|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Moving forward in the treatment of cholangiocarcinoma显示文摘Despite being the second most frequent primary liver tumor in humans,early diagnosis and treatment of cholangiocarcinoma(CCA)are still unsatisfactory.In fact,survival after 5 years is expected in less than one fourth of patients diagnosed with this disease.Rare incidence,late appearance of symptoms and heterogeneous biology are all factors contributing to our limited knowledge of this cancer and determining its poor prognosis in the clinical setting.Several efforts have been made in the last decades in order to achieve an improved classification/understanding with regard to the diverse CCA forms.Location within the biliary tree has helped to distinguish between intrahepatic,perihilar and distal CCA types.Sequence analysis contributed to identifying several characteristic genetic aberrations in CCA that may also serve as possible targets for therapy.Novel findings are expected to significantly improve the management of this malignancy in the near future.In this changing scenario our review focuses on the current and future strategies for CCA treatment.Both systemic and surgical treatments are discussed in detail.The results of the main studies in this field are reported,together with the ongoing trials.The current findings suggest that an integrated multidisciplinary approach to this malignancy would be helpful to improve its outcome. | Tommaso M Manzia Alessandro Parente Ilaria Lenci Bruno Sensi Martina Milana Carlo Gazia Alessandro Signorello Roberta Angelico Giuseppe Grassi Giuseppe Tisone Leonardo Baiocchi | 2021 | World Journal of Gastrointestinal Oncology2021，13，12： | 6 |
| 2 | Complete mesocolic excision and central vascular ligation in colorectal cancer in the era of minimally invasive surgery显示文摘Since the 19th century,appropriate lymphadenectomy has been considered a cornerstone of oncologic surgery and one of the most important prognostic factors.This approach can be applied to any surgery for gastrointestinal cancer.During surgery for colon and rectal cancer,an adequate portion of the mesentery is removed together with the segment of bowel affected by the disease.The adequate number of lymph nodes to be removed is standardized and reported by several guidelines.It is mandatory to determine the appropriate extent of lymphadenectomy and to balance its oncological benefits with the increased morbidity associated with its execution in cancer patients.Our review focuses on the concept of“complete mesenteric excision(CME)with central vascular ligation(CVL),”a radical lymphadenectomy for colorectal cancer that has gained increasing interest in recent years.The aim of this study was to evaluate the evolution of this approach over the years,its potential oncologic benefits and potential risks,and the improvements offered by laparoscopic techniques.Theoretical advantages of CME are improved local-relapse rates due to complete removal of the intact mesocolic fascia and improved distance recurrence rates due to ligation of vessels at their origin(CVL)which guarantees removal of a larger number of lymph nodes.The development and worldwide diffusion of laparoscopic techniques minimized postoperative trauma in oncologic surgery,providing the same oncologic results as open surgery.This has been widely applied to colorectal cancer surgery;however,CME entails a technical complexity that can limit its wide minimally-invasive application. This review analyzesresults of these procedures in terms of oncological outcomes, technical feasibilityand complexity, especially within the context of minimally invasive surgery. | Marzia Franceschilli Sara Di Carlo Danilo Vinci Bruno Sensi Leandro Siragusa Vittoria Bellato Roberto Caronna Piero Rossi Giuseppe Cavallaro Andrea Guida Simone Sibio | 2021 | World Journal of Clinical Cases2021，9，25： | 2 |
| 3 | Chronic rejection after liver transplantation:Opening the Pandora’s box显示文摘Chronic rejection(CR)of liver allografts causes damage to intrahepatic vessels and bile ducts and may lead to graft failure after liver transplantation.Although its prevalence has declined steadily with the introduction of potent immunosuppressive therapy,CR still represents an important cause of graft injury,which might be irreversible,leading to graft loss requiring re-transplantation.To date,we still do not fully appreciate the mechanisms underlying this process.In addition to T cell-mediated CR,which was initially the only recognized type of CR,recently a new form of liver allograft CR,antibody-mediated CR,has been identified.This has indeed opened an era of thriving research and renewed interest in the field.Liver biopsy is needed for a definitive diagnosis of CR,but current research is aiming to identify new non-invasive tools for predicting patients at risk for CR after liver transplantation.Moreover,the minimization or withdrawal of immunosuppressive therapy might influence the establishment of subclinical CR-related injury,which should not be disregarded.Therapies for CR may only be effective in the“early”phases,and a tailored management of the immunosuppression regimen is essential for preventing irreversible liver damage.Herein,we provide an overview of the current knowledge and research on CR,focusing on early detection,identification of non-invasive biomarkers,immunosuppressive management,re-transplantation and future perspectives of CR. | Roberta Angelico Bruno Sensi Tommaso M Manzia Giuseppe Tisone Giuseppe Grassi Alessandro Signorello Martina Milana Ilaria Lenci Leonardo Baiocchi | 2021 | World Journal of Gastroenterology2021，27，45： | 2 |
| 4 | The genomics of desmoplastic small round cell tumor reveals the deregulation of genes related to DNA damage response, epithelial-mesenchymal transition, and immune response显示文摘Background:Desmoplastic small round cell tumor(DSRCT)is a rare,aggressive,and poorly investigated simple sarcoma with a low frequency of genetic deregulation other than an Ewing sarcoma RNA binding protein 1(EWSR1)-Wilm’s tumor suppressor(WT1)translocation.We used whole-exome sequencing to interrogate six consecutive pretreated DSRCTs whose gene expression was previously investigated.Methods:DNA libraries were prepared from formalin-fixed,paraffin-embedded archival tissue specimens following the Agilent SureSelectXT2 target enrichment protocol and sequenced on Illumina NextSeq 500.Raw sequence data were aligned to the reference genome with Burrows-Wheeler Aligner algorithm.Somatic mutations and copy number alterations(CNAs)were identified using MuTect2 and EXCAVATOR2,respectively.Biological functions associated with altered genes were investigated through Ingenuity Pathway Analysis(IPA)software.Results:A total of 137 unique somatic mutations were identified:133 mutated genes were case-specific,and 2 were mutated in two cases but in different positions.Among the 135 mutated genes,27%were related to two biological categories:DNA damage-response(DDR)network that was also identified through IPA and mesenchymal-epithelial reverse transition(MErT)/epithelial-mesenchymal transition(EMT)already demonstrated to be relevant in DSRCT.The mutated genes in the DDR network were involved in various steps of transcription and particularly affected pre-mRNA.Half of these genes encoded RNA-binding proteins or DNA/RNA-binding proteins,which were recently rec-ognized as a new class of DDR players.CNAs in genes/gene families,involved in MErT/EMT and DDR,were recurrent across patients and mostly segregated in the MErT/EMT category.In addition,recurrent gains of regions in chromosome 1 involving many MErT/EMT gene families and loss of one arm or the entire chromosome 6 affecting relevant immune-regulatory genes were recorded.Conclusions:The emerging picture is an extreme inter-tumor heterogeneity,characterized by the concurrent deregulation of the DDR and MErT/EMT dynamic and plastic programs that could favour genomic instability and explain the refractory DSRCT profile. | Andrea Devecchi Loris De Cecco Matteo Dugo Donata Penso Gianpaolo Dagrada Silvia Brich Silvia Stacchiotti Marialuisa Sensi Silvana Canevari Silvana Pilotti | 2018 | Cancer Communications2018，38，1： | 2 |
| 5 | Bevacizumab with FOLFOXIRI (irinotecan, oxaliplatin, fluorouracil, and folinate) as first-line treatment for metastatic colorectal cancer: a phase 2 trial显示文摘 | Gianluca Masi Fotios Loupakis Lisa Salvatore Lorenzo Fornaro Chiara Cremolini Samanta Cupini Andrea Ciarlo Francesca Del Monte Enrico Cortesi Domenico Amoroso Cristina Granetto Gabriella Fontanini Elisa Sensi Cristiana Lupi Michele Andreuccetti Alfredo Fa | 2010 | Lancet Oncology2010，，9： | 2 |
| 6 | Zn2+:a novel ionic mediator of neural injury in brain disease显示文摘 | Weiss J H Sensi S L Koh J Y | | 0，，： | 1 |
| 7 | Analysis of TCR usage in human tumors:a new tool for assessing tumor-specific immune responses显示文摘 | Sensi M Parmiani G | 1995 | Immunol Today1995，16，12： | 1 |
| 8 | A new saliva-based composition for simple and effective treatment of dentinal sensitivity pain显示文摘 | Kleinberg I Sensi S | | 0，，12： | 1 |
| 9 | APAF-1 signaling in human melanoma显示文摘 | Aniehini A Mortarini R Sensi M | 2006 | Cancer Lett2006，238，9： | 1 |
| 10 | Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-Aspartate显示文摘 | Dugan LL Sensi SL Canzoniero CMT | 1995 | J Neurochem1995，15，10： | 1 |
| 11 | Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-d-aspartate显示文摘 | Dug an LL Sensi SL Canzoniero LM et | 1995 | J Neurosci1995，15，10： | 1 |
| 12 | Blockade of Ca^2+-permeable AMPA/kainate channels decreases oxygenglucose deprivation-induced Zn2+ accumulation and neuronal loss in hippocampal pyramidal neurons显示文摘 | Yin H Z Sensi S L Ogoshi F Weiss J H | 2002 | J Neurosci2002，22，4： | 1 |
| 13 | Calciumion ophores can induce either apoptosis or necrosis in cultured cortical neurons显示文摘 | Gwag BJ Canzoniero LM Sensi SL | 1999 | Neuro science1999，90，4： | 1 |
| 14 | Which allergen extract for grass pollen immunotherapy? An in vitro study 显示文摘 | MARCUCCI F SENSI L DI CARA G | 2010 | Immunol Invest2010，39，6： | 1 |
| 15 | TIMP3 regulates migration, invasion and in vivo tumorigenicity of thyroid tumor cells 显示文摘 | Anania MC Sensi M Radaelli E | 2011 | Oncogene2011，30，27： | 1 |
| 16 | The safety of sublin- gual - swallow immunotherapy: an analysis of published studies 显示文摘 | Gidaro GB Marcucci F Sensi L | 2005 | Clin Exp Allergy2005，35，5： | 1 |
| 17 | A new mitochondrial fluorescent zinc sensor 显示文摘 | SENSI S L TON-THAT D WEISS J H | 2003 | Cell Calcium2003，34，3： | 1 |
| 18 | Zn(2+): a nowl ionic mediator of nural injury in brain disease显示文摘 | Weiss JH Sensi SL Koh JY | 2000 | Trends Pbarmaeo Sci2000，21，10： | 1 |
| 19 | Rotational position of femoral and tibial components in TKA using the femoral transepicondylar axis显示文摘 | Aglietti P Sensi L Cuomo P | 2008 | Clin Orthop Relat Res2008，466，11： | 1 |
| 20 | How to avoid trivial mistakes during IPG replacement in patients treated with DBS for movement disorders: technical note from 13-years experience显示文摘 | Latini F Sensi M Preda F | 2015 | Int J Neurosci2015，125，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员