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| 1 | Levels of synthetic musk fragrances in human milk from three cities in the Yangtze River Delta in Eastern China显示文摘Synthetic musks are used as additives in many household products.After absorption into the human body,they accumulate and their concentrations in human milk reflect both the mother and her infant's exposure level.Concentrations of four synthetic musks,musk xylene(1-tert-butyl-2,6-dimethyl-2,4,6-trinitrobenzene,MX),musk ketone(4-tert-butyl-2,6-dimethyl-3,5-dinitroacetophenone,MK),1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[γ]-2-benzopyran(HHCB) and 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4tetrahydronaphthalene(AHTN),were determined in human milk samples collected from Shanghai,Wuxi,and Shaoxing in Eastern China.The four synthetic musks were found in most samples analyzed,with HHCB the dominant component followed by MX.The median(mean) values for HHCB,AHTN,MX and MK concentrations were 63(82),5(12),17(24) and 4(9) ng/g lipid weight,respectively.These data suggested the total synthetic musk contamination was low,and the distribution percentage was HHCB > MX > AHTN ≈ MK.The relative high ratio of nitro to polycylic musk indicated that nitro musks were still widely used.The musk concentrations in these cities were not significantly different from each other(p > 0.05).Principal components score plots were obtained,which showed similar exposure sources.The amount of total synthetic musks in human milk were not associated with mother's age,although HHCB was significantly correlated with AHTN(p < 0.05).Daily ingestion of HHCB,AHTN,MX and MK for infants from human milk were estimated as(2526 ± 2926),(370 ± 524),(7391 ± 832),and(277 ± 462) ng/day,respectively.Those doses were 1-2 orders of magnitude below the provisional tolerable daily intakes. | Xiaolan Zhang Gaofeng Liang Xiangying Zeng Jing Zhou Guoying Sheng Jiamo Fu | 2011 | Journal of Environmental Sciences2011，23，6： | 8 |
| 2 | A Predictive 6G Network with Environment Sensing Enhancement:From Radio Wave Propagation Perspective显示文摘In order to support the future digital society,sixth generation(6G)network faces the challenge to work efficiently and flexibly in a wider range of scenarios.The traditional way of system design is to sequentially get the electromagnetic wave propagation model of typical scenarios firstly and then do the network design by simulation offline,which obviously leads to a 6G network lacking of adaptation to dynamic environments.Recently,with the aid of sensing enhancement,more environment information can be obtained.Based on this,from radio wave propagation perspective,we propose a predictive 6G network with environment sensing enhancement,the electromagnetic wave propagation characteristics prediction enabled network(EWave Net),to further release the potential of 6G.To this end,a prediction plane is created to sense,predict and utilize the physical environment information in EWave Net to realize the electromagnetic wave propagation characteristics prediction timely.A two-level closed feedback workflow is also designed to enhance the sensing and prediction ability for EWave Net.Several promising application cases of EWave Net are analyzed and the open issues to achieve this goal are addressed finally. | Gaofeng Nie Jianhua Zhang Yuxiang Zhang Li Yu Zhen Zhang Yutong Sun Lei Tian Qixing Wang Liang Xia | 2022 | China Communications2022，19，6： | 4 |
| 3 | Silicon-enhanced resistance to cadmium toxicity in Brassica chinensis L. is attributed to Si-suppressed cadmium uptake and transport and Si-enhanced antioxidant defense capacity显示文摘 | Alin Song Zhaojun Li Jie Zhang Gaofeng Xue Fenliang Fan Yongchao Liang | 2009 | Journal of Hazardous Materials2009，，1： | 1 |
| 4 | Preoperative diagnosis and staging of rectal cancer using diffusion?weightedand water imaging combined with dynamic contrast?enhanced scanning显示文摘 | Qili Zhao Lijian Liu Qiuyan Wang Zexia Liang Gaofeng Shi | 2014 | Oncology Letters2014，，： | 1 |
| 5 | Silicon-enhanced resistance to rice blast is attributed to silicon-mediated defence resistance and its role as physical barrier显示文摘 | Wanchun Sun Jie Zhang Qionghua Fan Gaofeng Xue Zhaojun Li Yongchao Liang | 2010 | European Journal of Plant Pathology2010，，1： | 1 |
| 6 | Epidemic prevalence on random mobile dynamical networks: individual het- erogeneity and correlation显示文摘 | Li Xiang Cao Liang Cao Gaofeng | 2010 | The European Physical Journal B2010，75，： | 1 |
| 7 | Terahertz metalens of hyper-dispersion显示文摘Chromatic optical lenses have promising applications in three-dimensional imaging, which allows fast spectral tomography without mechanical moving parts. The scanning range of current chromatic optical lenses is limited by their dispersion ability. The recent development in metasurfaces provides ideal blocks for optical wavefront manipulation and dispersion engineering of artificial materials at sub-wavelength scales. Hyper-dispersive metalenses can be realized by utilizing dispersive meta-atoms, which have enhanced dispersion compared to regular diffractive lenses. This is critical for increasing the imaging depth of fast spectral tomography. In this work, a hyper-dispersive metalens is realized with a chromatic dispersion 1.76 times greater than that of a regular diffractive metalens in the THz frequency range of 2.40–2.61 THz by simultaneously controlling the frequencydependent phase, group delay(GD), and GD dispersion of the metalens. This approach can also be extended to other optical spectra and improve the performance of spectral tomography. | Fen Zhao Ziping Li Sheng Li Xuemei Dai Yi Zhou Xiaoyu Liao JCCao Gaofeng Liang Zhengguo Shang Zhihai Zhang Zhongquan Wen Hua Li Gang Chen | 2022 | Photonics Research2022，10，4： | 1 |
| 8 | Deep space multi-file delivery protocol based on LT codes显示文摘A deep space multi-file delivery protocol(DSMDP) based on LT codes is proposed to reduce the influence of long delay and a high bit error rate(BER) in deep space communication. The protocol increases sending redundancy by LT codes to improve the success rate of file delivery, and adopts different protective strategies for different situations of packet loss. At the same time, the multi-file united delivery strategy is adopted to make full use of the retransmission time to reduce the end-toend transmission delay. Furthermore, the protocol determines the quantity of encoded packets according to the feedback for controlling redundancy. The simulation results show that the proposed protocol can significantly reduce the transmission delay of files, which would be effectively suitable for deep space communication environment of high BER and long delay. | Ruyan Wang Hua Liang Hui Zhao Gaofeng Fang | 2016 | Journal of Systems Engineering and Electronics2016，27，3： | 0 |
| 9 | Highly controlled structured catalysts for on-board methanol reforming显示文摘The on-board methanol steam reforming(MSR) has long been considered as an effective approach to insitu produce hydrogen for fuel cell vehicles(FCVs). However, the conventional MSR catalyst pellets suffer from easy breakage during the vehicle movement, leading to increased pressure drop and reduced system stability. Herein, we introduce an integrated method to prepare the highly controlled structured catalysts based on coupled processes: direct prototyping the structured substrate using digital light processing(DLP) 3D printing technology, in-situ dynamic crystallization of active components assisted by magnetic resonance imaging(MRI) and calcination. The synthesized catalyst owns a gradient layer of active component, and exhibits better MSR performance, higher mechanical strength, reduced pressure drop, higher Cu dispersion and better adhesion of active compounds when compared with the conventional powder and pellet catalysts. The demonstrated successful application proves the feasibility of developed method,which has great potential to be used for preparing precisely other monolithic catalysts with customized structures. | Zhuangdian Liang Gang Wang Gaofeng Zeng Jie Zhang Zhiyong Tang | 2022 | Journal of Energy Chemistry2022，31，5： | 0 |
| 10 | Neutrophil membrane-camouflaged nanoparticles alleviate inflammation and promote angiogenesis in ischemic myocardial injury显示文摘Acute myocardial infarction(AMI)induces a sterile inflammatory response,leading to cardiomyocyte damage and adverse cardiac remodeling.Interleukin-5(IL-5)plays an essential role in developing eosinophils(EOS),which are beneficial for the resolution of inflammation.Furthermore,the proangiogenic properties of IL-5 also contribute to tissue healing following injury.Therefore,targeted delivery of IL-5 is an innovative therapeutic approach for treating AMI.It has been shown that conventional IL-5 delivery can result in undesirable adverse effects and potential drug overdose.In this study,we successfully synthesized a biomimetic IL-5 nanoparticle by camouflaging the IL-5 nanoparticle in a neutrophilic membrane.The administration of neutrophil membrane-camouflaged nanoparticles(NM-NPIL-5)in the in vivo model showed that these nanoparticles promoted EOS accumulation and angiogenesis in the infarcted myocardium,thereby limiting adverse cardiac remodeling after AMI.Our results also demonstrated that the NM-NPIL-5 could serve as neutrophil“decoys”to adsorb and neutralize the elevated neutrophil-related cytokines in the injured heart by inheriting multiple receptors from their“parent”neutrophils.Finally,the targeted delivery of NM-NPIL-5 protected the cardiomyocytes from excessive inflammatory-induced apoptosis and maintained cardiac function.Our findings provided a promising cardiac detoxification agent for acute cardiac injury. | Dongjian Han Fuhang Wang Zhentao Qiao Bo Wang Yi Zhang Qingjiao Jiang Miaomiao Liu Yuansong Zhuang Quanxu An Yan Bai Jiahong Shangguan Jinying Zhang Gaofeng Liang Deliang Shen | 2023 | Bioactive Materials2023，，5： | 0 |
| 11 | Low rumen degradable starch promotes the growth performance of goats by increasing protein synthesis in skeletal muscle via the AMPK-mTOR pathway显示文摘Since starch digestion in the small intestine provides more energy than digestion in the rumen of ru-minants,reducing dietary rumen degradable starch(RDS)content is beneficial for improving energy utilization of starch in ruminants.The present study tested whether the reduction of rumen degradable starch by restricting dietary corn processing for growing goats could improve growth performance,and further investigated the possible underlying mechanism.In this study,twenty-four 12-wk-old goats were selected and randomly allocated to receive either a high RDS diet(HRDS,crushed corn-based concen-trate,the mean of particle sizes of corn grain=1.64 mm,n=12)or a low RDS diet(LRDS,non-processed corn-based concentrate,the mean of particle sizes of corn grain>8 mm,n=12).Growth performance,carcass traits,plasma biochemical indices,gene expression of glucose and amino acid transporters,and protein expression of the AMPK-mTOR pathway were measured.Compared to the HRDS,LRDS tended to increase the average daily gain(ADG,P=0.054)and decreased the feed-to-gain ratio(F/G,P<0.05).Furthermore,LRDS increased the net lean tissue rate(P<0.01),protein content(P<0.05)and total free amino acids(P<0.05)in the biceps femoris(BF)muscle of goats.LRDS increased the glucose concen-tration(P<0.01),but reduced total amino acid concentration(P<0.05)and tended to reduce blood urea nitrogen(BUN)concentration(P=0.062)in plasma of goats.The mRNA expression of insulin receptors(INSR),glucose transporter 4(GLUT4),L-type amino acid transporter 1(LAT1)and 4F2 heavy chain(4F2hc)in BF muscle,and sodium-glucose cotransporters 1(SGLT1)and glucose transporter 2(GLUT2)in the small intestine were significantly increased(P<0.05)in LRDS goats.LRDS also led to marked activation of p70-S6 kinase(S6K)(P<0.05),but lower activation of AMP-activated protein kinase(AMPK)(P<0.05)and eukaryotic initiation factor 2a(P<0.01).Our findings suggested that reducing the content of dietary RDS enhanced postruminal starch digestion and increased plasma glucose,thereby improving amino acid utilization and promoting protein synthesis in the skeletal muscle of goats via the AMPK-mTOR pathway.These changes may contribute to improvement in growth performance and carcass traits in LRDS goats. | Ziqi Liang Chunjia Jin Hanxun Bai Gaofeng Liang Xiaodong Su Dangdang Wang Junhu Yao | 2023 | Animal Nutrition2023，，2： | 0 |
| 12 | Flat-field superoscillation metalens显示文摘Superoscillation metalenses have demonstrated promising prospects in breaking the theoretical diffraction limitations on the resolution of optical devices and systems. However, most reported superoscillation metalenses have a very small field of view of several tenths of a degree, which greatly limits their applications in imaging and microscopy. Therefore, it is of critical importance to achieve absolute high resolution by increasing the numerical apertures(NAs) of optical devices and systems. Unfortunately, similar to the case in traditional optics, it is challenging to realize a large field of view at high NA, especially in the superoscillation regime. To date, no attempt has been made to achieve flat-field focusing in the superoscillation regime, to our knowledge. Here, we demonstrate a high-NA superoscillation metalens with an entrance aperture stop, which is optimized for superoscillation performance with a comparatively large field of view. The proposed flat-field superoscillation metalens has an effective NA as large as 0.89 and achieves superoscillation focusing within a field of view of 9°. Such a superoscillation metalens may offer a promising way toward superoscillation imaging and fast-scanning label-free farfield superoscillation microscopy. | DINGPENG LIAO FENGLIANG DONG KUN ZHANG YI ZHOU GAOFENG LIANG ZHIHAI ZHANG ZHONGQUAN WEN ZHENGGUO SHANG GANG CHEN LURU DAI WEIGUO CHU | 2022 | Photonics Research2022，10，8： | 0 |
| 13 | Mesoporous magnetic nanoparticles conjugated aptamers for exosomes capture and detection of Alzheimer’s disease显示文摘Exosomes are nanoscale membrane-enclosed extracellular vesicles secreted by various cells,which have enormous potential as disease biomarkers for clinical application.However,the isolation and detection of exosomes remain enormous challenges,which limits their further application.Herein,inspired by immunomagnetic beads,a magnetic nanoparticle conjugated aptamer was repurposed for the effective capture and detection of exosomes.The magnetic nanoparticles,composed of Fe 3 O 4 synthesized by the hydrothermal method as the core and coupled with gold nanoparticles(Fe 3 O 4@Au),provide a large specific surface area,making the resulting composite material an effective platform for exosome capture.Furthermore,the elution of captured exosomes with 1.0 M NaCl made downstream analysis of exosomes possible.The preliminary clinical application value of the composite in exosome analyses of serum from healthy individuals and patients with Alzheimer’s disease(AD)has also been verified,which could provide a promising platform for biomedical and clinical diagnosis. | Guidan Wang Zhenshan Pan Xiaorui Zhu Ruyue Yang Rong Yang Tingting Yang Dong Hu Aihua Jing Gaofeng Liang | 2023 | Engineered Regeneration2023，4，4： | 0 |
| 14 | Biomimetic extracellular vesicles for the tumor targeted treatment显示文摘Extracellular vesicles(EVs)are nanoscale substances produced by most cells,which were not fully understood in the early years.However,with the development of advanced techniques,researchers have discovered that EVs play an essential role in information exchange and signal transduction between cells.Nowadays,EVs are being used,modified,and developed as a natural drug carrier in various medical fields because of their high biocompatibility and natural affinity with the source body.Many studies have shown that multiple sources of EVs have been modified and utilized in cancer therapy to improve patients’treatment windows and effectively prolong patient survival.In this paper,we review the advances in the treatment of cancer based on EVs.We summarize the types of EVs loading therapy,the modes of drug loading and the latest therapeutic applications of multiple modes combined with EVs in cancer treatment.We conclude with a discussion of the current status,challenges,and prospects of EVs as a tool for tumor therapy. | Ruolin Shi An Zhan Xinze Li Bin Kong Gaofeng Liang | 2023 | Engineered Regeneration2023，4，4： | 0 |
| 15 | Secure analysis over generalized-K channels显示文摘Dear editor,The secrecy outage probability(SOP)is used to estimate the secrecy outage performance when the transmitter has no state information about potential wiretap channels[1],i.e.,silent eavesdropping.Most previous work,such as[2,3],has focused on the SOP defined in[1],which we call the conventional SOP in this study,where both unreliable transmission from the transmitter to the legitimate receiver(i.e.,outage)and information leakage to eavesdroppers are considered to be secrecy outage.Thus,according to the conventional SOP definition,a secrecy outage does not necessarily imply that any information has been leaked to eavesdroppers.To capture the actual information leakage,Ref.[4]proposed a new SOP definition,which we call the proposed SOP in this study,that is exactly the information leakage probability.However,they only considered the SOP over Rayleigh fading channels,a simple small-scale channel model.In actual wireless communications scenarios,shadowing is typically involved,resulting in large-scale fading[5]. | Luyao ZHANG Hui ZHAO Gaofeng PAN Liang YANG Jiawei CHEN | 2020 | Science China(Information Sciences)2020，63，4： | 0 |
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