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| 1 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 2 | A prospective feasibility study of sub-millisievert abdominopelvic CT using iterative reconstruction in Crohn’s disease显示文摘 | Siobhan B O’Neill Patrick D Mc Laughlin Lee Crush Owen J O’Connor Sebastian R Mc Williams Orla Craig Anne Marie Mc Garrigle Fiona O’Neill Jackie Bye Max F. Ryan Fergus Shanahan Michael M Maher | 2013 | European Radiology2013，，： | 2 |
| 3 | The effect of operational parameters on the photocatalytic degradation of humic acid显示文摘 | Fiona L Palmer Brian R Eggins Heather M Coleman | 2002 | Journal of Photochemistry & Photobiology, A: Chemistry2002，，1： | 1 |
| 4 | Gait classification in children with cerebral palsy: A systematic review显示文摘 | Fiona D Morris ME Baker R | 2007 | Gait & Posture2007，25，1： | 1 |
| 5 | Long-range conserved non-coding SHOX sequences regulate expression in developing chicken limb and are associated with short stature phenotypes in human patients 显示文摘 | Nitin S Fiona B Ralph R | 2007 | Hum Mol Genet2007，16，： | 1 |
| 6 | Trachoma survey methods : a literature review 显示文摘 | Jeremiah N Mark R Fiona M | 2009 | Bull World Health Organ2009，87，2： | 1 |
| 7 | Estrogen reduces lipid content in the liver exclusively from membrane receptor signaling 显示文摘 | ALl P MAHNAZ R FIONA O | 2013 | SciSignal2013，6，276： | 1 |
| 8 | Gas chromatogra-mphic mass spectrometric determination of β 2-agonists in postmortem blood:application in forensic medicine显示文摘 | Couper B R Fiona J Drummer A D | 1996 | Chromatography Biomedical Science and Application1996，685，2： | 1 |
| 9 | Low molecular weight heparins and heparinoids in acute isehemie stroke: a meta analysis of randomized controlled trals显示文摘 | Philip MWB Iddenden R Fiona JB | 2000 | Stroke2000，31，1： | 1 |
| 10 | Regulation and expression of human Fabs under the control of the Escherichia coli arabinose promoter显示文摘 | MICHELLE A CLARK FIONA R HAMMOND | 1997 | Immunotechnology1997，3，3： | 1 |
| 11 | Subtotal hepatectomy: a porcine model for the study of liver regeneration显示文摘 | Fiona G Court Peter E Laws Charles P Morrison Benjamin D Teague Matthew S Metcalfe Simon A Wemyss-Holden Ashley R Dennison Guy J Maddern | 2004 | Journal of Surgical Research2004，，1： | 1 |
| 12 | Family carers in stroke care:examiningthe relationship between problem-solving,depression and generalhealth显示文摘 | Sue Y May HL Fiona R | 2007 | J Clin Nurs2007，16，2： | 1 |
| 13 | The effect of operational parameters on the photocatalytic degradation of humic acid 显示文摘 | Palmer Fiona L Eggins Brian R Coleman Heather M | 2002 | Journal of Photochemistry and Photobiology A: Chemistry2002，148，13： | 1 |
| 14 | Comparison of three selectable marker genes for transformation of wheat by microprojectile bombardment显示文摘 | Barbara Witrzens Richard IS Brettell Fiona R Murray | | 0，，01： | 1 |
| 15 | Crossley aetiology of rib stress fractures in rowers显示文摘 | Stuart J Warden Fiona R Gutschlag Henry Wajswelner | 2002 | Sports Med2002，13，： | 1 |
| 16 | Transferrin-gene expression in the rat mammary gland显示文摘 | Fiona J MCDONALD Nigel LATTA | 1990 | Biochem J1990，267，： | 1 |
| 17 | 查看详情显示文摘 | Manuel G R Fiona F John E O Andrew I M Wemer J B Johannes G V Marcinhet P | | 0，，： | 1 |
| 18 | Rapid Simultaneous Determination of Alkylxanthines by CZE and its Application in Analysis of Pharma- ceuticals and Food Samples显示文摘 | FIONA R YULIYA S | 2005 | Analytica Acta2005，540，： | 1 |
| 19 | Chitosan and depolymerized chitosan oligomers as condensing carriers for in vivo plasmid delivery显示文摘 | FIONA C MacLAUGHLIN R J MUMPER J W | 1998 | J Control Release1998，56，： | 1 |
| 20 | Global map of growth-regulated gene expression in burkholderia pseudomallei,the causative agent of melioidosis显示文摘 | Fiona R Mitali S T Sarah V H | 2006 | J Bacteriol2006，188，23： | 1 |
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