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| 1 | 限制热量摄入6个月对超重者寿命指标、代谢调节及氧化应激的影响——随机对照试验AuthorAffiliations:PenningtonBiomedicalResearchCenter.LouisianaStateUniversity.BatonRouge;andGarvan.InstituteforMedicalResearch.Dadinghurst,AustraIia(DrHeilbronn).显示文摘背景:长期限制热量摄入可延长啮齿类动物的寿命。但是,尚未有研究观测长期限制人体热量是否会影响其寿命及氧化应激指标,降低代谢率。
目的:在超重但不肥胖(体重指数为25—30)的人群中研究限制热量6个月伴/不伴运动对其产生的影响。
设计、地点及参试者:于2002年3月至2004年8月在位于路易斯安娜州首府巴顿鲁治的研究中心对48名不好动的健康人进行随机对照研究。
干预:参试者在6个月内随机分为4个组:对照组(饮食可维持体重);限制热量组(限制基线所需能量的25%);限制热量+运动组(限制12.5%的热量+运动增加12.5%的能耗);极低热量饮食组(每日摄入890keal,直至体重减少15%,随后采用维持体重的饮食)。
主要观测指标:机体组成;硫酸脱氢表雄酮(dehydroepiandrostemne sulfate,DHEAS)、葡萄糖及胰岛素水平;蛋白羰基化合物;DNA损伤;24小时能耗;核心体温。
结果:6个月时各组体重变化的均值(标准误)为:对照组-1.0%(1.1%);限制热量组-10.4%(0.9%);限制热量+运动组-10.0%(0.8%);极低热量饮食组-13.9%(0.7%)。6个月时,各干预组空腹血糖水平较基线明显降低(P均〈0.01),而DHEAS和葡萄糖水平没有改变。限制热量组及限制热量+运动组核心体温有所下降(P均〈0.05)。对机体组成进行校正后发现,对照组24小时静息能耗无变化,但限制热量组(-135kcal/d[42kcal/d])、限制热量+运动组(-117kcal/d[52kcal/d])和极低热量饮食组(-125kcal/d[35kcal/d])24小时静息能耗有所下降(P均〈0.008)。上述“代谢调节”(超出预计值的-6%)与对照组相比存在显著差异(P〈0.05)。6个月时,各组蛋白羰基化合物的浓度较基线时无变化,而各干预组DNA损伤有所减少(P〈0.005)。
结论:我们的研究结果显示,长期限制热量可降低人类寿命的2种指标(即空腹胰岛素水平和体温)。此外,我们的研究结果还支持下述理论,即限制热量能降低代谢率,且超过缩小代谢面积产生的相应效应。我们尚需开展远期研究来评价限制热量能否延缓人类衰老过程。 | Leonie K. Heibronn Lilian de Jonge Madlyn I. Frisard James P. DeLany D. Enette Larson-Meyer Jennifer Rood Tuong Nguyen Corby K. Martin Julia Volaufova Marlene M. Most Frank L. Greenway Steven R. Smith Walter A. Deutsch Donald A. Williamson Eric Ravussin 顾佳(译) | 2006 | 美国医学会杂志(中文版)2006，25，5： | 18 |
| 2 | Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA显示文摘 | Luigi Warren Philip D. Manos Tim Ahfeldt Yuin-Han Loh Hu Li Frank Lau Wataru Ebina Pankaj K. Mandal Zachary D. Smith Alexander Meissner George Q. Daley Andrew S. Brack James J. Collins Chad Cowan Thorsten M. Schlaeger Derrick J. Rossi | 2010 | Cell Stem Cell2010，，5： | 4 |
| 3 | Markers of Inflammation and Cardiovascular Disease: Application to Clinical and Public Health Practice: A Statement for Healthcare Professionals From the Centers for Disease Control and Prevention and the American Heart Association显示文摘 | Thomas A. Pearson George A. Mensah R. Wayne Alexander Jeffrey L. Anderson Richard O. Cannon Michael Criqui Yazid Y. Fadl Stephen P. Fortmann Yuling Hong Gary L. Myers Nader Rifai Sidney C. Smith Kathryn Taubert Russell P. Tracy Frank Vinicor | 2003 | Circulation: Journal of the American Heart Association2003，，3： | 2 |
| 4 | Effects of three pharmaceutical and personal care products on natural freshwater algal assemblages显示文摘 | Wilson B A Smith V H Frank D J R | 2003 | Environ Sci Technol2003，37，9： | 1 |
| 5 | Impact of dysphagia on quality of life after treatment of head-and-neck cancer显示文摘 | Nam P. Nguyen Cheryl Frank Candace C. Moltz Paul Vos Herbert J. Smith Ulf Karlsson Suresh Dutta Allan Midyett Jessica Barloon Sabah Sallah | 2005 | International Journal of Radiation Oncology Biology Physics2005，，3： | 1 |
| 6 | The Use of Microwave Ovens for Rapid Organic Synthesis显示文摘 | Richard Gedye Frank Smith Keneth Westaway | 1986 | Tetrahedron Lett1986，27，： | 1 |
| 7 | eBOMs和mBOMs集成的设想显示文摘产品生命周期管理(PLM)软件是连接制造和工程并改善生产过程的管理体系。 | Frank O Smith | 2010 | 软件2010，31，1： | 1 |
| 8 | Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man显示文摘 | SMITH E P BOYD J FRANK G R | 1994 | N Engl J Med1994，331，16： | 1 |
| 9 | Estrogen resistance Caused by a mutation in the estrogen receptor gene in man 显示文摘 | Smith EP Boyd J Frank GR | 1994 | N Eny J Med1994，331，： | 1 |
| 10 | A Three-Hybrid Approach to Scanning the Proteome for Targets of Small Molecule Kinase Inhibitors显示文摘 | Frank Becker Krishna Murthi Chase Smith | 2004 | Chemistry and Biology2004，11，： | 1 |
| 11 | Preparing pa- tients and caregivers to participate in care deliveredacross settings: The care transitions intervention 显示文摘 | Coleman E A Smith J D Frank J C | 2004 | J Am Geriatr Soc2004，52，11： | 1 |
| 12 | The ecology of algal biodiesel produc- tion显示文摘 | VAI H SMITH BELINDA S M STURM FRANK J DE- NOYELLES | 2009 | Trends in Ecology and Evolution2009，25，5： | 1 |
| 13 | Estrogen resisrtance caused by mutation in the estrogerr receptor gene in a man显示文摘 | Smith EP Boyd J Frank GR | 1994 | New Eng J Med1994，331，16： | 1 |
| 14 | Preparing patients and caregivers to participate in care delivered across settings:The care transitions intervention显示文摘 | Coleman EA Smith JD Frank JC | 2004 | Journal of the American Geriatrics Society2004，52，11： | 1 |
| 15 | The ecology of algal biodiesel production显示文摘 | Val H. Smith Belinda S.M. Sturm Frank J. deNoyelles Sharon A. Billings | 2009 | Trends in Ecology & Evolution2009，，5： | 1 |
| 16 | Characterization of two phosphate transporters from barley; evidence for diverse function and kinetic properties among members of the Pht1 family显示文摘 | Anne L. Rae Daisy H. Cybinski Janine M. Jarmey Frank W. Smith | 2003 | Plant Molecular Biology (-)2003，，1： | 1 |
| 17 | Development and testing of a measure designed to assess the quality of care transitions 显示文摘 | Coleman EA Smith JD Frank JC | 2002 | lnt J Integr Care2002，2，： | 1 |
| 18 | Preparing patients and care givers to participate in care delivered across settings:the Care Transitions Intervention显示文摘 | Coleman EA Smith JD Frank JC | 2004 | J Am Geriatr Soc2004，52，11： | 1 |
| 19 | Phosphate transport in plants显示文摘 | Frank W. Smith Stephen R. Mudge Anne L. Rae Donna Glassop | 2003 | Plant and Soil (-)2003，，1： | 1 |
| 20 | Preparing patients and caregivers to participate in care delivered across settings: The care transitions intervention 显示文摘 | Coleman EA Smith JD Frank JC | 2004 | Geriatr $oc2004，，2： | 1 |
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