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| 1 | New insights into follicular helper T cell response and regulation in autoimmune pathogenesis显示文摘Follicular helper T (Tfh) cells play a key role in driving B cell activation and differentiation during germinal center reactions in immune responses and autoimmune development, and these cells are characterized by high expression of CXCR5, PD1, ICOS, IL-21 and BCL6. Increasing evidence indicates that the functional dysregulation of Tfh cells contributes to the pathogenesis of autoimmune diseases, including primary Sjögren’s syndrome (pSS), which is a common autoimmune disease characterized by lymphocytic infiltration and tissue inflammation in salivary glands (SGs) and lacrimal glands that leads to dry mouth and dry eyes.1 Here, we provide a brief commentary on recent advances in understanding the Tfh cell response with a focus on new insights into Tfh cell regulation and therapeutic implications in autoimmune diseases. | Fan Xiao Man Han Ke Rui Xiangyan Ai Jie Tian Wen Zhang Futao Zhao Yan Zhao Quan Jiang Liwei Lu | 2021 | Cellular & Molecular Immunology2021，18，6： | 3 |
| 2 | Simulation modeling of nuclear steam generator water level process-a case study显示文摘 | Futao Zhao ing Ou Wei Du | 2000 | ISA Transactions2000，，39： | 1 |
| 3 | A timedelay compensation strategy for processes with uncertainties 显示文摘 | Zhao Futao Tian Yuchu Tade Moses O | 2002 | Computers and Chemical Engineering2002，，26： | 1 |
| 4 | Simulation modeling of nucle-ar steam generator water level process-A case study显示文摘 | Zhao Futao Ou Jing Du Wei | 2000 | ISA Transactions2000，39，2： | 1 |
| 5 | FWENet:a deep convolutional neural network for flood water body extraction based on SAR images显示文摘As one of the most severe natural disasters in the world,floods caused substantial economic losses and casualties every year.Timely and accurate acquisition of flood inundation extent could provide technical support for relevant departments in the field of flood emergency response and disaster relief.Given the accuracy of existing research works extracting flood inundation extent based on Synthetic Aperture Radar(SAR)images and deep learning methods is relatively low,this study utilized Sentinel-1 SAR images as the data source and proposed a novel model named flood water body extraction convolutional neural network(FWENet)for flood information extraction.Then three classical semantic segmentation models(UNet,Deeplab v3 and UNet++)and two traditional water body extraction methods(Otsu global thresholding method and Object-Oriented method)were compared with the FWENet model.Furthermore,this paper analyzed the water body area change situations of Poyang Lake.The main results of this paper were as follows:Compared with other five water body extraction methods,the FWENet model achieved the highest water body extraction accuracy,its F1 score and mean intersection over union(mIoU)were 0.9871 and 0.9808,respectively.This study could guarantee the subsequent research on flood extraction based on SAR images. | Jingming Wang Shixin Wang Futao Wang Yi Zhou Zhenqing Wang Jianwan Ji Yibing Xiong Qing Zhao | 2022 | International Journal of Digital Earth2022，15，1： | 1 |
| 6 | An integrated link quality estimation-based routing for wireless sensor networks 显示文摘 | Quan Wei Zhao Futao Guan Jianfeng | 2011 | The Journal of China University of Posts and Telecommunications2011，18，2： | 1 |
| 7 | Aryl hydrocarbon receptor activation drives polymorphonuclear myeloid-derived suppressor cell response and efficiently attenuates experimental Sjögren’s syndrome显示文摘Myeloid-derived suppressor cells(MDSCs)comprise heterogeneous myeloid cell populations with immunosuppressive capacity that contribute to immune regulation and tolerance induction.We previously reported impaired MDSC function in patients with primary Sjögren’s syndrome(pSS)and mice with experimental SS(ESS).However,the molecular mechanisms underlying MDSC dysfunction remain largely unclear.In this study,we first found that aryl hydrocarbon receptor(AhR)was highly expressed by human and murine polymorphonuclear MDSCs(PMN-MDSCs).Indole-3-propionic acid(IPA),a natural AhR ligand produced from dietary tryptophan,significantly promoted PMN-MDSC differentiation and suppressive function on CD4^(+)T cells.In contrast,feeding a tryptophan-free diet resulted in a decreased PMN-MDSC response,a phenotype that could be reversed by IPA supplementation.The functional importance of PMN-MDSCs was demonstrated in ESS mice by using a cell-depletion approach.Notably,AhR expression was reduced in PMN-MDSCs during ESS development,while AhR antagonism resulted in exacerbated ESS pathology and dysregulated T effector cells,which could be phenocopied by a tryptophan-free diet.Interferon regulatory factor 4(IRF4),a repressive transcription factor,was upregulated in PMN-MDSCs during ESS progression.Chromatin immunoprecipitation analysis revealed that IRF4 could bind to the promoter region of AhR,while IRF4 deficiency markedly enhanced AhR-mediated PMN-MDSC responses.Furthermore,dietary supplementation with IPA markedly ameliorated salivary glandular pathology in ESS mice with restored MDSC immunosuppressive function.Together,our results identify a novel function of AhR in modulating the PMN-MDSC response and demonstrate the therapeutic potential of targeting AhR for the treatment of pSS. | Yanxia Wei Na Peng Chong Deng Futao Zhao Jie Tian Yuan Tang Sulan Yu Yacun Chen Yu Xue Fan Xiao Yingbo Zhou Xiaomei Li Hejian Zou Ke Rui Xiang Lin Liwei Lu | 2022 | Cellular & Molecular Immunology2022，19，12： | 1 |
| 8 | Simulation modeling of nuclear steam generator water level process-a case study 显示文摘 | ZHAO Futao OU Jing DU Wei | 2000 | ISA Transactions2000，39，： | 1 |
| 9 | Simulation modeling of nuclear steam generator water level process: A case study显示文摘 | ZHAO Futao OU Jing DU Wei | 2000 | ISA Transactions2000，39，2： | 1 |
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