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| 1 | Non invasive blood flow measurement in cerebellum detects minimal hepatic encephalopathy earlier than psychometric tests显示文摘AIM: To assess whether non invasive blood flow measurement by arterial spin labeling in several brain regions detects minimal hepatic encephalopathy. METHODS: Blood flow(BF) was analyzed by arterial spin labeling(ASL) in different brain areas of 14 controls, 24 cirrhotic patients without and 16 cirrhotic patients with minimal hepatic encephalopathy(MHE). Images were collected using a 3 Tesla MR scanner(Achieva 3T-TX, Philips, Netherlands). Pulsed ASL was performed. Patients showing MHE were detected using the battery Psychometric Hepatic Encephalopathy Score(PHES) consisting of five tests. Different cognitive and motor functions were also assessed: alterations in selective attention were evaluated using the Stroop test. Patients and controls also performed visuo-motor and bimanual coordination tests. Several biochemical parameters were measured: serum pro-inflammatory interleukins(IL-6 and IL-18), 3-nitrotyrosine, cGMP and nitrates+nitrites in plasma, and blood ammonia. Bivariate correlations were evaluated.RESULTS: In patients with MHE, BF was increased in cerebellar hemisphere(P = 0.03) and vermis(P = 0.012) and reduced in occipital lobe(P = 0.017). BF in cerebellar hemisphere was also increased in patients without MHE(P = 0.02). Bimanual coordination was impaired in patients without MHE(P = 0.05) and much more in patients with MHE(P < 0.0001). Visuo-motor coordination was impaired only in patients with MHE(P < 0.0001). Attention was slightly affected in patients without MHE and more strongly in patients with MHE(P< 0.0001). BF in cerebellar hemisphere and vermis correlated with performance in most tests of PHES [(number connection tests A(NCT-A), B(NCT-B)and line tracing test] and in the congruent task of Stroop test. BF in frontal lobe correlated with NCT-A. Performance in bimanual and visuomotor coordination tests correlated only with BF in cerebellar hemisphere. BF in occipital lobe correlates with performance in the PHES battery and with CFF. BF in cerebellar hemisphere correlates with plasma cGMP and nitric oxide(NO) metabolites. BF in vermis cerebellar also correlates with NO metabolites and with 3-nitrotyrosine. IL-18 in plasma correlates with BF in thalamus and occipital lobe.CONCLUSION: Non invasive BF determination in cerebellum using ASL may detect MHE earlier than the PHES. Altered NO-cGMP pathway seems to be associated to altered BF in cerebellum. | Vicente Felipo Amparo Urios Carla Giménez-Garzó Omar Cauli Maria-Jesús Andrés-Costa Olga González Miguel A Serra Javier Sánchez-González Roberto Aliaga Remedios Giner-Durán Vicente Belloch Carmina Montoliu | 2014 | World Journal of Gastroenterology2014，20，33： | 12 |
| 2 | Protective effect of Bifidobacterium pseudocatenulatum CECT 7765 against induced bacterial antigen translocation in experimental cirrhosis显示文摘 | Alba Moratalla Isabel Gómez‐Hurtado Arlette Santacruz ángela Moya Gloria Peiró Pedro Zapater José M. González‐Navajas Paula Giménez José Such Yolanda Sanz Rubén Francés | 2014 | Liver Int2014，，6： | 2 |
| 3 | Effects of substrate temperature on properties of ITO-ZnO composition spread films fabricated by combinatorial RF magnetron sputtering显示文摘 | Heo G S Gim I G Park J W | 2009 | J Solid State Chem2009，182，10： | 1 |
| 4 | A two-dimen- sional tire model on uneven roads for vehicle dynamic simulation 1 显示文摘 | KIM S NIKRAVESH P E GIM G | 2008 | Vehicle System Dynamics2008，46，10： | 1 |
| 5 | Recombinant mussel adhesive protein Mgfp-5 as cell adhesion biomaterial 显示文摘 | Hwang D S Gim Y Kang D G | 2007 | J Biotechnol2007，127，4： | 1 |
| 6 | Effects of substrate temperature on properties of ITO-Zn O composition spread films fabricated by combinatorial RF magnetron sputtering显示文摘 | Heo G S Gim I G Park J W | 2009 | J Solid State Chem2009，182，10： | 1 |
| 7 | Expression of functional recombinant mussel adhesive protein type 3A in Escherichia coli 显示文摘 | Hwang D S Gim Y Cha H J | 2005 | Biotechnol Prog2005，21，3： | 1 |
| 8 | Meige's syndrome:Acute and chronic responses to clonazepan and anticholinergics显示文摘 | Hípola D Mateo D Giménez-Roldán S | 1984 | Eur Neurol1984，23，6： | 1 |
| 9 | Practical recombinant hybrid mussel bioadhesive fp-151 显示文摘 | Hwang D S Gim Y Yoo H J | 2007 | Biomatcrials2007，28，24： | 1 |
| 10 | Deposition of amorphous zinc indium tin oxide and indium tin oxide films on flexible poly(ether sulfone) substrate using RF magnetron co-sputtering system显示文摘 | Heo G S Matsumoto Y Gim I G | 2010 | Japanese Journal of Applied Physics2010，49，03： | 1 |
| 11 | Effects of S-adenosylmethionine on lipid peroxidation and liver fibrogenesis in carbon tetrachloride-induced cirrhosis显示文摘 | Marta Gassó Mireia Rubio Gregorio Varela María Cabré Joan Caballería Elena Alonso Ramón Deulofem Jordi Camps América Giménez María Pajares Albert Parés José M. Mato Joan Rodés | 1996 | Journal of Hepatology1996，，2： | 1 |
| 12 | Reperfusion syndrome:cellular mechanisms of microvascular dysfunction and potential therapeutic strategies显示文摘 | Gim HR Ahilathirunayagam S | 2007 | Vasc Endovascular Surg J2007，41，4： | 1 |
| 13 | The Muhifunctionality of Paddy Fanning in Korea 显示文摘 | Kim T C Gim U S Kim J S | 2006 | Paddy and Water Environment2006，4，4： | 1 |
| 14 | Metallic Conductivity in a Polyoxovanadate Salt of Bis-(ethylenedithio)tetrathiafulvalene(BEDT-TTF):Synthesis,Structure,and Physical Characterizat-ion of β-(BEDT-TTF)5- ·4H2O显示文摘 | CORONADO E GAL(A)N-MASCAR(O)S J R GIM(E)NEZ-SAIZ C | 2004 | Adv Mater2004，16，： | 1 |
| 15 | 查看详情显示文摘 | Samadpour M Boix P.P Giménez S Iraji Z.A. Taghavinia N. Mora-Ser6 I.N. Bisquert J | | 0，，： | 1 |
| 16 | Microstructural characterization of vacuum sintered T42 powder metallurgy high-speed steel after heat treatments 显示文摘 | Trabadelo V Gim S | 2009 | Materials Science and Engineering2009，499，12： | 1 |
| 17 | Role of mitogen-activated protein kinase (MAPK) in thesporadic renal cell carcinoma显示文摘 | Salinas-S 6 nchez A S Gim e nez-Bachs J M Serrano-OviedoL | 2012 | Actas urologicas espano丨as2012，36，2： | 1 |
| 18 | Mecha-nisms of prodigiosin cytotoxicity in human neuroblastoma cell lines显示文摘 | FRANCISCO R PREZ-TOMS R GIMNEZ-BONAFP | 2007 | European Journal of Pharmacology2007，572，23： | 1 |
| 19 | Ferulic acid regulates the AKT/GSK-313/CRMP-2 signaling pathway in a middle cerebral artery occlusion animal model 显示文摘 | Gim S A Sung J H Shah F A | 2013 | Lab Anim Res2013，29，2： | 1 |
| 20 | Photocatalytic degradation of non-steroidal antiinflammatory drugs with Ti O2and simulated solar irradiation显示文摘 | M\NDEZ-ARRIAGA F ESPLUGAS S GIMNEZ J | 2008 | Water Research2008，42，3： | 1 |
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