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| 1 | Endoscopic papillectomy: Data of a prospective observational study显示文摘AIM:To investigate the clinical value of endoscopic papillectomy indicated by feasibility and safety of the procedure in various diseases of the papilla in a representative number of patients in a setting of daily clinical and endoscopic practice and care by means of a systematic prospective observational study. METHODS:Through a defined time period, all consecutive patients with tumor-like lesions of the papilla, who were considered for papillectomy, were enrolled in this systematic bicenter prospective observational study, and subdivided into 4 groups according to endoscopic and endoscopic ultrasonography (EUS) findings as well as histopathological diagnosis:adenoma; carcinoma/ neuroendocrine tumor (NET)/lymphoma; papilla into which catheter can not be introduced; adenomyomatosis, respectively. Treatment results and outcome were characterized by R0 resection, complication, recurrence rates and tumor-free survival.RESULTS:Over a 7-year period, 58 patients underwent endoscopic papillectomy. Main symptoms prompting to diagnostic measures were unclear abdominal pain in 50% and cholestasis with and without pain in 44%. Overall, 54/58 patients [inclusion rate, 93.1%; sex ratio, males/females = 25/29 (1:1.16); mean age, 65 (range, 22-88) years] were enrolled in the study. Prior to papillectomy, EUS was performed in 79.6% (n = 43/54). Group 1 (adenoma, n = 24/54; 44.4%):91.6% (n = 22/24) with R0 resection; tumor-free survival after a mean of 18.5 mo, 86.4% (n = 19/22); recurrence, 13.6% (n = 3/22); minor complications, 12.5% (n = 3/24). Group 2 (carcinoma/NET/lymphoma, n = 18/54; 33.3%):75.0% (n = 10/18) with R0 resection; tumor-free survival after a mean of 18.5 (range, 1-84) mo, 88.9% (n = 8/9); recurrence, 11.1% (n = 1/9). Group 3 (adenomyomatosis, n = 4/54; 7.4%). Group 4 (primarily no introducible catheter into the papilla, n = 8; 14.8%). The overall complication rate was 18.5% (n = 10/54; 1 subject with 2 complications):Bleeding, n = 3; pancreatitis, n = 7; perforation, n = 1 (intervention-related mortality, 0%). In summary, EUS is a sufficient diagnostic tool to preoperatively clarify diseases of the papilla including suspicious tumor stage in conjunction with postinterventional histopathological investigation of a specimen. Endoscopic papillectomy with curative intention is a feasible and safe approach to treat adenomas of the papilla. In high-risk patients with carcinoma of the papilla with no hints of deep infiltrating tumor growth, endoscopic papillectomy can be considered a reasonable treatment option with low risk and an approximately 80% probability of no recurrence if an R0 resection can be achieved. In patients with jaundice and in case the catheter can not be introduced into the papilla, papillectomy may help to get access to the bile duct. CONCLUSION:Endoscopic papillectomy is a challenging interventional approach but a suitable patientand local finding-adapted diagnostic and therapeutic tool with adequate risk-benefit ratio in experienced hands. | Uwe Will Anne-Kathrin Müller Frank Fueldner Igor Wanzar Frank Meyer | 2013 | World Journal of Gastroenterology2013，19，27： | 10 |
| 2 | Differential treatment and early outcome in the interventional endoscopic management of pancreatic pseudocysts in 27 patients显示文摘瞄准:胰腺的假包囊(PPC ) 仅仅在腹的疼痛的情况中作为胰腺炎的复杂并发症被接近,感染,流血,并且压缩到胃肠道或胆汁的树上。方法:从 02/01/2002 到 05/31/2004,经历了 interventional 的有征兆的 PPC 的所有连续病人内视镜的途径在这飞行员盒子系列研究被评估:组(Gr ) 我主要经皮(外部) ,指导超声的排水。Gr。II 主要的指导 EUS 的胰囊肿胃吻合术。Gr。包括 intracystic necrosectomy 的 III-EUS-guided 胰囊肿胃吻合术。结果:( = “列在后面在上面”:n = 27 ) :Gr。我(n = 9;33.3%) :没有抱怨(n = 3 ) ;变化一进内部排水外部(n = 4 ) ;复杂并发症:(a) 流血(n = 1 ) 在 ICU 由 3 d 列在后面,在 40 d 以后的分泌物;(b) 腐败吃惊(n = 1 ) 由 ICU 和几剖腹术列在后面规划洗室年龄和 necrosectomy,在 74 d 以后的死亡。Gr。II (n = 13;48.1%) :没有抱怨(n = 11 ) ;外部排水(n = 2 ) ;从 13 个盒子的复杂并发症 / 问题:第二分开的假包囊(n = 1 ) 与外部排水(自从与主要内部排水的没有通讯) ;剩余包囊的感染(n = 1 )+ 追随者外部排水;自发的 PPC 穿孔(n = 1 ) 用片断并且随后的胰囊肿胃吻合术的开始的 + 追随者闭合为 2 d 的 ICU。Gr。III (n = 5;18.5%) :在所有病人的没有抱怨,在要求的一般水准二内视镜的过程(变化, 2-6 ) 。结论:胰腺的假包囊的 Interventional 内视镜的管理关于复杂并发症率(11.1%) 和死亡(3.7%) 是有与外科和可接受的结果相比的低侵略海角的一种合理其他的治疗选择,作为由这些证明起始的学习结果。 | Uwe Will Conrad Wegener Kai-Ivo Graf Igor Wanzar Thomas Manger Frank Meyer | 2006 | World Journal of Gastroenterology2006，12，26： | 9 |
| 3 | Endoscopic ultrasonography-guided drainage for patients with symptomatic obstruction and enlargement of the pancreatic duct显示文摘AIM: To evaluate the use of translumenal pancreatography with placement of endoscopic ultrasonography(EUS)-guided drainage of the pancreatic duct.METHODS: This study enrolled all consecutive patients between June 2002 and April 2014 who underwent EUSguided pancreatography and subsequent placement of a drain and had symptomatic retention of fluid in the pancreatic duct after one or more previous unsuccessful attempts at endoscopic retrograde cannulation of the pancreatic duct. In all,94 patients underwent 111 interventions with one of three different approaches:(1) EUS-endoscopic retrograde drainage with a rendezvous technique;(2) EUS-guided drainage of the pancreatic duct; and(3) EUS-guided,internal,antegrade drainage of the pancreatic duct.RESULTS: The mean duration of the interventions was 21 min(range,15-69 min). Mean patient age was 54 years(range,28-87 years); the M:F sex ratio was 60:34. The technical success rate was 100%,achieving puncture of the pancreatic duct including pancreatography in 94/94 patients. In patients requiring drainage,initial placement of a drain wassuccessful in 47/83 patients(56.6%). Of these,26 patients underwent transgastric/transbulbar positioning of a stent for retrograde drainage; plastic prostheses were used in 11 and metal stents in 12. A ring drain(antegrade internal drainage) was placed in three of these 26 patients because of anastomotic stenosis after a previous surgical intervention. The remaining 21 patients with successful drain placement had transpapillary drains using the rendezvous technique; the majority(n = 19) received plastic prostheses,and only two received metal stents(covered self-expanding metal stents). The median follow-up time in the 21 patients with transpapillary drainage was 28 mo(range,1-79 mo),while that of the 26 patients with successful transgastric/transduodenal drainage was 9.5 mo(range,1-82 mo). Clinical success,as indicated by reduced or absence of further pain after the EUS-guided intervention was achieved in 68/83 patients(81.9%),including several who improved without drainage,but with manipulation of the access route.CONCLUSION: EUS-guided drainage of the pancreatic duct is a safe,feasible alternative to endoscopic retrograde drainage when the papilla cannot be reached endoscopically or catheterized. | Uwe Will Andreas Reichel Frank Fueldner Frank Meyer | 2015 | World Journal of Gastroenterology2015，21，46： | 5 |
| 4 | Transgastric pancreatography and EUS-guided drainage of the pancreatic duct显示文摘 | Uwe Will Frank Fueldner Anne-Kathrin Thieme Bernhard Goldmann Rainer Gerlach Igor Wanzar Frank Meyer | 2007 | Journal of Hepato - Biliary - Pancreatic Surgery2007，，4： | 2 |
| 5 | Histone-deacetylase inhibition and butyrate formation: Fecal slurry incubations with apple pectin and apple juice extracts显示文摘 | Markus Waldecker Tanja Kautenburger Heike Daumann Selveraju Veeriah Frank Will Helmut Dietrich Beatrice Louise Pool-Zobel Dieter Schrenk | 2008 | Nutrition2008，，4： | 1 |
| 6 | Apple pomace liquefaction with pectinases and cellulases:analytical data of the corresponding juices显示文摘 | Frank Will Katri Bauckhage Helmut Dietrich | 2000 | Eur Food Res Technol2000，211，： | 1 |
| 7 | Apple pomace liquefaction with pectinases and celllulases: analytical data of the correspong ding j uices显示文摘 | Frank Will Katri Bauckhage | 2000 | Eur Food Res Technlo2000，211，： | 1 |
| 8 | Optimised processing technique for coiour and cloud stable plum juices and stability of bioactive substances显示文摘 | Frank Will Helmut Dietrich | 2006 | Eur Food Res Technol2006，223，6： | 1 |
| 9 | Soybean isoflavones, genistein and genistein, inhibit rat myoblast proliferation, fusion and myotube protein synthesis显示文摘 | Ji S Willes GM Frank GR etal | 1999 | J Nutr1999，129，7： | 1 |
| 10 | Alone and without purpose: Life loses meaning following social exclusion显示文摘 | Tyler F. Stillman Roy F. Baumeister Nathaniel M. Lambert A. Will Crescioni C. Nathan DeWall Frank D. Fincham | 2009 | Journal of Experimental Social Psychology2009，，4： | 1 |
| 11 | Impacts of Elevated Carbon Dioxide and Temperature on a Boreal Forest Ecosystem (CLIMEX Project)显示文摘 | Nico van Breemen Alan Jenkins Richard F. Wright David J. Beerling Wim J. Arp Frank Berendse Claus Beier Rob Collins Douwe van Dam Lennart Rasmussen Paul S. J. Verburg Mark A. Wills | 1998 | Ecosystems1998，，4： | 1 |
| 12 | Specificity of endothelial cell reorientation in response to cyclic mechanical stretching显示文摘 | James H.-C. Wang Pascal Goldschmidt-Clermont Jeremiah Wille Frank C.-P. Yin | 2001 | Journal of Biomechanics2001，，： | 1 |
| 13 | Apple pomace liquefaction with pectinases and celllulases:analytical data of the correspongding juices 显示文摘 | Frank Will Katri Bauckhage | 2000 | Eur Food Res Technlo2000，211，： | 1 |
| 14 | Processing and analytical characterization of pulp- enriched cloudy apple juices显示文摘 | Frank Will Manuela Roth Melanie Olk | 2008 | Food Science and Technology2008，41，10： | 1 |
| 15 | Optimised processing technique for colour and cloud stable plum juices and stability of bioactive substances显示文摘 | Frank Will Helmut Dietrich | 2006 | Fur Food Res Techno12006，223，： | 1 |
| 16 | Impacts of Elevated Carbon Dioxide and Temperature on a Boreal Forest Ecosystem (CLIMEX Project)显示文摘 | Nico van Breemen Alan Jenkins Richard F. Wright David J. Beerling Wim J. Arp Frank Berendse Claus Beier Rob Collins Douwe van Dam Lennart Rasmussen Paul S. J. Verburg Mark A. Wills | 1998 | Ecosystems1998，，4： | 1 |
| 17 | Processing and analytical characterization of pulp-enriched cloudy apple juices显示文摘 | FRANK WILL MANUELA ROTH MELANIE OLK | 2008 | Food Science and Technology2008，，41： | 1 |
| 18 | DYRK1A is a novel neg- ative regulator of cardiomyocyte hypertrophy显示文摘 | Kuhn C Frank D Will R | 2009 | J Biol Chem2009，284，17： | 1 |
| 19 | DYRK1A is a novel negative regulator of eardiomyocyte hypertrophy 显示文摘 | Kuhn C Frank D Will R Jaschinski C Frauen R Katus HA | 2009 | J Biol Chem2009，284，17： | 1 |
| 20 | Endoscopic treatment of a pseudocystocolonic fistula by band ligation and endoloop application: case report显示文摘 | Uwe Will Frank Meyer Stefan Hartmeier Harald Schramm Hans Bosseckert | 2004 | Gastrointestinal Endoscopy2004，，4： | 1 |
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