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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with moderate-severe active ulcerative colitis:A global survey of physicians'practice显示文摘AIM To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates(5ASA) with corticosteroids(CS) versus corticosteroids alone for patients with active ulcerative colitis(UC). METHODS A cross-sectional questionnaire exploring physicians' attitude toward 5ASA + CS combination therapy vs CS alone was developed and validated. The questionnaire was distributed to gastroenterology experts in twelve countries in five continents. Respondents' agreement with stated treatment choices were assessed by standardized Likert scale. Background professional characteristics of respondents were analyzed for correlation with responses. RESULTS Six hundred and sixty-four questionnaires were distributed and 349 received(52.6% response rate). Of 340 eligible respondents, 221(65%) would continue 5ASA in a patient hospitalized for intravenous CS treatment due to a moderate-severe UC flare, while 108(32%) would stop the 5ASA(P < 0.001), and 11(3%) are undecided. Similarly, 62% would continue 5ASA in an out-patient starting oral CS. However, only 140/340(41%) would proactively start 5ASA in a hospitalized patient not receiving 5ASA before admission. Most(94%) physicians consider the safety profile of 5ASA as very good. Only 52% consider them inexpensive, 35% perceive them to be expensive and 12% are undecided. On multi-variable analysis, less years of practice and perception of a plausible additive mechanistic effect of 5ASA + CS were positively associated with the decision to continue 5ASA with CS. CONCLUSION Despite the absence of data supporting its benefit, most gastroenterologists endorse combination of 5ASA + CS for patients with active moderate-to-severe UC. Randomized controlled trials are needed to assess if 5ASA confer any benefit for these patients. | Shomron Ben-Horin Jane M Andrews Konstantinos H Katsanos Florian Rieder Flavio Steinwurz Konstantinos Karmiris Jae Hee Cheon Gordon William Moran Monica Cesarini Christian D Stone Doron Schwartz Marijana Protic Xavier Roblin Giulia Roda Min-Hu Chen Ofir Har-Noy Charles N Bernstein | 2017 | World Journal of Gastroenterology2017，23，16： | 3 |
| 3 | Phosphorus nutrition andwater deficits in field-grown soybeans 显示文摘 | Flavio H Gutierrez B Grant W T | 1999 | Plant Soil1999，207，1： | 1 |
| 4 | Embolization of Pulmonary Arteriovenous Malformation 显示文摘 | Jmaes L Flavio Castaneda H Bob Smouse | 2000 | Intervent Radiol2000，17，2： | 1 |
| 5 | Embolization of pulmonary arteriovenous malformation显示文摘 | James L Flavio Castaneda H Bob Smouse | 2000 | International Radiology2000，17，2： | 1 |
| 6 | Phosphorus nutrition and water deficits in field-grown soybeans显示文摘 | Flavio H Gutierrez B Thomas G W | 1999 | Plant and Soil1999，207，： | 1 |
| 7 | Late season nitrogen fertilization of soybeans: effects on leaf senescence, yield and environment显示文摘 | Flavio H GutieR Javier D S Helena R | 2004 | Nutrient Cycling in Agroecosystems2004，68，： | 1 |
| 8 | Embolization of Pulmonary Arteriovenous Malformation显示文摘 | Jmaes L Flavio Castaneda H Bob Smouse | 2000 | Intervent Radiol2000，17，2： | 1 |
| 9 | Are chemical compounds import for soybean resistance to Anticarsia gemmatalis 显示文摘 | Giorla C P Clara B H Flavio M | 2005 | Journal of Chemical Ecology2005，31，： | 1 |
| 10 | Note on the effects of winter and spring waterlogging on growth, chemical com- position and yield of rapeseed 显示文摘 | Flavio H Ra61 S L Claudia A P | 1996 | Field Crops Res1996，47，： | 1 |
| 11 | Blind beamforming on a randomly distributed sensor array system显示文摘 | Yao K Ralph E H Chris W R Chen D C Flavio Lorenzelli | 2004 | IEEE Journal on Selected Areas in Communications2004，16，8： | 1 |
| 12 | Adaptive output feedback control of uncertain nonlinear systems using single-hidden-layer neural networks显示文摘 | NAIRA H FLAVIO N KIM N | 2002 | IEEE Trans on Neural Networks2002，13，6： | 1 |
| 13 | A novel error observer-based adaptive output feedback approach for control of uncertain systems显示文摘 | NAIRA H FLAVIO N CALISE A | 2002 | IEEE Transactions on Automatic Control2002，47，8： | 1 |
| 14 | Adaptive output feedback control of uncertain nonlinear systems using single-Hiddenlayer neural networks显示文摘 | NAIRA H FLAVIO N CALISE A | 2002 | IEEE Transactions on Neural Networks2002，13，6： | 1 |
| 15 | APP processing and synaptic function显示文摘 | Flavio K Taisuke T Helen H | 2003 | Neuron2003，37，6： | 1 |
| 16 | Embolization of Pulmonary Arteriovenous Malformation显示文摘 | Jmaes L Flavio Castaneda H Bob Smouse | 2000 | Int Radiol2000，17，2： | 1 |
| 17 | Late season nitrogen fertilization of soybeans: effects on leaf senescence, yield and environment 显示文摘 | Flavio H G Javier D S Helena R K Ra61 S L | 2004 | Nutrient Cycling Agroecosystems2004，68，9： | 1 |
| 18 | Phosphorus nutrition and water deficits in field-grown soybeans显示文摘 | Flavio H Gutierrez-boem Grant W T | 1999 | Plant and Soil1999，207，： | 1 |
| 19 | A prospec- tive trial comparing laparoscopic and open surgery for the treatment of impacted ureteral stones 显示文摘 | Gilberto L A Flavio L H Tulio M G | 2009 | Actas Urol Esp2009，33，10： | 1 |
| 20 | Phosphorus nutrition and water deficits in field-grown soybeans显示文摘 | Flavio H Gutiérrez B Grant W T | 1999 | Plant and Soil1999，207，： | 1 |
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