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| 1 | COVID-19 Outbreak Caused by Contaminated Packaging of Imported Cold-Chain Products—Liaoning Province,China,July 2020显示文摘Summary What is known about this topic?Few major outbreaks of coronavirus disease 2019(COVID-19)have occurred in China after major nonpharmaceutical interventions and vaccines have been deployed and implemented.However,sporadic outbreaks that had high possibility to be linked to cold chain products were reported in several cities of China..What is added by this report?In July 2020,a COVID-19 outbreak occurred in Dalian,China.The investigations of this outbreak strongly suggested that the infection source was from COVID-19 virus-contaminated packaging of frozen seafood during inbound unloading personnel contact.What are the implications for public health practice?Virus contaminated paper surfaces could maintain infectivity for at least 17–24 days at-25℃.Exposure to COVID-19 virus-contaminated surfaces is a potential route for introducing the virus to a susceptible population.Countries with no domestic transmission of COVID-19 should consider introducing prevention strategies for both inbound travellers and imported goods.Several measures to prevent the introduction of the virus via cold-chain goods can be implemented. | Huilai Ma1 Jianqun Zhang Ji Wang Ying Qin Cao Chen Yang Song Liang Wang Jun Meng Lingling Mao Fengqin Li Ning Li Jian Cai Yong Zhang Dayan Wang Yunting Xia Hong Wang Shaofeng Jiang Xiang Zhao Peihua Niu Wenjie Tan Tao Ma Yecheng Yao Naiying Mao Zhen Zhu Tianjiao Ji Qian Yang Baoying Huang Li Zhao Jianxing Yu Li Bai Shuangli Zhu Dongyan Wang Yan Zhang Yingwei Sun Mingchun Luan Yanhai Wang Haibo Sun Shihong Yang Zhijian Bo Xiang Ren Zhongjie Li George Fu Gao Wei Yao Wenqing Yao Zijian Feng Wenbo Xu | 2021 | China CDC weekly2021，3，21： | 16 |
| 2 | Human fused NKG2D-IL-15 protein controls xenografted human gastric cancer through the recruitment and activation of NK cells显示文摘Interleukin (IL )-15 在生来的杀手(NK ) 和 CD8+T 房间增长和功能起一个重要作用并且是比为肿瘤免疫疗法的 IL-2 更有效的。由附近的房间的 IL-15 的 trans 演讲比它的可溶的 IL-15 为 NK 房间激活是更有效的。在这研究,熔化蛋白质 dsNKG2D-IL-15,由经由一个连接器联合到人的 IL-15 的人的 NKG2D 的二相同的细胞外的域组成了,在 Escherichia coli 被设计。DsNKG2D-IL-15 能高效地与二个 NKG2D 领域和 trans 礼品 IL-15 把人的肿瘤房间的链相关的蛋白质 A (云母) 绑在主要 histocompatibility 建筑群一级到 NK 或 CD8+ T 房间。我们移植了人的胃的癌症(SGC-7901 ) 房间进裸体老鼠和有进 C57BL/6 老鼠的云母(B16BL6 云母) 的宫外的表示的老鼠黑瘤房间。然后,我们学习了反肿瘤效果在二个 xenografted 肿瘤模特儿由 dsNKG2D-IL-15 调停了。人的 dsNKG2D-IL-15 在压制胃的癌症生长比 IL-15 展出了更高的效率。外长的人的 dsNKG2D-IL-15 集中地在老鼠肿瘤纸巾被散布基于在 vivo 实时成像。房间渗入了进跟随外部血 mononuclear 房间的注射进忍受人的胃的癌症的裸体老鼠的肿瘤纸巾的人的 CD56+ 的频率被人的 dsNKG2D-IL-15 治疗显著地增加。人的 dsNKG2D-IL-15 也由激活和招募的老鼠 NK 和 CD8+ T 房间推迟了移植黑瘤(B16BL6 云母) 的生长。在 C57BL/6 老鼠的人的 dsNKG2D-IL-15 的反黑瘤效果主要被减少由在里面老鼠 NK 房间的 vivo 弄空。这些数据热点为肿瘤的人的 dsNKG2D-IL-15 的潜在的使用治疗。 | Yan Chen Bei Chen Ti Yang Weiming Xiao Li Qian Yanbing Ding Mingchun Ji Xiaoqun Ge Weijuan Gong | 2017 | Cellular & Molecular Immunology2017，14，3： | 6 |
| 3 | Establishment and Characterization of a Cell Based Artificial Antigen-Presenting Cell for Expansion and Activation of CD8^+ T Cells Ex Vivo显示文摘Artificial antigen-presenting cells are expected to stimulate the expansion and acquisition of optimal therapeutic features of T cells before infusion. Here CD32 that binds to a crystallizable fragment of IgG monoclonal antibody was genetically expressed on human K562 leukemia cells to provide a ligand for T-cell receptor. CD86 and 4-1BBL,which are ligands of co-stimulating receptors of CD28 and 4-1BB,respectively,were also expressed on K562 cells. Then we accomplished the artificial antigen-presenting cells by coupling K32/CD86/4-1BBL cell with OKT3 monoclonal antibody against CD3,named K32/CD86/4-1BBL/OKT3 cells. These artificial modified cells had the abilities of inducing CD8+ T cell activation,promoting CD8+ T cell proliferation,division,and long-term growth,inhibiting CD8+ T cell apoptosis,and enhancing CD8+ T cell secretion of IFN-γ and perforin. Furthermore,antigen-specific cytotoxic T lymphocytes could be retained in the culture stimulated with K32/CD86/4-1BBL/OKT3 cells at least within 28 days. This approach was robust,simple,reproducible and economical for expansion and activation of CD8+ T cells and may have important therapeutic implications for adoptive immunotherapy. | Weijuan Gong Mingchun Ji Zhengfeng Cao Liheng Wang Yayun Qian Maozhi Hu Li Qian Xingyuan Pan | 2008 | Cellular & Molecular Immunology2008，5，1： | 5 |
| 4 | Immobilized MHC class I chain-related protein A synergizes with IL-15 and soluble 4-1BB ligand to expand NK cells with high cytotoxicity ex vivo显示文摘Major histocompatibility complex(MHC)class I chain-related protein A(MICA),which is a ligand for human NKG2D,is expressed by a variety of epithelial tumor cells and promotes the activation of natural killer(NK),CD81 and cd-T cells.Although ectopic expression of MICA on tumor cells elicits anti-tumor responses,soluble MICA downregulates the activities of lymphocytes.In this study,we showed that recombinant,immobilized MICA(iMICA)molecules coated on plastic wells weakly promote peripheral NK cell activation,secretion of interferon(IFN)-c and degranulation without inducing apoptosis.In addition,iMICA synergized with IL-15 and soluble 4-1BB ligand(s4-1BBL)to expand NK cells 25-to 42-fold in a 13-day culture,whereas NK cells stimulated only with IL-15 and s4-1BBL expanded 10-to 16-fold.In contrast toNKcells expanded by IL-15 and s4-1BBL stimulation,NKcells expanded long term in the presence of iMICA exhibited increased cytotoxicity against leukemia cells.These results suggest that large numbers ofNKcells with high cytotoxicity can be generated by stimulation with IL-15 and s4-1BBL in the presence of iMICA and that these cells can be used for adoptive cancer immunotherapy. | Weijuan Gong Weiming Xiao Li Qian Chunxiang Gong Maozhi Hu Xianyuan Pan Mingchun Ji | 2010 | Cellular & Molecular Immunology2010，7，6： | 2 |
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