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| 1 | Th22细胞在自身免疫性疾病中的研究进展显示文摘Th22细胞是一种新发现的CD4^(+)Th细胞亚群。T淋巴细胞是人体免疫系统的重要组成部分,可进一步分为CD4^(+)T细胞和CD8^(+)T细胞。根据功能、表面标志物和分泌的效应分子,CD4^(+)T细胞,也称为T辅助(Th)细胞,主要包括Th1、Th2、Th9、Th17、Th22、调节性T(Treg)细胞和滤泡辅助T(Tfh)细胞等^([1])。对于Th22细胞的认识主要来源于对IL-22的研究。 | 杨雅淋 赵卫卫 李静 冯景 | 2022 | 湖北医药学院学报2022，41，6： | 1 |
| 2 | Epigenetic regulation of B cells and its role in autoimmune pathogenesis显示文摘B cells play a pivotal role in the pathogenesis of autoimmune diseases.Although previous studies have shown many genetic polymorphisms associated with B-cell activation in patients with various autoimmune disorders,progress in epigenetic research has revealed new mechanisms leading to B-cell hyperactivation.Epigenetic mechanisms,including those involving histone modifications,DNA methylation,and noncoding RNAs,regulate B-cell responses,and their dysregulation can contribute to the pathogenesis of autoimmune diseases.Patients with autoimmune diseases show epigenetic alterations that lead to the initiation and perpetuation of autoimmune inflammation.Moreover,many clinical and animal model studies have shown the promising potential of epigenetic therapies for patients.In this review,we present an up-to-date overview of epigenetic mechanisms with a focus on their roles in regulating functional B-cell subsets.Furthermore,we discuss epigenetic dysregulation in B cells and highlight its contribution to the development of autoimmune diseases.Based on clinical and preclinical evidence,we discuss novel epigenetic biomarkers and therapies for patients with autoimmune disorders. | Fan Xiao Ke Rui Xiaofei Shi Haijing Wu Xiaoyan Cai Kathy O.Lui Qianjin Lu Esteban Ballestar Jie Tian Hejian Zou Liwei Lu | 2022 | Cellular & Molecular Immunology2022，19，11： | 0 |
| 3 | Artesunate suppresses Th17 response via inhibiting IRF4-mediated glycolysis and ameliorates Sjogren's syndrome显示文摘Dear Editor,Primary Sjogren's syndrome(pSS)is an autoimmune disease characterized by dry eyes and dry mouth caused by glandular inflammation in salivary glands(SG)and lacrimal glands.Currently,pSS patients are suffering from a lack of effective therapies.Many studies have revealed dysregulated immune responses during pSS development,in which Th17 cells are considered as the key driver in disease initiation and perpetuation. | Fan Xiao Ke Rui Man Han Liyun Zou Enyu Huang Jie Tian Lijun Zhang Quan Jiang Yuzhang Wu Liwei Lu | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 0 |
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