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| 1 | Remimazolam benzenesulfonate anesthesia effectiveness in cardiac surgery patients under general anesthesia显示文摘BACKGROUND Sedation with propofol injections is associated with a risk of addiction,but remimazolam benzenesulfonate is a comparable anesthetic with a short elimination half-life and independence from cell P450 enzyme metabolism.Compared to remimazolam,remimazolam benzenesulfonate has a faster effect,is more quickly metabolized,produces inactive metabolites and has weak drug interactions.Thus,remimazolam benzenesulfonate has good effectiveness and safety for diagnostic and operational sedation.AIM To investigate the clinical value of remimazolam benzenesulfonate in cardiac surgery patients under general anesthesia.METHODS A total of 80 patients who underwent surgery in the Department of Cardiothoracic Surgery from August 2020 to April 2021 were included in the study.Using a random number table,patients were divided into two anesthesia induction groups of 40 patients each:remimazolam(0.3 mg/kg remimazolam benzenesulfonate)and propofol(1.5 mg/kg propofol).Hemodynamic parameters,inflammatory stress response indices,respiratory function indices,perioperative indices and adverse reactions in the two groups were monitored over time for comparison.RESULTS At pre-anesthesia induction,the remimazolam and propofol groups did not differ regarding heart rate,mean arterial pressure,cardiac index or volume per wave index.After endotracheal intubation and when the sternum was cut off,mean arterial pressure and volume per wave index were significantly higher in the remimazolam group than in the propofol group(P<0.05).After endotracheal intubation,the oxygenation index and the respiratory index did not differ between the groups.After endotracheal intubation and when the sternum was cut off,the oxygenation index values were significantly higher in the remimazolam group than in the propofol group(P<0.05).Serum interleukin-6 and tumor necrosis factor-αlevels 12 h after surgery were significantly higher than before surgery in both groups(P<0.05).The observation indices were re-examined 2 h after surgery,and the epinephrine,cortisol and blood glucose levels were significantly higher in the remimazolam group than in the propofol group(P<0.05).The recovery and extubation times were significantly lower in the remimazolam group than in the propofol group(P<0.05);there were significantly fewer adverse reactions in the remimazolam group(10.00%)than in the propofol group(30.00%;P<0.05).CONCLUSION Compared with propofol,remimazolam benzenesulfonate benefited cardiac surgery patients under general anesthesia by reducing hemodynamic fluctuations.Remimazolam benzenesulfonate influenced the surgical stress response and respiratory function,thereby reducing anesthesia-related adverse reactions. | Fang Tang Jian-Min Yi Hong-Yan Gong Zi-Yun Lu Jie Chen Bei Fang Chen Chen Zhi-Yi Liu | 2021 | World Journal of Clinical Cases2021，9，34： | 19 |
| 2 | A Trusted Attestation Mechanism for the Sensing Nodes of Internet of Things Based on Dynamic Trusted Measurement显示文摘Internet of things has been widely applied to industrial control, smart city and environmental protection, in these application scenarios, sensing node needs to make real-time response to the feedback control of the application layer. Therefore, it is necessary to monitor whether or not awareness nodes are trusted in real time, but the existing mechanisms for trusted certification lack the real-time measurement and tracking of the sensing node. To solve the above problems,this paper proposes a dynamic metric based authentication mechanism for sensing nodes of Internet of things. Firstly, the dynamic trustworthiness measure of the sensing nodes is carried out by introducing the computational function such as the trust function, the trustworthiness risk assessment function, the feedback control function and the active function of the sensing node. The dynamic trustworthiness measure of sensing nodes from multiple dimensions can effectively describe the change of trusted value of sensing nodes. Then, on the basis of this, a trusted attestation based on node trusted measure is realized by using the revocable group signature mechanism of local verifier. The mechanism has anonymity, unforgeability and traceability, which is proved the security in the standard model. Simulationexperiments show that the proposed trusted attestation mechanism is flexible, practical and efficient and has better attack resistance. It can effectively guarantee the reliable data transmission of nodes and realize the dynamic tracking of node reliability, which has a lower impact on system performance. | Bei Gong Yubo Wang Xiangang Liu Fazhi Qi Zhihui Sun | 2018 | China Communications2018，15，2： | 10 |
| 3 | Human fused NKG2D-IL-15 protein controls xenografted human gastric cancer through the recruitment and activation of NK cells显示文摘Interleukin (IL )-15 在生来的杀手(NK ) 和 CD8+T 房间增长和功能起一个重要作用并且是比为肿瘤免疫疗法的 IL-2 更有效的。由附近的房间的 IL-15 的 trans 演讲比它的可溶的 IL-15 为 NK 房间激活是更有效的。在这研究,熔化蛋白质 dsNKG2D-IL-15,由经由一个连接器联合到人的 IL-15 的人的 NKG2D 的二相同的细胞外的域组成了,在 Escherichia coli 被设计。DsNKG2D-IL-15 能高效地与二个 NKG2D 领域和 trans 礼品 IL-15 把人的肿瘤房间的链相关的蛋白质 A (云母) 绑在主要 histocompatibility 建筑群一级到 NK 或 CD8+ T 房间。我们移植了人的胃的癌症(SGC-7901 ) 房间进裸体老鼠和有进 C57BL/6 老鼠的云母(B16BL6 云母) 的宫外的表示的老鼠黑瘤房间。然后,我们学习了反肿瘤效果在二个 xenografted 肿瘤模特儿由 dsNKG2D-IL-15 调停了。人的 dsNKG2D-IL-15 在压制胃的癌症生长比 IL-15 展出了更高的效率。外长的人的 dsNKG2D-IL-15 集中地在老鼠肿瘤纸巾被散布基于在 vivo 实时成像。房间渗入了进跟随外部血 mononuclear 房间的注射进忍受人的胃的癌症的裸体老鼠的肿瘤纸巾的人的 CD56+ 的频率被人的 dsNKG2D-IL-15 治疗显著地增加。人的 dsNKG2D-IL-15 也由激活和招募的老鼠 NK 和 CD8+ T 房间推迟了移植黑瘤(B16BL6 云母) 的生长。在 C57BL/6 老鼠的人的 dsNKG2D-IL-15 的反黑瘤效果主要被减少由在里面老鼠 NK 房间的 vivo 弄空。这些数据热点为肿瘤的人的 dsNKG2D-IL-15 的潜在的使用治疗。 | Yan Chen Bei Chen Ti Yang Weiming Xiao Li Qian Yanbing Ding Mingchun Ji Xiaoqun Ge Weijuan Gong | 2017 | Cellular & Molecular Immunology2017，14，3： | 6 |
| 4 | Design,synthesis and antiproliferative activities of diaryl urea derivatives bearing N-acylhydrazone moiety显示文摘A new series of diaryl urea derivatives bearing N-acylhydrazone moiety were designed and synthesized.All the target compounds were evaluated for their antiproliferative activities against human leukemia cell line(HL-60),human lung adenocarcinoma epithelial cell line(A549) and human breast cancer cell line(MDA-MB-231) in vitro by standard MTT assay.The pharmacological results indicated that some compounds exhibited promising antitumor activities.Compound 1j showed the most potent antiproliferative activity against the tested three cell lines with IC values of 0.13 mmol/L,0.7 mmol/L and 0.5 mmol/L,respectively. | Bei Zhang Yan Fang Zhao Xin Zhai Wei Jie Fan Jun Ling Ren Chun Fu Wu Ping Gong | 2012 | Chinese Chemical Letters2012，23，8： | 6 |
| 5 | Behavior Measurement Model Based on Prediction and Control of Trusted Network显示文摘In order to construct the trusted network and realize the trust of network behavior,a new multi-dimensional behavior measurement model based on prediction and control is presented.By using behavior predictive equation,individual similarity function,group similarity function,direct trust assessment function,and generalized predictive control,this model can guarantee the trust of an end user and users in its network.Compared with traditional measurement model,the model considers different characteristics of various networks.The trusted measurement policies established according to different network environments have better adaptability.By constructing trusted group,the threats to trusted group will be reduced greatly.Utilizing trusted group to restrict individuals in network can ensure the fault tolerance of trustworthiness of trusted individuals and group.The simulation shows that this scheme can support behavior measurement more efficiently than traditional ones and the model resists viruses and Trojans more efficiently than older ones. | Gong Bei Zhang Jianbiao Shen Changxiang Zhang Xing | 2012 | China Communications2012，9，5： | 5 |
| 6 | Scheme on Cross-Domain Identity Authentication Based on Group Signature for Cloud Computing显示文摘In the cloud computing, different cloud service providers are often in different trust domains. As the traditional identity authentication mode cannot be applied to the cloud computing, the cross-domain identity authentication mechanism is needed to solve the identity authentication problem in the cloud computing. In view of the security problems in cloud computing, a cross-domain identity authentication scheme based on group signature is proposed. This scheme introduces a group of cloud service providers and users who are located in different trust domains. Any member of the group can generate the signature on behalf of the whole group, making the user access the cloud service provider in the case of privacy security. At the same time, with traceability it can track illegal operation of illegal users. In addition, the scheme uses the Chinese Remainder Theorem to integrate the message, and it can control the length of the data in the calculation process, simplifying the calculation process. It also realizes the join and revocation of group members without changing the key of other legitimate group members, and the maintenance cost of authentication schemes is low. The results show that the scheme has the advantages of anonymity, anti-counterfeit, traceability, anti-joint attack and so on. It can not only realize tracking function under the condition of guaranteeing user's privacy, but can also simplify the authentication calculation process to improve the efficiency of the cross domain identity authentication, and its performance is more suitable for large-scale cloud computing environment. | YANG Yanyan HU Mingsheng KONG Shan GONG Bei LIU Xinxin | 2019 | Wuhan University Journal of Natural Sciences2019，24，2： | 3 |
| 7 | EEG Source Localization Using Spatio-Temporal Neural Network显示文摘Source localization of focal electrical activity from scalp electroencephalogram (sEEG) signal is generally modeled as an inverse problem that is highly ill-posed. In this paper, a novel source localization method is proposed to model the EEG inverse problem using spatio-temporal long-short term memory recurrent neural networks (LSTM). The network model consists of two parts, sEEG encoding and source decoding, to model the sEEG signal and receive the regression of source location. As there does not exist enough annotated sEEG signals correspond to specific source locations, simulated data is generated with forward model using finite element method (FEM) to act as a part of training signals. A framework for source localization is proposed to estimate the source position based on simulated training data. Experiments are done on simulated testing data. The results on simulated data exhibit good robustness on noise signal, and the proposed network solves the EEG inverse problem with spatio-temporal deep network. The result show that the proposed method overcomes the highly ill-posed linear inverse problem with data driven learning. | Song Cui Lijuan Duan Bei Gong Yuanhua Qiao Fan Xu Juncheng Chen Changming Wang | 2019 | China Communications2019，16，7： | 3 |
| 8 | A Trusted Measurement Scheme Suitable for the Clients in the Trusted Network显示文摘The trusted network connection is a hot spot in trusted computing field and the trust measurement and access control technology are used to deal with network security threats in trusted network.But the trusted network connection lacks fine-grained states and real-time measurement support for the client and the authentication mechanism is difficult to apply in the trusted network connection,it is easy to cause the loss of identity privacy.In order to solve the abovedescribed problems,this paper presents a trust measurement scheme suitable for clients in the trusted network,the scheme integrates the following attributes such as authentication mechanism,state measurement,and real-time state measurement and so on,and based on the authentication mechanism and the initial state measurement,the scheme uses the realtime state measurement as the core method to complete the trust measurement for the client.This scheme presented in this paper supports both static and dynamic measurements.Overall,the characteristics of this scheme such as fine granularity,dynamic,real-time state measurement make it possible to make more fine-grained security policy and therefore it overcomes inadequacies existing in the current trusted network connection. | GONG Bei ZHANG Jianbiao YE Xiaolie SHEN Changxiang | 2014 | China Communications2014，11，4： | 3 |
| 9 | ACE2-independent infection of T lymphocytes by SARS-CoV-2显示文摘SARS-CoV-2 induced marked lymphopenia in severe patients with COVID-19.However,whether lymphocytes are targets of viral infection is yet to be determined,although SARS-CoV-2 RNA or antigen has been identified in T cells from patients.Here,we confirmed that SARS-CoV-2 viral antigen could be detected in patient peripheral blood cells(PBCs)or postmortem lung T cells,and the infectious virus could also be detected from viral antigen-positive PBCs.We next prove that SARS-CoV-2 infects T lymphocytes,preferably activated CD4+T cells in vitro.Upon infection,viral RNA,subgenomic RNA,viral protein or viral particle can be detected in the T cells.Furthermore,we show that the infection is spike-ACE2/TMPRSS2-independent through using ACE2 knockdown or receptor blocking experiments.Next,we demonstrate that viral antigen-positive T cells from patient undergone pronounced apoptosis.In vitro infection of T cells induced cell death that is likely in mitochondria ROS-HIF-1a-dependent pathways.Finally,we demonstrated that LFA-1,the protein exclusively expresses in multiple leukocytes,is more likely the entry molecule that mediated SARS-CoV-2 infection in T cells,compared to a list of other known receptors.Collectively,this work confirmed a SARS-CoV-2 infection of T cells,in a spike-ACE2-independent manner,which shed novel insights into the underlying mechanisms of SARS-CoV2-induced lymphopenia in COVID-19 patients. | Xu-Rui Shen Rong Geng Qian Li Ying Chen Shu-Fen Li Qi Wang Juan Min Yong Yang Bei Li Ren-Di Jiang Xi Wang Xiao-Shuang Zheng Yan Zhu Jing-Kun Jia Xing-Lou Yang Mei-Qin Liu Qian-Chun Gong Yu-Lan Zhang Zhen-Qiong Guan Hui-Ling Li Zhen-Hua Zheng Zheng-Li Shi Hui-Lan Zhang Ke Peng Peng Zhou | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 2 |
| 10 | Bottleneck Analysis for Data Acquisition in High-Speed Network Traffic Monitoring显示文摘The increasing network throughput challenges the current network traffic monitor systems to have compatible high-performance data processing.The design of packet processing systems is guided by the requirements of high packet processing throughput.In this paper,we depict an in-depth research on the related techniques and an implementation of a high-performance data acquisition mechanism.Through the bottleneck analysis with the aid of queuing network model,several performance optimising methods,such as service rate increasing,queue removing and model simplification,are integrated.The experiment results indicate that this approach is capable of reducing the CPU utilization ratio while improving the efficiency of data acquisition in high-speed networks. | JIANG Wei TIAN Zhihong CAI Chao GONG Bei | 2014 | China Communications2014，11，1： | 2 |
| 11 | Reduced functional connectivity in early-stage drug-naive Parkinson’s disease: a resting-state fMRI study显示文摘 | ChunYan Luo Wei Song Qin Chen ZhenZhen Zheng Ke Chen Bei Cao Jing Yang JianPeng Li XiaoQi Huang QiYong Gong Hui-Fang Shang | 2014 | Neurobiology of Aging2014，，2： | 1 |
| 12 | Trust Attestation Mechanism for the Sensing Layer Nodes of Internet of Things显示文摘The main function of Internet of Things is to collect and transmit data.At present,the data transmission in Internet of Things lacks effective trust attestation mechanism and trust traceability mechanism of data source.To solve the above problems,a trust attestation mechanism for sensing layer nodes is presented.First a trusted group is established,and the node which is going to join the group needs to attest its identity and key attributes to the higher level node.Then the dynamic trust measurement value of the node can be obtained by measuring the node data transmission behavior.Finally the node encapsulates the key attributes and trust measurement value to use short message group signature to attest its trust to the challenger.This mechanism can measure the data sending and receiving behaviors of sensing nodes and track the data source,and it does not expose the privacy information of nodes and the sensing nodes can be traced effectively.The trust measurement for sensing nodes and verification is applicable to Internet of Things and the simulation experiment shows the trust attestation mechanism is flexible,practical and efficient.Besides,it can accurately and quickly identify the malicious nodes at the same time.The impact on the system performance is negligible. | WANG Yubo GONG Bei | 2017 | Wuhan University Journal of Natural Sciences2017，22，4： | 1 |
| 13 | Diurnal Temperature Range and Daily Emergency Room Admissions among the Elderly in Beijing,China显示文摘In recent years,more attentions have been paid to the association between climate change and human health.Increasing and more variable global surface temperature is one of the key climatic change factors which have been consistently reported about the effect on human health.So far,more | TENG Huai Jin ZHEN Shan WANG Min Zhen LI Bei YIN Ling LI Jing Xin WANG Shi Gong ZHOU Zhong Yu QIU Hong Yan LI Tan Shi | 2013 | Biomedical and Environmental Sciences2013，26，10： | 1 |
| 14 | A Low Power, Fully Integrated SiGe BiCMOS Baseband Circuitry for a Direct Conversion CMMB Tuner IC显示文摘 | GONG Zheng CHEN Bei HU Xueqing SHI Yin Fa Foster Dai | 2012 | Chinese Journal of Electronics2012，21，2： | 1 |
| 15 | Brain-like synaptic memristor based on lithiumdoped silicate for neuromorphic computing显示文摘Artificial synapse is one of the potential electronics for constructing neural network hardware.In this work,Pt/LiSiO_(x)/TiN analog artificial synapse memristor is designed and investigated.With the increase of compliance current(C.C.)under 0.6 mA,1 mA,and 3 mA,the current in the high resistance state(HRS)presents an increasing variation,which indicates lithium ions participates in the operation process for Pt/LiSiO_(x)/TiN memristor.Moreover,depending on the movement of lithium ions in the functional layer,the memristor illustrates excellent conduction modulation property,so the long-term potentiation(LTP)or depression(LTD)and paired-pulse facilitation(PPF)synaptic functions are successfully achieved.The neural network simulation for pattern recognition is proposed with the recognition accuracy of 91.4%.These findings suggest the potential application of the LiSiO_(x)memristor in the neuromorphic computing. | Shanwu Ke Li Jiang Yifan Zhao Yongyue Xiao Bei Jiang Gong Cheng Facai Wu Guangsen Cao Zehui Peng Min Zhu Cong Ye | 2022 | Frontiers of physics2022，17，5： | 1 |
| 16 | An Association Ring Signature for Block Chain E-Money Transactions显示文摘Block chain is widely used in the financial field for its characteristics of decentralization, anonymity and trust. Electronic money payment is an important application hotspot. Ring signature is widely used in strong anonymous authentication such as electronic cash and electronic voting because of its unconditional anonymity, spontaneity and flexible group structure. Among them, the correlation ring signature can prove whether two signatures are issued by the same person without revealing the identity of the real signer. Therefore, the signature right breach can be avoided based on the premise of guaranteeing anonymity, such as repeated voting, electronic money repetition cost and so on. Most of the existing correlation ring signature security is based on the discrete logarithm problem, and most of the schemes result in the degradation of anonymity because of strong association. These methods do not apply to the block chain electronic currency transaction scene with strong anonymity. Therefore, this paper first proposes a blockchain-based electronic currency transaction security model. The model ensures not only the anonymity of both parties but also a certain degree of traceability. In order to support these two characteristics, this paper proposes an association ring signature method based on large integer decomposition problem. This method has strong anonymity and can be applied to blockchain scenes. On the other hand, it can be converted into group signatures in specific scenarios. It is therefore traceable. Finally, the adaptive selection message of the scheme and the unforgeability under the selection of public key attack are proved under the random oracle model. | YANG Kai HU Mingsheng JIA Zhijuan GONG Bei ZHANG Xiaofei | 2019 | Wuhan University Journal of Natural Sciences2019，24，2： | 0 |
| 17 | The Intramolecular Coupling Reaction of 1,6-Bis(1-Alky1-2-Methylindol-3-yl)hexane-1,6-dione Induced by Low-valent Titanium显示文摘The intramolecular reductive coupling reaction of 1,6-bis(subshtuted indolyl)hexane-1,6-dione using zero-valent titanium reagent as catalyst proderes the novel photochromic 1,2-diheterocyclic cyclohexenes 2, together with unexpected compounds | Zhen Nian HUANG Sheng JIN Mei Gong FAN(State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, 2 Department ofChemistry, Peking University, Beijing 100871, 3. Institute of Photographic Chemistry, Academ Sciences Sinica Bei | 1997 | Chinese Chemical Letters1997，8，1： | 0 |
| 18 | The structure of phospholamban and its MD simulations显示文摘Phospholamban is an important protein with responsibility for regulating the activity of the sarcoplasmic reticulum Ca2+ pump through reversible phosphorylation.And its three-dimensional structure in living cell has been a focus of attention.In the current case, we summarized the investigations on phospholamban structure, and on this base, employed long time-scale molecular dy-namics simulations to study its structure systematically.The first 22 residues from one chain of phospholamban in bellflower structure determined by NMR experiments, together with its phosphorylation at position 16 and mutation at position 9 were picked up as three different systems.By molecular dynamics simulations of 10 ns in the explicit solution surroundings, it was found that the 3–15 residues of the original structure retained their helix structures, while the phosphorylation and mutation had less probability to form helix structures.These structural changes might result in inhibition decrease to the sarcoplasmic reticulum Ca2+ pump, which is in accordance with previous experimental results. | TANG Bei GONG Ke WANG JingFang LI YiXue WEI DongQing | 2010 | Chinese Science Bulletin2010，55，16： | 0 |
| 19 | Research on the Trusted Energy-Saving Transmission of Data Center Network显示文摘According to the high operating costs and a large number of energy waste in the current data center network architectures, we propose a kind of trusted flow preemption scheduling combining the energy-saving routing mechanism based on typical data center network architecture. The mechanism can make the network flow in its exclusive network link bandwidth and transmission path, which can improve the link utilization and the use of the network energy efficiency. Meanwhile, we apply trusted computing to guarantee the high security, high performance and high fault-tolerant routing forwarding service, which helps improving the average completion time of network flow. | Yubo Wang Bei Gong Mowei Gong | 2016 | China Communications2016，13，12： | 0 |
| 20 | Targeting small GTPases:emerging grasps on previously untamable targets.pioneered by KRAS显示文摘Small GTPases including Ras,Rho,Rab,Arf,and Ran are omnipresent molecular switches in regulating key cellular functions.Their dysregulation is a therapeutic target for tumors,neurodegeneration,cardiomyopathies,and infection.However,small GTPases have been historically recognized as“undruggable”.Targeting KRAS,one of the most frequently mutated oncogenes,has only come into reality in the last decade due to the development of breakthrough strategies such as fragment-based screening,covalent ligands,macromolecule inhibitors,and PROTACs.Two KRAS^(G12C)covalent inhibitors have obtained accelerated approval for treating KRAS^(G12C)mutant lung cancer,and allele-specific hotspot mutations on G12D/S/R have been demonstrated as viable targets.New methods of targeting KRAS are quickly evolving,including transcription,immunogenic neoepitopes,and combinatory targeting with immunotherapy.Nevertheless,the vast majority of small GTPases and hotspot mutations remain elusive,and clinical resistance to G12C inhibitors poses new challenges.In this article,we summarize diversified biological functions,shared structural properties,and complex regulatory mechanisms of small GTPases and their relationships with human diseases.Furthermore,we review the status of drug discovery for targeting small GTPases and the most recent strategic progress focused on targeting KRAS.The discovery of new regulatory mechanisms and development of targeting approaches will together promote drug discovery for small GTPases. | Guowei Yin Jing Huang Johnny Petela Hongmei Jiang Yuetong Zhang Siqi Gong Jiaxin Wu Bei Liu Jianyou Shi Yijun Gao | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 0 |
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