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| 1 | Hepatic steatosis is associated with an increased risk of carotid atherosclerosis显示文摘AIM: Although an association between helatic steatosis and vascular risk factors has been described, direct relationships between fatty liver and atherosclerosis have not yet been investigated. The aim of the present study has been to investigate those relationships.METHODS: The Study of Health in Pomerania examined a random population sample aged between 20 and 79 years.A study population of 4 222 subjects without hepatitis B and C infections and without liver cirrhosis was available for the present analysis. Hepatic steatosis was defined sonographically and intima-media thickness (IMT) as well as plaque prevalence were estimated by carotid ultrasound.RESULTS: The prevalence rate of hepatic steatosis was 29.9%. Among subjects aged ≥45 years, an association between hepatic steatosis and IMT of the carotid arteries was found in bivariate analysis, but not after adjustment for atherosclerotic risk factors. Individuals with fatty liver had more often carotid plaques than persons without fatty liver (plaque prevalence rate 76.8% vs 66.6%; P<0.001).This association persisted after adjustment for confounding factors and was predominantly present in subjects with no to mild alcohol consumption.CONCLUSION: There is an independent association between hepatic steatosis and carotid atherosclerotic plaques. Metabolic changes due to nonalcoholic fatty liver disease may explain this relationship. | Henry V(o|¨)lzke Daniel M.Robinson Volker Kleine Roland Deutscher Wolfgang Hoffmann Jan Lüdemann Ulf Schminke Christof Kessler Ulrich John | 2005 | World Journal of Gastroenterology2005，11，12： | 29 |
| 2 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 3 | Effect of sustained virological response on long-term clinical outcome in 113 patients with compensated hepatitis C-related cirrhosis treated by interferon alpha and ribavirin显示文摘AIM:To assess the long-term clinical benefit of sustained virological response(SVR)in patients with hepatitis C virus(HCV)cirrhosis treated by antiviral therapy using mostly ribavirin plus interferon either standard or pegylated.METHODS:One hundred and thirteen patients with uncomplicated HCV biopsy-proven cirrhosis,treated by at least one course of antiviral treatment ≥ 3 mo and followed ≥ 30 mo were included.The occurrence of clinical events hepatocellular carcinoma(HCC),decompensation and death was compared in SVR and non SVR patients.RESULTS:Seventy eight patients received bitherapy and 63 had repeat treatments.SVR was achieved in 37 patients(33%).During a mean follow-up of 7.7 years,clinical events occurred more frequently in non SVR than in SVR patients,with a significant difference for HCC(24/76 vs 1/37,P = 0.01).No SVR patient died while 20/76 non-SVR did(P = 0.002),mainly in relation to HCC(45%).CONCLUSION:In patients with HCV-related cirrhosis,SVR is associated with a significant decrease in the incidence of HCC and mortality during a follow-up period of 7.7 years.This result is a strong argument to perform and repeat antiviral treatments in patients with compensated cirrhosis. | Roland El Braks Nathalie Ganne-Carrié Hélène Fontaine Jacques Paries Véronique Grando-Lemaire Michel Beaugrand Stanislas Pol Jean-Claude Trinchet | 2007 | World Journal of Gastroenterology2007，13，42： | 3 |
| 4 | International experts consensus guidelines on robotic liver resection in 2023显示文摘The robotic liver resection(RLR)has been increasingly applied in recent years and its benefits shown in some aspects owing to the technical advancement of robotic surgical system,however,controversies still exist.Based on the foundation of the previous consensus statement,this new consensus document aimed to update clinical recommendations and provide guidance to improve the outcomes of RLR clinical practice.The guideline steering group and guideline expert group were formed by 29 international experts of liver surgery and evidence-based medicine(EBM).Relevant literature was reviewed and analyzed by the evidence evaluation group.According to the WHO Handbook for Guideline Development,the Guidance Principles of Development and Amendment of the Guidelines for Clinical Diagnosis and Treatment in China 2022,a total of 14 recommendations were generated.Among them were 8 recommendations formulated by the GRADE method,and the remaining 6 recommendations were formulated based on literature review and experts’opinion due to insufficient EBM results.This international experts consensus guideline offered guidance for the safe and effective clinical practice and the research direction of RLR in future. | Rong Liu Mohammed Abu Hilal Go Wakabayashi Ho-Seong Han Chinnusamy Palanivelu Ugo Boggi Thilo Hackert Hong-Jin Kim Xiao-Ying Wang Ming-Gen Hu Gi Hong Choi Fabrizio Panaro Jin He Mikhail Efanov Xiao-Yu Yin Roland S Croner Yu-Man Fong Ji-Ye Zhu Zheng Wu Chuan-Dong Sun Jae Hoon Lee Marco V Marino Iyer Shridhar Ganpati Peng Zhu Zi-Zheng Wang Ke-Hu Yang Jia Fan Xiao-Ping Chen Wan Yee Lau | 2023 | World Journal of Gastroenterology2023，29，32： | 2 |
| 5 | Prenatal androgenization of fe- male mice programs an increase in firing activity of gona- dotropin-rclcasing hormone (GnRH) neurons that is re- versed by metformin treatment in adulthood 显示文摘 | Roland A V Moenter S M | 2011 | Endocri- nology2011，152，2： | 1 |
| 6 | Lack of antioxidant activity of the antiatherogenic compound L-arginine 显示文摘 | ADAMS M R CO V P ROLAND S | 1999 | Atherosclerosis1999，146，2： | 1 |
| 7 | Prolonged Low- Dose Intravenous Thrombolysis in a Stroke Patient Wilh Dislal Basilar Thromhus 显示文摘 | Roland V Christian J Bodo K | 2006 | Stroke (S0039 - 2499)2006，37，1： | 1 |
| 8 | Effect of core stability training on throwing velocity in female handball players显示文摘 | A H ROLAND V D T Seiler S | 2011 | J Strength Cond Res2011，25，3： | 1 |
| 9 | Development of a PCR based assay for rapid and reliable identification of pathogenic Fusarium显示文摘 | Prashant K M Roland T V Alastair C | 2003 | FEMS Microbiology Letters2003，218，2： | 1 |
| 10 | Nutrient-chlorophyll relationships in tropical-subtropical lakes:do temperate models fit?显示文摘 | Huszar V L M Caraco N F Roland F | 2006 | Biogeochemistry2006，79，12： | 1 |
| 11 | The complexity of sjogren,s syn-drome :novel aspects on pathogenesis 显示文摘 | Roland J Petra V Roman V | 2011 | Lmmunology Letters2011，141，1： | 1 |
| 12 | Prenatal androgenization of femalemice programs an increase in firing activity of gonadotropin-releasing hormone ( GnRH ) neurons that is reversed bymetformin treatment in adulthood 显示文摘 | Roland A V Moenter S M | 2011 | Endocrinology2011，152，： | 1 |
| 13 | Electronic and field emission properties of boron nitride/carbon nano- tube superlattices 显示文摘 | Meunier V Roland C Beruholc J | 2002 | Applied Physics Letters2002，81，1： | 1 |
| 14 | Mitochondrial potassium channel opener diazoxide preserves neuronal-vascular function after cerebral ischemia in newborn pigs显示文摘 | Ferenc D James V Roland V et al | 1999 | Stroke1999，30，： | 1 |
| 15 | Correlation of intratumoeal microvessel density and p53 protein overexpression in human colorectal adenocarcinoma显示文摘 | Vermeulen PB Roland L Mertens V | 1996 | Microvasc Res1996，51，： | 1 |
| 16 | A comparison of suture repair with mesh repair for incisional hernia 显示文摘 | Roland W Wim C J Petrousjka V D | 2000 | N Engl J Med2000，343，10： | 1 |
| 17 | Technique for laparoscopic running urethrovesical anastomosis:the single knot method显示文摘 | Roland F Van Velthoven Thomas E Ahlering Alexandre Peltier Douglas W Skarecky Ralph V Clayman | 2003 | Urology2003，，4： | 1 |
| 18 | Disease mechanisms of Sjgren'ssyndrome显示文摘 | Nicolas D Malin V Roland J | 2004 | Drug Discovery Today:Disease Mechanisms2004，1，3： | 1 |
| 19 | Comparative assessment of large-scale data sets of protein- protein interactions 显示文摘 | CHRISTIAN V M ROLAND K BEREND S | 2002 | Nature2002，417，6887： | 1 |
| 20 | Endothelin-A receptor blockade prevents left ventricular hypertrophy and dysfunction in salt-sensitive experimental hypertension显示文摘 | Lars R Roland V Maike D | 2002 | Circulation2002，106，： | 1 |
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