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| 1 | 2008中西方BNP专家共识显示文摘1.前言
2008年6月,来自中国、美国、欧洲的急诊科、心血管科、实验室及内科临床专家相聚在中国上海。 | Alan Maise Christian Mueller W. Frank Peacock Gerasimos Filippatos Hu Dayi 胡大一(主译) 刘梅颜(主译) 吴寸草(翻译) 王博雅(翻译) 黄睿(翻译) | 2009 | 中国医药导刊2009，11，10： | 76 |
| 2 | Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine?显示文摘Frequent activation of phosphatidylinositol-3 kinases(PI3K)/Akt/m TOR signaling pathway in gastric cancer(GC) is gaining immense popularity with identification of mutations and/or amplifications of PIK3 CA gene or loss of function of PTEN,a tumor suppressor protein,to name a few; both playing a crucial role in regulating this pathway. These aberrations result in dysregulation of this pathway eventually leading to gastric oncogenesis,hence,there is a need for targeted therapy for more effective anticancer treatment. Several inhibitors are currently in either preclinical or clinical stages for treatment of solid tumors like GC. With so many inhibitors under development,further studies on predictive biomarkers are needed to measure the specificity of any therapeutic intervention. Herein,we review the common dysregulation of PI3K/Akt/m TOR pathway in GC and the various types of single or dual pathway inhibitors under development that might have a superior role in GC treatment. We also summarize the recent developments in identification of predictive biomarkers and propose use of predictive biomarkers to facilitate more personalized cancer therapy with effective PI3K/Akt/m TOR pathway inhibition. | Shikha Satendra Singh Wei Ney Yap Frank Arfuso Shreya Kar Chao Wang Wanpei Cai Arunasalam M Dharmarajan Gautam Sethi Alan Prem Kumar | 2015 | World Journal of Gastroenterology2015，21，43： | 36 |
| 3 | Tuberculosis is associated with expansion of a motile, permissive and immunomodulatory CD16" monocyte population via the IL-10/STAT3 axis显示文摘 | Claire Lastrucci Alan Benard Luciana Balboa Karine Pingris Shanti Sourian Renaud Poincloux Talal A Saati Voahangy Rasolofo Pablo Gonzfilez-Montaner Sandra Inwentarz Eduardo Jose Morafia Ivanela Kondova Frank AW Verreck Maria del Carmen Sasiain Olivier Neyrolles Isabelle Maridonneau-Parini Geanncarlo Lugo-Villarino Ce1ine Cougoule | 2015 | Cell Research2015，25，12： | 7 |
| 4 | Temporal clinical, proteomic, histological and cellular immune responses of dextran sulfate sodium-induced acute colitis显示文摘AIM To investigate the temporal clinical, proteomic, histological and cellular immune profiles of dextran sulfate sodium(DSS)-induced acute colitis.METHODS Acute colitis was induced in C57 BL/6 female mice by administration of 1%, 2% or 3% DSS in drinking water for 7 d. Animals were monitored daily for weight loss, stool consistency and blood in the stool, while spleens and colons were harvested on day 8. A time course analysis was performed in mice ingesting 3% DSS, which included colon proteomics through multiplex assay, colon histological scoring by a blinded investigator, and immune response through flow cytometry or immunohistochemistry of the spleen, mesenteric lymph node and colon.RESULTS Progressive worsening of clinical colitis was observed with increasing DSS from 1% to 3%. In mice ingesting 3% DSS, colon shortening and increase in proinflammatory factors starting at day 3 was observed, with increased spleen weights at day 6 and day 8. This coincided with cellular infiltration in the colon from day 2 to day 8, with progressive accumulation of macrophages F4/80^+, T helper CD4^+(Th), T cytotoxic CD8^+(Tcyt) and T regulatory CD25^+(Treg) cells, and progressive changes in colonic pathology including destruction of crypts, loss of goblet cells and depletion of the epithelial barrier. Starting on day 4, mesenteric lymph node and/or spleen presented with lower levels of Treg, Th and Tcyt cells, suggesting an immune cell tropism to the gut. CONCLUSION These results demonstrate that the severity of experimental colitis is dependent on DSS concentration, correlated with clinical, proteomic, histological and cellular immune response on 3% DSS. | Natalia Schneider Nunes Saejeong Kim Maggie Sundby Parwathy Chandran Scott Robert Burks Ana Helena Paz Joseph Alan Frank | 2018 | World Journal of Gastroenterology2018，24，38： | 5 |
| 5 | World Gastroenterology Organisation Global Guidelines: Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis显示文摘 | Douglas R. LaBrecque Zaigham Abbas Frank Anania Peter Ferenci Aamir G. Khan Khean-Lee Goh Saeed S. Hamid Vasily Isakov Maribel Lizarzabal Manuel M. Pe?aranda Juan F.R. Ramos Shiv Sarin Davor Stimac Alan B.R. Thomson Muhammed Umar Justus Krabshuis Anton Le | 2014 | Journal of Clinical Gastroenterology2014，，6： | 3 |
| 6 | Diagnostic accuracy of tests for Helicobacter pylori in an Alaska Native population显示文摘AIM:To evaluate the accuracy of two non-invasivetests in a population of Alaska Native persons. Highrates of Helico bacter pylori(H. pylori) infection,H. pylori treatment failure,and gastric cancer in this population necessitate documentation of infection status atmultiple time points over a patient's life.METHODS:In 280 patients undergoing endoscopy,H. pylori was diagnosed by culture,histology,rapidurease test,13C urea breath test(UBT) ,and immuno-globulin G antibodies to H. pylori in serum. The performances of 13C-UBT and antibody test were compared to a gold standard defined by a positive H. pylori testby culture or,in case of a negative culture result,bypositive histology and a positive rapid urease test.RESULTS:The sensitivity and specificity of the 13C-UBT were 93% and 88%,respectively,relative to thegold standard. The antibody test had an equivalents ensitivity of 93% with a reduced specificity of 68%.The false positive results for the antibody test were as-sociated with previous treatment for an H. pylori infection [relative risk(RR) = 2.8]. High levels of antibodiesto H. pylori were associated with chronic gastritis and male gender,while high scores in the 13C-UBT testwere associated with older age and with the H. pyloribacteria load on histological examination(RR = 4.4) .CONCLUSION:The 13C-UBT out performed the anti-body test for H. pylori and could be used when a non-invasive test is clinically necessary to document treatment out come or when monitoring for reinfection. | Dana L Bruden Michael G Bruce Karen M Miernyk Julie Morris Debby Hurlburt Thomas W Hennessy Helen Peters Frank Sacco Alan J Parkinson Brian J McMahon | 2011 | World Journal of Gastroenterology2011，17，42： | 3 |
| 7 | Multicenter evaluation of the Roche NT-proBNP assay and comparison to the Biosite Triage BNP assay显示文摘 | Kiang-Teck J. Yeo Alan H.B. Wu Fred S. Apple Martin H. Kroll Robert H. Christenson Kent B. Lewandrowski Frank A. Sedor Anthony W. Butch | 2003 | Clinica Chimica Acta2003，，1： | 2 |
| 8 | Acute care needs in an Indian emergency department: A retrospective analysis显示文摘BACKGROUND: Emergencies such as road traffic accidents(RTAs), acute myocardial infarction(AMI) and cerebrovascular accident(CVA) are the most common causes of death and disability in India. Robust emergency medicine(EM) services and proper education on acute care are necessary. In order to inform curriculum design for training programs, and to improve the quality of EM care in India, a better understanding of patient epidemiology and case burden presenting to the emergency department(ED) is needed.METHODS: This study is a retrospective chart review of cases presenting to the ED at Kerala Institute of Medical Sciences(KIMS), a private hospital in Trivandrum, Kerala, India, from November 1, 2011 to April 21, 2012 and from July 1, 2013 to December 21, 2013. De-identified charts were systematically sampled and reviewed.RESULTS: A total of 1 196 ED patient charts were analyzed. Of these patients, 55.35%(n=662) were male and 44.7%(n=534) were female. The majority(67.14%, n=803) were adults, while only 3.85%(n=46) were infants. The most common chief complaints were fever(21.5%, n=257), renal colic(7.3%, n=87), and dyspnea(6.9%, n=82). The most common ED diagnoses were gastrointestinal(15.5%, n=185), pulmonary(12.3%, n=147), tropical(11.1%, n=133), infectious disease and sepsis(9.9%, n=118), and trauma(8.4%, n=101).CONCLUSION: The patient demographics, diagnoses, and distribution of resources identifi ed by this study can help guide and shape Indian EM training programs and faculty development to more accurately refl ect the burden of acute disease in India. | Elizabeth G. Clark Jessica Watson Allison Leemann Alan H. Breaud Frank G. Feeley III James Wolff Tamorish Kole Gabrielle A. Jacquet | 2016 | World Journal of Emergency Medicine2016，7，3： | 2 |
| 9 | 极低视力视觉功能观察评估量表汉化及修订显示文摘目的:汉化并修订极低视力视觉功能观察评估量表(FLORA)。方法:分两步对FLORA进行汉化。第一步将FLORA翻译成中文,再回译成英文,通过对比原文和译文的一致性,修订和讨论译文的合理性,形成FLORA—C1;第二步组织低视力康复领域专家根据中国国情,对FLORA—C1进行多次讨论修订,形成FLORA.C2。结果:专家对低视力康复领域熟悉,权威系数为0.86,并熟悉人工视网膜领域的相关研究进展。经过翻译.修订后,形成的FLORA.C2由患者基本信息、填表说明、评估量表主体3个模块构成。评估量表主体又分为患者的自我评估、康复医师的观察评估及汇总报告3部分。自我评估部分由12个开放式问题组成;观察评估部分包括定向、行走、日常生活、人际交往4方面的能力,共43个评估条目;汇总报告为康复专家针对前两部分的结果进行总结。结论:FLORA—C2可用于评估人工视网膜系统在不同状态下对中国患者视觉功能及生活质量的影响,并为其他极低视力治疗的方法提供评估参考。 | 邓如芝 林娜 倪灵芝 于翠 杜蓓 胡建民 杨晓慧 于旭东 Frank Thron Alan Johnston 吕帆 | 2018 | 中华眼视光学与视觉科学杂志2018，20，2： | 2 |
| 10 | Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography显示文摘 | Sherif F. Nagueh Christopher P. Appleton Thierry C. Gillebert Paolo N. Marino Jae K. Oh Otto A. Smiseth Alan D. Waggoner Frank A. Flachskampf Patricia A. Pellikka Arturo Evangelista | 2009 | Journal of the American Society of Echocardiography2009，，2： | 2 |
| 11 | Clamp-Assisted Reduction of High Subtrochanteric Fractures of the Fe- mur显示文摘 | Alan Afsari Frank Liporance Eric Lind- vail | 2010 | JBJS2010，92，： | 1 |
| 12 | Biological variation of galectin-3 and soluble ST2 for chronic heart failure: Implication on interpretation of test results显示文摘 | Alan H.B. Wu Frank Wians Allan Jaffe | 2013 | American Heart Journal2013，，6： | 1 |
| 13 | Phased array antenna calibration and pattern prediction using mutual coupling measurements 显示文摘 | HERBERT MAUMANN ALAN JFENG FRANK GWLLWERTH | 1989 | IEEE Transactions on Antennas and Propagation1989，37，7： | 1 |
| 14 | Sequential annual administration of purified fusion protein vaccine against respiratory syncytial virus in children with cystic fibrosis显示文摘 | PEDRO A. PIEDRA SUSAN GRACE ALAN JEWELL SUSAN SPINELLI DEBORAH A. HOGERMAN FRANK MALINOSKI PETER W. HIATT | 1998 | The Pediatric Infectious Disease Journal1998，，3： | 1 |
| 15 | A new model for the effective thermal conductivity of packed beds of solid spheroids: alumina in helium between 100 and 500℃ 显示文摘 | Alan J Slavin Frank A Londry Joy Harrison | 2000 | Internation Journal of Heat and Mass Transfer2000，43，： | 1 |
| 16 | Electrostatic fabrication of ultrafine conducting fibers: polyaniline/polyethylene oxide blends显示文摘 | Ian D Norris Manal M Shaker Frank K Ko Alan G MacDiarmid | 2000 | Synthetic Metals2000，，2： | 1 |
| 17 | The Case of the Speluncean Explorers Revisited 显示文摘 | Paul Butler Alan Dershowitz Frank Easterbrook Alex Kozinski Cass Sunstein and Robin West | 1999 | Harvard Law Re-view1999，112，8： | 1 |
| 18 | Inspection of Pesticide Residues on Food by Surface-Enhanced Raman Spectroscopy显示文摘 | CHETAN S ALAN G FRANK I | 2004 | Proc of SPIE2004，5271，： | 1 |
| 19 | Analysis of Pesticides on or in Fruit by Surface-Enhanced Raman Spectroscopy显示文摘 | CHETAN S FRANK I ALAN G | 2004 | Proc of SPIE2004，5587，： | 1 |
| 20 | Atrial Tachycardia After Circumferential Pulmonary Vein Ablation of Atrial Fibrillation显示文摘 | Sanders Chae Hakan Oral Eric Good Sujoya Dey Alan Wimmer Thomas Crawford Darryl Wells Jean-Francois Sarrazin Nagib Chalfoun Michael Kuhne Jackie Fortino Elizabeth Huether Tammy Lemerand Frank Pelosi Frank Bogun Fred Morady Aman Chugh | 2007 | Journal of the American College of Cardiology2007，，18： | 1 |
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