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| 1 | Analysis of characteristics and predictive factors of immune checkpoint inhibitor-related adverse events显示文摘Objective:We aimed to retrospectively analyze the toxicity profiles and predictors of immune-related adverse events(irAEs)as well as the correlation between irAEs and the clinical efficacy of multi-type immune checkpoint inhibitors(ICIs)in patients with advanced pan-cancer in a real-world setting.Methods:We retrospectively analyzed data from 105 patients with advanced pan-cancer treated with multi-type ICIs at the First Hospital of Jilin University between January 1,2016 and August 1,2020.We used logistic regression analyses to investigate the associations of irAEs with clinical baseline characteristics,blood count parameters,and biochemical indicators during treatment.Receiver operating characteristic curves were used to determine cutoff values for parameters and area under the curve values.Kaplan–Meier and Cox multivariate regression analyses were performed to estimate the relationships of baseline characteristics and irAEs with progression-free survival(PFS)and overall survival(OS).Results:A lower relative lymphocyte count(cutoff=28.5%),higher albumin level(cutoff=39.05 g/L),and higher absolute eosinophil count(AEC)(cutoff=0.175×10^(9)/L)were significantly associated with the occurrence of irAEs,among which a higher AEC(cutoff=0.205×10^(9)/L)was strongly associated with skin-related irAEs[odds ratios(ORs)=0.163,P=0.004].Moreover,a higher lactate dehydrogenase level(cutoff=237.5 U/L)was an independent predictor of irAEs of grade≥3(OR=0.083,P=0.023).In immune cell subgroup analysis,a lower absolute count of CD8+CD28−suppressor T cells(OR=0.806;95%confidence interval:0.643–1.011;P=0.062),which are regulatory T lymphocytes,was associated with the occurrence of irAEs,although the difference was not statistically significant.Furthermore,a higher percentage of CD19+B cells was associated with the occurrence of irAEs of grade≥3(P=0.02)and grade≥2(P=0.051).In addition,patients with any grade of irAE had a significantly high PFS(8.37 vs.3.77 months,hazard ratios(HR)=2.02,P=0.0038)and OS(24.77 vs.13.83 months,HR=1.84;P=0.024).Conclusions:This retrospective study reports clinical profile data for irAEs in unselected patients in a real-world setting and explored some parameters that may be potential predictive markers of the occurrence,type,or grade of irAEs in clinical practice.Evidence of a correlation between safety and efficacy may facilitate a complete assessment of the risk-benefit ratio for patients treated with ICIs. | Rilan Bai Naifei Chen Xiao Chen Lingyu Li Wei Song Wei Li Yuguang Zhao Yongfei Zhang Fujun Han Zheng Lyu Jiuwei Cui | 2021 | Cancer Biology & Medicine2021，18，4： | 4 |
| 2 | A high-energy-density sodium-ion full battery based on tin anode显示文摘Sodium-ion batteries(SIBs) have been considered as promising candidates for large-scale energy storage, owing to the high abundance and low cost of sodium(Na) resources. However, the development of full SIB has been hindered by low energy density because of the sluggish kinetics of large Na^+. Here, we report a full SIB with commercial tin(Sn) anode, cross-linked Na_3V_2(PO_4)_3/carbon nanotubes composites(NVP-CNT) cathode, and ether-based electrolyte. Sn is capable of delivering high reversible capacity via formation of Na15 Sn4 and stable solid-electrolyte interface(SEI) in initial cycles. Meanwhile, the NASICON-type NVP enables ultrafast and stable Na^+intercalation/extraction, and the incorporation of CNT can improve its electrical conductivity. The assembled full SIB delivers high output voltage of ~3.2 V, high energy density of 253.4 W h kg^(-1) at1600 W kg^(-1) based on total mass of both cathode and anode, and remarkable capacity retention of 96.1% after 180 cycles. These merit construction of high-energy full SIBs and will promote the development of SIBs. | Mingming Song Chenchen Wang Dongfeng Du Fujun Li Jun Chen | 2019 | Science China Chemistry2019，62，5： | 3 |
| 3 | Combined effects of 1-MCP and MAP on the fruit quality of pear ( Pyrus bretschneideri Reld cv. Laiyang) during cold storage显示文摘 | Fujun Li Xinhua Zhang Baicheng Song Jiazheng Li Zhonglin Shang Junfeng Guan | 2013 | Scientia Horticulturae2013，，： | 1 |
| 4 | The effect of annealing treatment on the performance of bulk heterojunction solar cells with donor and acceptor different weight ratios显示文摘Bulk heterojunction organic solar cells(OSCs) based on the blend of poly(2-methoxy-5(2'-ethyl-hexyloxy)-1,4-phenylenevinylene(MEH-PPV) and [6,6]-phenyl C61 butyric acid methyl ester(PCBM) with different weight ratios(from 1:3 to 1:5) have been fabricated and the effect of annealing treatment on the performance of OSCs has also been studied.Experimental results point to the best optimized doping concentration 1:4 for MEH-PPV:PCBM.Furthermore,it is found that the devices with annealing treatment at 150℃ with 8 min show better performance compared with the devices without treatment.The series resistance(Rs) is decreased,while the shunt resistance(Rsh) increased by nearly 1.5 times.The short-circuit current density(Jsc) and fill factor(FF) are improved by annealing treatment.As a result,the power conversion efficiency(PCE) of the devices increases from 0.49 % to 1.21 % with the ratio of 1:3 and from 1.09% to 1.42% with the ratio of 1:4. | SONG JingLu XU Zheng ZHANG FuJun ZHAO SuLing HU Tao LI JunMing LIU XiaoDong YUE Xin WANG YongSheng | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，10： | 1 |
| 5 | Interaction of methionine sulfoxide reductase B5 with SlMYC2 stimulates the transcription of MeJA-mediated autophagy-related genes in tomato fruit显示文摘Methyl jasmonate(MeJA)has been shown to induce autophagy in various plant stress responses and metabolic pathways.MYC2 is involved in MeJA-mediated postharvest fruit biological metabolism,but it is unclear how it affects MeJA-induced fruit autophagy.In this study,we noticed that silencing SlMYC2 significantly reduced the increase in autophagy-related genes(SlATGs)expression induced by MeJA.SlMYC2 could also bind to the promoters of several SlATGs,including SlATG13a,SlATG13b,SlATG18a,and SlATG18h,and activate their transcript levels.Moreover,SlMsrB5,a methionine sulfoxide reductase,could interact with SlMYC2.Methionine oxidation in SlMYC2 and mimicking sulfoxidation in SlMYC2 by mutation of methionine-542 to glutamine reduced the DNA-binding ability and transcriptional activity of SlMYC2,respectively.SlMsrB5 partially repaired oxidized SlMYC2 and restored its DNA-binding ability.On the other hand,silencing SlMsrB5 inhibited the transcript levels of SlMYC2-targeted genes(SlATG13a,SlATG13b,SlATG18a,and SlATG18h).Similarly,dual-luciferase reporter(DLR)analysis revealed that SlMsrB5–SlMYC2 interaction significantly increased the ability of SlMYC2-mediated transcriptional activation of SlATG13a,SlATG13b,SlATG18a,and SlATG18h.These findings demonstrate that SlMsrB5-mediated cyclic oxidation/reduction of methionine in SlMYC2 inf luences SlATGs expression.Collectively,these findings reveal the mechanism of SlMYC2 in SlATGs transcriptional regulation,providing insight into the mechanism of MeJA-mediated postharvest fruit quality regulation. | Dedong Min Fujun Li Maratab Ali Jiong Liu Xiaodong Fu Yanan Song Jun Ding Xiaoan Li Nana Ji Xinhua Zhang | 2023 | Horticulture Research2023，10，3： | 0 |
| 6 | Water Vapor Detection System Based on Scanning Spectra显示文摘扫描吸收光谱通过在 1368.597nm 附近的波长的水蒸汽的线成功地被用来测量微潮湿的内容的价值。原来的信号算法的同步重叠一般水准基于 labview 被改革并且适用于检测弱光谱吸收信号而不是低通行证过滤器。二个数据处理方法被用来在 ppm 得到水蒸汽的集中:当压力等于时,一个人是最新推出了一个一般公式与温度和横梁紧张比率计算气体的集中的一个一般公式方法或比 1 atm 大;当温度变化从 1atm 形成 258 K 到 305 K 和压力范围到 5 atm 时,其它正在设计被证明在 ppm 与横梁紧张比率和集中的适合的曲线有高分辨率和精确性的刻度方法。 | Shicong ZHANG Qiang WANG Yan ZHANG Fujun SONG Kun CHEN Guoqing CHOU Jun CHANG Pengpeng WANG Delong KONG Zongliang WANG Weijie WANG Yongning LIU Haiyong SONG | 2012 | Photonic Sensors2012，2，1： | 0 |
| 7 | LRRC25 plays a key role in all-trans retinoic acid-induced granulocytic differentiation as a novel potential leukocyte differentiation antigen显示文摘 | Weili Liu Ting Li Pingzhang Wang Wanchang Liu Fujun Liu Xiaoning Mo Zhengyang Liu Quansheng Song Ping Lv Guorui Ruan Wenling Han | 2018 | Protein & Cell2018，9，9： | 0 |
| 8 | New Approach for Noninvasive Determination of Tissue Optical Properties显示文摘A state-of-the-art radiative transfer model for the coupled air/tissue system is introduced. We then present a feasibility study of a new method for determining the tissue optical properties. | Bingquan Chen, Shangming Yang, Ruiping Chen, Fujun Zhang, Dongcao Song, Shengzhi ZhaoInstitute of Biomedical Optics, Yantai University, Shandong 264005, China, Tel: +86-535-6901993, Fax: +86-535-6903201, chen_bingquan@163.com. Department of Physics and Engineering Physics, Stevens Institute ofTechnology, Hoboken, NJ 07030, USA, Tel: +1-201-216-5587, Fax: +1-201-216-5638, bchenl@stevens-tech.edu.school of Informatics and Engineering, Shandong University, Shandong 250100, China. | 2003 | 光学学报2003，23，S1： | 0 |
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