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| 1 | Genomic and genetic alterations influence the progression of gastric cancer显示文摘Gastric cancer is one of the leading causes of cancerrelated deaths worldwide, although the incidence has gradually decreased in many Western countries. Two main gastric cancer histotypes, intestinal and diffuse, are recognised. Although most of the described genetic alterations have been observed in both types, different genetic pathways have been hypothesized. Genetic and epigenetic events, including 1q loss of heterozygosity (LOH), microsatellite instability and hypermethylation, have mostly been reported in intestinal-type gastric carcinoma and its precursor lesions, whereas 17p LOH, mutation or loss of E-cadherin are more often implicated in the development of diffuse-type gastric cancer.In this review, we summarize the sometimes contradictory findings regarding those markers which influence the progression of gastric adenocarcinoma. | Stefania Nobili Lorenzo Bruno Ida Landini Cristina Napoli Paolo Bechi Francesco Tonelli Carlos A Rubio Enrico Mini Gabriella Nesi | 2011 | World Journal of Gastroenterology2011，17，3： | 17 |
| 2 | Biliary tree gastrinomas in multiple endocrine neoplasia type 1 syndrome显示文摘AIM:To describe our patients affected with ectopic biliary tree gastrinoma and review the literature on this topic.METHODS:Between January 1992 and June 2012,28 patients affected by duodenopancreatic endocrine tumors in multiple endocrine neoplasia type 1(MEN1)syndrome underwent surgery at our institution.This retrospective review article analyzes our experience regarding seventeen of these patients subjected to duodenopancreatic surgery for Zollinger-Ellison syndrome(ZES).Surgical treatment consisted of duodenopancreatectomy(DP)or total pancreatectomy(TP).Regional lymphadenectomy was always performed.Any hepatic tumoral lesions found were removed during surgery.In MEN1 patients,removal of duodenal lesions can sometimes lead to persistence or recurrence of hypergastrinemia.One possible explanation for this unfavorable outcome could be unrecognized ectopic localization of gastrin-secreting tumors.This study described three cases among the seventeen patients who were found to have an ectopic gastrinoma located in the biliary tree.RESULTS:Seventeen MEN1 patients affected with ZES were analyzed.The mean age was 40 years.Fifteen patients underwent DP and two TP.On histopathological examination,duodeno pancreatic endocrine tumors were found in all 17 patients.Eighty-one gastrinomas were detected in the first three portions of the duodenum.Only one gastrinoma was found in the pancreas.The mean number of gastrinomas per patient was 5(range 1-16).Malignancy was established in 12 patients(70.5%)after lymph node,liver and omental metastases were found.Three patients exhibited biliary tree gastrinomas as well as duodenal gastrinoma(s).In two cases,the ectopic gastrinoma was removed at the same time as pancreatic surgery,while in the third case,the biliary tree gastrinoma was resected one year after DP because of recurrence of ZES.CONCLUSION:These findings suggest the importance of checking for the presence of ectopic gastrinomas in the biliary tree in MEN1 patients undergoing ZES surgery. | Francesco Tonelli Francesco Giudici Gabriella Nesi Giacomo Batignani Maria Luisa Brandi | 2013 | World Journal of Gastroenterology2013，19，45： | 3 |
| 3 | Well-differentiated endocrine tumor of the distal common bile duct: a case study and literature review显示文摘 | Gabriella Nesi Antonella Lombardi Giacomo Batignani Ferdinando Ficari Carlos A. Rubio Francesco Tonelli | 2006 | Virchows Archiv2006，，1： | 2 |
| 4 | A micrometric classification of intramucosal of the stomach 显示文摘 | Calos A Rubio Gabriella Nesi | 2000 | Gastric cancer2000，3，： | 1 |
| 5 | Pancreatectomy in Multiple Endocrine Neoplasia Type 1-Related Gastrinomas and Pancreatic Endocrine Neoplasias显示文摘 | Francesco Tonelli Geri Fratini Gabriella Nesi Maria Silvia Tommasi Giacomo Batignani Alberto Falchetti Maria Luisa Brandi | 2006 | Annals of Surgery2006，，1： | 1 |
| 6 | Pathology of the thoracic aorta: a morphologic review of 338 surgical specimens over a 7-year period显示文摘 | Gabriella Nesi Chiara Anichini Silvia Tozzini | 2009 | Cardiovascular Pathology2009，18，： | 1 |
| 7 | COUP‐TFII in pancreatic adenocarcinoma: Clinical implication for patient survival and tumor progression显示文摘 | Simone Polvani Mirko Tarocchi Sara Tempesti Tommaso Mello Elisabetta Ceni Francesca Buccoliero Massimo D’Amico Vieri Boddi Marco Farsi Silvia Nesi Gabriella Nesi Stefano Milani Andrea Galli | 2014 | Int. J. Cancer2014，，7： | 1 |
| 8 | Gastric cancer with high-level microsatellite instability: target gene mutations, clinicopathologic features, and long-term survival显示文摘 | Mario Falchetti Calogero Saieva Ramona Lupi Giovanna Masala Piera Rizzolo Ines Zanna Ketty Ceccarelli Francesco Sera Renato Mariani-Costantini Gabriella Nesi Domenico Palli Laura Ottini | 2008 | Human Pathology2008，，6： | 1 |
| 9 | COUP‐TFII in pancreatic adenocarcinoma: Clinical implication for patient survival and tumor progression显示文摘 | Simone Polvani Mirko Tarocchi Sara Tempesti Tommaso Mello Elisabetta Ceni Francesca Buccoliero Massimo D’Amico Vieri Boddi Marco Farsi Silvia Nesi Gabriella Nesi Stefano Milani Andrea Galli | 2014 | Int J Cancer2014，，7： | 1 |
| 10 | Peripancreatic paraganglioma:Lesson from a round table显示文摘We described the case of a peripancreatic paraganglioma(PGL)misdiagnosed as pancreatic lesion.Surgical exploration revealed an unremarkable pancreas and a large well-defined cystic mass originating at the mesocolon root.Radical enucleation of the mass was performed,preserving the pancreatic tail.Histologically,a diagnosis of PGL was rendered.Interestingly,two previously unreported mutations,one affecting the KDR gene in exon 7 and another on the JAK3 gene in exon 4 were detected.Both mutations are known to be pathogenetic.Imaging and cytologic findings were blindly reviewed by an expert panel of clinicians,radiologists,and pathologists to identify possible causes of the misdiagnosis.The major issue was lack of evidence of a cleavage plane from the pancreas at imaging,which prompted radiologists to establish an intraparenchymal origin.The blinded revision shifted the diagnosis towards an extrapancreatic lesion,as the pancreatic parenchyma showed no structural alterations and no dislocation of the Wirsung duct.Ex post,the identified biases were the emergency setting of the radiologic examination and the very thin mesocolon sheet,which hindered clear definition of the lesion borders.Original endoscopic ultrasonography diagnosis was confirmed,emphasizing the intrinsic limit of this technique in detecting large masses.Finally,pathologic review favored a diagnosis of PGL due to the morphological features and immonohistochemical profile.Eighteen months after tumor excision,the patient is asymptomatic with no disease relapse evident by either radiology or laboratory tests.Our report strongly highlights the difficulties in rendering an accurate preoperative diagnosis of PGL. | Federica Petrelli Geri Fratini Andrea Sbrozzi-Vanni Andrea Giusti Raffele Manta Claudio Vignali Gabriella Nesi Andrea Amorosi Andrea Cavazzana Marco Arganini Maria Raffaella Ambrosio | 2022 | World Journal of Gastroenterology2022，28，21： | 0 |
| 11 | Epithelial turnover in duodenal familial adenomatous polyposis: A possible role for estrogen receptors?显示文摘AIM: To investigate estrogen receptors expression in duodenal familial adenomatous polyposis(FAP) and any relationship with epithelial proliferation/apoptosis markers.METHODS: Twenty-two patients affected by FAP undergoing duodenal resection for malignancies were recruited. Controls were 15 healthy subjects undergoing endoscopy for dyspeptic symptoms. ER-α, ER-α, Ki-67, TUNEL and caspase 3 expression(labeling index: percentage of positive cells) were evaluated by immunohistochemistry or immunofluorescence and examined by light or confocal microscopy. Samples were assigned to four groups: normal tissue, low(LGD)and high-grade dysplasia(HGD), adenocarcinoma(AC). One-way analysis of variance, corrected by Bonferroni's test, and Pearson's correlation test were applied for statistical analysis.RESULTS: ER-beta showed a progressive decline: normal tissue(23.5 ± 4.9), LGD(21.1 ± 4.8), HGD(9.3 ± 3.5), AC(7.1 ± 3.1). The normal tissue of FAP subjects expressed ER-beta like the controls(23.9 ± 6.2). Conversely, ER-α showed a progressive increase from normal tissue(24.8 ± 5.6) to AC(52.0 ± 8.2); the expression in normal tissue was similar to controls(22.5 ± 5.3). Ki67 demonstrated a statistically significant progressive increase at each disease stage up to AC. TUNEL did not reveal differences between controls and normal tissue of FAP subjects, but progressive decreases were observed in LGD, through HGD to AC. Pearson's correlation test showed a direct relationship between ER-b and TUNEL LI(r = 0.8088, P < 0.0001). Conversely, ER-α was inversely correlated with TUNEL LI(r =- 0.7257, P < 0.0001). The co-expression of ER-b and caspase 3 declined progressively from normal to neoplastic tissue.CONCLUSION: This study confirmed that ER-b is strongly decreased in duodenal FAP carcinomas, declining in a multiple step fashion, thereby suggesting a putative anti-carcinogenic effect. ER-α showed the opposite trend. ER-b/caspase 3 co-expression suggests this hormone's possible involvement in apoptosis. Hormonal influences in FAP duodenal tumorigenesis, and modulation of these as a possible chemoprevention strategy, may be a promising approach. | Alfredo Di Leo Gabriella Nesi Mariabeatrice Principi Domenico Piscitelli Bruna Girardi Maria Pricci Giuseppe Losurdo Andrea Iannone Enzo Ierardi Francesco Tonelli | 2016 | World Journal of Gastroenterology2016，22，11： | 0 |
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