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| 1 | Bevacizumab in the pre-operative treatment of locally advanced rectal cancer: A systematic review显示文摘Despite advances in the management of patients with locally advanced,non-metastatic rectal adenocarcinoma(LARC),prognosis remains largely unsatisfactory due to a high rate of distant relapse.In fact,currently available neoadjuvant protocols,represented by fluoropyrimidine-based chemo-radiotherapy(CT-RT)or short-course RT,together with improved surgical techniques,have largely reduced the risk of local relapse,with limited impact on distant recurrence.Available results of phaseⅢtrials with additional cytotoxic agents combined with standard CT-RT are disappointing,as no significant reduction in the risk of recurrence has been demonstrated.In order to improve the control of micrometastatic disease,integrating targeted agents into neoadjuvant treatment protocols thus offers a rational approach.In particular,the antiangiogenic agent bevacizumab has demonstrated synergistic activity with both CT and RT in pre-clinical and clinical models,and thusmay represent a suitable companion in the neoadjuvant treatment of LARC.Preliminary results of phase?Ⅰ-Ⅱclinical studies are promising and suggest potential clinical parameters and molecular predictive biomarkers useful for patient selection:treatment personalization is indeed the key in order to maximize the benefit while reducing the risk of more complex neoadjuvant treatment schedules. | Lorenzo Fornaro Chiara Caparello Caterina Vivaldi Virginia Rotella Gianna Musettini Alfredo Falcone Editta Baldini Gianluca Masi | 2014 | World Journal of Gastroenterology2014，20，20： | 5 |
| 2 | Role of neurotrophic factors in enhancing linear axonal growth of ganglionic sensory neurons in vitro显示文摘Neurotrophins play a major role in the regulation of neuronal growth such as neurite sprouting or regeneration in response to nerve injuries. The role of nerve growth factor, neurotrophin-3, and brain-derived neurotrophic factor in maintaining the survival of peripheral neurons remains poorly understood. In regenerative medicine, different modalities have been investigated for the delivery of growth factors to the injured neurons, in search of a suitable system for clinical applications. This study was to investigate the influence of nerve growth factor, neurotrophin-3 and brain-derived neurotrophic factor on the growth of neurites using two in vitro models of dorsal root ganglia explants and dorsal root ganglia-derived primary cell dissociated cultures. Quantitative data showed that the total neurite length and tortuosity were differently influenced by trophic factors. Nerve growth factor and, indirectly, brain-derived neurotrophic factor stimulate the tortuous growth of sensory fibers and the formation of cell clusters. Neurotrophin-3, however, enhances neurite growth in terms of length and linearity allowing for a more organized and directed axonal elongation towards a peripheral target compared to the other growth factors. These findings could be of considerable importance for any clinical application of neurotrophic factors in peripheral nerve regeneration. Ethical approval was obtained from the Regione Piemonte Animal Ethics Committee ASLTO1(file # 864/2016-PR) on September 14, 2016. | Michele Fornaro Alessia Giovannelli Angelica Foggetti Luisa Muratori Stefano Geuna Giorgia Novajra Isabelle Perroteau | 2020 | Neural Regeneration Research2020，15，9： | 3 |
| 3 | Psychopathological aspects of kidney transplantation: Efficacy of a multidisciplinary team显示文摘Renal transplantation is a well established treatment for end-stage renal disease, allowing most patients to return to a satisfactory quality of life. Studies have identified many problems that may affect adaptation to the transplanted condition and postoperative compliance. The psychological implications of transplantation have important consequences even on strictly physical aspects. Organ transplantation is very challenging for the patient and acts as an intense stressor stimulus to which the patient reacts with neurotransmitter and endocrine-metabolic changes. Transplantation can result in a psychosomatic crisis that requires the patient to mobilize all bio-psychosocial resources during the process of adaptation to the new foreign organ which may result in an alteration in self-representation and identity, with possible psychopathologic repercussions. These reactions are feasible in mental disorders, e.g., post-traumatic stress disorder, adjustment disorder, and psychosomatic disorders. In organ transplantation, the fruitful collaboration between professionals with diverse scientific expertise, calls for both a guarantee for mental health and greater effectiveness in challenging treatments for a viable association between patients, family members and doctors. Integrated and multidisciplinary care should include uniform criteria and procedures for standard assessments, for patient autonomy, adherence to therapy, new coping strategies and the adoption of more appropriate lifestyles. | Concetta De Pasquale Massimiliano Veroux Luisa Indelicato Nunzia Sinagra Alessia Giaquinta Michele Fornaro Pierfrancesco Veroux Maria L Pistorio | 2014 | World Journal of Transplantation2014，4，4： | 3 |
| 4 | Bevacizumab with FOLFOXIRI (irinotecan, oxaliplatin, fluorouracil, and folinate) as first-line treatment for metastatic colorectal cancer: a phase 2 trial显示文摘 | Gianluca Masi Fotios Loupakis Lisa Salvatore Lorenzo Fornaro Chiara Cremolini Samanta Cupini Andrea Ciarlo Francesca Del Monte Enrico Cortesi Domenico Amoroso Cristina Granetto Gabriella Fontanini Elisa Sensi Cristiana Lupi Michele Andreuccetti Alfredo Fa | 2010 | Lancet Oncology2010，，9： | 2 |
| 5 | Three-dimensional focusing with mulitpass SAR data显示文摘 | Fornaro G and Serafino F | 2003 | IEEE Transactions on Geoscience and Remote Sensing2003，41，3： | 1 |
| 6 | Wet deposition and related atmospheric chemistry in the Sao Paulo metropolis, Brazil:Part 2-contribution of formic and acetic acids 显示文摘 | Fornaro A Gutz G R I | 2003 | Atmospheric Environment2003，，37： | 1 |
| 7 | Fibroblast growth factor-2 over-rides Insulin-like Growth Factor-1 induced proliferation and cell survival in human neuroblastoma cells显示文摘 | RUSSO VC ANDALORO E FORNARO SA | 2004 | J Cell Physiol2004，199，： | 1 |
| 8 | Toward epitaxial lead-iodide films for X-ray digital imaging显示文摘 | FORNARO L SAUCEDO E MUSSIO L | 2002 | IEEE Trans Nucl Sci2002，49，5： | 1 |
| 9 | Trajectory deviations in airborne SAR: analysis and compensation显示文摘 | Fornaro G | 1999 | IEEE Transactions on Aerospace and Electeonic Systems1999，35，3： | 1 |
| 10 | Fibronectin protects prostate cancer cells from tumor necrosis factor-α-induced apoptosis via the AKT/Survivin pathway显示文摘 | FORNARO M PLESCIA J CHHEANG S | 2003 | J Biol Chem2003，278，50： | 1 |
| 11 | Interfero- metric SAR phase unwrapping using Green' s formulation 显示文摘 | FORNARO G FRANCESCHETTI G LANARI R | 1996 | IEEE Trans Geosci Remote Sensing1996，34，5： | 1 |
| 12 | Palliative treatment of unresectable metastatic colorectal cancer显示文摘 | Fornaro L Masi G Loupakis F | | 0，，01： | 1 |
| 13 | Phase difference-based multi-channel phase unwrapping显示文摘 | Fornaro G Pauciullo A and Sansosti E | 2005 | IEEE Transactions on Image Processing2005，14，7： | 1 |
| 14 | Matrix metalloprotein- ase (MMP)-2 and MMP-9 as inflammation markers of Trichinella spiralis and Trichinella pseudospiralis infections in mice 显示文摘 | Bruschi F Bianchi C Fornaro M | 2014 | Par- asite Immunol2014，36，10： | 1 |
| 15 | A New Algorithm for Surface Deformation Monitoring based on Small Baseline Dif- ferential SAR Interferograms显示文摘 | Berardino P Fornaro G Lanari R | 2002 | IEEE Transactions on Geo- science and Remote Sensing2002，40，23： | 1 |
| 16 | Motion compensation errors effects on the accuracy of airborne SAR images显示文摘 | Fornaro G Franceschetti G Perna S | 2005 | IEEE Transaction on Aerospace and Electronic Systems2005，41，4： | 1 |
| 17 | Three-dimensional multipass SAR focusing experiments with long-term spaceborne data显示文摘 | Fornaro G Lombardini F and Serafino F | 2005 | IEEE Transactions on Geoscience and Remote Sensing2005，43，4： | 1 |
| 18 | Trajectory deviations in airborne SAR:Analysis and compensation显示文摘 | Fornaro G | 1999 | IEEE Transaction on Aerospace and Electronic Systems1999，35，3： | 1 |
| 19 | Lead iodide platelets:correlation between surface,optical,and electrical properties with X-ray and Y-ray spectrometric performance显示文摘 | FORNARO L SAUCEDO E MUSSIO L | 2002 | IEEE Trans Nucl Sci2002，49，6： | 1 |
| 20 | 3D spatial variability of soil strength and its change over time in a durum wheat field in Southern Italy显示文摘 | A Castrignanò M Maiorana F Fornaro N Lopez | 2002 | Soil & Tillage Research2002，，1： | 1 |
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