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| 1 | Different effects of ghrelin, des-acyl ghrelin and obestatin on gastroduodenal motility in conscious rats显示文摘Three peptides, ghrelin, des-acyl ghrelin and obestatin are derived from a common prohormone, preproghrelin by posttranslational processing, originating from endocrine cells in the stomach. To examine the effects of these peptides, we applied the manometric measurement of gastrointestinal motility in freely moving conscious rat models. Ghrelin exerts stimulatory effects on the motility of antrum and duodenum in both fed and fasted state of animals. Des-acyl ghrelin exerts inhibitory effects on the motility of antrum, but not on the motility of duodenum in the fasted state of animals. Obestatin exerts inhibitory effects on the motility of antrum and duodenum in the fed state, but not in the fasted state of animals. NPY Y2 or Y4 receptors in the brain may mediate the action of ghrelin, CRF type 2 receptors in the brain mediate the action of des-acy ghrelin, whereas CRF type 1 and type 2 receptors in the brain mediate the action of obestatin. Vagal afferent pathways might be involved in the action of ghrelin, but not involved in the action of des-acyl ghrelin, whereas vagal afferent pathways might be partially involved in the action of obestatin. | Mineko Fujimiya Akihiro Asakawa Koji Ataka Ikuo Kato Akio Inui | 2008 | World Journal of Gastroenterology2008，14，41： | 12 |
| 2 | Potential effects of mesenchymal stem cell derived extracellular vesicles and exosomal miRNAs in neurological disorders显示文摘Mesenchymal stem cells are multipotent cells that possess anti-inflammatory,antiapoptotic and immunomodulatory properties.The effects of existing drugs for neurodegenerative disorders such as Alzheimer’s disease are limited,thus mesenchymal stem cell therapy has been anticipated as a means of ameliorating neuronal dysfunction.Since mesenchymal stem cells are known to scarcely differentiate into neuronal cells in damaged brain after transplantation,paracrine factors secreted from mesenchymal stem cells have been suggested to exert therapeutic effects.Extracellular vesicles and exosomes are small vesicles released from mesenchymal stem cells that contain various molecules,including proteins,mRNAs and microRNAs.In recent years,administration of exosomes/extracellular vesicles in models of neurological disorders has been shown to improve neuronal dysfunctions,via exosomal transfer into damaged cells.In addition,various microRNAs derived from mesenchymal stem cells that regulate various genes and reduce neuropathological changes in various neurological disorders have been identified.This review summarizes the effects of exosomes/extracellular vesicles and exosomal microRNAs derived from mesenchymal stem cells on models of stroke,subarachnoid and intracerebral hemorrhage,traumatic brain injury,and cognitive impairments,including Alzheimer’s disease. | Masako Nakano Mineko Fujimiya | 2021 | Neural Regeneration Research2021，16，12： | 9 |
| 3 | Anal cushion lifting method is a novel radical management strategy for hemorrhoids that does not involve excision or cause postoperative anal complications显示文摘AIM: To describe the anal cushion lifting(ACL) method with preliminary clinical results. METHODS: Between January to September 2007, 127 patients who received ACL method for hemorrhoid was investigated with informed consent. In this study, three surgeons who specialized in anorectal surgery performed the procedures. Patients with grade two or more severe hemorrhoids according to Goligher's classification were considered to be indicated for surgery. The patients were given the choice to undergo either the ACL method or theligation and excision method. ACL method is an original technique for managing hemorrhoids without excision. After dissecting the anal cushion from the internal sphincter muscle, the anal cushion was lifted to oral side and ligated at the proper position. Clinical characteristics and outcomes of patients were recorded including complications after surgery. RESULTS: A total of 127 patients were enrolled. Their median age was 42(19-84) years, and 74.8% were female. In addition, more than 99% of the patients had grade 3 or worse hemorrhoids. The median followup period was 26(0-88) mo, and the median operative time was 15(4-30) min. After surgery, analgesics were used for a median period of three days(0-21). Pain control was achieved using extra-oral analgesic drugs, although some patients required intravenous injections of analgesic drugs. The median duration of the patients' postoperative hospital stay was 7(2-13) d. A total of 10 complications(7.9%) occurred. Bleeding was observed in one patient and was successfully controlled with manual compression. Urinary retention occurred in 6 patients, but it disappeared spontaneously in all cases. Recurrent hemorrhoids developed in 3 patients after 36, 47, and 61 mo, respectively. No anal stenosis or persistent anal pain occurred. CONCLUSION: We consider that the ACL method might be better than all other current methods for managing hemorrhoids. | Gentaro Ishiyama Toshihiko Nishidate Yuji Ishiyama Akihiko Nishio Ken Tarumi Maiko Kawamura Kenji Okita Toru Mizuguchi Mineko Fujimiya Koichi Hirata | 2015 | World Journal of Gastrointestinal Surgery2015，7，10： | 3 |
| 4 | Carvedilol Attenuates the Progression of Alcohol Fatty Liver Disease in Rats显示文摘 | Jinyao Liu Izumi Takase Ayako Hakucho Nanako Okamura Tatsuya Fujimiya | 2012 | Alcohol Clin Exp Res2012，，9： | 2 |
| 5 | Suppression of NO production in activa- ted maerophages in vitro and ex vivo by neoandrogra- pholide isolated from Andrographis paniculata显示文摘 | Batkhuu J Hattori K Takano F Fushiya S Oshiman K Fujimiya Y | 2002 | Bi- ol Pharm Buli2002，25，： | 1 |
| 6 | 显示文摘 | Kojima H Fujimiya M Matsumura K | 2004 | PNAS2004，101，： | 1 |
| 7 | Orally administered beta-1,6-D-polyglucose extracted from Agaricus blazei results in tumor regression in tumor-bearing mice显示文摘 | Oshiman K Fujimiya Y Ebina T | 2002 | Planta Med2002，68，7： | 1 |
| 8 | Extrapancreatic insulin-producing cells in multiple organs in diabetes显示文摘 | Kojima H Fujimiya M Matsumura K | | 0，，： | 1 |
| 9 | Modulation of ingestive behavior and gastrointestinal motility by ghrelin in diabetic animals and humans显示文摘 | CHEN C Y FUJIMIYA M LAVIANO A | 2010 | Journal of the Chinese Medi- cal Association: JCMA2010，73，5： | 1 |
| 10 | Phosphoinositide 3-kinase accelerates autophagic cell death during glucose deprivation in the rat cardiomyocyte-derived cell line H9c2显示文摘 | Aki T Yamaguchi K Fujimiya T | 2003 | Oncogene2003，22，52： | 1 |
| 11 | Selective tumoricidal effect of soluble proteoglucan extracted from the basidiomycete,Agaricus blazei Murill, mediated via natural killer cell activation and apoptosis 显示文摘 | FUJIMIYA Y SUZUKI Y | 1998 | Cancer Immunology and Immunotherapy1998，46，： | 1 |
| 12 | Peptidergic regulation of gastrointestinal motility in rodents显示文摘 | Fujimiya M Inui A | 2000 | Peptides2000，21，10： | 1 |
| 13 | Ghrelin, des-acyl gh- relin, and ohestatin: Regulatory roles on the gastrointestinal motility显示文摘 | Fujimiya M Asakawa A Ataka K | 2010 | Int J Pept2010，，： | 1 |
| 14 | Ghrelin, des- acyl ghrelin and obestatin on the gastrointestinal motility显示文摘 | FUJIMIYA M ATAKA K ASAKAWA A | 2011 | Pep- tides2011，32，11： | 1 |
| 15 | Stomach regulates energy balance via acylated ghrelin and desacyl ghrelin显示文摘 | Asakawa A Inui A Fujimiya M | | 0，，1： | 1 |
| 16 | Antitumor effect of a peptide - glucan preparation extracted tram Agaricus blazei in double - grafted tumor system in mice显示文摘 | Ebina T Fujimiya Y | 1998 | Biotherapy1998，11，4： | 1 |
| 17 | NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice 显示文摘 | Kojima H Fujimiya M Matsumura K | 2003 | Nat Med2003，9，5： | 1 |
| 18 | Regulation of gastroduo- denal motility: acyl ghrelin, des-aeyl ghrelin and obestatin and hy- pothalamie peptides 显示文摘 | Fujimiya M Ataka K Asakawa A | 2012 | Digestion2012，85，2： | 1 |
| 19 | Neuropeptide Y induces fasted pattern of duodenal motility via Y (2) receptors in conscious fed rats 显示文摘 | Fujimiya M Itoh E Kihara N | 2000 | Am J Physiol Gastrointest Liver Physiol2000，278，1： | 1 |
| 20 | Tumor-specific Cytocidal and Immunopotentiating Effects of Relatively Low Molecular Products Derived From the Basidiomycete,Agaricus Blazei Murrill显示文摘 | Fujimiya Y Suzuki Y Katakura R | 1999 | Anticancer Research1999，19，14： | 1 |
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