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| 1 | Near-infrared fluorescence sentinel lymph node detection in gastric cancer: A pilot study显示文摘AIM: To investigate feasibility and accuracy of nearinfrared fluorescence imaging using indocyanine green: nanocolloid for sentinel lymph node(SLN) detection in gastric cancer.METHODS: A prospective, single-institution, phaseI feasibility trial was conducted. Patients suffering from gastric cancer and planned for gastrectomy were included. During surgery, a subserosal injection of 1.6 m L ICG:Nanocoll was administered around the tumor. NIR fluorescence imaging of the abdominal cavity was performed using the Mini-FLARE? NIR fluorescence imaging system. Lymphatic pathways and SLNs were visualized. Of every detected SLN, the corresponding lymph node station, signal-to-background ratio and histopathological diagnosis was determined. Patients underwent standard-of-care gastrectomy. Detected SLNs outside the standard dissection planes were also resected and evaluated.RESULTS: Twenty-six patients were enrolled. Four patients were excluded because distant metastases were found during surgery or due to technical failure of the injection. In 21 of the remaining 22 patients, at least 1 SLN was detected by NIR Fluorescence imaging(mean 3.1 SLNs; range 1-6). In 8 of the 21 patients, tumor-positive LNs were found. Overall accuracy of the technique was 90%(70%-99%; 95%CI), which decreased by higher p T-stage(100%, 100%, 100%, 90%, 0% for respectively Tx, T1, T2, T3, T4 tumors). All NIR-negative SLNs were completely effaced by tumor. Mean fluorescence signal-to-background ratio of SLNs was 4.4(range 1.4-19.8). In 8 of the 21 patients, SLNs outside the standard resection plane were identified, that contained malignant cells in 2 patients.CONCLUSION: This study shows successful use of ICG:Nanocoll as lymphatic tracer for SLN detection in gastric cancer. Moreover, tumor-containing LNs outside the standard dissection planes were identified. | Quirijn RJG Tummers Leonora SF Boogerd Wobbe O de Steur Floris PR Verbeek Martin C Boonstra Henricus JM Handgraaf John V Frangioni Cornelis JH van de Velde Henk H Hartgrink Alexander L Vahrmeijer | 2016 | World Journal of Gastroenterology2016，22，13： | 9 |
| 2 | Application of the acute respiratory distress syndrome network low - tidal volume strategy to pediatric acute lung injury 显示文摘 | Hanson JH Flori H | 2006 | Respir Care Clin N Am2006，12，3： | 1 |
| 3 | Comparision of PCR,caputure ELISA and immunoblotting for detection of Toxoplasma gondii in infected mice显示文摘 | Hafid J Flori P Raberin H | 2001 | J Med Microbiol2001，50，： | 1 |
| 4 | Monte Carlo simulation of wells显示文摘 | de Groot P F M Bril A H Floris F J T | 1996 | Geophysics1996，61，3： | 1 |
| 5 | High pressure can reduce the antigenicity of bovine whey protein hydrolysates 显示文摘 | Penas E Snel H Floris R | 2006 | International Dairy Journal2006，16，： | 1 |
| 6 | Endothelial function in migraine: a cross-sectional study 显示文摘 | Floris H Vanmolkot Jan N de Hoon | 2010 | BioMed Central2010，10，： | 1 |
| 7 | Pathobiology of acute respiratory distress syndrome显示文摘 | SAPRUA FLORI H QUASNEY M W | 2015 | Pediatr Crit Care Med2015，16，51： | 1 |
| 8 | MED12 Controls the Response to Multiple Cancer Drugs through Regulation of TGF-β Receptor Signaling显示文摘 | Sidong Huang Michael H?lzel Theo Knijnenburg Andreas Schlicker Paul Roepman Ultan McDermott Mathew Garnett Wipawadee Grernrum Chong Sun Anirudh Prahallad Floris H. Groenendijk Lorenza Mittempergher Wouter Nijkamp Jacques Neefjes Ramon Salazar Peter ten Di | 2012 | Cell2012，，5： | 1 |
| 9 | Clinical symptoms and symptom signatures of Alzheimer's disease subgroups显示文摘 | Iqbal K Flory M Soininen H | 2013 | J Alzheimers Dis2013，37，3： | 1 |
| 10 | Update on trlple-nega- tive breast cancer: prognosis and management strategies 显示文摘 | Brouckaert O Wildiers H Floris G | 2012 | Int J Womens Health2012，4，： | 1 |
| 11 | Endothelial function in migraine: a cross-sectional study 显示文摘 | Floris H Vanmolkot Jan N de Hoon | 2010 | Bio Med Central2010，，10： | 1 |
| 12 | The negative predictive value of electrical impedance scanning in BI-RADS category IV breast lesions 显示文摘 | Michael H Flory D Cacilia S | 2005 | Invest Radiol2005，40，： | 1 |
| 13 | Positive fluid balance is associated with higher mortality and prolonged mechanical ventilation in pediatric patients with acute lung injury显示文摘 | FLORI H R CHURCH G LIU K D et aI | 2011 | Crit Care Res Pract2011，85，： | 1 |
| 14 | Pathobiology of acute respiratory distress syndrome显示文摘 | Sapru A Flori H Quasney MW | 2015 | Pediatr Crit Care Med2015，16，51： | 1 |
| 15 | Early elevation of plasma soluble intercellular adhesion molecule 1 in pediatric acute lung injury identifies patients at increased risk of death and prolonged mechanical ventilation 显示文摘 | Flori H R Ware L B Glidden D | 2003 | Pediatr Crit Care Med2003，4，3： | 1 |
| 16 | High pressure can reduce the antigenicity of bovine whey protein hydrolysates显示文摘 | Penas E Snel H Floris R | 2006 | International Dairy Journal2006，16，： | 1 |
| 17 | Application of the acute respiratory distress syndrome network low-tidal vol- ume strategy to pediatric acute lung injury显示文摘 | HANSON J H FLORI H | 2006 | Respir Care Clin N Am2006，12，3： | 1 |
| 18 | High pressure can reduce the antigenicity of bovine whey protein hydrolysates显示文摘 | PENAS E SNEL H FLORIS R | 2006 | International Dairy Journal2006，16，9： | 1 |
| 19 | Surgical treatment of Meniere's disease显示文摘 | Floris W Boudewyns | 2005 | Current Opinion in Neurology2005，18，： | 1 |
| 20 | Pathobiology of acute respi- ratory distress syndrome显示文摘 | Sapru A Flori H Quasney MW | 2015 | Pediatr Crit Care Med2015，16，51： | 1 |
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