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| 1 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 2 | Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial显示文摘 | Charles S Fuchs Jiri Tomasek Cho Jae Yong Filip Dumitru Rodolfo Passalacqua Chanchal Goswami Howard Safran Lucas Vieira dos Santos Giuseppe Aprile David R Ferry Bohuslav Melichar Mustapha Tehfe Eldar Topuzov John Raymond Zalcberg Ian Chau William Campbell | 2014 | The Lancet2014，，9911： | 3 |
| 3 | Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial显示文摘 | Charles S Fuchs Jiri Tomasek Cho Jae Yong Filip Dumitru Rodolfo Passalacqua Chanchal Goswami Howard Safran Lucas Vieira dos Santos Giuseppe Aprile David R Ferry Bohuslav Melichar Mustapha Tehfe Eldar Topuzov John Raymond Zalcberg Ian Chau William Campbell | 2014 | 2014 (9911)2014，，9911： | 2 |
| 4 | Evaluation of possible tourniquet systems for use in the Canadian Forces显示文摘 | King R B Filips D Blitz S | 2006 | J Trauma2006，60，5： | 1 |
| 5 | Trans fatty acids in food and their influence on human health显示文摘 | FILIP S FINK R HRIBAR J | 2010 | Food Technology and Biotechnology2010，48，2： | 1 |
| 6 | Trans fatty acids in food and their influence on human health 显示文摘 | Filip S Fink R | 2010 | Food Technology and Biotechnology2010，48，2： | 1 |
| 7 | Trans Fatty Acids in Food and Their Influence on Human Health 显示文摘 | Filip S Fink R | 2010 | Food Technology and Bioteehnology2010，48，2： | 1 |
| 8 | Age and BMD related differences in biochemical markers of bone metabolism in rural and urban women from Lublin Region,Poland显示文摘 | Filip R S Zag6rski J | | 0，，2： | 1 |
| 9 | Weighted total least squares RAIM algorithm using carrier phase measurements 显示文摘 | FILIPE S JOSE S ANTONIO R | 2012 | Satellite Navigation Technologies and European Workshop on GNSS Signals and Signal Processing2012，6，： | 1 |
| 10 | Vanadium haloperoxidases from brown algae of the Laminariaceae family显示文摘 | Almeida M Filipe S Humanes M Maia M F Melo R Severino N Da Silva J A L Da Silva J J R F Wever R | 2001 | Phytochemistry2001，57，： | 1 |
| 11 | Age ang BMD related differences in biochemical markers of bone metabolism in rural and urban women from Lulin Region,Poland显示文摘 | Filip R S Zagórski J | 2004 | Ann Agric Environ Med2004，1，123： | 1 |
| 12 | Age and BMD-related differences in biochemical markers of bone metabolism in rural and urban women from Lublin Region,Poland显示文摘 | FILIP R S ZAGORSKI J | | 0，，02： | 1 |
| 13 | Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial显示文摘 | Charles S Fuchs Jiri Tomasek Cho Jae Yong Filip Dumitru Rodolfo Passalacqua Chanchal Goswami Howard Safran Lucas Vieira dos Santos Giuseppe Aprile David R Ferry Bohuslav Melichar Mustapha Tehfe Eldar Topuzov John Raymond Zalcberg Ian Chau William Campbell | 2014 | The Lancet . 2014 (9911)2014，，9911： | 1 |
| 14 | Carbon nanotube field-effect transistor detector associated to gas chromatography for speciation of benzene, toluene, ethylbenzene, ( o-, m- and p-) xylene 显示文摘 | LURDES I B S FILIPE D P F TERESA A P R S | 2009 | Journal of Chromatography A2009，1216，37： | 1 |
| 15 | Health Promotion and Health Education with Particular Emphasis on Bone Diseases among Rural Population in Poland显示文摘 | Filip R S Bylina J Zagórski J | 2006 | Ann Agric Environ Med2006，13，1： | 1 |
| 16 | A thermodynamic analy- sis of hydrogen production by steam reforming of glycerol 显示文摘 | Adhikaria S Femandoa S Gwaltney S R Filip S D Bfic- ka R M Steele P H Haryanto A | 2007 | International Journal of Hydrogen Energy2007，32，： | 1 |
| 17 | Zero-valent iron nanoparticles in treatment of acid mine water from in situ uranium leaching 显示文摘 | Klimkova S Cernik M Lacinova L Filip J Jancik D Zboril R | 2011 | Chemosphere2011，82，8： | 1 |
| 18 | Primary angioplasty in acute myocardial infarction with right bundle branch block: should new onset right bundle branch block be added to future guide- lines as an indication for reperfusion therapy? 显示文摘 | Petr W Filip R Josef S | 2012 | Eur Heart J2012，33，1： | 1 |
| 19 | Adsorption and covalent coupling of ATP-binding DNA aptamers onto cellulose显示文摘 | SU S NUTIU R FILIPE C D M | 2007 | Langmuir2007，23，： | 1 |
| 20 | Temperature excludes N2-fixing heterocystous cyanobacteria in the tropical oceans显示文摘 | Marc S Filip J R M Lucas J S | 2003 | Nature2003，425，： | 1 |
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