)显示文摘 | Ferenc T Stalinska L Turant M Sygut J Tosik D Dziki A | 2006 | Pol J Pathol2006，57，： | 1 |
| 6 | Hepato eellular carcinoma (HCC):a global perspective显示文摘 | Ferenci P Fried M Labrecque D | 2010 | J Clin Gastroenterol2010，44，4： | 1 |
| 7 | An elective course in information mastery显示文摘 | Longyhore D Ference K Nansitel B | 2011 | Am J Pharm Educ2011，75，2： | 1 |
| 8 | Fenoxycarb levels and their effects on general and juvenile hormone esterase activity in the hemolymph of the silkworm,Bombyx mori显示文摘 | Skarlatos G D Ferenc S Andras S | 2003 | Pesticide Biochemistry and Physiology2003，73，： | 1 |
| 9 | An elective course in information mastery显示文摘 | Longyhore D Ference K Nansitel B | 2011 | Am J Pharm Edue2011，75，2： | 1 |
| 10 | Diazoxide and dimethyl sulphoxide prevent cerebral hypoperfusion-related learning dysfunction and brain damage after carotid artery occlusion显示文摘 | Eszter Farkas ádám Institóris Ferenc Domoki András Mihály Paul G.M Luiten Ferenc Bari | 2004 | Brain Research2004，，2： | 1 |
| 11 | Analysis of nm23-H1 pro- tein immunoreactivity in follicular thyroid tumors 显示文摘 | Ferenc T Lewifiski A Lange D | 2004 | Pol J Pathol2004，55，4： | 1 |
| 12 | Heavy metal accumulation and tolerance of energy grass ( Elymus elongatus subsp. ponticus cv. Szarvasi-1) grown in hydroponic culture显示文摘 | Gyula Sipos ádám Solti Viktória Czech Ildikó Vashegyi Brigitta Tóth Edit Cseh Ferenc Fodor | 2013 | Plant Physiology and Biochemistry2013，，： | 1 |
| 13 | ABT-450/r-om- bitasvir and dasabuvir with or without ribavirin for HCV 显示文摘 | Ferenci P Bernstein D Lalezari J | 2014 | NEnglJ Med2014，370，21： | 1 |
| 14 | Hepatocellular carcinoma(HCC):a global perspective 显示文摘 | FERENCI P FRIED M LABRECQUE D | 2010 | Journal of Clinical Gastroenterology2010，44，4： | 1 |
| 15 | Hepatocellular Carci- noma (HCC): A Global Perspective 显示文摘 | Ferenci P Fried M Labrecque D | 2010 | J Clin Gastroenterol2010，44，4： | 1 |
| 16 | Mitochondrial potassium channel opener diazoxide preserves neuronal-vascular function after cerebral ischemia in newborn pigs显示文摘 | Ferenc D James V Roland V et al | 1999 | Stroke1999，30，： | 1 |
| 17 | Telaprevir for previously untreated chronic hepatitis C virus infection 显示文摘 | Jacobson IM McHutchison JG Dusheiko G Di Bisceglie AM Reddy KR Bzowej NH Marcellin P Muir AJ Ferenci P Flisiak R George J Rizzetto M Shouval D Sola R Terg RA Yoshida EM Adda N Bengtsson L Sankoh AJ Kieffer TL George S Kauffman RS Zeuzem S ADVANCE Study Team | 2011 | N Engl J Med2011，364，25： | 1 |
| 18 | Telaprevir for retreatment of HCV infection 显示文摘 | Zeuzem S Andreone P Pol S Lawitz E Diago M Roberts S Foeaccia R Younossi Z Foster GR Horban A Ferenci P Nevens F Mullhaupt B Pockros P Terg R Shouval D van Hoek B Weiland O Van Heeswijk R De Meyer S Luo D Boogaerts G Polo R Picchio G Beumont M REALIZE Study Team | 2011 | N Engl J Med2011，364，25： | 1 |
| 19 | Hepatocellular carcinoma(HCC): a global perspective显示文摘 | Ferenci P Fried M Labrecque D | 2010 | J Clin Gastroenterol2010，44，4： | 1 |
| 20 | Hepatocellularcarcinoma (HCC) : A global perspective显示文摘 | Ferenci P Fried M Labrecque D | 2010 | J Clin Gas-troenterol2010，44，4： | 1 |
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