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| 1 | Management of syndesmotic injuries:What is the evidence?显示文摘Ankle fractures are accompanied by a syndesmotic injury in about 10% of operatively treated ankle fractures. Usually, the total rupture of the syndesmotic ligaments with an external rotation force is associated with a Weber type B or C fracture or a Maisonneuve fracture. The clinical assessment should consist of a comprehensive history including mechanism of injury followed by a specific physical examination. Radiographs, and if in doubt magnetic resonance imaging, are needed to ascertain the syndesmotic injury. In the case of operative treatment the method of fixation, the height and number of screws and the need for hardware removal are still under discussion. Furthermore, intraoperative assessment of the accuracy of reduction of the fibula in the incisura using fluoroscopy is difficult. A possible solution might be the assessment with intraoperative three-dimensional imaging. The aim of this article is to provide a current concepts review of the clinical presentation, diagnosis and treatment of syndesmotic injuries. | Marc Schnetzke Sven Y Vetter Nils Beisemann Benedict Swartman Paul A Grützner Jochen Franke | 2016 | World Journal of Orthopedics2016，7，11： | 4 |
| 2 | Significance of scintigraphy for the localisation of obscure gastrointestinal bleedings显示文摘AIM: To determine the role of scintigraphy in patients with gastrointestinal (GI) bleeding of unknown localisation. METHODS: We performed retrospective analyses on 92 patients receiving scintigraphies from 1993 to 2000 in the University of Regensburg hospital, which were done for localisation of GI bleeding as a diagnostic step after an unsuccessful endoscopy. In addition to the scintigraphies, further diagnostic steps such as endoscopy, angiography or operations were performed. In some of the scintigraphies with negative results, a provocation test for bleeding with heparinisation was carried out. RESULTS: 73% of all scintigraphies showed a positive result. In 4.5% of the positive results, the source was located in the stomach, in 37% the source was the small bowel, in 25% the source was the right colon, in 4.5% the source was the left colon, and in 20% no clear localisation was possible. Only 4% of all scintigraphies were false positive. A reliablepositive scintigraphy was independent of the age of the examined patient. A provocation test for bleeding with heparin resulted in an additional 46% of positive scintigraphies with a reliable localisation in primary negative scintigraphies. CONCLUSION: Our results show that scintigraphy and scintigraphy with heparin provocation tests are reliable procedures. They enable a reliable localisation in about half of the obscure GI-bleeding cases. Scintigraphy is superior to angiography in locating a bleeding. It is shown that even in the age of video capsule endoscopy and double-balloon enteroscopy, scintigraphy provides a reliable and directed localization of GI bleeding and offers carefully targeted guidance for other procedures. | Tanja Brünnler Frank Klebl Sascha Mundorff Christoph Eilles Michael Reng Hans von Korn Jürgen Schlmerich Julia Langgartner Stefan Grüne | 2008 | World Journal of Gastroenterology2008，14，32： | 3 |
| 3 | Golimumab in real-world practice in patients with ulcerative colitis:Twelve-month results显示文摘BACKGROUND The introduction of biologics has revolutionized the management of the chronic inflammatory bowel disease,ulcerative colitis(UC),with many patients experiencing significant improvements not only in their symptoms but in other outcomes relevant to individuals and society as a whole.In Germany,there are no prospective data>3 mo that assess the work productivity,daily activities and quality of life(QoL)of patients with moderate-to-severe UC treated with golimumab.AIM To assess change in work productivity,capacity for daily activities and QoL in UC patients treated with golimumab in Germany.METHODS The validated Work Productivity Activity Impairment(WPAI)Questionnaire was used to analyze the change in work productivity,the capacity for daily activities after three months(primary endpoint)and disease specific and health related QoL(HRQoL)up to 1 year(secondary endpoints).The changes in work productivity and activity impairment were evaluated every three months until month twelve compared to baseline.Disease-specific and health-related QoL were assessed with the inflammatory bowel disease questionnaire and with the short-form 12 health survey questionnaire(SF-12).RESULTS This prospective non-interventional study included 287 patients.The analysis population was comprised of 282 patients who had completed at least two visits.At baseline,61%of patients had moderate UC and 18%had severe UC.Furthermore,75%of patients worked full-time or part-time at baseline.A total of 212 patients who were employed at the start of the study(employed population)were evaluated for the primary endpoint.Golimumab significantly reduced all WPAI sub-scores compared to baseline after three,six,nine and twelve months after the start of treatment(P<0.0001).In addition,disease-specific QoL and HRQoL,as measured by the SF-12 questionnaire,improved significantly with golimumab at all evaluation times(P<0.0001 in each case vs baseline).CONCLUSION Treatment of moderate-to-severe UC with golimumab leads to significant improvements in patient´s work productivity,daily activity and QoL over twelve months. | Niels Teich Harald Grümmer Eric Jorgensen Thomas Liceni Frank Holtkamp-Endemann Tim Fischer Susanne Hohenberger | 2020 | World Journal of Gastroenterology2020，26，21： | 3 |
| 4 | Variant adiponutrin (PNPLA3) represents a common fibrosis risk gene: Non-invasive elastography-based study in chronic liver disease显示文摘 | Marcin Krawczyk Frank Grünhage Vincent Zimmer Frank Lammert | 2011 | Journal of Hepatology2011，，2： | 2 |
| 5 | Laminin decreases PRL and IGFBP-1 expression during in vitro deciduaiization of human endometrial stromal cells显示文摘 | Brar AK Frank GR Richards RG | 1995 | J Cell Physiol1995，163，1： | 1 |
| 6 | Estrogen resistance Caused by a mutation in the estrogen receptor gene in man 显示文摘 | Smith EP Boyd J Frank GR | 1994 | N Eny J Med1994，331，： | 1 |
| 7 | 查看详情显示文摘 | Neale N R Kopidakis N van de Lagemaat J Gr?tzel M Arthur J Frank A J | | 0，，： | 1 |
| 8 | Twenty-four hour ambulatory blood pressure monitoring in adolescents with type 1 diabetes: getting started显示文摘 | Pellizzari M Speiser PW Carey DE Fort P Kreitzer PM Frank GR | 2008 | J Diabetes Sci Technol2008，2，6： | 1 |
| 9 | Soybean isoflavones, genistein and genistin,inhibit rat myoblastproliferation,fusion and myotube protein synthesis显示文摘 | Ji S Willis GM Frank GR | 1999 | J Nutr1999，129，7： | 1 |
| 10 | Estrogen resisrtance caused by mutation in the estrogerr receptor gene in a man显示文摘 | Smith EP Boyd J Frank GR | 1994 | New Eng J Med1994，331，16： | 1 |
| 11 | Gastrectomy with isoperistaltic jejunal parallel pouch in a 15-year-old adolescent boy with gastric adenocarcinoma and autosomal recessive agammaglobulinemia显示文摘 | Jan E. Slotta Sabine Heine Anne Kauffels Thomas Krenn Frank Grünhage Mathias Wagner Norbert Graf Martin K. Schilling Jochen Schuld | 2011 | Journal of Pediatric Surgery2011，，9： | 1 |
| 12 | The CXCL1 rs4074 A allele is associated with enhanced CXCL1 responses to TLR2 ligands and predisposes to cirrhosis in HCV genotype 1-infected Caucasian patients显示文摘 | Hans Dieter Nischalke Cordula Berger Carolin Luda Tobias Müller Thomas Berg Martin Coenen Benjamin Kr?mer Christian K?rner Jonel Trebicka Frank Grünhage Frank Lammert Jacob Nattermann Tilman Sauerbruch Ulrich Spengler | 2011 | Journal of Hepatology2011，，4： | 1 |
| 13 | Giant cell tumor of the distal common bile duct: report of a rare, benign entity that may mimic malignant biliary obstruction显示文摘 | Theodoros Kolokotronis Matthias Glanemann Mathias Wagner Rainer M. Bohle Frank Grünhage | 2014 | International Journal of Colorectal Disease2014，，3： | 1 |
| 14 | Liver fibrosis: How many samples in transjugular liver biopsy are sufficient? Histological vs. clinical value显示文摘 | Malgorzata Wolska-Krawczyk Marcin Krawczyk Marcus Katoh Frank Grünhage Kai Schmitt Rainer M. Bohle Frank Lammert Arno Buecker | 2013 | Abdominal Imaging2013，，3： | 1 |
| 15 | Current status of thalidomide and its role in the treatment of metastatic prostate cancer显示文摘 | Macpherson GR Franks M Tomoaia-Cotisel A | 2003 | Critical Reviews in Oncology/Hematology2003，46，： | 1 |
| 16 | Thalidomide 显示文摘 | Franks ME Macpherson GR Figg WD | 2004 | Lancet2004，363，9423： | 1 |
| 17 | Soybean isoflavones, genistein and genistein, inhibit rat myoblast proliferation, fusion and myotube protein synthesis显示文摘 | Ji S Willes GM Frank GR etal | 1999 | J Nutr1999，129，7： | 1 |
| 18 | Estrogen resistance caused by a mutation in the estrogen - receptor gene in a man显示文摘 | Smith EP Boyd J Frank GR | 1994 | N Engl Med1994，331，： | 1 |
| 19 | Quantitative histological assessment of hepatic ischemia-reperfusion injuries following ischemic pre- and post-conditioning in the rat liver显示文摘 | Anders R. Knudsen Anne-Sofie Kannerup Henning Gr?nb?k Stephen H. Dutoit Jens R. Nyengaard Peter Funch-Jensen Frank V. Mortensen | 2012 | Journal of Surgical Research2012，，： | 1 |
| 20 | Influence of geometric and hemodynamic parameters on aneurysm visualization during three-dimensional rotational angiography:an in vitro study显示文摘 | Ulrike U Ernemanna Eckart Gr(o)new(a)llera Frank B Duffnerb | | 0，，04： | 1 |
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