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| 1 | The role of gut microbiota(commensal bacteria)and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer:contribution of germ-free and gnotobiotic animal models of human diseases显示文摘Metagenomic approaches are currently being used to decipher the genome of the microbiota(microbiome),and,in parallel,functional studies are being performed to analyze the effects of the microbiota on the host.Gnotobiological methods are an indispensable tool for studying the consequences of bacterial colonization.Animals used as models of human diseases can be maintained in sterile conditions(isolators used for germ-free rearing)and specifically colonized with defined microbes(including non-cultivable commensal bacteria).The effects of the germ-free state or the effects of colonization on disease initiation and maintenance can be observed in these models.Using this approach we demonstrated direct involvement of components of the microbiota in chronic intestinal inflammation and development of colonic neoplasia(i.e.,using models of human inflammatory bowel disease and colorectal carcinoma).In contrast,a protective effect of microbiota colonization was demonstrated for the development of autoimmune diabetes in non-obese diabetic(NOD)mice.Interestingly,the development of atherosclerosis in germ-free apolipoprotein E(ApoE)-deficient mice fed by a standard low-cholesterol diet is accelerated compared with conventionally reared animals.Mucosal induction of tolerance to allergen Bet v1 was not influenced by the presence or absence of microbiota.Identification of components of the microbiota and elucidation of the molecular mechanisms of their action in inducing pathological changes or exerting beneficial,disease-protective activities could aid in our ability to influence the composition of the microbiota and to find bacterial strains and components(e.g.,probiotics and prebiotics)whose administration may aid in disease prevention and treatment. | Helena Tlaskalova-Hogenova Renata Stepankova Hana Kozakova Tomas Hudcovic Luca Vannucci Ludmila Tuckova Pavel Rossmann TomasHrncır Miloslav Kverka Zuzana Zakostelska Klara Klimesova Jaroslava Pribylova Jirina Bartova Daniel Sanchez Petra Fundova Dana Borovska Dagmar Sru˚tkova Zdenek Zıdek Martin Schwarzer Pavel Drastich David P Funda | 2011 | Cellular & Molecular Immunology2011，8，2： | 47 |
| 2 | Cost-utility of molecular adsorbent recirculating system treatment in acute liver failure显示文摘AIM:To determine the short-term cost-utility of mo-lecular adsorbent recirculating system(MARS) treatment in acute liver failure(ALF).METHODS:A controlled retrospective study was conducted with 90 ALF patients treated with MARS from 2001 to 2005.Comparisons were made with a historical control group of 17 ALF patients treated from 2000 to 2001 in the same intensive care unit(ICU) specializing in liver diseases.The 3-year outcomes and number of liver transplantations were recorded.All direct liver disease-related medical expenses from 6 mo before to 3 years after ICU treatment were determined for 31 MARS patients and 16 control patients.The health-related quality of life(HRQoL) before MARS treatment was estimated by a panel of ICU doctors and after MARS using a mailed 15D(15-dimensional generic healthrelated quality of life instrument) questionnaire.The HRQoL,cost,and survival data were combined and the incremental cost/quality-adjusted life years(QALYs) was calculated.RESULTS:In surviving ALF patients,the health-related quality of life after treatmeant was generally high and comparable to the age-and gender-matched general Finnish population.Compared to the controls,the average cost per QALY was considerably lower in the MARS group(64 732€ vs 133 858€) within a timeframe of 3.5 years.The incremental cost of standard medical treatment alone compared to MARS was 10 928€,and the incremental number of QALYs gained by MARS was 0.66.CONCLUSION:MARS treatment combined with standard medical treatment for ALF in an ICU setting is more cost-effective than standard medical treatment alone. | Taru Kantola Suvi Mklin Anna-Maria Koivusalo Pirjo Rsnen Anne Rissanen Risto Roine Harri Sintonen Krister Hckerstedt Helena Isoniemi | 2010 | World Journal of Gastroenterology2010，16，18： | 3 |
| 3 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 4 | Global surveillance of cancer survival 1995–2009: analysis of individual data for 25 676 887 patients from 279 population-based registries in 67 countries (CONCORD-2)显示文摘 | Claudia Allemani Hannah K Weir Helena Carreira Rhea Harewood Devon Spika Xiao-Si Wang Finian Bannon Jane V Ahn Christopher J Johnson Audrey Bonaventure Rafael Marcos-Gragera Charles Stiller Gulnar Azevedo e Silva Wan-Qing Chen Olufemi J Ogunbiyi Bernard R | 2015 | The Lancet . 2015 (9972)2015，，： | 2 |
| 5 | Fertility-sparing surgery in patients with cervical Cancer显示文摘 | Lukas R Petr S Helena R | | 0，，02： | 1 |
| 6 | Detection of leakage freshwater and friction factor calibration in drinking networks using central force optimization 显示文摘 | ALI H HELENA M R | 2012 | Water Resource Manage2012，26，8： | 1 |
| 7 | The administration of olanzapine and fluoxetine has synergistic effects on intracellular survival pathways in the rat brain显示文摘 | Gislaine Z Réus Helena M Abelaira Fabiano R Agostinho | | 0，，08： | 1 |
| 8 | The influence of layered compounds on the properties of starch/layered compound composites 显示文摘 | Helena - M Wilhelm Maria - R Sierakowski Gabriel P Souza | 2003 | Polymer International2003，52，： | 1 |
| 9 | Modulation of P-glycoprotein efflux pump: Induction and activation as a therapeutic strategy 显示文摘 | SILVA R VILAS-BOAS V HELENA C | 2015 | Pharmacol Ther2015，149，： | 1 |
| 10 | Survival of young and older breast cancer patients in Geneva From 1990 to 2001 显示文摘 | Elisabetta R Gerald F Helena M | 2005 | Eur J Cancer2005，41，2： | 1 |
| 11 | Cisplatin-induced growth arrest of head and neck cancer cells correlares with increased expression of p16 and p53显示文摘 | Yip Helena T Chopra R Chakrabarti R | 2006 | Archives of Otolaryngology Head&Neck Surgery2006，132，3： | 1 |
| 12 | Tribological analysis of TiN and DLC coated contacts by 3D FEM modeling and stress simulation 显示文摘 | KENNETH H HELENA R ANSSI L | 2008 | Wear2008，264，910： | 1 |
| 13 | Treatment of obesity in polycycstic ovary syndrome: a position statement of the Andro- gen Excess and Polycystic Ovary Syndrome Society 显示文摘 | Lisa J Pasquali R Helena J | 2009 | Fertil Steril2009，92，6： | 1 |
| 14 | Younger women with breast carcinoma have a poorer prognosis the Han older women 显示文摘 | Maureen C Helena R Kirby B | 1996 | Caneer1996，77，3： | 1 |
| 15 | An Analysis of Question Asking on Scientific Texts Explaining Natural Phenomena 显示文摘 | Jorge Costa Helena Caldeira Juan R GallaA stegui JoseA Otero | 2004 | Journal of Research in Science Teaching2004，37，6： | 1 |
| 16 | Temporal evolution of groundwater composition in an alluvial aquifer (Pisuerga River, Spain) by principal component analysis显示文摘 | Helena B Pardo R Vega M | 2000 | Water Research2000，34，80： | 1 |
| 17 | Analysis of SHA-1in encryption mode显示文摘 | Helena Handschuh Lars R Knudsen Matthew J Robshaw | 2001 | Computer Sicience2001，，： | 1 |
| 18 | The presence of banana streak virus has been confirmed in plantain(Musa AAB Simmonds),sugarcane:(Saccharum officinarum)and edible canna(Canna edulis)in Colombia显示文摘 | Helena R Sylvio B Gladys M | 1997 | Infomusa1997，6，1： | 1 |
| 19 | Detection of Leakage Freshwater and Friction Factor Calibration in Drinking Networks Using Central Force Optimization显示文摘 | Helena A H Helena M R | 2012 | Water Resource Management2012，26，8： | 1 |
| 20 | Job-shop scheduling: computational study oflocal search and larger-step optimization methods 显示文摘 | Helena R L | 1995 | European Journal of Operational Research1995，83，1： | 1 |
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