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| 1 | Effects of aeration method and aeration rate on greenhouse gas emissions during composting of pig feces in pilot scale显示文摘The aim of this study was to uncover ways to mitigate greenhouse gas(GHG) emissions and reduce energy consumption during the composting process. We assessed the effects of different aeration rates(0, 0.18, 0.36, and 0.54 L/(kg dry matter(dm)·min)) and methods(continuous and intermittent) on GHG emissions. Pig feces and corn stalks were mixed at a ratio of 7:1. The composting process lasted for 10 weeks, and the compost was turned approximately every 2 weeks. Results showed that both aeration rate and method significantly affected GHG emissions. Higher aeration rates increased NH3 and N2O losses,but reduced CH4 emissions. The exception is that the CH4 emission of the passive aeration treatment was lower than that of the low aeration rate treatment. Without forced aeration,the CH4 diffusion rates in the center of the piles were very low and part of the CH4 was oxidized in the surface layer. Intermittent aeration reduced NH3 and CH4 losses, but significantly increased N2 O production during the maturing periods. Intermittent aeration increased the nitrification/denitrification alternation and thus enhanced the N2 O production. Forced aeration treatments had higher GHG emission rates than the passive aeration treatment. Forced aeration accelerated the maturing process, but could not improve the quality of the end product. Compared with continuous aeration, intermittent aeration could increase the O2 supply efficiency and reduced the total GHG emission by 17.8%, and this reduction increased to 47.4% when composting was ended after 36 days. | Tao Jiang Guoxue Li Qiong Tang Xuguang Ma Gang Wang Frank Schuchardt | 2015 | Journal of Environmental Sciences2015，27，5： | 21 |
| 2 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 3 | Report on Childhood Obesity in China(8):Effects and Sustainability of Physical Activity Intervention on Body Composition of Chinese Youth显示文摘Objectives To determine whether a large-scale physical activity intervention could affect body composition in primary school students in Beijing,China.Methods The study design was one-year cluster randomized controlled trial of physical activity intervention(20 min of daily exercise in the classroom) with an additional year of follow-up among 4 700 students aged 8-11 years at baseline.Results After the one-year intervention,BMI increased by 0.56 kg/m^2(SD 1.15) in the intervention group and by 0.72 kg/m^2(SD 1.20) in the control group,with a mean difference of-0.15 kg/m^2(95%CI:-0.28 to-0.02).BMI z score decreased by-0.05(SD 0.44) in the intervention group,but increased by 0.01(SD 0.46) in the control group,with a mean difference of-0.07(-0.13 to-0.01).After another year of follow up,compared to the control group,children in the intervention group had significantly lower BMI(-0.13,-0.25 to-0.01),BMI z score(-0.05,-0.10 to-0.01),fat mass(-0.27 kg,-0.53 to-0.02) and percent body fat(-0.53,-1.00 to-0.05).The intervention had a more pronounced effect on weight,height,BMI,BMI z score,and body composition among obese children than among normal weight or overweight children.Compared to the control group,the intervention group had a significantly higher percentage of children who maintained or reduced their BMI z score at year 1(P=0.008) and year 2(P=0.04).Conclusions These findings suggest that 20 min of daily moderate to vigorous physical activity during the school year is a feasible and effective way to prevent excessive gain of body weight,BMI,and body fatness in primary school students. | YAN-PING LI XIAO=QI HU EVERT G. SCHOUTEN AI-LING LIU SONG-MING DU LIN-ZHONG LI ZHAO-HuI CUI DONG WANG FRANS J KOK FRANK B HU GUAN-SHENG MA | 2010 | Biomedical and Environmental Sciences2010，23，3： | 5 |
| 4 | DICER-LIKE3 Activity in Physcomitrella patens DICER-LIKE4 Mutants Causes Severe Developmental Dysfunction and Sterility显示文摘交易的小介入 RNA (ta-siRNAs ) 是在 microRNA 依赖的劈开,进双 stranded RNA 的变换,和骰子依赖者分阶段执行处理以后,免除 TAS 先锋抄本的植物特定的 siRNAs。象 microRNAs (miRNAs ) 一样, ta-siRNAs 在广泛的补充的地点的目标 RNA 的直接地点特定的劈开。这里,我们证明像骰子 Physcomitrella 圣餐盘(PpDCL4 ) 的 4 蛋白质为 21 核苷酸(nt ) 的生物的续生说是必要的 ta-siRNAs。在 PpDCL4 异种,离开缩放 23 并且 24-nt ta-siRNAs 作为 PpDCL3 的结果积累了活动。PpDCL4 异种在整个 Physcomitrella 开发显示严重畸形,包括绝育,那充分在 PpDCL3/PpDCL4 双异种植物被颠倒。因此, PpDCL3 活动,不是 PpDCL4 功能本身的损失,是 PpDCL4 显型的原因。另外,我们描述几新 Physcomitrella 交易 siRNA loci,其三属于一个新家庭, TAS6。TAS6 loci 被切的 miR156 和 miR529 目标地点代表并且在到 PpTAS3 loci 的靠近的最近。 | M. Asif Arif Isam Fattash Zhaorong Ma Sung Hyun Cho Anna K. Beike Ralf Reski Michael J. Axtell Wolfgang Frank | 2012 | Molecular Plant2012，5，6： | 4 |
| 5 | Who may benefit from lower dosages of intravenous tissue plasminogen activator? Results from a cluster data analysis显示文摘background The risk of symptomatic intracranial haemorrhage(sICH)after thrombolysis is low but severe.Lower dose of alteplase may reduce the risk of sICH.We aim to identify subsets of patients who could benefit from lower dose of alteplase compared with standard dose.Methods Data from two observational registries were pooled together.A total of 3479 patients who had acute ischaemic stroke were entered into the interaction tree model.The response variable was the rate of sICH per the definition of the National Institute of Neurological Disorders and Stroke Study.Clinical improvement was measured by the National Institutes of Health Stroke Scale(NIHSS)and defined as NIHSS 0 or 1 or an improvement of more than 4 points(within 7 days or at discharge).Rare event logistic regression was performed to analyse the OR of safety outcome.results To optimise the interaction effect between tissue plasminogen activator(tPA)dosage(standard/lower)and patient subgroups,three subgroups based on the severity of stroke were identified:(1)NIHSS≤4,(2)NIHSS between 5 and 14,and(3)NIHSS≥15.The estimated difference of OR of having sICH was 2.71(95%CI 0.80 to 7.69,p=0.10)for mild,0.13(95%CI 0.02 to 0.68,p=0.01)for moderate,and 0.65(95%CI 0.19 to 2.55,p=0.52)for severe,respectively.In addition,patients who had moderate stroke treated with lower dose had comparable efficacy outcome(OR 1.23,95%CI 0.71 to 2.13,p=0.45).Conclusion Our analysis demonstrated that in patients who had moderate stroke,lower doses of alteplase are associated with significant sICH reduction and non-inferior performance in efficacy,compared with those in the standard dose group. | Yi Dong Ye Han Haipeng Shen Yilong Wang Frank Ma Hao Li Yongjun Wang Qiang Dong | 2020 | Stroke & Vascular Neurology2020，5，4： | 3 |
| 6 | Epithelial-mesenchymal transition in organ fibrosis development:current understanding and treatment strategies显示文摘Organ fibrosis is a process in which cellular homeostasis is disrupted and extracellular matrix is excessively deposited.Fibrosis can lead to vital organ failure and there are no effective treatments yet.Although epithelial-mesenchymal transition(EMT)may be one of the key cellular mechanisms,the underlying mechanisms of fibrosis remain largely unknown.EMT is a cell phenotypic process in which epithelial cells lose their cell-to-cell adhesion and polarization,after which they acquire mesenchymal features such as infiltration and migration ability.Upon injurious stimulation in different organs,EMT can be triggered by multiple signaling pathways and is also regulated by epigenetic mechanisms.This narrative review summarizes the current understanding of the underlying mechanisms of EMT in fibrogenesis and discusses potential strategies for attenuating EMT to prevent and/or inhibit fibrosis.Despite better understanding the role of EMT in fibrosis development,targeting EMT and beyond in developing therapeutics to tackle fibrosis is challenging but likely feasible. | Lexin Liu Qizhe Sun Frank Davis Jianhua Mao Hailin Zhao Daqing Ma | 2022 | Burns & Trauma2022，10，1： | 3 |
| 7 | Recent progress in perovskite solar cells:material science显示文摘Perovskite solar cells represent a promising third-generation photovoltaic technology with low fabrication cost and high power conversion efficiency.In light of the rapid development of perovskite materials and devices,a systematic survey on the latest advancements covering a broad range of related work is urgently needed.This review summarizes the recent major advances in the research of perovskite solar cells from a material science perspective.The discussed topics include the devices based on different type of perovskites(organic-inorganic hybrid,all-inorganic,and lead-free perovskite and perovskite quantum dots),the properties of perovskite defects,different type of charge transport materials(organic,polymeric,and inorganic hole transport materials and inorganic and organic electron transport materials),counter electrodes,and interfacial materials used to improve the efficiency and stability of devices.Most discussions focus on the key progresses reported within the recent five years.Meanwhile,the major issues limiting the production of perovskite solar cells and the prospects for the future development of related materials are discussed. | Jiang-Yang Shao Dongmei Li Jiangjian Shi Chuang Ma Yousheng Wang Xiaomin Liu Xianyuan Jiang Mengmeng Hao Luozheng Zhang Chang Liu Yiting Jiang Zhenhan Wang Yu-Wu Zhong Shengzhong(Frank)Liu Yaohua Mai Yongsheng Liu Yixin Zhao Zhijun Ning Lianzhou Wang Baomin Xu Lei Meng Zuqiang Bian Ziyi Ge Xiaowei Zhan Jingbi You Yongfang Li Qingbo Meng | 2023 | Science China Chemistry2023，66，1： | 3 |
| 8 | Community phylogenetic structure of grasslands and its relationship with environmental factors on the Mongolian Plateau显示文摘The community assembly rules and species coexistence have always been interested by ecologists. The community phylogenetic structure is the consequence of the interaction process between the organisms and the abiotic environment and has been used to explain the relative impact of abiotic and biotic factors on species co-existence. In recent years, grassland degradation and biodiversity loss have become increasingly severe on the Mongolian Plateau, while the drivers for these changes are not clearly explored, especially whether climate change is a main factor is debated in academia. In this study, we examined the phylogenetic structure of grassland communities along five transects of climate aridity on the Mongolian Plateau, and analyzed their relations with environmental factors, with the aims to understand the formation mechanism of the grassland communities and the role of climatic factors. We surveyed grassland communities at 81 sites along the five transects, and calculated their net relatedness index(NRI) at two different quadrat scales(small scale of 1 m2 and large scale of 5 m2) to characterize the community phylogenetic structure and analyze its relationship with the key 11 environmental factors. We also calculated the generalized UniFrac distance(GUniFrac) among the grassland communities to quantify the influence of spatial distance and environmental distance on the phylogenetic β diversity. The results indicated that plant community survey using the large scale quadrat contained sufficient species to represent community compositions. The community phylogenetic structure of grasslands was significantly overdispersed at both the small and large scales, and the degree of overdispersion was greater at the large scale than at the small scale, suggesting that competitive exclusion instead of habitat filtering played a major role in determination of community composition. Altitude was the main factor affecting the community phylogenetic structure, whereas climatic factors, such as precipitation and temperature, had limited influence. The principal component analysis of the 11 environmental factors revealed that 94.04% of their variation was accounted by the first four principal components. Moreover only 14.29% and 23.26% of the variation in community phylogenetic structure were explained by the first four principal components at the small and large scales, respectively. Phylogenetic β diversity was slightly significantly correlated with both spatial distance and environmental distance, however, environmental distance had a less explanatory power than spatial distance, indicating a limited environmental effect on the community phylogenetic structure of grasslands on the Mongolian Plateau. In view of the limited effect of climatic factors on the community phylogenetic structure of grasslands, climate change may have a smaller impact on grassland degradation than previously thought. | DONG Lei LIANG Cunzhu LI Frank Yonghong ZHAO Liqing MA Wenhong WANG Lixin WEN Lu ZHENG Ying LI Zijing ZHAO Chenguang Indree TUVSHINTOGTOKH | 2019 | Journal of Arid Land2019，11，4： | 2 |
| 9 | Dynamic Stability Analysis of Linear Time-varying Systems via an Extended Modal Identification Approach显示文摘The problem of linear time-varying(LTV) system modal analysis is considered based on time-dependent state space representations, as classical modal analysis of linear time-invariant systems and current LTV system modal analysis under the ‘‘frozen-time'' assumption are not able to determine the dynamic stability of LTV systems.Time-dependent state space representations of LTV systems are first introduced, and the corresponding modal analysis theories are subsequently presented via a stabilitypreserving state transformation. The time-varying modes of LTV systems are extended in terms of uniqueness, and are further interpreted to determine the system's stability. An extended modal identification is proposed to estimate the time-varying modes, consisting of the estimation of the state transition matrix via a subspace-based method and the extraction of the time-varying modes by the QR decomposition. The proposed approach is numerically validated by three numerical cases, and is experimentally validated by a coupled moving-mass simply supported beam experimental case. The proposed approach is capable of accurately estimating the time-varying modes, and provides a new way to determine the dynamic stability of LTV systems by using the estimated time-varying modes. | Zhisai MA Li LIU Sida ZHOU Frank NAETS Ward HEYLEN Wim DESMET | 2017 | Chinese Journal of Mechanical Engineering2017，30，2： | 2 |
| 10 | Paget disease of the nipple:radiologic pathologic correlation显示文摘 | Ikeda DM Heivie MA Frank TS | 1993 | Radiology1993，189，： | 1 |
| 11 | Science review:Mechanismsof ventilator-induced injury显示文摘 | Frank JA Matthay MA | 2003 | Crit Care2003，7，3： | 1 |
| 12 | Novel nanoprocessing route for bulk graphene nanoplatelets reinforced metal matrix nanocomposites显示文摘 | Lian-Yi Chen Hiromi Konishi Axel Fehrenbacher Chao Ma Jia-Quan Xu Hongseok Choi Hui-Fang Xu Frank E. Pfefferkorn Xiao-Chun Li | 2012 | Scripta Materialia2012，，1： | 1 |
| 13 | Reconstructing Pathfinder AVHRR Land NDVI Time-series Data for the Northwest of China显示文摘 | Ma M G Frank V | 2006 | Ad- vances in Space Research2006，37，： | 1 |
| 14 | Socioeconomic status and health: bow education, income, and occupation contribute to risk factors for cardiovascular disease 显示文摘 | Winkleby MA Jatulis DE Frank E | 1992 | American Journal of Public Heahh1992，82，6： | 1 |
| 15 | Characterization of the signaling interactions that promote the survival and growth of developing retinal ganglion cells in culture 显示文摘 | Kaplan MR Pfrieger FW | 1995 | Neuron1995，15，4： | 1 |
| 16 | Stresses and satisfactions of family caregivers to older stroke patients显示文摘 | Kinney JM Stephens MA Frank MM | 1995 | The Journal of Applied Gerontology1995，14，1： | 1 |
| 17 | Socioeconomic status and health:how education,income and occupation contribute to riak factors for cardiovascular disease显示文摘 | Winkelby MA Jatulis DE Frank E | 1992 | Am J Public Health1992，82，： | 1 |
| 18 | Socioeconomic status and health:how education,income,and occupation contribute to risk factors for cardiovascular disease显示文摘 | Winkleby MA Jatulis DE Frank E | 1992 | Am J Public Health1992，82，6： | 1 |
| 19 | Obesity relationships with community design,physical activity,and time spent in cars显示文摘 | Frank LD Andresen MA Schmid TL | 2004 | Am J Prev Med2004，27，： | 1 |
| 20 | Getting rich and eating out: consumption of food away from home in urban China显示文摘 | Ma Hengyun Huang Jikun Fuller Frank | 2006 | Canadian Journal of Agricultural Economics2006，54，1： | 1 |
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